{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:48:18Z","timestamp":1776772098264,"version":"3.51.2"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"DOI":"10.1186\/s12944-025-02475-z","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:57:49Z","timestamp":1740376669000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plasma lipidomic analysis reveals disruption of ether phosphatidylcholine biosynthesis and facilitates early detection of hepatitis B-related hepatocellular carcinoma"],"prefix":"10.1186","volume":"24","author":[{"given":"Yuyao","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4102-0043","authenticated-orcid":false,"given":"Yuxin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"issue":"3","key":"2475_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363.","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"2475_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jncc.2024.01.006","volume":"4","author":"B Han","year":"2024","unstructured":"Han B, Zheng R, Zeng H, Wang S, Sun K, Chen R, Li L, Wei W, He J. Cancer incidence and mortality in China, 2022. J Natl Cancer Cent. 2024;4(1):47\u201353.","journal-title":"J Natl Cancer Cent"},{"issue":"1","key":"2475_CR3","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","volume":"7","author":"JM Llovet","year":"2021","unstructured":"Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, Lencioni R, Koike K, Zucman-Rossi J, Finn RS. Hepatocellular carcinoma. Nature Rev Dis Prim. 2021;7(1):6.","journal-title":"Nature Rev Dis Prim"},{"key":"2475_CR4","doi-asserted-by":"crossref","unstructured":"Cao WH, Zhang YQ, Li XX, Zhang ZY, Li MH. Advances in immunotherapy for hepatitis B virus associated hepatocellular carcinoma patients. World J Hepatol. 2024;16(10):1158\u201368.","DOI":"10.4254\/wjh.v16.i10.1158"},{"issue":"3","key":"2475_CR5","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/j.1572-0241.2006.00467.x","volume":"101","author":"A Colli","year":"2006","unstructured":"Colli A, Fraquelli M, Casazza G, Massironi S, Colucci A, Conte D, Duca P. Accuracy of ultrasonography, spiral CT, magnetic resonance, and alpha-fetoprotein in diagnosing hepatocellular carcinoma: a systematic review. Am J Gastroenterol. 2006;101(3):513\u201323.","journal-title":"Am J Gastroenterol"},{"key":"2475_CR6","doi-asserted-by":"crossref","unstructured":"Colli A, Nadarevic T, Miletic D, Giljaca, Fraquelli M, Stimac D, Casazza G. Abdominal ultrasound and alpha-foetoprotein for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease. Cochrane Database Syst Rev. 2021(4):CD013346.","DOI":"10.1002\/14651858.CD013346.pub2"},{"issue":"2","key":"2475_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.canlet.2010.11.014","volume":"305","author":"MJ Bouchard","year":"2011","unstructured":"Bouchard MJ, Navas-Martin S. Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges. Cancer Lett. 2011;305(2):123\u201343.","journal-title":"Cancer Lett"},{"issue":"6","key":"2475_CR8","doi-asserted-by":"publisher","first-page":"101930","DOI":"10.1016\/j.clinre.2022.101930","volume":"46","author":"Y Shen","year":"2022","unstructured":"Shen Y, Liu J, Han Z, Jiang W, Cui H, Xun Y. Risk prediction models for hepatocellular carcinoma in chronic hepatitis B patients on antiviral therapy: A meta-analysis. Clin Res Hepatol Gastroenterol. 