{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:11:09Z","timestamp":1793481069842,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T00:00:00Z","timestamp":1672444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T00:00:00Z","timestamp":1672444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Tianjin Union Medical Centre Project","award":["2020YJ019"],"award-info":[{"award-number":["2020YJ019"]}]},{"name":"Tianjin Union Medical Centre Project","award":["2020YJ019"],"award-info":[{"award-number":["2020YJ019"]}]},{"name":"Tianjin Union Medical Centre Project","award":["2020YJ019"],"award-info":[{"award-number":["2020YJ019"]}]},{"name":"Tianjin Union Medical Centre Project","award":["2020YJ019"],"award-info":[{"award-number":["2020YJ019"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Both hyperuricaemia and hyperlipidaemia are common metabolic diseases that are closely related to each other, and both are independent risk factors for the development of a variety of diseases. HUA combined with hyperlipidaemia increases the risk of nonalcoholic fatty liver disease and coronary heart disease. This study aimed to investigate the relationship between HUA and hyperlipidaemia and study the metabolic pathway changes in patients with HUA associated with hyperlipidaemia using metabolomics.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was a case\u2012control study. The prevalence of hyperlipidaemia in HUA patients in the physical examination population of Tianjin Union Medical Centre in 2018 was investigated. Metabolomics analysis was performed on 308 HUA patients and 100 normal controls using Orbitrap mass spectrometry. A further metabolomics\u00a0study of 30 asymptomatic HUA patients, 30 HUA patients with hyperlipidaemia, and 30\u00a0age-and\u00a0sex-matched\u00a0healthy\u00a0controls was conducted. Differential metabolites were obtained from the three groups by orthogonal partial least-squares discrimination analysis, and relevant metabolic pathways changes were analysed using MetaboAnalyst 5.0 software.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The prevalence of hyperlipidaemia in HUA patients was 69.3%. Metabolomic analysis found that compared with the control group, 33 differential metabolites, including arachidonic acid, alanine, aspartate, phenylalanine and tyrosine, were identified in asymptomatic HUA patients. Pathway analysis showed that these changes were mainly related to 3 metabolic pathways, including the alanine, aspartate and glutamate metabolism pathway. Thirty-eight differential metabolites, including linoleic acid, serine, glutamate, and tyrosine, were identified in HUA patients with hyperlipidaemia. Pathway analysis showed that they were mainly related to 7 metabolic pathways, including the linoleic acid metabolism pathway, phenylalanine, tyrosine and tryptophan biosynthesis pathway, and glycine, serine and threonine metabolism pathway.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Compared to the general population, the HUA population had a higher incidence of hyperlipidaemia. HUA can cause hyperlipidaemia. by affecting the metabolic pathways of linoleic acid metabolism and alanine, aspartate and glutamate metabolism. Fatty liver is closely associated with changes in the\u00a0biosynthesis\u00a0pathway\u00a0of\u00a0pahenylalanine, tyrosine, and tryptophan in HUA patients with hyperlipidaemia. Changes in the glycine, serine and threonine metabolism pathway in HUA patients with hyperlipidaemia may lead to chronic kidney disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12944-022-01765-0","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T03:02:43Z","timestamp":1672455763000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Metabolic pathway analysis of hyperuricaemia patients with hyperlipidaemia based on high-throughput mass spectrometry: a case\u2012control study"],"prefix":"10.1186","volume":"21","author":[{"given":"Xue","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanning","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,31]]},"reference":[{"issue":"18","key":"1765_CR1","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.3390\/molecules24183248","volume":"24","author":"W Zhang","year":"2019","unstructured":"Zhang W, Du W, Li G, Zhang C, Yang W, Yang S, et al. Constituents and Anti-Hyperuricemia Mechanism of Traditional Chinese Herbal Formulae Erding Granule. Molecules. 