{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T13:25:34Z","timestamp":1786195534411,"version":"build-2736575974"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"DOI":"10.1186\/s12944-024-02223-9","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T13:02:30Z","timestamp":1722344550000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The association between fat distribution and \u03b11-acid glycoprotein levels among adult females in the United States"],"prefix":"10.1186","volume":"23","author":[{"given":"Siqi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqi","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"issue":"4","key":"2223_CR1","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.fertnstert.2017.02.104","volume":"107","author":"DR Meldrum","year":"2017","unstructured":"Meldrum DR, Morris MA, Gambone JC. Obesity pandemic: causes, consequences, and solutions\u2014but do we have the will? Fertil Steril. 2017;107(4):833\u20139.\u00a0Available from:\u00a0https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0015028217302236. Cited 2024 Jan 23.","journal-title":"Fertil Steril"},{"key":"2223_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/289645","volume":"2010","author":"R Monteiro","year":"2010","unstructured":"Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators of Inflammation. 2010;2010:1\u201310.\u00a0Available from:\u00a0http:\/\/www.hindawi.com\/journals\/mi\/2010\/289645\/. Cited 2024 Jan 12.","journal-title":"Mediators of Inflammation"},{"issue":"7121","key":"2223_CR3","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature05485","volume":"444","author":"GS Hotamisligil","year":"2006","unstructured":"Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444(7121):860\u20137.\u00a0Available from:\u00a0https:\/\/www.nature.com\/articles\/nature05485. Cited 2024 Jan 12.","journal-title":"Nature"},{"issue":"7","key":"2223_CR4","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1172\/JCI29069","volume":"116","author":"SE Shoelson","year":"2006","unstructured":"Shoelson SE. Inflammation and insulin resistance. J Clin Invest. 2006;116(7):1793\u2013801.\u00a0Available from:\u00a0http:\/\/www.jci.org\/cgi\/doi\/10.1172\/JCI29069. Cited 2024 Jan 12.","journal-title":"J Clin Invest"},{"issue":"1","key":"2223_CR5","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3945\/an.115.010207","volume":"7","author":"CJ Andersen","year":"2016","unstructured":"Andersen CJ, Murphy KE, Fernandez ML. Impact of obesity and metabolic syndrome on immunity. Adv Nutr. 2016;7(1):66\u201375.\u00a0Available from:\u00a0https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2161831323001412. Cited 2024 Jan 12.","journal-title":"Adv Nutr"},{"issue":"1","key":"2223_CR6","doi-asserted-by":"publisher","first-page":"E24","DOI":"10.1152\/ajpendo.00179.2022","volume":"324","author":"Z Jiang","year":"2023","unstructured":"Jiang Z, Wang Y, Zhao X, Cui H, Han M, Ren X, et al. Obesity and chronic kidney disease. Am J Physiol Endocrinol Metab. 2023;324(1):E24-41.\u00a0Available from:\u00a0https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00179.2022. Cited 2024 Jan 12.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"11","key":"2223_CR7","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1161\/CIRCRESAHA.115.306883","volume":"118","author":"FB Ortega","year":"2016","unstructured":"Ortega FB, Lavie CJ, Blair SN. Obesity and cardiovascular disease. Circ Res. 2016;118(11):1752\u201370.\u00a0Available from:\u00a0https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.115.306883. Cited 2024 Jan 12.","journal-title":"Circ Res"},{"issue":"3","key":"2223_CR8","doi-asserted-by":"publisher","first-page":"R79","DOI":"10.1530\/REP-18-0583","volume":"158","author":"AP Snider","year":"2019","unstructured":"Snider AP, Wood JR. Obesity induces ovarian inflammation and reduces oocyte quality. Reproduction. 2019;158(3):R79-90.","journal-title":"Reproduction"},{"issue":"3","key":"2223_CR9","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.ijcard.2013.08.077","volume":"169","author":"S Lim","year":"2013","unstructured":"Lim S, Meigs JB. Ectopic fat and cardiometabolic and vascular risk. Int J Cardiol. 