{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T19:35:03Z","timestamp":1771961703197,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"This research was supported by Molecular network of metadherin regulating metabolism in hepatocellular carcinoma based on post-translational modification integrated protein technology","award":["AHWJ2023BAa20083"],"award-info":[{"award-number":["AHWJ2023BAa20083"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"DOI":"10.1186\/s12944-025-02570-1","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T09:08:07Z","timestamp":1746522487000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The association between the intake of polyunsaturated fatty acids and chronic constipation and diarrhea: NHANES 2005\u20132010"],"prefix":"10.1186","volume":"24","author":[{"given":"Ping","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"issue":"12","key":"2570_CR1","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1111\/apt.16369","volume":"53","author":"A Sharma","year":"2021","unstructured":"Sharma A, Rao SSC, Kearns K, Orleck KD, Waldman SA. Review Article: diagnosis, management and patient perspectives of the spectrum of constipation disorders. Aliment Pharmacol Ther. 2021;53(12):1250\u201367. https:\/\/doi.org\/10.1111\/apt.16369","journal-title":"Aliment Pharmacol Ther"},{"issue":"8","key":"2570_CR2","doi-asserted-by":"publisher","first-page":"e43749","DOI":"10.1371\/journal.pone.0043749","volume":"7","author":"YF Zhao","year":"2012","unstructured":"Zhao YF, Guo XJ, Zhang ZS, Ma XQ, Wang R, Yan XY, et al. Epidemiology of functional diarrhea and comparison with diarrhea-predominant irritable bowel syndrome: a population-based survey in China. PLoS ONE. 2012;7(8):e43749. https:\/\/doi.org\/10.1371\/journal.pone.0043749","journal-title":"PLoS ONE"},{"issue":"1","key":"2570_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/advances\/nmz061","volume":"11","author":"MW Rohr","year":"2020","unstructured":"Rohr MW, Narasimhulu CA, Rudeski-Rohr TA, Parthasarathy S. Negative effects of a High-Fat diet on intestinal permeability: A review. Adv Nutr. 2020;11(1):77\u201391. https:\/\/doi.org\/10.1093\/advances\/nmz061","journal-title":"Adv Nutr"},{"issue":"7","key":"2570_CR4","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1007\/s00394-023-03172-2","volume":"62","author":"B Seethaler","year":"2023","unstructured":"Seethaler B, Lehnert K, Yahiaoui-Doktor M, Basrai M, Vetter W, Kiechle M, et al. Omega-3 polyunsaturated fatty acids improve intestinal barrier integrity-albeit to a lesser degree than short-chain fatty acids: an exploratory analysis of the randomized controlled LIBRE trial. Eur J Nutr. 2023;62(7):2779\u201391. https:\/\/doi.org\/10.1007\/s00394-023-03172-2","journal-title":"Eur J Nutr"},{"issue":"1","key":"2570_CR5","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1006\/mgme.2001.3170","volume":"73","author":"SA Lagerstedt","year":"2001","unstructured":"Lagerstedt SA, Hinrichs DR, Batt SM, Magera MJ, Rinaldo P, McConnell JP. Quantitative determination of plasma c8-c26 total fatty acids for the biochemical diagnosis of nutritional and metabolic disorders. Mol Genet Metab. 2001;73(1):38\u201345. https:\/\/doi.org\/10.1006\/mgme.2001.3170","journal-title":"Mol Genet Metab"},{"issue":"4","key":"2570_CR6","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/ajg.2018.24","volume":"113","author":"P Singh","year":"2018","unstructured":"Singh P, Mitsuhashi S, Ballou S, Rangan V, Sommers T, Cheng V, et al. Demographic and dietary associations of chronic diarrhea in a representative sample of adults in the united States. Am J Gastroenterol. 