2022;46(6):101930.","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"2","key":"2475_CR9","first-page":"526","volume":"13","author":"HW Wang","year":"2023","unstructured":"Wang HW, Chen CY, Lai HC, Hu TH, Su WP, Lu SN, Hung CH, Chuang PH, Wang JH, Chen CH, Peng CY. Prediction model of hepatocellular carcinoma in patients with hepatitis B virus-related compensated cirrhosis receiving antiviral therapy. Am J Cancer Res. 2023;13(2):526\u201337.","journal-title":"Am J Cancer Res"},{"issue":"7747","key":"2475_CR10","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41586-019-0987-8","volume":"567","author":"Y Jiang","year":"2019","unstructured":"Jiang Y, Sun A, Zhao Y, Ying W, Sun H, Yang X, Xing B, Sun W, Ren L, Hu B, et al. Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma. Nature. 2019;567(7747):257\u201361.","journal-title":"Nature"},{"issue":"2","key":"2475_CR11","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.cell.2019.08.052","volume":"179","author":"Q Gao","year":"2019","unstructured":"Gao Q, Zhu H, Dong L, Shi W, Chen R, Song Z, Huang C, Li J, Dong X, Zhou Y, et al. Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma. Cell. 2019;179(2):561-577 e522.","journal-title":"Cell"},{"issue":"7","key":"2475_CR12","doi-asserted-by":"publisher","first-page":"100574","DOI":"10.1016\/j.mcpro.2023.100574","volume":"22","author":"M Xu","year":"2023","unstructured":"Xu M, Xu K, Yin S, Chang C, Sun W, Wang G, Zhang K, Mu J, Wu M, Xing B, et al. In-depth serum proteomics reveals the trajectory of hallmarks of cancer in hepatitis B virus-related liver diseases. Mol Cell Proteomics. 2023;22(7):100574.","journal-title":"Mol Cell Proteomics"},{"issue":"3","key":"2475_CR13","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/ijc.28706","volume":"135","author":"Y Liu","year":"2014","unstructured":"Liu Y, Hong Z, Tan G, Dong X, Yang G, Zhao L, Chen X, Zhu Z, Lou Z, Qian B, et al. NMR and LC\/MS-based global metabolomics to identify serum biomarkers differentiating hepatocellular carcinoma from liver cirrhosis. Int J Cancer. 2014;135(3):658\u201368.","journal-title":"Int J Cancer"},{"issue":"2","key":"2475_CR14","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1002\/hep.29561","volume":"67","author":"P Luo","year":"2018","unstructured":"Luo P, Yin P, Hua R, Tan Y, Li Z, Qiu G, Yin Z, Xie X, Wang X, Chen W, et al. A Large-scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma. Hepatology. 2018;67(2):662\u201375.","journal-title":"Hepatology"},{"issue":"7","key":"2475_CR15","doi-asserted-by":"publisher","first-page":"M110004945","DOI":"10.1074\/mcp.M110.004945","volume":"10","author":"T Chen","year":"2011","unstructured":"Chen T, Xie G, Wang X, Fan J, Qiu Y, Zheng X, Qi X, Cao Y, Su M, Wang X, et al. Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma. Mol Cell Proteomics. 2011;10(7):M110004945.","journal-title":"Mol Cell Proteomics"},{"issue":"12","key":"2475_CR16","doi-asserted-by":"publisher","first-page":"5914","DOI":"10.1021\/pr300673x","volume":"11","author":"JF Xiao","year":"2012","unstructured":"Xiao JF, Varghese RS, Zhou B, Nezami Ranjbar MR, Zhao Y, Tsai TH, Di Poto C, Wang J, Goerlitz D, Luo Y, et al. LC-MS based serum metabolomics for identification of hepatocellular carcinoma biomarkers in Egyptian cohort. J Proteome Res. 2012;11(12):5914\u201323.","journal-title":"J Proteome Res"},{"issue":"38","key":"2475_CR17","doi-asserted-by":"publisher","first-page":"63890","DOI":"10.18632\/oncotarget.19173","volume":"8","author":"ZG Gong","year":"2017","unstructured":"Gong ZG, Zhao W, Zhang J, Wu X, Hu J, Yin GC, Xu YJ. Metabolomics and eicosanoid analysis identified serum biomarkers for distinguishing hepatocellular carcinoma from hepatitis B virus-related cirrhosis. Oncotarget. 