2019;24(18):3248. https:\/\/doi.org\/10.3390\/molecules24183248.","journal-title":"Molecules"},{"issue":"12","key":"1765_CR2","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1007\/s11255-019-02256-5","volume":"51","author":"C Hu","year":"2019","unstructured":"Hu C, Wu X. Treatment of asymptomatic hyperuricemia complicated by renal damage: a controversial issue. Int Urol Nephrol. 2019;51(12):2227\u201333. https:\/\/doi.org\/10.1007\/s11255-019-02256-5.","journal-title":"Int Urol Nephrol"},{"key":"1765_CR3","doi-asserted-by":"publisher","first-page":"114545","DOI":"10.1016\/j.jep.2021.114545","volume":"281","author":"B Shan","year":"2021","unstructured":"Shan B, Chen T, Huang B, Liu Y, Chen J. Untargeted metabolomics reveal the therapeutic effects of Ermiao wan categorized formulas on rats with hyperuricemia. J Ethnopharmacol. 2021;281:114545. https:\/\/doi.org\/10.1016\/j.jep.2021.114545.","journal-title":"J Ethnopharmacol"},{"key":"1765_CR4","doi-asserted-by":"publisher","unstructured":"Guo LF, Chen X, Lei SS, Li B, Zhang NY, Ge HZ, et al. Effects and Mechanisms of\u00a0Dendrobium officinalis\u00a0Six Nostrum for Treatment of Hyperuricemia with Hyperlipidemia.\u00a0Evid Based Complement Alternat Med. 2020;2914019. doi:https:\/\/doi.org\/10.1155\/2020\/2914019.","DOI":"10.1155\/2020\/2914019"},{"issue":"12","key":"1765_CR5","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s11906-020-01116-3","volume":"22","author":"JT Kielstein","year":"2020","unstructured":"Kielstein JT, Pontremoli R, Burnier M. Management of Hyperuricemia in Patients with Chronic Kidney Disease: a Focus on Renal Protection. Curr Hypertens Rep. 2020;22(12):102. https:\/\/doi.org\/10.1007\/s11906-020-01116-3.","journal-title":"Curr Hypertens Rep"},{"issue":"9","key":"1765_CR6","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1002\/acr.24013","volume":"72","author":"F Wang","year":"2020","unstructured":"Wang F, Sun L, Zong G, Gao X, Zhang H, Xiong Q, et al. Associations of Amino Acid and Acylcarnitine Profiles With Incident Hyperuricemia in Middle-Aged and Older Chinese Individuals. Arthritis Care Res (Hoboken). 2020;72(9):1305\u201314. https:\/\/doi.org\/10.1002\/acr.24013.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"1765_CR7","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.cca.2020.08.002","volume":"510","author":"H Zhao","year":"2020","unstructured":"Zhao H, Zhang Y, Liu B, Zhang L, Bao M, Li L, et al. A pilot study to identify the longitudinal serum metabolite profiles to predict the development of hyperuricemia in essential hypertension. Clin Chim Acta. 2020;510:466\u201374. https:\/\/doi.org\/10.1016\/j.cca.2020.08.002.","journal-title":"Clin Chim Acta"},{"issue":"8","key":"1765_CR8","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.metabol.2016.05.003","volume":"65","author":"N Katsiki","year":"2016","unstructured":"Katsiki N, Mikhailidis DP, Mantzoros CS. Non-alcoholic fatty liver disease and dyslipidemia: An update. Metabolism. 2016;65(8):1109\u201323. https:\/\/doi.org\/10.1016\/j.metabol.2016.05.003.","journal-title":"Metabolism"},{"issue":"1","key":"1765_CR9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s11154-016-9402-z","volume":"18","author":"MR Hager","year":"2017","unstructured":"Hager MR, Narla AD, Tannock LR. Dyslipidemia in patients with chronic kidney disease. Rev Endocr Metab Disord. 