2013;169(3):166\u201376.","journal-title":"Int J Cardiol"},{"issue":"1","key":"2223_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1515\/hmbci-2014-0023","volume":"19","author":"GE Walker","year":"2014","unstructured":"Walker GE, Marzullo P, Ricotti R, Bona G, Prodam F. The pathophysiology of abdominal adipose tissue depots in health and disease. Horm Mol Biol Clin Investig. 2014;19(1):57\u201374.","journal-title":"Horm Mol Biol Clin Investig"},{"issue":"1","key":"2223_CR11","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1002\/jcsm.13142","volume":"14","author":"B Yu","year":"2023","unstructured":"Yu B, Sun Y, Du X, Zhang H, Chen C, Tan X, et al. Age-specific and sex-specific associations of visceral adipose tissue mass and fat-to-muscle mass ratio with risk of mortality. J Cachexia Sarcopenia Muscle. 2023;14(1):406\u201317.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"2","key":"2223_CR12","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.physbeh.2007.10.010","volume":"94","author":"GH Goossens","year":"2008","unstructured":"Goossens GH. The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol Behav. 2008;94(2):206\u201318.","journal-title":"Physiol Behav"},{"issue":"9497","key":"2223_CR13","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1016\/S0140-6736(05)67663-5","volume":"366","author":"S Yusuf","year":"2005","unstructured":"Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, et al. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet. 2005;366(9497):1640\u20139.","journal-title":"Lancet"},{"issue":"12","key":"2223_CR14","doi-asserted-by":"publisher","first-page":"4556","DOI":"10.3390\/nu13124556","volume":"13","author":"SH Ko","year":"2021","unstructured":"Ko SH, Jung Y. Energy metabolism changes and dysregulated lipid metabolism in postmenopausal women. Nutrients. 2021;13(12):4556. Available from:\u00a0https:\/\/www.mdpi.com\/2072-6643\/13\/12\/4556. Cited 2024 Jan 12.","journal-title":"Nutrients"},{"key":"2223_CR15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.mce.2014.11.029","volume":"402","author":"BF Palmer","year":"2015","unstructured":"Palmer BF, Clegg DJ. The sexual dimorphism of obesity. Molecular and Cellular Endocrinology. 2015;402:113\u20139.\u00a0Available from:\u00a0https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720714004213. Cited 2024 Jan 13.","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2223_CR16","doi-asserted-by":"publisher","first-page":"828780","DOI":"10.3389\/fendo.2022.828780","volume":"13","author":"JI Bjune","year":"2022","unstructured":"Bjune JI, Str\u00f8mland PP, Jersin R\u00c5, Mellgren G, Dankel SN. Metabolic and epigenetic regulation by estrogen in adipocytes. Front Endocrinol. 2022;13:828780.\u00a0Available from:\u00a0https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.828780\/full. Cited 2024 Jan 13.","journal-title":"Front Endocrinol"},{"issue":"14","key":"2223_CR17","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1001\/archinte.160.14.2117","volume":"160","author":"AR Folsom","year":"2000","unstructured":"Folsom AR, Kushi LH, Anderson KE, Mink PJ, Olson JE, Hong CP, et al. Associations of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women\u2019s Health Study. Arch Intern Med. 2000;160(14):2117\u201328.","journal-title":"Arch Intern Med"},{"issue":"12","key":"2223_CR18","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1042\/CS20210384","volume":"135","author":"JL Faulkner","year":"2021","unstructured":"Faulkner JL. Obesity-associated cardiovascular risk in women: hypertension and heart failure. Clin Sci (Lond). 2021;135(12):1523\u201344.","journal-title":"Clin Sci (Lond)"},{"issue":"11","key":"2223_CR19","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1007\/s43032-023-01280-2","volume":"30","author":"X Wang","year":"2023","unstructured":"Wang X, Zhu R, Han H, Jin J. Body fat distribution and female infertility: a cross-sectional analysis among US women. Reprod Sci. 2023;30(11):3243\u201352.","journal-title":"Reprod Sci"},{"issue":"3","key":"2223_CR20","doi-asserted-by":"publisher","first-page":"C375","DOI":"10.1152\/ajpcell.00379.2020","volume":"320","author":"T Kawai","year":"2021","unstructured":"Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320(3):C375\u201391.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"9","key":"2223_CR21","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1161\/ATVBAHA.114.303035","volume":"34","author":"S Lim","year":"2014","unstructured":"Lim S, Meigs JB. Links between ectopic fat and vascular disease in humans. ATVB. 2014;34(9):1820\u20136.