2017;8(38):63890\u2013900.","journal-title":"Oncotarget"},{"issue":"2","key":"2475_CR18","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1021\/acsomega.0c04259","volume":"6","author":"HY Pan","year":"2021","unstructured":"Pan HY, Wu QQ, Yin QQ, Dai YN, Huang YC, Zheng W, Hui TC, Chen MJ, Wang MS, Zhang JJ, et al. LC\/MS-based global metabolomic identification of serum biomarkers differentiating hepatocellular carcinoma from chronic hepatitis b and liver cirrhosis. ACS Omega. 2021;6(2):1160\u201370.","journal-title":"ACS Omega"},{"issue":"1","key":"2475_CR19","first-page":"956","volume":"15","author":"L Zhang","year":"2018","unstructured":"Zhang L, Wu GY, Wu YJ, Liu SY. The serum metabolic profiles of different Barcelona stages hepatocellular carcinoma associated with hepatitis B virus. Oncol Lett. 2018;15(1):956\u201362.","journal-title":"Oncol Lett"},{"issue":"3","key":"2475_CR20","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1053\/j.gastro.2015.11.043","volume":"150","author":"H Reinke","year":"2016","unstructured":"Reinke H, Asher G. Circadian clock control of liver metabolic functions. Gastroenterology. 2016;150(3):574\u201380.","journal-title":"Gastroenterology"},{"issue":"52","key":"2475_CR21","doi-asserted-by":"publisher","first-page":"eabh2724","DOI":"10.1126\/sciadv.abh2724","volume":"7","author":"G Wang","year":"2021","unstructured":"Wang G, Yao H, Gong Y, Lu Z, Pang R, Li Y, Yuan Y, Song H, Liu J, Jin Y, et al. Metabolic detection and systems analyses of pancreatic ductal adenocarcinoma through machine learning, lipidomics, and multi-omics. Sci Adv. 2021;7(52):eabh2724.","journal-title":"Sci Adv"},{"issue":"3","key":"2475_CR22","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41416-021-01395-w","volume":"125","author":"Y Yuan","year":"2021","unstructured":"Yuan Y, Zhao Z, Xue L, Wang G, Song H, Pang R, Zhou J, Luo J, Song Y, Yin Y. Identification of diagnostic markers and lipid dysregulation in oesophageal squamous cell carcinoma through lipidomic analysis and machine learning. Br J Cancer. 2021;125(3):351\u20137.","journal-title":"Br J Cancer"},{"key":"2475_CR23","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","volume":"25","author":"DS Chandrashekar","year":"2022","unstructured":"Chandrashekar DS, Karthikeyan SK, Korla PK, Patel H, Shovon AR, Athar M, Netto GJ, Qin ZS, Kumar S, Manne U, et al. UALCAN: An update to the integrated cancer data analysis platform. Neoplasia. 2022;25:18\u201327.","journal-title":"Neoplasia"},{"issue":"1","key":"2475_CR24","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/s41392-024-01848-7","volume":"9","author":"S Zhang","year":"2024","unstructured":"Zhang S, Xiao X, Yi Y, Wang X, Zhu L, Shen Y, Lin D, Wu C. Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets. Signal Transduct Target Ther. 2024;9(1):149.","journal-title":"Signal Transduct Target Ther"},{"key":"2475_CR25","doi-asserted-by":"publisher","first-page":"42710","DOI":"10.1038\/srep42710","volume":"7","author":"T Wu","year":"2017","unstructured":"Wu T, Zheng X, Yang M, Zhao A, Li M, Chen T, Panee J, Jia W, Ji G. Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients. Sci Rep. 2017;7:42710.","journal-title":"Sci Rep"},{"issue":"10","key":"2475_CR26","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.3390\/metabo13101047","volume":"13","author":"MM Rashid","year":"2023","unstructured":"Rashid MM, Varghese RS, Ding Y, Ressom HW. Biomarker discovery for hepatocellular carcinoma in patients with liver cirrhosis using untargeted metabolomics and lipidomics studies. Metabolites. 