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Although the relationship between periodontitis and systemic disease constitutes an important aspect of periodontal clinical research, the systemic effects of NIR-PBM in periodontitis are not well known. In this study, we aimed to investigate the effects of NIR-PBM on systemic oxidative stress and inflammation in an apolipoprotein E (ApoE) knockout mouse model of periodontal disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We evaluated alveolar bone loss by measuring the distance from the cementoenamel junction (CEJ) to the alveolar bone crest (ABC), reactive oxygen species (ROS) production in blood cells, inflammatory activity, plasma cholesterol levels, and lipid peroxidation levels in three experimental groups: (1) ApoEC, control group without intervention; (2) ApoEP, first molar ligation-induced periodontitis for 4 weeks; and (3) ApoEP\u2009+\u2009PBM, exposed to 808\u00a0nm continuous wave, \u00f8 ~ 3 mm2, 100 mW, 60\u00a0s of NIR-PBM for 7 consecutive days after 4 weeks of periodontitis. At the end of the experimental protocols, ApoEP mice presented significantly increased alveolar bone loss, ROS production, inflammatory activity, plasma cholesterol, and lipid peroxidation levels compared to the ApoEC group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). NIR-PBM for 7 days in the ApoEP\u2009+\u2009PBM mice significantly decreased systemic ROS production, inflammatory response, plasma cholesterol, and lipid peroxidation levels, similar to those found in the ApoEC group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, it was not capable of preventing alveolar bone loss (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05 compared to ApoEP mice).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A 7-day treatment with NIR-PBM effectively reduces systemic oxidative stress and inflammatory parameters in hypercholesterolemic mice with PD. However, more studies with longer evaluation times are needed to confirm the systemic effects of locally applied NIR-PBM on PD associated with hypercholesterolemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12944-023-01934-9","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:02:02Z","timestamp":1696939322000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Infrared laser therapy decreases systemic oxidative stress and inflammation in hypercholesterolemic mice with periodontitis"],"prefix":"10.1186","volume":"22","author":[{"given":"Isadora Martins","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eduarda","family":"de Souza Barroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar Hell","family":"Kampke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Trarbach Figueiredo","family":"Braga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca Prandi","family":"Campagnaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana dos Santos","family":"Meyrelles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"1934_CR1","doi-asserted-by":"publisher","DOI":"10.1117\/2.1200802.10144","author":"H Whelan","year":"2008","unstructured":"Whelan H, Desmet K, Buchmann E, Henry M, Wong-Riley M, Eells J, Verhoeve J. 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