\u00a0Available from:\u00a0https:\/\/www.ahajournals.org\/doi\/10.1161\/ATVBAHA.114.303035. Cited 2024 Jan 13.","journal-title":"ATVB"},{"issue":"9","key":"2223_CR22","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.numecd.2019.05.066","volume":"29","author":"M Cabral","year":"2019","unstructured":"Cabral M, Bangdiwala SI, Severo M, Guimar\u00e3es JT, Nogueira L, Ramos E. Central and peripheral body fat distribution: Different associations with low-grade inflammation in young adults?\u00a0\u00a0Nutr Metab Cardiovasc Dis. 2019;29(9):931\u20138. Available from:\u00a0https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0939475319302261. Cited 2023 Nov 30.","journal-title":"Nutrition, Metabolism and Cardiovascular Diseases"},{"issue":"11","key":"2223_CR23","doi-asserted-by":"publisher","first-page":"3785","DOI":"10.2337\/db14-0385","volume":"63","author":"KE Pinnick","year":"2014","unstructured":"Pinnick KE, Nicholson G, Manolopoulos KN, McQuaid SE, Valet P, Frayn KN, et al. Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications. Diabetes. 2014;63(11):3785\u201397.","journal-title":"Diabetes"},{"issue":"6","key":"2223_CR24","doi-asserted-by":"publisher","first-page":"505","DOI":"10.2174\/1389203720666190405101138","volume":"20","author":"F Ceciliani","year":"2019","unstructured":"Ceciliani F, Lecchi C. The immune functions of \u03b11 acid glycoprotein. CPPS. 2019;20(6):505\u201324. Available from:\u00a0http:\/\/www.eurekaselect.com\/171309\/article. Cited 2024 Jan 12.","journal-title":"CPPS"},{"issue":"17","key":"2223_CR25","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.1158\/0008-5472.CAN-20-3471","volume":"81","author":"K Matsusaka","year":"2021","unstructured":"Matsusaka K, Fujiwara Y, Pan C, Esumi S, Saito Y, Bi J, et al. \u03b11-acid glycoprotein enhances the immunosuppressive and protumor functions of tumor-associated macrophages. Cancer Res. 2021;81(17):4545\u201359.\u00a0Available from:\u00a0https:\/\/aacrjournals.org\/cancerres\/article\/81\/17\/4545\/670275\/1-Acid-Glycoprotein-Enhances-the-Immunosuppressive. Cited 2024 Jul 1.","journal-title":"Cancer Res"},{"issue":"1","key":"2223_CR26","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/hep.510290113","volume":"29","author":"N Mejdoubi","year":"1999","unstructured":"Mejdoubi N, Henriques C, Bui E, Durand G, Lardeux B, Porquet D. Growth hormone inhibits rat liver alpha-1-acid glycoprotein gene expression in vivo and in vitro. Hepatology. 1999;29(1):186\u201394.","journal-title":"Hepatology"},{"issue":"6","key":"2223_CR27","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.cellbi.2006.11.033","volume":"31","author":"G Castriota","year":"2007","unstructured":"Castriota G, Thompson GM, Lin Y, Scherer PE, Moller DE, Berger JP. Peroxisome proliferator-activated receptor gamma agonists inhibit adipocyte expression of alpha1-acid glycoprotein. Cell Biol Int. 2007;31(6):586\u201391.","journal-title":"Cell Biol Int"},{"key":"2223_CR28","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1515\/hukin-2017-0027","volume":"56","author":"\u00c9 T\u00e9kus","year":"2017","unstructured":"T\u00e9kus \u00c9, V\u00e1czi M, Horv\u00e1th-Szalai Z, Lud\u00e1ny A, K\u0151szegi T, Wilhelm M. Plasma actin, gelsolin and orosomucoid levels after eccentric exercise. J Hum Kinet. 2017;56:99\u2013108.","journal-title":"J Hum Kinet"},{"issue":"7","key":"2223_CR29","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1007\/s00394-021-02539-7","volume":"60","author":"T Kim","year":"2021","unstructured":"Kim T, Xie Y, Li Q, Artegoitia VM, Lebrilla CB, Keim NL, et al. Diet affects glycosylation of serum proteins in women at risk for cardiometabolic disease. Eur J Nutr. 2021;60(7):3727\u201341.","journal-title":"Eur J Nutr"},{"issue":"3","key":"2223_CR30","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0009-9120(00)00048-5","volume":"33","author":"JC Duch\u00e9","year":"2000","unstructured":"Duch\u00e9 JC, Urien S, Simon N, Malaurie E, Monnet I, Barr\u00e9 J. Expression of the genetic variants of human alpha-1-acid glycoprotein in cancer. Clinical Biochemistry. 2000;33(3):197\u2013202.