{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T19:40:10Z","timestamp":1749325210154,"version":"3.41.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373696"],"award-info":[{"award-number":["82373696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"DOI":"10.1186\/s12944-025-02598-3","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T09:05:35Z","timestamp":1749287135000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The health status and the prevalence of metabolic disorders of adult endemic cretinism\u2014An epidemiological study in China"],"prefix":"10.1186","volume":"24","author":[{"given":"Yanhong","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingxuan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianshuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxue","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8807-9897","authenticated-orcid":false,"given":"Hongmei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"key":"2598_CR1","unstructured":"WHO U, ICCIDD. Assessment of iodine deficiency disorders and monitoring their elimination."},{"issue":"1","key":"2598_CR2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.beem.2009.08.014","volume":"24","author":"ZP Chen","year":"2010","unstructured":"Chen ZP, Hetzel BS. Cretinism revisited. Best Pract Res Clin Endocrinol Metab. 2010;24(1):39\u201350.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2598_CR3","unstructured":"Jianqun Li QH. Zhong Wei investigation of endemic goiter and endemic cretinism in the Jixian village. China Endemic Dis Newsl. 1979;(03):1\u20137."},{"issue":"3","key":"2598_CR4","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1093\/ije\/dys070","volume":"41","author":"P Pharoah","year":"2012","unstructured":"Pharoah P, Buttfield IH, Hetzel BS. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Int J Epidemiol. 2012;41(3):589\u201392.","journal-title":"Int J Epidemiol"},{"key":"2598_CR5","doi-asserted-by":"crossref","unstructured":"Li J, He Y, Ren B, Zhang Z, Meng F, Zhang X et al. The thyroid condition and residual clinical signs in 31 existing endemic neurological cretins after 42 years of iodine supplementation in China. Front Endocrinol. 2022;13.","DOI":"10.3389\/fendo.2022.911487"},{"issue":"5","key":"2598_CR6","first-page":"220","volume":"28","author":"JB Stanbury","year":"1974","unstructured":"Stanbury JB, Ermans AM, Hetzel BS, Pretell EA, Querido A. Endemic goitre and Cretinism: public health significance and prevention. WHO Chron. 1974;28(5):220\u20138.","journal-title":"WHO Chron"},{"issue":"12","key":"2598_CR7","first-page":"441","volume":"43","author":"R McCarrison","year":"1908","unstructured":"McCarrison R. Observations on endemic cretinism in the chitral and Gilgit valleys. Indian Med Gaz. 1908;43(12):441\u20139.","journal-title":"Indian Med Gaz"},{"issue":"6","key":"2598_CR8","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s11886-004-0054-3","volume":"6","author":"EN Pearce","year":"2004","unstructured":"Pearce EN. Hypothyroidism and dyslipidemia: modern concepts and approaches. Curr Cardiol Rep. 2004;6(6):451\u20136.","journal-title":"Curr Cardiol Rep"},{"key":"2598_CR9","unstructured":"Branch CMAD. Chinese guidelines for the prevention and control of type 2 diabetes mellitus (2020). Chin J Diabetes. 2021;13(04):315\u2013409."},{"issue":"1","key":"2598_CR10","first-page":"25","volume":"24","author":"Committee CHPaTGR","year":"2019","unstructured":"Committee CHPaTGR. Chinese guidelines for the prevention and treatment of hypertension (2018 Revision). Chin Cardiovasc J. 2019;24(1):25.","journal-title":"Chin Cardiovasc J"},{"issue":"6","key":"2598_CR11","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1210\/jc.2003-030398","volume":"88","author":"AR Cappola","year":"2003","unstructured":"Cappola AR, Ladenson PW. Hypothyroidism and atherosclerosis. J Clin Endocrinol Metab. 2003;88(6):2438\u201344.","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2598_CR12","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1111\/j.1464-5491.1995.tb00553.x","volume":"12","author":"PMR Perros","year":"1995","unstructured":"Perros PMR, Shaw G, Frier BM. Frequency of thyroid dysfunction in diabetic patients: value of annual screening. Diabet Med. 1995;12(7):622\u20137.","journal-title":"Diabet Med"},{"issue":"8","key":"2598_CR13","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.2337\/diacare.25.8.1346","volume":"25","author":"AK Olga Kordonouri","year":"2002","unstructured":"Olga Kordonouri AK, Egbert B, Lang A, Gr\u00fcters-Kieslich M, Grabert, Reinhard W, Holl. Thyroid autoimmunity in children and adolescents with type 1 diabetes: A multicenter survey. Diabetes Care. 2002;25(8):1346\u201350.","journal-title":"Diabetes Care"},{"issue":"3","key":"2598_CR14","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3390\/nu8030171","volume":"8","author":"KW Lee","year":"2016","unstructured":"Lee KW, Shin D, Song WO. Low urinary iodine concentrations associated with dyslipidemia in US adults. Nutrients. 