2017;18(1):29\u201340. https:\/\/doi.org\/10.1007\/s11154-016-9402-z.","journal-title":"Rev Endocr Metab Disord"},{"issue":"7","key":"1765_CR10","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1097\/MCA.0000000000000911","volume":"31","author":"P He","year":"2020","unstructured":"He P, Fan SY, Guan JQ, Song WJ, Obore N, Chen WQ, et al. Mediation analysis for the relationship between dyslipidemia and coronary artery disease via hypersensitive C-reactive protein in a case-control study. Coron Artery Dis. 2020;31(7):613\u20139. https:\/\/doi.org\/10.1097\/MCA.0000000000000911.","journal-title":"Coron Artery Dis"},{"issue":"14","key":"1765_CR11","first-page":"155","volume":"6","author":"HP Xu","year":"2016","unstructured":"Xu HP, Rao LL, Huang H, Zhou QQ. Epidemiological investigation on TCM syndrome of patients with hyperuricemia and hyperlipidemia in Hakka population in Huizhou. China Med Pharmacy. 2016;6(14):155\u20137+165.","journal-title":"China Med Pharmacy"},{"issue":"07","key":"1765_CR12","first-page":"801","volume":"47","author":"J Guo","year":"2019","unstructured":"Guo J, Luo WH, Xian W. Study on the correlation between high blood uric acid level and hyperlipidemia. Mod Med. 2019;47(07):801\u20134.","journal-title":"Mod Med"},{"key":"1765_CR13","unstructured":"Dong PF. Correlation between fatty liver and hyperlipidemia, diabetes, hyperuricemia and hypertension in middle-aged and elderly people.Medical Diet and Health. 2019;(11):35+38."},{"issue":"06","key":"1765_CR14","doi-asserted-by":"publisher","first-page":"895","DOI":"10.13820\/j.cnki.gdyx.2016.06.027","volume":"37","author":"RK Lai","year":"2016","unstructured":"Lai RK, Sheng XG, Pan GM. Correlation between hyperlipidemia with hyperuricemia and coronary artery disease. Guangdong Medical Journal. 2016;37(06):895\u20137. https:\/\/doi.org\/10.13820\/j.cnki.gdyx.2016.06.027.","journal-title":"Guangdong Medical Journal"},{"issue":"22","key":"1765_CR15","first-page":"3437","volume":"38","author":"XL Liu","year":"2016","unstructured":"Liu XL. Study on the correlation between hyperlipidemia with hyperuricemia and coronary heart disease. Hebei Medical Journal. 2016;38(22):3437\u20139.","journal-title":"Hebei Medical Journal"},{"issue":"1","key":"1765_CR16","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1186\/s13071-021-04834-y","volume":"14","author":"XM Wu","year":"2021","unstructured":"Wu XM, Yang X, Fan XC, Chen X, Wang YX, Zhang LX, et al. Serum metabolomics in chickens infected with Cryptosporidium baileyi. Parasit Vectors. 2021;14(1):336. https:\/\/doi.org\/10.1186\/s13071-021-04834-y.","journal-title":"Parasit Vectors"},{"key":"1765_CR17","doi-asserted-by":"publisher","first-page":"617050","DOI":"10.3389\/fmicb.2021.617050","volume":"12","author":"J Li","year":"2021","unstructured":"Li J, Zhang Y, Wang X, Walk ST, Wang G. Integrated Metabolomics and Targeted Gene Transcription Analysis Reveal Global Bacterial Antimonite Resistance Mechanisms. Front Microbiol. 2021;12:617050. https:\/\/doi.org\/10.3389\/fmicb.2021.617050.","journal-title":"Front Microbiol"},{"issue":"4","key":"1765_CR18","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1152\/physrev.00035.2018","volume":"99","author":"DS Wishart","year":"2019","unstructured":"Wishart DS. Metabolomics for Investigating Physiological and Pathophysiological Processes. Physiol Rev. 2019;99(4):1819\u201375. https:\/\/doi.org\/10.1152\/physrev.00035.2018.","journal-title":"Physiol Rev"},{"issue":"33","key":"1765_CR19","doi-asserted-by":"publisher","first-page":"11938","DOI":"10.1074\/jbc.REV119.007624","volume":"295","author":"YP Wang","year":"2020","unstructured":"Wang YP, Li JT, Qu J, Yin M, Lei QY. Metabolite sensing and signaling in cancer. J Biol Chem. 