\u00a0Available from:\u00a0https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912000000485. Cited 2024 Jan 12.","journal-title":"Clinical Biochemistry"},{"issue":"1\u20132","key":"2223_CR31","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0009-8981(02)00427-8","volume":"329","author":"K Higai","year":"2003","unstructured":"Higai K, Azuma Y, Aoki Y, Matsumoto K. Altered glycosylation of \u03b11-acid glycoprotein in patients with inflammation and diabetes mellitus. Clinica Chimica Acta. 2003;329(1\u20132):117\u201325. Available from:\u00a0https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898102004278. Cited 2024 Jan 12.","journal-title":"Clinica Chimica Acta"},{"key":"2223_CR32","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ejogrb.2022.05.023","volume":"274","author":"M Durmu\u015f","year":"2022","unstructured":"Durmu\u015f M, Uzunlar \u00d6, \u00c7elik H, \u00c7andar T. Does alpha-1-acid glycoprotein determine for infertility in polycystic ovary syndrome? Eur J Obstet Gynecol Reprod Biol. 2022;274:155\u20139.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"5","key":"2223_CR33","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1093\/ajcn\/nqaa056","volume":"111","author":"S Palaniswamy","year":"2020","unstructured":"Palaniswamy S, Gill D, De Silva NM, Lowry E, Jokelainen J, Karhu T, et al. Could vitamin D reduce obesity-associated inflammation? Observational and Mendelian randomization study. Am J Clin Nutr. 2020;111(5):1036\u201347.","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"2223_CR34","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1002\/osp4.570","volume":"8","author":"A Prioreschi","year":"2022","unstructured":"Prioreschi A, Koethe JR, Aronoff DM, Goldstein JA, Norris SA. Relationships between adiposity distribution and metabolic health in preconception women in South Africa. Obes Sci Pract. 2022;8(4):500\u20139.","journal-title":"Obes Sci Pract"},{"issue":"5","key":"2223_CR35","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/j.1365-3083.2009.02240.x","volume":"69","author":"L Levander","year":"2009","unstructured":"Levander L, Gunnarsson P, Greneg\u00e5rd M, Ryd\u00e9n I, P\u00e5hlsson P. Effects of \u03b11\u2010acid glycoprotein fucosylation on its Ca2+ mobilizing capacity in neutrophils. Scand J Immunol. 2009;69(5):412\u201320.\u00a0Available from:\u00a0https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3083.2009.02240.x. Cited 2024 Jan 12.","journal-title":"Scand J Immunol"},{"issue":"7","key":"2223_CR36","doi-asserted-by":"publisher","first-page":"112697","DOI":"10.1016\/j.celrep.2023.112697","volume":"42","author":"L Li","year":"2023","unstructured":"Li L, Sun H, Chen J, Ding C, Yang X, Han H, et al. Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1\/2-PPAR\u03b3-Cd36 pathway. Cell Rep. 2023;42(7):112697.","journal-title":"Cell Rep"},{"key":"2223_CR37","unstructured":"NHANES - NCHS Research Ethics Review Board Approval. Available from: https:\/\/www.cdc.gov\/nchs\/nhanes\/irba98.htm (2022)"},{"key":"2223_CR38","unstructured":"NHANES - National Health and Nutrition Examination Survey Homepage. 2023. Available from: https:\/\/www.cdc.gov\/nchs\/nhanes\/index.htm. Cited 2023 Nov 4."},{"issue":"20","key":"2223_CR39","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1002\/sim.3222","volume":"27","author":"SP Caudill","year":"2008","unstructured":"Caudill SP, Schleicher RL, Pirkle JL. Multi-rule quality control for the age-related eye disease study. Stat Med. 2008;27(20):4094\u2013106.","journal-title":"Stat Med"},{"issue":"5","key":"2223_CR40","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1002\/jbmr.5650110510","volume":"11","author":"Y Lu","year":"1996","unstructured":"Lu Y, Mathur AK, Blunt BA, Gluer CC, Will AS, Fuerst TP, et al. Dual X-ray absorptiometry quality control: comparison of visual examination and process-control charts. J Bone Miner Res. 1996;11(5):626\u201337.","journal-title":"J Bone Miner Res"},{"issue":"10","key":"2223_CR41","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1002\/jbmr.1654","volume":"27","author":"JA Shepherd","year":"2012","unstructured":"Shepherd JA, Fan B, Lu Y, Wu XP, Wacker WK, Ergun DL, et al. A multinational study to develop universal standardization of whole-body bone density and composition using GE healthcare Lunar and hologic DXA systems. J Bone Miner Res. 2012;27(10):2208\u201316.","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2223_CR42","first-page":"72","volume":"25","author":"MM Ram\u00edrez Alvarado","year":"2010","unstructured":"Ram\u00edrez Alvarado MM, S\u00e1nchez Roitz C, P\u00e9rez D\u00edaz A, Mill\u00e1n BE. [Effect of a high saturated fatty acids load on serum concentrations of C-reactive protein, alpha1-antitrypsin, fibrinogen and alpha1-acid glycoprotein in obese women]. Nutr Hosp. 2010;25(1):72\u20139.","journal-title":"Nutr Hosp"},{"issue":"3","key":"2223_CR43","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1159\/000471488","volume":"10","author":"GH Goossens","year":"2017","unstructured":"Goossens GH. The metabolic phenotype in obesity: fat mass, body fat distribution, and adipose tissue function. Obes Facts. 