2023;13(10):1047.","journal-title":"Metabolites"},{"issue":"3","key":"2475_CR27","doi-asserted-by":"publisher","first-page":"e28510","DOI":"10.1097\/MD.0000000000028510","volume":"101","author":"N Feng","year":"2022","unstructured":"Feng N, Yu F, Yu F, Feng Y, Zhu X, Xie Z, Zhai Y. Metabolomic biomarkers for hepatocellular carcinoma: A systematic review. Medicine (Baltimore). 2022;101(3):e28510.","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"2475_CR28","first-page":"1184","volume":"11","author":"SJ Feng","year":"2023","unstructured":"Feng SJ, Wang JH, Wang LH, Qiu QX, Chen DD, Su H, Li XL, Xiao Y, Lin CY. Current status and analysis of machine learning in hepatocellular carcinoma. J Clin Transl Hepatol. 2023;11(5):1184\u201391.","journal-title":"J Clin Transl Hepatol"},{"key":"2475_CR29","doi-asserted-by":"crossref","unstructured":"Buechler C, Aslanidis C. Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma. Biochim Et Biophys Acta-Mol Cell Biol Lipids 2020;1865(5):158658.","DOI":"10.1016\/j.bbalip.2020.158658"},{"key":"2475_CR30","doi-asserted-by":"crossref","unstructured":"Caponigro V, Tornesello AL, Merciai F, La Gioia D, Salviati E, Basilicata MG, Musella S, Izzo F, Megna AS, Buonaguro L, et al. Integrated plasma metabolomics and lipidomics profiling highlights distinctive signature of hepatocellular carcinoma in HCV patients. J Transl Med. 2023;21(1):918.","DOI":"10.1186\/s12967-023-04801-4"},{"key":"2475_CR31","doi-asserted-by":"publisher","unstructured":"Liu QB, Zhang XY, Qi JJ, Tian XC, Dovjak E, Zhang JQ, Du HH, Zhang N, Zhao J, Zhang YM, et al. Comprehensive profiling of lipid metabolic reprogramming expands precision medicine for HCC. Hepatology 2024. https:\/\/doi.org\/10.1097\/HEP.0000000000000962.","DOI":"10.1097\/HEP.0000000000000962"},{"key":"2475_CR32","doi-asserted-by":"crossref","unstructured":"Lewinska M, Santos-Laso A, Arretxe E, Alonso C, Zhuravleva E, Jimenez-Ag\u00fcero R, Eizaguirre E, Pareja MJ, Romero-G\u00f3mez M, Arrese M, et al. The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma. Ebiomedicine. 2021;73:103661.","DOI":"10.1016\/j.ebiom.2021.103661"},{"key":"2475_CR33","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.2147\/JHC.S474010","volume":"11","author":"H Powell","year":"2024","unstructured":"Powell H, Coarfa C, Ruiz-Echartea E, Grimm SL, Najjar O, Yu B, Olivares L, Scheurer ME, Ballantyne C, Alsarraj A, et al. Differences in prediagnostic serum metabolomic and lipidomic profiles between cirrhosis patients with and without incident hepatocellular carcinoma. J Hepatocell Carcinoma. 2024;11:1699\u2013712.","journal-title":"J Hepatocell Carcinoma"},{"issue":"2","key":"2475_CR34","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1097\/HEP.0000000000000553","volume":"79","author":"BH Li","year":"2024","unstructured":"Li BH, Li YZ, Zhou HJ, Xu YC, Cao YJ, Cheng CX, Peng J, Li H, Zhang LZ, Su K, et al. Multiomics identifies metabolic subtypes based on fatty acid degradation allocating personalized treatment in hepatocellular carcinoma. Hepatology. 2024;79(2):289\u2013306.","journal-title":"Hepatology"},{"issue":"11","key":"2475_CR35","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.1002\/1878-0261.13520","volume":"17","author":"Y Azbazdar","year":"2023","unstructured":"Azbazdar Y, Demirci Y, Heger G, Ipekgil D, Karabicici M, Ozhan G. Comparative membrane lipidomics of hepatocellular carcinoma cells reveals diacylglycerol and ceramide as key regulators of Wnt\/\u03b2-catenin signaling and tumor growth. Mol Oncol. 