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Statins are primarily used in the treatment of dyslipidemia and possess pleiotropic effects that are not yet fully understood. Moreover, there is insufficient evidence to support their use in attenuating cardiovascular outcomes or their potential role in modulating the ABCA-1 transporter in CKD. Thus, the aim of this study was to investigate the effect of statins on ABCA-1 modulation in cultures of human umbilical vein endothelial cells (HUVEC) incubated with uremic serum from CKD patients. The results demonstrate that statins influence the inflammatory response of HUVEC exposed to a uremic environment by reducing TNF-\u03b1 secretion compared to baseline levels. Furthermore, the uremic environment was found to decrease the expression of LxR-\u03b2 and RxR-\u03b1, leading to a consequent reduction in ABCA-1 expression in HUVEC. Cells pre-treated with simvastatin exhibited increased expression of ABCA-1, LxR-\u03b2, and RxR-\u03b1, along with a significant increase in the transcription of ABCA-1, LXR-\u03b2, and RxR-\u03b1, indicating that statins may exert a positive modulation on LxR-\u03b2 and RxR-\u03b1 receptors, activating ABCA-1 transcription.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1186\/s12944-024-02420-6","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:08:53Z","timestamp":1742368133000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Action of 3-Hydroxy-3-Methylglutaryl-CoA Reductase Inhibitors on ABCA-1 protein (ATP-Binding Cassette Transporter-1) in endothelial cells stimulated with uremic serum"],"prefix":"10.1186","volume":"24","author":[{"given":"Silmara","family":"de Melo Carmona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Pereira","family":"Jardim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida","family":"Dalboni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Nakamichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Kuniyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Marrocos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata Marie Redublo","family":"Quinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Costa","family":"Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"issue":"11","key":"2420_CR1","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1080\/15384101.2022.2042777","volume":"21","author":"L Chen","year":"2022","unstructured":"Chen L, Zhao ZW, Zeng PH, Zhou YJ, Yin WJ. 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Given the retrospective nature of the analysis and the use of anonymized data, the requirement for informed consent was waived. All procedures followed in this study adhered to the ethical standards outlined by the Declaration of Helsinki. The study was conducted in accordance with the ethical guidelines set forth by the medical ethics committee of UNIFESP, and received approval under institutional registration number 616429. The research was further reviewed to ensure compliance with all applicable laws and regulations regarding privacy and data protection.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The data supporting the findings of this study are not available in a public repository. However, the data are available upon request from the corresponding author.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data sharing statement"}}],"article-number":"100"}}