2017;10(3):207\u201315.\u00a0Available from:\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5644968\/. Cited 2023 Nov 15.","journal-title":"Obes Facts"},{"issue":"7","key":"2223_CR44","doi-asserted-by":"publisher","first-page":"6310","DOI":"10.3390\/ijms24076310","volume":"24","author":"J Chen","year":"2023","unstructured":"Chen J, Li K, Shao J, Lai Z, Feng Y, Liu B. The Correlation of Apolipoprotein B with Alterations in Specific Fat Depots Content in Adults. Int J Mol Sci. 2023;24(7):6310.\u00a0Available from:\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10094599\/. Cited 2023 Nov 20.","journal-title":"Int J Mol Sci"},{"issue":"338","key":"2223_CR45","doi-asserted-by":"publisher","first-page":"b2393","DOI":"10.1136\/bmj.b2393","volume":"29","author":"JAC Sterne","year":"2009","unstructured":"Sterne JAC, White IR, Carlin JB, Spratt M, Royston P, Kenward MG, et al. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ. 2009;29(338):b2393.","journal-title":"BMJ"},{"issue":"4","key":"2223_CR46","doi-asserted-by":"publisher","first-page":"228","DOI":"10.7326\/M16-2472","volume":"167","author":"SY Park","year":"2017","unstructured":"Park SY, Freedman ND, Haiman CA, Le Marchand L, Wilkens LR, Setiawan VW. Association of coffee consumption with total and cause-specific mortality among nonwhite populations. Ann Intern Med. 2017;167(4):228\u201335.","journal-title":"Ann Intern Med"},{"key":"2223_CR47","unstructured":"\u6613\u4f95\u7edf\u8ba1 | \u751f\u7269\u4e0e\u6d41\u884c\u75c5\u5b66\u7edf\u8ba1\u8f6f\u4ef6 | EmpowerStats. 2023. Available from: https:\/\/www.empowerstats.net\/cn\/. Cited 2023 Nov 6."},{"issue":"6","key":"2223_CR48","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3390\/biom9060223","volume":"9","author":"K Suzuki","year":"2019","unstructured":"Suzuki K. Chronic inflammation as an immunological abnormality and effectiveness of exercise. Biomolecules. 2019;9(6):223.\u00a0Available from:\u00a0https:\/\/www.mdpi.com\/2218-273X\/9\/6\/223. Cited 2024 Jan 12.","journal-title":"Biomolecules"},{"issue":"1","key":"2223_CR49","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000335722","volume":"30","author":"A Batra","year":"2012","unstructured":"Batra A, Siegmund B. The role of visceral fat. Dig Dis. 2012;30(1):70\u20134.\u00a0Available from:\u00a0https:\/\/www.karger.com\/Article\/FullText\/335722. Cited 2024 Jan 12.","journal-title":"Dig Dis"},{"issue":"10","key":"2223_CR50","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1093\/glycob\/cwv041","volume":"25","author":"CL Fernandes","year":"2015","unstructured":"Fernandes CL, Ligabue-Braun R, Verli H. Structural glycobiology of human \u03b1 1 -acid glycoprotein and its implications for pharmacokinetics and inflammation. Glycobiology. 2015;25(10):1125\u201333. Available from:\u00a0https:\/\/academic.oup.com\/glycob\/article-lookup\/doi\/10.1093\/glycob\/cwv041. Cited 2024 Jan 12.","journal-title":"Glycobiology"},{"issue":"11\u201312","key":"2223_CR51","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/S0899-9007(01)00672-4","volume":"17","author":"UN Das","year":"2001","unstructured":"Das UN. Is obesity an inflammatory condition? Nutrition. 2001;17(11\u201312):953\u201366.","journal-title":"Nutrition"},{"issue":"2","key":"2223_CR52","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/ejcn.2014.154","volume":"69","author":"M Ferrari","year":"2015","unstructured":"Ferrari M, Cuenca-Garc\u00eda M, Valtue\u00f1a J, Moreno LA, Censi L, Gonz\u00e1lez-Gross M, et al. Inflammation profile in overweight\/obese adolescents in Europe: an analysis in relation to iron status. Eur J Clin Nutr. 2015;69(2):247\u201355.","journal-title":"Eur J Clin Nutr"},{"issue":"19","key":"2223_CR53","first-page":"493","volume":"24","author":"M Sobieska","year":"2013","unstructured":"Sobieska M, Gajewska E, Kalmus G, Samborski W. Obesity, physical fitness, and inflammatory markers in Polish children. Med Sci Monit. 