2023;17(11):2314\u201336.","journal-title":"Mol Oncol"},{"key":"2475_CR36","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.plipres.2019.04.003","volume":"74","author":"S Paul","year":"2019","unstructured":"Paul S, Lancaster GI, Meikle PJ. Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease. Prog Lipid Res. 2019;74:186\u201395.","journal-title":"Prog Lipid Res"},{"issue":"2","key":"2475_CR37","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s13238-017-0423-5","volume":"9","author":"JM Dean","year":"2018","unstructured":"Dean JM, Lodhi IJ. Structural and functional roles of ether lipids. Protein Cell. 2018;9(2):196\u2013206.","journal-title":"Protein Cell"},{"key":"2475_CR38","doi-asserted-by":"crossref","unstructured":"Donovan EL, Pettine SM, Hickey MS, Hamilton KL, Miller BF. Lipidomic analysis of human plasma reveals ether-linked lipids that are elevated in morbidly obese humans compared to lean. Diabetol Metab Syndr. 2013;5(1):24.","DOI":"10.1186\/1758-5996-5-24"},{"issue":"17","key":"2475_CR39","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1002\/1873-3468.13465","volume":"593","author":"N Jim\u00e9nez-Rojo","year":"2019","unstructured":"Jim\u00e9nez-Rojo N, Riezman H. On the road to unraveling the molecular functions of ether lipids. FEBS Lett. 2019;593(17):2378\u201389.","journal-title":"FEBS Lett"},{"issue":"7","key":"2475_CR40","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1083\/jcb.201903090","volume":"218","author":"RJ Schulze","year":"2019","unstructured":"Schulze RJ, Schott MB, Casey CA, Tuma PL, McNiven MA. The cell biology of the hepatocyte: a membrane trafficking machine. J Cell Biol. 2019;218(7):2096\u2013112.","journal-title":"J Cell Biol"},{"key":"2475_CR41","doi-asserted-by":"crossref","unstructured":"von Gerichten J, Saunders K, Bailey MJ, Gethings LA, Onoja A, Geifman N, Spick M. Challenges in lipidomics biomarker identification: avoiding the pitfalls and improving reproducibility. Metabolites. 2024;14(8):461.","DOI":"10.3390\/metabo14080461"},{"issue":"8","key":"2475_CR42","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s42255-019-0094-z","volume":"1","author":"G Liebisch","year":"2019","unstructured":"Liebisch G, Ahrends R, Arita M, Arita M, Bowden JA, Ejsing CS, Griffiths WJ, Holcapek M, K\u00f6feler H, Mitchell TW, et al. Lipidomics needs more standardization. Nat Metab. 2019;1(8):745\u20137.","journal-title":"Nat Metab"},{"key":"2475_CR43","doi-asserted-by":"crossref","unstructured":"K\u00f6feler HC, Ahrends R, Baker ES, Ekroos K, Han XL, Hoffmann N, Holcapek M, Wenk MR, Liebisch G. Recommendations for good practice in MS-based lipidomics. J Lipid Res. 2021;62:100138.","DOI":"10.1016\/j.jlr.2021.100138"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02475-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12944-025-02475-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02475-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:57:55Z","timestamp":1740376675000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/s12944-025-02475-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2475"],"URL":"https:\/\/doi.org\/10.1186\/s12944-025-02475-z","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"27 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Beijing Youan Hospital (No. LL-2024\u2013130-K). Informed consents were obtained from all study subjects. All methods were performed in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"69"}}