2020;295(33):11938\u201346. https:\/\/doi.org\/10.1074\/jbc.REV119.007624.","journal-title":"J Biol Chem"},{"key":"1765_CR20","doi-asserted-by":"publisher","first-page":"108182","DOI":"10.1016\/j.exer.2020.108182","volume":"199","author":"B Du","year":"2020","unstructured":"Du B, Jin N, Zhu X, Lu D, Jin C, Li Z, et al. A prospective study of serum metabolomic and lipidomic changes in myopic children and adolescents. Exp Eye Res. 2020;199:108182. https:\/\/doi.org\/10.1016\/j.exer.2020.108182.","journal-title":"Exp Eye Res"},{"issue":"1","key":"1765_CR21","doi-asserted-by":"publisher","first-page":"3750","DOI":"10.1038\/s41598-018-22167-2","volume":"8","author":"J Pan","year":"2018","unstructured":"Pan J, Ren Z, Li W, Wei Z, Rao H, Ren H, et al. Prevalence of hyperlipidemia in Shanxi Province, China and application of Bayesian networks to analyse its related factors. Sci Rep. 2018;8(1):3750. https:\/\/doi.org\/10.1038\/s41598-018-22167-2.","journal-title":"Sci Rep"},{"key":"1765_CR22","doi-asserted-by":"publisher","unstructured":"Han B, Gong M, Li Z, Qiu Y, Zou Z. NMR-Based Metabonomic Study Reveals Intervention Effects of Polydatin on Potassium Oxonate-Induced Hyperuricemia in Rats. Oxid Med Cell Longev. 2020;6943860. doi: https:\/\/doi.org\/10.1155\/2020\/6943860.","DOI":"10.1155\/2020\/6943860"},{"issue":"10","key":"1765_CR23","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.2337\/db12-1814","volume":"62","author":"RJ Johnson","year":"2013","unstructured":"Johnson RJ, Nakagawa T, Sanchez-Lozada LG, Shafiu M, Sundaram S, Le M, et al. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes. 2013;62(10):3307\u201315. https:\/\/doi.org\/10.2337\/db12-1814.","journal-title":"Diabetes"},{"key":"1765_CR24","doi-asserted-by":"publisher","unstructured":"Qin N, Jiang Y, Shi W, Wang L, Kong L, Wang C, et al. High-Throughput Untargeted Serum Metabolomics Analysis of Hyperuricemia Patients by UPLC-Q-TOF\/MS. Evid Based Complement Alternat Med. 2021;5524772. doi: https:\/\/doi.org\/10.1155\/2021\/5524772.","DOI":"10.1155\/2021\/5524772"},{"issue":"Pt B","key":"1765_CR25","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.prostaglandins.2015.09.003","volume":"121","author":"D Maciejewska","year":"2015","unstructured":"Maciejewska D, Ossowski P, Drozd A, Ryterska K, Jamio\u0142-Milc D, Banaszczak M, et al. Metabolites of arachidonic acid and linoleic acid in early stages of non-alcoholic fatty liver disease\u2013A pilot study. Prostaglandins Other Lipid Mediat. 2015;121(Pt B):184\u20139. https:\/\/doi.org\/10.1016\/j.prostaglandins.2015.09.003.","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"9","key":"1765_CR26","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1194\/jlr.M083741","volume":"59","author":"S Schuster","year":"2018","unstructured":"Schuster S, Johnson CD, Hennebelle M, Holtmann T, Taha AY, Kirpich IA, et al. Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice. J Lipid Res. 2018;59(9):1597\u2013609. https:\/\/doi.org\/10.1194\/jlr.M083741.","journal-title":"J Lipid Res"},{"issue":"3","key":"1765_CR27","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3945\/an.113.003772","volume":"4","author":"J Whelan","year":"2013","unstructured":"Whelan J, Fritsche K. Linoleic acid. Adv Nutr. 2013;4(3):311\u20132. https:\/\/doi.org\/10.3945\/an.113.003772.","journal-title":"Adv Nutr"},{"issue":"Z3","key":"1765_CR28","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.13417\/j.gab.040.003364","volume":"40","author":"YM Zhao","year":"2021","unstructured":"Zhao YM, Yang QX, Zuo LF, Zhan Y, Yin YJ, Zhang J. Effects of saturated and unsaturated fatty acids on the inflammatory state of macrophages. Genomics and Applied Biology. 