{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:58:07Z","timestamp":1792886287567,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"DOI":"10.1186\/s12944-025-02589-4","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:20:41Z","timestamp":1747210841000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Obesity indicators mediate the association between the aggregate index of systemic inflammation (AISI) and type 2 diabetes mellitus (T2DM)"],"prefix":"10.1186","volume":"24","author":[{"given":"Ziying","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"2589_CR1","doi-asserted-by":"crossref","unstructured":"Qi MH, Zhang HY, Hou YY, Nguepi Tsopmejio IS, Liu W, Chang WG, Chen C, Wang Z, Li W. Ginseng-derived GABAFG ameliorates type 2 diabetes mellitus by modulating autophagy-lysosome pathway and gut microbiota. J Adv Res. 2025.","DOI":"10.1016\/j.jare.2025.01.003"},{"key":"2589_CR2","doi-asserted-by":"publisher","first-page":"e151","DOI":"10.2337\/dci23-0036","volume":"46","author":"DB Sacks","year":"2023","unstructured":"Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Lernmark \u00c5, Metzger BE, Nathan DM, Kirkman MS. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care. 2023;46:e151\u201399.","journal-title":"Diabetes Care"},{"key":"2589_CR3","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1186\/s12933-024-02438-1","volume":"23","author":"X Ouyang","year":"2024","unstructured":"Ouyang X, Peng L, Huang Z, Wang T, Wang J, Wu H, Zhong J, Wu B, Wu L, Li Y, et al. Effects of adipose tissues on the relationship between type 2 diabetes mellitus and reduced heart rate variability: mediation analysis. Cardiovasc Diabetol. 2024;23:353.","journal-title":"Cardiovasc Diabetol"},{"key":"2589_CR4","doi-asserted-by":"publisher","first-page":"e13349","DOI":"10.1111\/obr.13349","volume":"23","author":"R Hariharan","year":"2022","unstructured":"Hariharan R, Odjidja EN, Scott D, Shivappa N, H\u00e9bert JR, Hodge A, de Courten B. The dietary inflammatory index, obesity, type 2 diabetes, and cardiovascular risk factors and diseases. Obes Rev. 2022;23:e13349.","journal-title":"Obes Rev"},{"key":"2589_CR5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","volume":"55","author":"TV Rohm","year":"2022","unstructured":"Rohm TV, Meier DT, Olefsky JM, Donath MY. Inflammation in obesity, diabetes, and related disorders. Immunity. 2022;55:31\u201355.","journal-title":"Immunity"},{"key":"2589_CR6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12933-024-02129-x","volume":"23","author":"J Luo","year":"2024","unstructured":"Luo J, Qin X, Zhang X, Zhang Y, Yuan F, Shi W, Liu B, Wei Y. Prognostic implications of systemic immune-inflammation index in myocardial infarction patients with and without diabetes: insights from the NOAFCAMI-SH registry. Cardiovasc Diabetol. 2024;23:41.","journal-title":"Cardiovasc Diabetol"},{"key":"2589_CR7","doi-asserted-by":"publisher","first-page":"491","DOI":"10.2217\/fca-2018-0045","volume":"14","author":"RJ Henning","year":"2018","unstructured":"Henning RJ. Type-2 diabetes mellitus and cardiovascular disease. Future Cardiol. 2018;14:491\u2013509.","journal-title":"Future Cardiol"},{"key":"2589_CR8","doi-asserted-by":"publisher","first-page":"7991","DOI":"10.1038\/s41467-024-52258-w","volume":"15","author":"L Qi","year":"2024","unstructured":"Qi L, Groeger M, Sharma A, Goswami I, Chen E, Zhong F, Ram A, Healy K, Hsiao EC, Willenbring H, Stahl A. Adipocyte inflammation is the primary driver of hepatic insulin resistance in a human iPSC-based microphysiological system. Nat Commun. 