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Infectious mononucleosis is a self-limiting, benign lymphoproliferative disorder. This study aimed to investigate the serum triglyceride concentrations and their change over time in patients with infectious mononucleosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We evaluated an adult patient with severe hypertriglyceridemia (&gt;1000\u00a0mg\/dL) during infectious mononucleosis and reviewed the records of 360 patients admitted to our hospital because of infectious mononucleosis (median age, 19 years; range, 15-87 years; 51.4% male). We compared the serum triglyceride concentrations with those of a control sample from the general population (\n                      <jats:italic>n<\/jats:italic>\n                      =75). A second triglyceride measurement, obtained during convalescence (median of 30 days after the initial determination), was available for 160 patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The triglyceride concentrations in the acute phase (median: 156\u00a0mg\/dL) were significantly higher than those of the controls (median, 76\u00a0mg\/dL;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). A total of 194 (53.9%) patients presented with hypertriglyceridemia (&gt;150\u00a0mg\/dL), which was more common in the patients older than 30 years than in the younger patients (78.6% vs. 50.6%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). A significant correlation (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.005) was observed between the triglyceride levels and white blood cell counts, total cholesterol levels, and liver damage markers. The triglyceride concentrations decreased during convalescence (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) and were lower than the initial measurement in 83.7% of the cases. Conversely, the total cholesterol concentrations during the acute phase were lower than those of the controls and increased during convalescence (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with severe infectious mononucleosis frequently show mild, transient hypertriglyceridemia. Further studies are needed to elucidate the mechanisms underlying this finding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12944-021-01603-9","type":"journal-article","created":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T12:02:27Z","timestamp":1639310547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Transient hypertriglyceridemia: a common finding during Epstein-Barr virus-induced infectious mononucleosis"],"prefix":"10.1186","volume":"20","author":[{"given":"Emilio-Manuel","family":"P\u00e1ez-Guill\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Campos-Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Alende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yago","family":"Garitaonaind\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Gonz\u00e1lez-Quintela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,12]]},"reference":[{"key":"1603_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.7326\/0003-4819-118-1-199301010-00009","volume":"118","author":"SE Straus","year":"1993","unstructured":"Straus SE, Cohen JI, Tosato G, Meier J. 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