2018;113(4):593\u2013600. https:\/\/doi.org\/10.1038\/ajg.2018.24","journal-title":"Am J Gastroenterol"},{"key":"2570_CR7","doi-asserted-by":"publisher","first-page":"239821282311944","DOI":"10.1177\/23982128231194452","volume":"7","author":"AM Rakshasa-Loots","year":"2023","unstructured":"Rakshasa-Loots AM, Hamana T, Fanqa B, Lindani F, van Wyhe K, Kruger S, et al. IsiXhosa translation of the patient health questionnaire (PHQ-9) shows satisfactory psychometric properties for the measurement of depressive symptoms [Stage 2]. Brain Neurosci Adv. 2023;7:23982128231194452. https:\/\/doi.org\/10.1177\/23982128231194452","journal-title":"Brain Neurosci Adv"},{"key":"2570_CR8","doi-asserted-by":"publisher","unstructured":"Chen Y, Wu T, Lu W, Yuan W, Pan M, Lee YK, et al. Predicting the role of the human gut Microbiome in constipation using Machine-Learning methods: A Meta-Analysis. Microorganisms. 2021;9(10). https:\/\/doi.org\/10.3390\/microorganisms9102149","DOI":"10.3390\/microorganisms9102149"},{"issue":"4","key":"2570_CR9","doi-asserted-by":"publisher","first-page":"482","DOI":"10.2307\/3426014","volume":"88","author":"SM Hanson","year":"1988","unstructured":"Hanson SM. Write on. Am J Nurs. 1988;88(4):482\u20133.","journal-title":"Am J Nurs"},{"issue":"11","key":"2570_CR10","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1136\/gutjnl-2017-314968","volume":"67","author":"H Watson","year":"2018","unstructured":"Watson H, Mitra S, Croden FC, Taylor M, Wood HM, Perry SL, et al. A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota. Gut. 2018;67(11):1974\u201383. https:\/\/doi.org\/10.1136\/gutjnl-2017-314968","journal-title":"Gut"},{"key":"2570_CR11","doi-asserted-by":"publisher","first-page":"8879227","DOI":"10.1155\/2021\/8879227","volume":"2021","author":"Y Fu","year":"2021","unstructured":"Fu Y, Wang Y, Gao H, Li D, Jiang R, Ge L, et al. Associations among dietary Omega-3 polyunsaturated fatty acids, the gut microbiota, and intestinal immunity. Mediators Inflamm. 2021;2021:8879227. https:\/\/doi.org\/10.1155\/2021\/8879227","journal-title":"Mediators Inflamm"},{"key":"2570_CR12","doi-asserted-by":"publisher","unstructured":"Szklany K, Engen PA, Naqib A, Green SJ, Keshavarzian A, Lopez Rincon A, et al. Dietary supplementation throughout life with Non-Digestible oligosaccharides and\/or n-3 Poly-Unsaturated fatty acids in healthy mice modulates the Gut-Immune System-Brain Axis. Nutrients. 2021;14(1). https:\/\/doi.org\/10.3390\/nu14010173","DOI":"10.3390\/nu14010173"},{"key":"2570_CR13","doi-asserted-by":"publisher","unstructured":"Skoufou M, Tsigalou C, Vradelis S, Bezirtzoglou E. The networked interaction between probiotics and intestine in health and disease: A promising success story. Microorganisms. 2024;12(1). https:\/\/doi.org\/10.3390\/microorganisms12010194","DOI":"10.3390\/microorganisms12010194"},{"key":"2570_CR14","doi-asserted-by":"publisher","unstructured":"Linsalata M, Ignazzi A, D\u2019Attoma B, Riezzo G, Mallardi D, Orlando A, et al. Relationship between markers of gut barrier function and erythrocyte membrane PUFAs in Diarrhea-Predominant IBS patients undergoing a Low-FODMAP diet. Nutrients. 2024;16(16). https:\/\/doi.org\/10.3390\/nu16162706","DOI":"10.3390\/nu16162706"},{"key":"2570_CR15","doi-asserted-by":"publisher","first-page":"604989","DOI":"10.3389\/fimmu.2020.604989","volume":"11","author":"AR Basson","year":"2020","unstructured":"Basson AR, Chen C, Sagl F, Trotter A, Bederman I, Gomez-Nguyen A, et al. Regulation of intestinal inflammation by dietary fats. Front Immunol. 