2024;15:7991.","journal-title":"Nat Commun"},{"key":"2589_CR9","doi-asserted-by":"publisher","first-page":"851","DOI":"10.5114\/aoms.2016.58928","volume":"13","author":"MS Ellulu","year":"2017","unstructured":"Ellulu MS, Patimah I, Khaza\u2019ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017;13:851\u2013863.","journal-title":"Arch Med Sci"},{"key":"2589_CR10","doi-asserted-by":"publisher","first-page":"1446160","DOI":"10.3389\/fmed.2024.1446160","volume":"11","author":"X Yin","year":"2024","unstructured":"Yin X, Zou J, Yang J. The association between the aggregate index of systemic inflammation and risk of rheumatoid arthritis: retrospective analysis of NHANES 1999\u20132018. Front Med (Lausanne). 2024;11:1446160.","journal-title":"Front Med (Lausanne)"},{"key":"2589_CR11","first-page":"66","volume":"29","author":"A Alirezaei","year":"2024","unstructured":"Alirezaei A, Toudeshki KK, Taherian M, Pashapour H, Rahmani F, Norouzi N, Fazeli SA. Comparison of complete blood count parameters in different severity of proteinuria among patients with type 2 diabetes mellitus. J Res Med Sci. 2024;29:66.","journal-title":"J Res Med Sci"},{"key":"2589_CR12","doi-asserted-by":"publisher","first-page":"1163900","DOI":"10.3389\/fcvm.2023.1163900","volume":"10","author":"J Xiu","year":"2023","unstructured":"Xiu J, Lin X, Chen Q, Yu P, Lu J, Yang Y, Chen W, Bao K, Wang J, Zhu J, et al. The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension. Front Cardiovasc Med. 2023;10:1163900.","journal-title":"Front Cardiovasc Med"},{"key":"2589_CR13","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12902-024-01637-x","volume":"24","author":"HL Chen","year":"2024","unstructured":"Chen HL, Wu C, Cao L, Wang R, Zhang TY, He Z. The association between the neutrophil-to-lymphocyte ratio and type 2 diabetes mellitus: a cross-sectional study. BMC Endocr Disord. 2024;24:107.","journal-title":"BMC Endocr Disord"},{"key":"2589_CR14","doi-asserted-by":"crossref","unstructured":"Aljuraiban GS, Alharbi FJ, Aljohi AO, Almeshari AZ, Alotaibi MN, AlShammari SS, Al-Musharaf S, Aldhwayan MM, Abudawood M. Systemic Immune-Inflammation index in relation to diabetes markers in Saudi adults: A retrospective study. Med (Kaunas). 2024;60.","DOI":"10.3390\/medicina60030442"},{"key":"2589_CR15","doi-asserted-by":"publisher","first-page":"1362077","DOI":"10.3389\/fendo.2024.1362077","volume":"15","author":"J Liu","year":"2024","unstructured":"Liu J, Wang X, Gao TY, Zhang Q, Zhang SN, Xu YY, Yao WQ, Yang ZH, Yan HJ. Red blood cell distribution width to albumin ratio associates with prevalence and long-term diabetes mellitus prognosis: an overview of NHANES 1999\u20132020 data. Front Endocrinol (Lausanne). 2024;15:1362077.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2589_CR16","doi-asserted-by":"publisher","first-page":"111575","DOI":"10.1016\/j.diabres.2024.111575","volume":"209","author":"J Zhang","year":"2024","unstructured":"Zhang J, Fan X, Xu Y, Wang K, Xu T, Han T, Hu C, Li R, Lin X, Jin L. Association between inflammatory biomarkers and mortality in individuals with type 2 diabetes: NHANES 2005\u20132018. Diabetes Res Clin Pract. 