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Extracellular vesicles (EVs) secreted by cancer cells actively engage in inter-tissue communication; EVs and enclosed cytokines are largely undefined in CC adipocytes wasting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EVs derived from Lewis lung carcinoma (LLC) and colorectal cancer C26 cells were extracted and characterized. Conditioned medium and EVs from cancer cells were applied to 3\u2009T3-L1 adipocytes. Recombinant IL-8, IL-8 neutralizing antibody, CXCR2 and NF-\u03baB inhibitor were examined in functional assays. Lipolysis of adipocytes was monitored by Western blots, Oil red O staining and glycerol assays. Furthermore, LLC and C26 cell lines were established as cachexia model to explore the relevance of IL-8 and NF-\u03baB signaling in CC adipose wasting. Adipose tissues were collected for histology analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LLC and C26 cell-derived EVs induced lipolysis of 3\u2009T3-L1 adipocytes. Specially, Dil-labeled EVs were effectively taken up by 3\u2009T3-L1 adipocytes, which were motivated by the delivered IL-8 to elicit the NF-\u03baB pathway. In comparison, special IL-8 neutralizing antibody relieved that lipolysis of 3\u2009T3-L1 adipocytes induced by EVs together with conditioned medium of LLC and C26 cells, respectively. Consistently, both CXCR2 and NF-\u03baB inhibitors would lessen the phenotype of lipolysis in 3\u2009T3-L1 adipocytes. In the in vivo settings, both LLC and C26-tumor bearing mice had higher serum IL-8 levels as compared to the control groups. Two typical lipolysis markers, PGC1\u03b1 and UCP1, were also up-regulated in the adipose tissues of LLC and C26-tumor mice groups, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EVs secreted by LLC and C26 tumor cells would induce adipocyte wasting via extracellular IL-8-mediated NF-\u03baB signaling. Our study pointed out the physiological and therapeutic values of exosomal IL-8 in CC lipolysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12944-022-01755-2","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T05:02:36Z","timestamp":1672290156000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Exosomal IL-8 derived from Lung Cancer and Colon Cancer cells induced adipocyte atrophy via NF-\u03baB signaling pathway"],"prefix":"10.1186","volume":"21","author":[{"given":"Hairong","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kairu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"issue":"3","key":"1755_CR1","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1002\/jcsm.12528","volume":"11","author":"DSS Peixoto","year":"2020","unstructured":"Peixoto DSS, Santos J, Costa ESM, Gil DCR, Medeiros R. 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