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In accordance with the original GWAS protocol, all participants provided informed consent, and all ethical approvals related to the GWAS were issued by the original authors of the GWAS. The experimental verification part of this study has been approved by the Institutional Review Board of Tianjin Medical University General Hospital (Tianjin, China) (No. IRB2020-YX-029-01\/No.IRB2023-YX-204-01) and received consent from the patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"113"}}