2024;209:111575.","journal-title":"Diabetes Res Clin Pract"},{"key":"2589_CR17","doi-asserted-by":"publisher","first-page":"1455521","DOI":"10.3389\/fnut.2024.1455521","volume":"11","author":"T Mo","year":"2024","unstructured":"Mo T, Wei M, Fu J. Dietary inflammatory index and type 2 diabetes in US women: a cross-sectional analysis of the National health and nutrition examination survey, 2007\u20132018. Front Nutr. 2024;11:1455521.","journal-title":"Front Nutr"},{"key":"2589_CR18","doi-asserted-by":"publisher","first-page":"e038674","DOI":"10.1161\/JAHA.124.038674","volume":"14","author":"D Tu","year":"2025","unstructured":"Tu D, Sun J, Wang P, Xu Q, Ma C. Overall sleep quality is associated with advanced stages in patients with Cardiovascular-Kidney-Metabolic syndrome. J Am Heart Assoc. 2025;14:e038674.","journal-title":"J Am Heart Assoc"},{"key":"2589_CR19","doi-asserted-by":"publisher","first-page":"1526801","DOI":"10.3389\/fnut.2025.1526801","volume":"12","author":"Y Lei","year":"2025","unstructured":"Lei Y, Tao S, Yang Y, Xie F, Xie W. Association between prognostic nutritional index and all-cause mortality and cardiovascular disease mortality in American adults with non-alcoholic fatty liver disease. Front Nutr. 2025;12:1526801.","journal-title":"Front Nutr"},{"key":"2589_CR20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.ajo.2025.03.010","volume":"274","author":"W Guo","year":"2025","unstructured":"Guo W, Xue H, Li Q, Wen Z, Zhou Z, Dong Y, He M, Li Y, Li F, Tong Y. Association between visceral fat metabolism score and cataract risk in US adults: National health and nutrition examination survey 1999 to 2008. Am J Ophthalmol. 2025;274:184\u2013195.","journal-title":"Am J Ophthalmol"},{"key":"2589_CR21","doi-asserted-by":"publisher","first-page":"1345411","DOI":"10.3389\/fendo.2024.1345411","volume":"15","author":"Z Wang","year":"2024","unstructured":"Wang Z, Shao X, Xu W, Xue B, Zhong S, Yang Q. The relationship between weight-adjusted-waist index and diabetic kidney disease in patients with type 2 diabetes mellitus. Front Endocrinol (Lausanne). 2024;15:1345411.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2589_CR22","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12944-025-02432-w","volume":"24","author":"X Sun","year":"2025","unstructured":"Sun X, Song J, Yan R, Diao J, Liu Y, Zhu Z, Lu W. The association between lipid-related obesity indicators and severe headache or migraine: a nationwide cross sectional study from NHANES 1999 to 2004. Lipids Health Dis. 2025;24:10.","journal-title":"Lipids Health Dis"},{"key":"2589_CR23","doi-asserted-by":"publisher","first-page":"1535655","DOI":"10.3389\/fnut.2025.1535655","volume":"12","author":"H Liu","year":"2025","unstructured":"Liu H, Kang J, Liu W, Shen Y. Association between a body shape index and colorectal cancer in US population: a cross-sectional study based on NHANES. Front Nutr. 2025;12:1535655.","journal-title":"Front Nutr"},{"key":"2589_CR24","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12944-024-02143-8","volume":"23","author":"MY Tan","year":"2024","unstructured":"Tan MY, Weng L, Yang ZH, Zhu SX, Wu S, Su JH. The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with type 2 diabetes mellitus: recent findings from NHANES 2007\u20132018. Lipids Health Dis. 2024;23:151.","journal-title":"Lipids Health Dis"},{"key":"2589_CR25","doi-asserted-by":"publisher","first-page":"16634","DOI":"10.1038\/s41598-024-67430-x","volume":"14","author":"H Zhou","year":"2024","unstructured":"Zhou H, Li T, Li J, Zhuang X, Yang J. The association between visceral adiposity index and risk of type 2 diabetes mellitus. Sci Rep. 2024;14:16634.","journal-title":"Sci