2020;11:604989. https:\/\/doi.org\/10.3389\/fimmu.2020.604989","journal-title":"Front Immunol"},{"key":"2570_CR16","doi-asserted-by":"publisher","unstructured":"Tu M, Wang W, Zhang G, Hammock BD. \u03c9-3 polyunsaturated fatty acids on colonic inflammation and Colon cancer: roles of Lipid-Metabolizing enzymes involved. Nutrients. 2020;12(11). https:\/\/doi.org\/10.3390\/nu12113301","DOI":"10.3390\/nu12113301"},{"key":"2570_CR17","doi-asserted-by":"publisher","first-page":"1286667","DOI":"10.3389\/fimmu.2023.1286667","volume":"14","author":"D Yan","year":"2023","unstructured":"Yan D, Ye S, He Y, Wang S, Xiao Y, Xiang X, et al. Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment. Front Immunol. 2023;14:1286667. https:\/\/doi.org\/10.3389\/fimmu.2023.1286667","journal-title":"Front Immunol"},{"issue":"10","key":"2570_CR18","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1021\/acschemneuro.3c00127","volume":"14","author":"JM Sasso","year":"2023","unstructured":"Sasso JM, Ammar RM, Tenchov R, Lemmel S, Kelber O, Grieswelle M, et al. Gut Microbiome-Brain alliance: A landscape view into mental and Gastrointestinal health and disorders. ACS Chem Neurosci. 2023;14(10):1717\u201363. https:\/\/doi.org\/10.1021\/acschemneuro.3c00127","journal-title":"ACS Chem Neurosci"},{"key":"2570_CR19","doi-asserted-by":"publisher","first-page":"1380713","DOI":"10.3389\/fphys.2024.1380713","volume":"15","author":"TR Dmytriv","year":"2024","unstructured":"Dmytriv TR, Storey KB, Lushchak VI. Intestinal barrier permeability: the influence of gut microbiota, nutrition, and exercise. Front Physiol. 2024;15:1380713. https:\/\/doi.org\/10.3389\/fphys.2024.1380713","journal-title":"Front Physiol"},{"key":"2570_CR20","doi-asserted-by":"publisher","unstructured":"Pan R, Wang L, Xu X, Chen Y, Wang H, Wang G, et al. Crosstalk between the gut Microbiome and colonic motility in chronic constipation: potential mechanisms and microbiota modulation. Nutrients. 2022;14(18). https:\/\/doi.org\/10.3390\/nu14183704","DOI":"10.3390\/nu14183704"},{"issue":"1","key":"2570_CR21","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s40104-022-00690-7","volume":"13","author":"TS Sundaram","year":"2022","unstructured":"Sundaram TS, Giromini C, Rebucci R, Pistl J, Bhide M, Baldi A. Role of omega-3 polyunsaturated fatty acids, citrus pectin, and milk-derived exosomes on intestinal barrier integrity and immunity in animals. J Anim Sci Biotechnol. 2022;13(1):40. https:\/\/doi.org\/10.1186\/s40104-022-00690-7","journal-title":"J Anim Sci Biotechnol"},{"issue":"1","key":"2570_CR22","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/s41598-021-03787-7","volume":"12","author":"F Rubbino","year":"2022","unstructured":"Rubbino F, Garlatti V, Garzarelli V, Massimino L, Span\u00f2 S, Iadarola P, et al. GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity. Sci Rep. 2022;12(1):381. https:\/\/doi.org\/10.1038\/s41598-021-03787-7","journal-title":"Sci Rep"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02570-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12944-025-02570-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02570-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T09:08:08Z","timestamp":1746522488000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/s12944-025-02570-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,6]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2570"],"URL":"https:\/\/doi.org\/10.1186\/s12944-025-02570-1","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,6]]},"assertion":[{"value":"6 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"164"}}