2021;40(Z3):3364\u201371. https:\/\/doi.org\/10.13417\/j.gab.040.003364.","journal-title":"Genomics and Applied Biology"},{"issue":"11","key":"1765_CR29","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1007\/s00726-018-2627-2","volume":"50","author":"Y Luo","year":"2018","unstructured":"Luo Y, Wang L, Liu XY, Chen X, Song YX, Li XH, et al. Plasma profiling of amino acids distinguishes acute gout from asymptomatic hyperuricemia. Amino Acids. 2018;50(11):1539\u201348. https:\/\/doi.org\/10.1007\/s00726-018-2627-2.","journal-title":"Amino Acids"},{"issue":"1","key":"1765_CR30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12199-017-0609-8","volume":"22","author":"MH Mahbub","year":"2017","unstructured":"Mahbub MH, Yamaguchi N, Takahashi H, Hase R, Amano H, Kobayashi-Miura M, et al. Alteration in plasma free amino acid levels and its association with gout. Environ Health Prev Med. 2017;22(1):7. https:\/\/doi.org\/10.1186\/s12199-017-0609-8.","journal-title":"Environ Health Prev Med"},{"issue":"9","key":"1765_CR31","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1002\/art.41733","volume":"73","author":"X Shen","year":"2021","unstructured":"Shen X, Wang C, Liang N, Liu Z, Li X, Zhu ZJ, et al. Serum Metabolomics Identifies Dysregulated Pathways and Potential Metabolic Biomarkers for Hyperuricemia and Gout. Arthritis Rheumatol. 2021;73(9):1738\u201348. https:\/\/doi.org\/10.1002\/art.41733.","journal-title":"Arthritis Rheumatol"},{"key":"1765_CR32","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jchromb.2019.04.032","volume":"1118\u20131119","author":"B Huang","year":"2019","unstructured":"Huang B, Hu X, Wang J, Li P, Chen J. Study on chemical constituents of herbal formula Er Miao Wan and GC-MS based metabolomics approach to evaluate its therapeutic effects on hyperuricemic rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2019;1118\u20131119:101\u20138. https:\/\/doi.org\/10.1016\/j.jchromb.2019.04.032.","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"03","key":"1765_CR33","first-page":"404","volume":"29","author":"JC Zhao","year":"2022","unstructured":"Zhao JC, Song YJ, Wang Z, Li CL. Relationship between phenylalanine\/tyrosine metabolic pathway and its related products and nonalcoholic fatty liver disease. Chinese J Bases and Clin Gen Surg. 2022;29(03):404\u20139.","journal-title":"Chinese J Bases and Clin Gen Surg"},{"key":"1765_CR34","doi-asserted-by":"publisher","first-page":"111042","DOI":"10.1016\/j.nut.2020.111042","volume":"82","author":"R Suzuki","year":"2021","unstructured":"Suzuki R, Sato Y, Fukaya M, Suzuki D, Yoshizawa F, Sato Y. Energy metabolism profile of the effects of amino acid treatment on hepatocytes: Phenylalanine and phenylpyruvate inhibit glycolysis of hepatocytes. Nutrition. 2021;82:111042. https:\/\/doi.org\/10.1016\/j.nut.2020.111042.","journal-title":"Nutrition"},{"key":"1765_CR35","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/978-3-319-48382-5_12","volume":"960","author":"D Yaz\u0131c\u0131","year":"2017","unstructured":"Yaz\u0131c\u0131 D, Sezer H. Insulin Resistance, Obesity and Lipotoxicity. Adv Exp Med Biol. 2017;960:277\u2013304. https:\/\/doi.org\/10.1007\/978-3-319-48382-5_12.","journal-title":"Adv Exp Med Biol"},{"key":"1765_CR36","doi-asserted-by":"crossref","unstructured":"Maru\u0161i\u0107 M, Pai\u0107 M, Knobloch M, Liberati Pr\u0161o AM. NAFLD, Insulin Resistance, and Diabetes Mellitus Type 2. Can J Gastroenterol Hepatol. 2021;6613827.","DOI":"10.1155\/2021\/6613827"},{"issue":"10","key":"1765_CR37","first-page":"4480","volume":"32","author":"LQ He","year":"2020","unstructured":"He LQ, Jin SS, Zhou XH, Li TJ, Yin YL. Research progress on the effect of serine on animal health. Chinese J Anim Nutri. 2020;32(10):4480\u201390.","journal-title":"Chinese J Anim Nutri"},{"issue":"2","key":"1765_CR38","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.apsb.2019.10.007","volume":"10","author":"L Pan","year":"2020","unstructured":"Pan L, Han P, Ma S, Peng R, Wang C, Kong W, et al. Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia. Acta Pharm Sin B. 2020;10(2):249\u201361. https:\/\/doi.org\/10.1016\/j.apsb.2019.10.007.","journal-title":"Acta Pharm Sin B"},{"issue":"6","key":"1765_CR39","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.4049\/jimmunol.1801166","volume":"202","author":"R Liu","year":"2019","unstructured":"Liu R, Liao XY, Pan MX, Tang JC, Chen SF, Zhang Y, et al. Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-\u03baB p65\/Hif-1\u03b1 Signaling Pathway. J Immunol. 2019;202(6):1704\u201314. https:\/\/doi.org\/10.4049\/jimmunol.1801166.","journal-title":"J Immunol"},{"issue":"20","key":"1765_CR40","doi-asserted-by":"publisher","first-page":"7695","DOI":"10.3390\/ijms21207695","volume":"21","author":"Y Wang","year":"2020","unstructured":"Wang Y, Kong W, Wang L, Zhang T, Huang B, Meng J, et al. Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis. Int J Mol Sci. 2020;21(20):7695. https:\/\/doi.org\/10.3390\/ijms21207695.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"1765_CR41","doi-asserted-by":"publisher","first-page":"e0228684","DOI":"10.1371\/journal.pone.0228684","volume":"15","author":"M Son","year":"2020","unstructured":"Son M, Seo J, Yang S. Association between dyslipidemia and serum uric acid levels in Korean adults: Korea National Health and Nutrition Examination Survey 2016\u20132017. PLoS ONE. 2020;15(2):e0228684. https:\/\/doi.org\/10.1371\/journal.pone.0228684.","journal-title":"PLoS ONE"},{"issue":"1","key":"1765_CR42","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12944-020-01211-z","volume":"19","author":"F Liu","year":"2020","unstructured":"Liu F, Du GL, Song N, Ma YT, Li XM, Gao XM, et al. Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008\u20132012). Lipids Health Dis. 2020;19(1):58. https:\/\/doi.org\/10.1186\/s12944-020-01211-z.","journal-title":"Lipids Health Dis"},{"issue":"6","key":"1765_CR43","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.4268\/cjcmm20160627","volume":"41","author":"SL Zhang","year":"2016","unstructured":"Zhang SL, Wang YP, Du ZX, Xue M, Zhang J, Ma Q. Lipid metabolomics in serum of hyperuricemic rats induced by fructose based on UPC2-Q\/TOF-MS. China J Chin Materia Med. 2016;41(6):1135\u20139. https:\/\/doi.org\/10.4268\/cjcmm20160627.","journal-title":"China J Chin Materia Med"},{"issue":"09","key":"1765_CR44","first-page":"1134","volume":"44","author":"LY Song","year":"2019","unstructured":"Song LY. Research progress on the relationship between hyperuricemia and metabolic syndrome. Heilongjiang Med J. 2019;44(09):1134\u201311351138.","journal-title":"Heilongjiang Med J"}],"updated-by":[{"DOI":"10.1186\/s12944-023-01785-4","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T00:00:00Z","timestamp":1675468800000}}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-022-01765-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12944-022-01765-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-022-01765-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T07:11:19Z","timestamp":1675494679000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/s12944-022-01765-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,31]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1765"],"URL":"https:\/\/doi.org\/10.1186\/s12944-022-01765-0","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,31]]},"assertion":[{"value":"5 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2023","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12944-023-01785-4","URL":"https:\/\/doi.org\/10.1186\/s12944-023-01785-4","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the\u00a0Tianjin Union Medical Centre committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors read and approved of this manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"151"}}