Rep"},{"key":"2589_CR26","doi-asserted-by":"crossref","unstructured":"Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604\u201312.","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"2589_CR27","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.2337\/dc21-2371","volume":"45","author":"Z Qiu","year":"2022","unstructured":"Qiu Z, Chen X, Geng T, Wan Z, Lu Q, Li L, Zhu K, Zhang X, Liu Y, Lin X, et al. Associations of serum carotenoids with risk of cardiovascular mortality among individuals with type 2 diabetes: results from NHANES. Diabetes Care. 2022;45:1453\u201361.","journal-title":"Diabetes Care"},{"key":"2589_CR28","doi-asserted-by":"publisher","first-page":"1148417","DOI":"10.3389\/fendo.2023.1148417","volume":"14","author":"C Wu","year":"2023","unstructured":"Wu C, Ren C, Song Y, Gao H, Pang X, Zhang L. Gender-specific effects of oxidative balance score on the prevalence of diabetes in the US population from NHANES. Front Endocrinol (Lausanne). 2023;14:1148417.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2589_CR29","doi-asserted-by":"publisher","first-page":"36093","DOI":"10.1038\/srep36093","volume":"6","author":"Y Song","year":"2016","unstructured":"Song Y, Liu X, Zhu X, Zhao B, Hu B, Sheng X, Chen L, Yu M, Yang T, Zhao J. Increasing trend of diabetes combined with hypertension or hypercholesterolemia: NHANES data analysis 1999\u20132012. Sci Rep. 2016;6:36093.","journal-title":"Sci Rep"},{"key":"2589_CR30","doi-asserted-by":"publisher","first-page":"13884","DOI":"10.1038\/s41598-024-63886-z","volume":"14","author":"S Xiao","year":"2024","unstructured":"Xiao S, Zhang Q, Yang HY, Tong JY, Yang RQ. The association between triglyceride glucose-body mass index and all-cause and cardiovascular mortality in diabetes patients: a retrospective study from NHANES database. Sci Rep. 2024;14:13884.","journal-title":"Sci Rep"},{"key":"2589_CR31","doi-asserted-by":"publisher","first-page":"100953","DOI":"10.1016\/j.bbih.2025.100953","volume":"44","author":"J Zhang","year":"2025","unstructured":"Zhang J, Yang C, An J, Fan Y, Dong X. Evaluating sleep\u2019s role in type 2 diabetes mellitus: evidence from NHANES. Brain Behav Immun Health. 2025;44:100953.","journal-title":"Brain Behav Immun Health"},{"key":"2589_CR32","doi-asserted-by":"publisher","first-page":"6234","DOI":"10.1038\/s41598-025-90854-y","volume":"15","author":"Z Wu","year":"2025","unstructured":"Wu Z, Gong C, Wang B. The relationship between dietary index for gut microbiota and diabetes. Sci Rep. 2025;15:6234.","journal-title":"Sci Rep"},{"key":"2589_CR33","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1186\/s12903-025-05597-z","volume":"25","author":"J Zhu","year":"2025","unstructured":"Zhu J, Xu W, Wu S, Song D. Vitamin B6 status, type 2 diabetes mellitus, and periodontitis: evidence from the NHANES database 2009\u20132010. BMC Oral Health. 2025;25:299.","journal-title":"BMC Oral Health"},{"key":"2589_CR34","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.3233\/THC-231101","volume":"32","author":"A Fajki\u0107","year":"2024","unstructured":"Fajki\u0107 A, Jahi\u0107 R, Begi\u0107 E, Dervi\u0161evi\u0107 A, Kurtovi\u0107 A, Lepara O. Complete blood count inflammation derived indexes as predictors of metabolic syndrome in type 2 diabetes mellitus. Technol Health Care. 2024;32:2321\u201330.","journal-title":"Technol Health Care"},{"key":"2589_CR35","doi-asserted-by":"publisher","first-page":"634900","DOI":"10.3389\/fcell.2021.634900","volume":"9","author":"W