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The aim of this study was to explore the effect of comorbid HTG and AO and discuss which is the dominant disorder.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this study, 1219 AP patients who presented with HTG or AO were stratified into four groups: non-HTG\u2009+\u2009non-AO, HTG\u2009+\u2009non-AO, non-HTG\u2009+\u2009AO, and HTG\u2009+\u2009AO.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The 328 patients with comorbid HTG\u2009+\u2009AO were much younger (42.29\u2009\u00b1\u200911.77), mainly male (79.57%), and had higher TG levels, larger waist circumferences, and more past medical histories than the patients in the other three non-comorbid groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The comorbidity group developed more incidences of persistent organ failure and local complications (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multivariate logistic regression analysis showed that AO (OR\u2009=\u20093.205, 95% CI\u2009=\u20091.570\u20136.544), mild HTG (OR\u2009=\u20092.746, 95% CI\u2009=\u20091.125\u20136.701), and moderate to very severe HTG (OR\u2009=\u20093.649, 95% CI\u2009=\u20091.403\u20139.493) were independent risk factors for persistent respiratory failure (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Age\u2009&gt;\u200960\u2009years (OR\u2009=\u20091.326, 95% CI\u2009=\u20091.047\u20131.679), AO (OR\u2009=\u20091.701, 95% CI\u2009=\u20091.308\u20132.212), diabetes mellitus (OR\u2009=\u20091.551, 95% CI\u2009=\u20091.063\u20132.261), mild HTG (OR\u2009=\u20091.549, 95% CI\u2009=\u20091.137\u20132.112), and moderate to very severe HTG (OR\u2009=\u20092.810, 95% CI\u2009=\u20091.926\u20134.100) were independent risk factors associated with local complications (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Moreover, HTG seemed to be more dangerous than AO. The higher the serum TG level was, the greater the likelihood of persistent respiratory failure and local complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Comorbid HTG and AO will aggravate the severity and increase the incidence of local complications of AP. HTG may play a dominant role of risk in the condition of comorbidity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Chinese clinical trial registry<\/jats:title>\n                <jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.chictr.org.cn\/showproj.aspx?proj=127374\">ChiCTR2100049566<\/jats:ext-link>. Registered on\u00a03<jats:sup>rd<\/jats:sup> August, 2021. Retrospectively registered, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.chictr.org.cn\/edit.aspx?pid=127374&amp;htm=4\">https:\/\/www.chictr.org.cn\/edit.aspx?pid=127374&amp;htm=4<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12944-021-01597-4","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T17:02:32Z","timestamp":1638032552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The role of comorbid hypertriglyceridemia and abdominal obesity in the severity of acute pancreatitis: a retrospective study"],"prefix":"10.1186","volume":"20","author":[{"given":"Xiaoxi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuli","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaowu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8423-1177","authenticated-orcid":false,"given":"Weiwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"issue":"10","key":"1597_CR1","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1038\/ajg.2015.261","volume":"110","author":"H Nawaz","year":"2015","unstructured":"Nawaz H, Koutroumpakis E, Easler J, Slivka A, Whitcomb DC, Singh VP, et al. 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