2013;24(19):493\u2013500.","journal-title":"Med Sci Monit"},{"issue":"372","key":"2223_CR54","doi-asserted-by":"publisher","first-page":"n365","DOI":"10.1136\/bmj.n365","volume":"16","author":"B Liu","year":"2021","unstructured":"Liu B, Du Y, Wu Y, Snetselaar LG, Wallace RB, Bao W. Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011\u201318: population based study. BMJ. 2021;16(372):n365.","journal-title":"BMJ"},{"issue":"1","key":"2223_CR55","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1353\/hpu.2014.0038","volume":"25","author":"KD Lincoln","year":"2014","unstructured":"Lincoln KD, Abdou CM, Lloyd D. Race and socioeconomic differences in obesity and depression among Black and non-Hispanic White Americans. J Health Care Poor Underserved. 2014;25(1):257\u201375.","journal-title":"J Health Care Poor Underserved"},{"issue":"2","key":"2223_CR56","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1210\/jcem-54-2-254","volume":"54","author":"AH Kissebah","year":"1982","unstructured":"Kissebah AH, Vydelingum N, Murray R, Evans DJ, Kalkhoff RK, Adams PW. Relation of body fat distribution to metabolic complications of obesity*. J Clin Endocrinol Metab. 1982;54(2):254\u201360.\u00a0Available from:\u00a0https:\/\/academic.oup.com\/jcem\/article-lookup\/doi\/10.1210\/jcem-54-2-254. Cited 2024 Jan 12.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2223_CR57","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.2337\/diacare.14.12.1132","volume":"14","author":"P Bj\u00f6rntorp","year":"1991","unstructured":"Bj\u00f6rntorp P. Metabolic implications of body fat distribution. Diabetes Care. 1991;14(12):1132\u201343.\u00a0Available from:\u00a0https:\/\/diabetesjournals.org\/care\/article\/14\/12\/1132\/16502\/Metabolic-Implications-of-Body-Fat-Distribution. Cited 2024 Jan 12.","journal-title":"Diabetes Care"},{"issue":"2","key":"2223_CR58","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1210\/jcem-70-2-473","volume":"70","author":"MA Kirschner","year":"1990","unstructured":"Kirschner MA, Samojlik E, Drejka M, Szmal E, Schneider G, Ertel N. Androgen-estrogen metabolism in women with upper body versus lower body obesity*. J Clin Endocrinol Metab. 1990;70(2):473\u20139. Available from:\u00a0https:\/\/academic.oup.com\/jcem\/article-lookup\/doi\/10.1210\/jcem-70-2-473. Cited 2024 Jan 12.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2223_CR59","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1046\/j.1467-789X.2001.00041.x","volume":"2","author":"E Diamanti-Kandarakis","year":"2001","unstructured":"Diamanti-Kandarakis E, Bergiele A. The influence of obesity on hyperandrogenism and infertility in the female. Obes Rev. 2001;2(4):231\u20138.\u00a0Available from:\u00a0https:\/\/onlinelibrary.wiley.com\/doi\/10.1046\/j.1467-789X.2001.00041.x.","journal-title":"Obes Rev"},{"issue":"2","key":"2223_CR60","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1034\/j.1600-0412.2002.810210.x","volume":"81","author":"T Douchi","year":"2002","unstructured":"Douchi T, Kuwahata R, Yamamoto S, Oki T, Yamasaki H, Nagata Y. Relationship of upper body obesity to menstrual disorders. Acta Obstet Gynecol Scand. 2002;81(2):147\u201350. Available from:\u00a0https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0412.2002.810210.x.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"1","key":"2223_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000010052","volume":"47","author":"C Mor\u00e1n","year":"1999","unstructured":"Mor\u00e1n C, Hern\u00e1ndez E, Ru\u00edz JE, Fonseca ME, Berm\u00fadez JA, Z\u00e1rate A. Upper Body Obesity and Hyperinsulinemia Are Associated with Anovulation. Gynecol Obstet Invest. 1999;47(1):1\u20135. Available from:\u00a0https:\/\/www.karger.com\/Article\/FullText\/10052. Cited 2024 Jan 12.","journal-title":"Gynecol Obstet Invest"},{"issue":"4","key":"2223_CR62","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.fertnstert.2017.01.017","volume":"107","author":"DE Broughton","year":"2017","unstructured":"Broughton DE, Moley KH. Obesity and female infertility: potential mediators of obesity\u2019s impact. Fertil Steril. 