Jia","year":"2021","unstructured":"Jia W, Bai T, Zeng J, Niu Z, Fan D, Xu X, Luo M, Wang P, Zou Q, Dai X. Combined administration of Metformin and Atorvastatin attenuates diabetic cardiomyopathy by inhibiting inflammation, apoptosis, and oxidative stress in type 2 diabetic mice. Front Cell Dev Biol. 2021;9:634900.","journal-title":"Front Cell Dev Biol"},{"key":"2589_CR36","doi-asserted-by":"publisher","first-page":"e1503","DOI":"10.1002\/ctm2.1503","volume":"13","author":"H Lee","year":"2023","unstructured":"Lee H, Joo JY, Song JM, Kim HJ, Kim YH, Park HR. Immunological link between periodontitis and type 2 diabetes Deciphered by single-cell RNA analysis. Clin Transl Med. 2023;13:e1503.","journal-title":"Clin Transl Med"},{"key":"2589_CR37","doi-asserted-by":"publisher","first-page":"1294317","DOI":"10.3389\/fimmu.2023.1294317","volume":"14","author":"J Li","year":"2023","unstructured":"Li J, Li L, Zhang Z, Chen P, Shu H, Yang C, Chu Y, Liu J. Ferroptosis: an important player in the inflammatory response in diabetic nephropathy. Front Immunol. 2023;14:1294317.","journal-title":"Front Immunol"},{"key":"2589_CR38","doi-asserted-by":"publisher","first-page":"7658","DOI":"10.1038\/s41467-023-43067-8","volume":"14","author":"L Yang","year":"2023","unstructured":"Yang L, Zhang D, Li W, Lin H, Ding C, Liu Q, Wang L, Li Z, Mei L, Chen H, et al. Biofilm microenvironment triggered self-enhancing photodynamic Immunomodulatory microneedle for diabetic wound therapy. Nat Commun. 2023;14:7658.","journal-title":"Nat Commun"},{"key":"2589_CR39","doi-asserted-by":"publisher","first-page":"e2202590","DOI":"10.1002\/advs.202202590","volume":"9","author":"W Luo","year":"2022","unstructured":"Luo W, Lin K, Hua J, Han J, Zhang Q, Chen L, Khan ZA, Wu G, Wang Y, Liang G. Schisandrin B attenuates diabetic cardiomyopathy by targeting MyD88 and inhibiting MyD88-Dependent inflammation. Adv Sci (Weinh). 2022;9:e2202590.","journal-title":"Adv Sci (Weinh)"},{"key":"2589_CR40","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/s12933-023-01956-8","volume":"22","author":"EM Gram-Kampmann","year":"2023","unstructured":"Gram-Kampmann EM, Olesen TB, Hansen CD, Hugger MB, Jensen JM, Handberg A, Beck-Nielsen H, Krag A, Olsen MH, H\u00f8jlund K. A six-month low-carbohydrate diet high in fat does not adversely affect endothelial function or markers of low-grade inflammation in patients with type 2 diabetes: an open-label randomized controlled trial. Cardiovasc Diabetol. 2023;22:212.","journal-title":"Cardiovasc Diabetol"},{"key":"2589_CR41","doi-asserted-by":"publisher","first-page":"811081","DOI":"10.3389\/fnut.2021.811081","volume":"8","author":"E Rodr\u00edguez-Rodr\u00edguez","year":"2021","unstructured":"Rodr\u00edguez-Rodr\u00edguez E, Salas-Gonz\u00e1lez MD, Ortega RM, L\u00f3pez-Sobaler AM. Leukocytes and Neutrophil-Lymphocyte ratio as indicators of insulin resistance in overweight\/obese School-Children. Front Nutr. 2021;8:811081.","journal-title":"Front Nutr"},{"key":"2589_CR42","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.jinf.2019.02.006","volume":"78","author":"CD Russell","year":"2019","unstructured":"Russell CD, Parajuli A, Gale HJ, Bulteel NS, Schuetz P, de Jager CPC, Loonen AJM, Merekoulias GI, Baillie JK. The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis. J Infect. 