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However, population-based morbidity assessments need to be updated. Early, rapid, and effective lipid-lowering may minimize pancreatic injury and improve clinical prognosis. It is essential to choose the proper treatment. However, treatment options for HLAP are controversial, and there is no uniform treatment protocol.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this retrospective study, 127 patients with hyperlipidemic severe acute pancreatitis (HL-SAP) were registered from January 2018 to December 2022 at the General Hospital of Ningxia Medical University. Medical and radiological records of hospitalized patients were collected to determine clinical features, severity, complications, mortality, recurrence rate, and treatment. Risk factors for HL-SAP were analyzed using multifactorial logistic regression. A propensity score matching method was used to compare the clinical outcomes of standard and plasma exchange therapies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In this research, the prevalence of HLAP increased about 1.6 times, and the prevalence of HL-SAP was 50.60%. HL-SAP occurs most often in people between the ages of 30 and 39. Amylase exceeded 110 U\/L in 84.3% of patients and 330 U\/L in only 47.2%. 83.5% of HL-SAP patients had fatty livers and high body mass index (BMI). A total of 48.0% of patients experienced organ failure, ICU treatment (55.1%), recurrence (33.1%), and death (21.3%). Between the hyperlipidemic group and the biliary group in terms of age, gender, BMI, fatty liver, pleural effusion, abdominal constriction syndrome (ACS), multiple organ dysfunction syndrome (MODS), length of hospital, medical costs, morbidity and mortality, triglyceride, cholesterol, creatinine, blood glucose, D-dimer, amylase, albumin, lactate dehydrogenase, serum phosphorus, serum calcium, oxygenation index, and recurrence rate were statistically significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). High BMI (<jats:italic>P<\/jats:italic>\u2009=\u20090.0038, odds ratio (OR)\u2009=\u20091.336, 95%CI: 0.99\u20131.804), high C-reactive protein (CRP) (<jats:italic>P<\/jats:italic>\u2009=\u20090.022, OR\u2009=\u20091.011, 95%CI: 1.003\u20131.019), low calcium (<jats:italic>P<\/jats:italic>\u2009=\u20090.003, OR\u2009=\u20090.016, 95%CI. 0.001\u20130.239), low albumin (<jats:italic>P<\/jats:italic>\u2009=\u20090.012, OR\u2009=\u20090.045, 95%CI: -0.062-0.192), and high D-dimer (<jats:italic>P<\/jats:italic>\u2009=\u20090.041, OR\u2009=\u20090.619, 95%CI: 0.053\u20132.510) were risk factors for HL-SAP, according to multifactorial logistic regression analysis. Adjusted for propensity score matching (PSM), Serum triglyceride (TG) was significantly lower in both the standard treatment (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and plasma exchange (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) groups at 48\u00a0h compared with the initial test after the attack. Clearance (83.20% \u00b1 0.0% vs. 84.4% \u00b1 0.0%, <jats:italic>P<\/jats:italic>\u2009=\u20090.531), length of hospital stay (19.9\u2009\u00b1\u20094.9 vs. 19.8\u2009\u00b1\u200911.1, <jats:italic>P<\/jats:italic>\u2009=\u20090.092), and death (26.3% vs. 23.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.791) showed no difference between the two groups. However, the difference in medical costs(<jats:italic>P<\/jats:italic>\u2009=\u20090.039)between the two groups was statistically significant.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The incidence of HLAP exhibited a significant increase, remarkable severity, recurrent trend, and mortality. High BMI, high CRP, low calcium, low albumin, and high D-dimer are risk factors for HL-SAP. Compared with standardized treatment, plasma exchange does not improve the prognosis of HL-SAP patients, and standardized treatment is equally effective, safe, and low-cost in early treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12944-024-02057-5","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T08:02:06Z","timestamp":1709884926000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Analysis of the clinical profile and treatment efficiency of hyperlipidemic acute pancreatitis"],"prefix":"10.1186","volume":"23","author":[{"given":"Weidong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinfu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"2057_CR1","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1093\/jcag\/gwab002.244","volume":"4","author":"J Iannuzzi","year":"2021","unstructured":"Iannuzzi J, Leong JH, Quan J, et al. 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Informed written consent was obtained from the patient to publish this report and any accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have agreed to the publication of this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"70"}}