2017;107(4):840\u20137.","journal-title":"Fertil Steril"},{"issue":"4","key":"2223_CR63","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1161\/HYPERTENSIONAHA.108.110320","volume":"53","author":"P Mathieu","year":"2009","unstructured":"Mathieu P, Poirier P, Pibarot P, Lemieux I, Despr\u00e9s JP. Visceral obesity: the link among inflammation, hypertension, and cardiovascular disease. Hypertension. 2009;53(4):577\u201384.","journal-title":"Hypertension"},{"key":"2223_CR64","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.metabol.2016.11.008","volume":"67","author":"IJ Neeland","year":"2017","unstructured":"Neeland IJ, Hughes C, Ayers CR, Malloy CR, Jin ES. Effects of visceral adiposity on glycerol pathways in gluconeogenesis. Metabolism. 2017;67:80\u20139.","journal-title":"Metabolism"},{"issue":"5","key":"2223_CR65","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11051427","volume":"11","author":"M W\u00fcrfel","year":"2023","unstructured":"W\u00fcrfel M, Bl\u00fcher M, Stumvoll M, Ebert T, Kovacs P, T\u00f6njes A, et al. Adipokines as clinically relevant therapeutic targets in obesity. Biomedicines. 2023;11(5): 1427.","journal-title":"Biomedicines"},{"issue":"1","key":"2223_CR66","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1186\/s12916-022-02672-y","volume":"20","author":"H Kolb","year":"2022","unstructured":"Kolb H. Obese visceral fat tissue inflammation: from protective to detrimental? BMC Med. 2022;20(1):494.","journal-title":"BMC Med"},{"issue":"3","key":"2223_CR67","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/BF00731326","volume":"12","author":"A Mackiewicz","year":"1995","unstructured":"Mackiewicz A, Mackiewicz K. Glycoforms of serum\u202f?1-acid glycoprotein as markers of inflammation and cancer. Glycoconjugate J. 1995;12(3):241\u20137.\u00a0Available from:\u00a0http:\/\/link.springer.com\/10.1007\/BF00731326.","journal-title":"Glycoconjugate J"},{"issue":"3","key":"2223_CR68","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/s41588-023-01306-0","volume":"55","author":"GT Hansen","year":"2023","unstructured":"Hansen GT, Sobreira DR, Weber ZT, Thornburg AG, Aneas I, Zhang L, et al. Genetics of sexually dimorphic adipose distribution in humans. Nat Genet. 2023;55(3):461\u201370.\u00a0Available from:\u00a0https:\/\/www.nature.com\/articles\/s41588-023-01306-0.","journal-title":"Nat Genet"},{"issue":"12","key":"2223_CR69","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.2337\/diab.45.12.1684","volume":"45","author":"N Abate","year":"1996","unstructured":"Abate N, Garg A, Peshock RM, Stray-Gundersen J, Adams-Huet B, Grundy SM. Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM. Diabetes. 1996;45(12):1684\u201393.\u00a0Available from:\u00a0https:\/\/diabetesjournals.org\/diabetes\/article\/45\/12\/1684\/9046\/Relationship-of-Generalized-and-Regional-Adiposity.","journal-title":"Diabetes"},{"key":"2223_CR70","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1014778","volume":"14","author":"A Bensussen","year":"2023","unstructured":"Bensussen A, Torres-Magallanes JA, Roces de \u00c1lvarez-Buylla E. Molecular tracking of insulin resistance and inflammation development on visceral adipose tissue. Front Immunol. 2023;14: 1014778.","journal-title":"Front Immunol"},{"key":"2223_CR71","doi-asserted-by":"crossref","unstructured":"Bergman RN, Kim SP, Catalano KJ, Hsu IR, Chiu JD, Kabir M, et al. Why visceral fat is bad: mechanisms of the metabolic syndrome. Obesity. 2006;14(S2). Available from: https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2006.277. Cited 2024 Jan 12.","DOI":"10.1038\/oby.2006.277"},{"issue":"7","key":"2223_CR72","first-page":"2044","volume":"82","author":"JMH Elbers","year":"1997","unstructured":"Elbers JMH, Asscheman H, Seidell JC, Megens JAJ, Gooren LJG. Long-term testosterone administration increases visceral fat in female to male transsexuals1. J Clin Endocrinol Metab. 1997;82(7):2044.\u00a0Available from:\u00a0https:\/\/academic.oup.com\/jcem\/article\/82\/7\/2044\/2865884. Cited 2024 Jan 12.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2223_CR73","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1097\/00000542-199710000-00023","volume":"87","author":"LC Tsen","year":"1997","unstructured":"Tsen LC, Arthur GR, Datta S, Hornstein MD, Bader AM. Estrogen-induced changes in protein binding of bupivacaine during in vitro fertilization. Anesthesiology. 