2019;78:339\u201348.","journal-title":"J Infect"},{"key":"2589_CR43","doi-asserted-by":"crossref","unstructured":"Guglielmini G, Falcinelli E, Piselli E, Mezzasoma AM, Tondi F, Alfonsi L, De Luca C, Fino V, Favilli A, Parrettini S, et al. Gestational diabetes mellitus is associated with in vivo platelet activation and platelet hyperreactivity. Am J Obstet Gynecol. 2025;232:120.e121-120.e114.","DOI":"10.1016\/j.ajog.2024.04.003"},{"key":"2589_CR44","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/s41423-021-00832-3","volume":"19","author":"A Herrero-Cervera","year":"2022","unstructured":"Herrero-Cervera A, Soehnlein O, Kenne E. Neutrophils in chronic inflammatory diseases. Cell Mol Immunol. 2022;19:177\u201391.","journal-title":"Cell Mol Immunol"},{"key":"2589_CR45","doi-asserted-by":"publisher","first-page":"e2306685","DOI":"10.1002\/advs.202306685","volume":"11","author":"Y Liu","year":"2024","unstructured":"Liu Y, Su W, Liu Z, Hu Z, Shen J, Zheng Z, Ding D, Huang W, Li W, Cai G, et al. Macrophage CREBZF orchestrates inflammatory response to potentiate insulin resistance and type 2 diabetes. Adv Sci (Weinh). 2024;11:e2306685.","journal-title":"Adv Sci (Weinh)"},{"key":"2589_CR46","doi-asserted-by":"publisher","first-page":"eadn2136","DOI":"10.1126\/sciadv.adn2136","volume":"10","author":"T Pant","year":"2024","unstructured":"Pant T, Lin CW, Bedrat A, Jia S, Roethle MF, Truchan NA, Ciecko AE, Chen YG, Hessner MJ. Monocytes in type 1 diabetes families exhibit high cytolytic activity and subset abundances that correlate with clinical progression. Sci Adv. 2024;10:eadn2136.","journal-title":"Sci Adv"},{"key":"2589_CR47","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.2337\/db22-0246","volume":"71","author":"CEM Verhulst","year":"2022","unstructured":"Verhulst CEM, van Heck JIP, Fabricius TW, Stienstra R, Teerenstra S, McCrimmon RJ, Tack CJ, Pedersen-Bjergaard U, de Galan BE. Sustained Proinflammatory effects of hypoglycemia in people with type 2 diabetes and in people without diabetes. Diabetes. 2022;71:2716\u201327.","journal-title":"Diabetes"},{"key":"2589_CR48","doi-asserted-by":"publisher","first-page":"4270","DOI":"10.1200\/JCO.2016.67.4283","volume":"34","author":"NM Iyengar","year":"2016","unstructured":"Iyengar NM, Gucalp A, Dannenberg AJ, Hudis CA. Obesity and Cancer mechanisms: tumor microenvironment and inflammation. J Clin Oncol. 2016;34:4270\u20136.","journal-title":"J Clin Oncol"},{"key":"2589_CR49","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1136\/thorax-2022-219268","volume":"78","author":"HA Scott","year":"2023","unstructured":"Scott HA, Ng SH, McLoughlin RF, Valkenborghs SR, Nair P, Brown AC, Carroll OR, Horvat JC, Wood LG. Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis. Thorax. 2023;78:957\u201365.","journal-title":"Thorax"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02589-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12944-025-02589-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02589-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T09:05:52Z","timestamp":1747213552000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/s12944-025-02589-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2589"],"URL":"https:\/\/doi.org\/10.1186\/s12944-025-02589-4","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"17 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The data utilized in this study, which were neither generated nor analyzed by the authors, can be accessed through the NHANES database.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"176"}}