1997;87(4):879\u201383.","journal-title":"Anesthesiology"},{"key":"2223_CR74","doi-asserted-by":"crossref","unstructured":"Van Dijk W, Brinkman-Van Der Linden ECM, Havenaar EC. Glycosylation of .ALPHA.1-Acid Glycoprotein(Orosomucoid) in health and disease: occurrence, regulation and possible funtional implications. Trends in Glycoscience and Glycotechnology. 1998;10(53):235\u201345. Available from: http:\/\/www.jstage.jst.go.jp\/article\/tigg1989\/10\/53\/10_53_235\/_article\/-char\/ja\/. Cited 2024 Jan 12.","DOI":"10.4052\/tigg.10.235"},{"issue":"5","key":"2223_CR75","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1089\/jir.2013.0078","volume":"34","author":"C Shi","year":"2014","unstructured":"Shi C, Zhu L, Chen X, Gu N, Chen L, Zhu L, et al. IL-6 and TNF-\u03b1 induced obesity-related inflammatory response through transcriptional regulation of miR-146b. J Interferon Cytokine Res. 2014;34(5):342\u20138.\u00a0Available from:\u00a0http:\/\/www.liebertpub.com\/doi\/10.1089\/jir.2013.0078.","journal-title":"J Interferon Cytokine Res"},{"issue":"2","key":"2223_CR76","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/ijo.2010.137","volume":"35","author":"NJ Timpson","year":"2011","unstructured":"Timpson NJ, Nordestgaard BG, Harbord RM, Zacho J, Frayling TM, Tybj\u00e6rg-Hansen A, et al. C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. Int J Obes. 2011;35(2):300\u20138.\u00a0Available from:\u00a0https:\/\/www.nature.com\/articles\/ijo2010137.","journal-title":"Int J Obes"},{"key":"2223_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/658913","volume":"2014","author":"E Nigro","year":"2014","unstructured":"Nigro E, Scudiero O, Monaco ML, Palmieri A, Mazzarella G, Costagliola C, et al. New insight into adiponectin role in obesity and obesity-related diseases. Biomed Res Int. 2014;2014:1\u201314. Available from:\u00a0http:\/\/www.hindawi.com\/journals\/bmri\/2014\/658913\/. Cited 2024 Jun 3.","journal-title":"Biomed Res Int"},{"issue":"8","key":"2223_CR78","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrendo.2012.49","volume":"8","author":"BK Pedersen","year":"2012","unstructured":"Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol. 2012;8(8):457\u201365.\u00a0Available from:\u00a0https:\/\/www.nature.com\/articles\/nrendo.2012.49. Cited 2024 Jun 3.","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"2223_CR79","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.cmet.2011.04.013","volume":"14","author":"H Yadav","year":"2011","unstructured":"Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, et al. Protection from obesity and diabetes by blockade of TGF-\u03b2\/Smad3 signaling. Cell Metabolism. 2011;14(1):67\u201379. Available from:\u00a0https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413111002154. Cited 2024 Jun 3.","journal-title":"Cell Metabolism"},{"issue":"11","key":"2223_CR80","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nrm3198","volume":"12","author":"AG Cristancho","year":"2011","unstructured":"Cristancho AG, Lazar MA. Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol. 2011;12(11):722\u201334.\u00a0Available from:\u00a0https:\/\/www.nature.com\/articles\/nrm3198. Cited 2024 Jun 3.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"2223_CR81","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev-physiol-031620-095446","volume":"83","author":"S Corvera","year":"2021","unstructured":"Corvera S. Cellular heterogeneity in adipose tissues. Annu Rev Physiol. 2021;83(1):257\u201378. Available from:\u00a0https:\/\/www.annualreviews.org\/doi\/10.1146\/annurev-physiol-031620-095446. Cited 2024 Jun 3.","journal-title":"Annu Rev Physiol"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-024-02223-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12944-024-02223-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-024-02223-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T13:07:44Z","timestamp":1722344864000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/s12944-024-02223-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":81,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2223"],"URL":"https:\/\/doi.org\/10.1186\/s12944-024-02223-9","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,30]]},"assertion":[{"value":"26 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"235"}}