2016;8(3):171.","journal-title":"Nutrients"},{"issue":"5","key":"2598_CR15","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1097\/MED.0b013e32833d6d46","volume":"17","author":"X Zhu","year":"2010","unstructured":"Zhu X, Cheng SY. New insights into regulation of lipid metabolism by thyroid hormone. Curr Opin Endocrinol Diabetes Obes. 2010;17(5):408\u201313.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"5","key":"2598_CR16","doi-asserted-by":"publisher","first-page":"e19839","DOI":"10.1371\/journal.pone.0019839","volume":"6","author":"C Verga Falzacappa","year":"2011","unstructured":"Verga Falzacappa C, Mangialardo C, Madaro L, Ranieri D, Lupoi L, Stigliano A, et al. Thyroid hormone T3 counteracts STZ induced diabetes in mouse. PLoS ONE. 2011;6(5):e19839.","journal-title":"PLoS ONE"},{"issue":"2","key":"2598_CR17","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1089\/thy.2007.0249","volume":"18","author":"M-EP Sarah Crunkhorn","year":"2008","unstructured":"Sarah Crunkhorn M-EP. Links between thyroid hormone action, oxidative metabolism, and diabetes risk. Thyroid. 2008;18(2):227\u201337.","journal-title":"Thyroid"},{"issue":"25","key":"2598_CR18","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1161\/CIRCULATIONAHA.118.036859","volume":"139","author":"AR Cappola","year":"2019","unstructured":"Cappola AR, Desai AS, Medici M, Cooper LS, Egan D, Sopko G, et al. Thyroid and cardiovascular disease: research agenda for enhancing knowledge, prevention, and treatment. Circulation. 2019;139(25):2892\u2013909.","journal-title":"Circulation"},{"issue":"5","key":"2598_CR19","doi-asserted-by":"publisher","first-page":"R76","DOI":"10.1530\/EC-19-0096","volume":"8","author":"M von Hafe","year":"2019","unstructured":"von Hafe M, Neves JS, Vale C, Borges-Canha M, Leite-Moreira A. The impact of thyroid hormone dysfunction on ischemic heart disease. Endocr Connect. 2019;8(5):R76\u201390.","journal-title":"Endocr Connect"},{"issue":"36","key":"2598_CR20","first-page":"141","volume":"14","author":"J Tao","year":"2019","unstructured":"Tao J. Effect of thyroxine treatment of hypothyroid patients on their lipids and blood rheology. Chin J Practical Med. 2019;14(36):141\u20132.","journal-title":"Chin J Practical Med"},{"issue":"4","key":"2598_CR21","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1089\/thy.2019.0067","volume":"30","author":"Y Li","year":"2020","unstructured":"Li Y, Teng D, Ba J, Chen B, Du J, He L, et al. Efficacy and safety of Long-Term universal salt Iodization on thyroid disorders: epidemiological evidence from 31 provinces of Mainland China. Thyroid. 2020;30(4):568\u201379.","journal-title":"Thyroid"},{"issue":"8","key":"2598_CR22","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1089\/thy.2015.0613","volume":"26","author":"Z Shan","year":"2016","unstructured":"Shan Z, Chen L, Lian X, Liu C, Shi B, Shi L, et al. Iodine status and prevalence of thyroid disorders after introduction of mandatory universal salt Iodization for 16 years in China: A Cross-Sectional study in 10 cities. Thyroid. 2016;26(8):1125\u201330.","journal-title":"Thyroid"},{"key":"2598_CR23","unstructured":"Zupei Chen MQ, Yuqin YW, Dai FW, Yuxin Zhang. Diagnosis for endemic cretinism and endemic subclinical cretinism [WS\/T 104\u20132014(replaced WS 014-1999)]. National Health Commission of the People\u2019s Republic of China; 2014."},{"issue":"19","key":"2598_CR24","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","volume":"285","author":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults","year":"2001","unstructured":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III). JAMA: J Am Med Association. 2001;285(19):2486\u201397.","journal-title":"JAMA: J Am Med Association"},{"key":"2598_CR25","unstructured":"Chunming Chen WZ, Xiaoguang YJ, Chen K, Li L, Zhao X, Zhao G, Li W, Jia D, Gu D, Zhao Z. Yang. Criteria of weight for adults(WS\/T 428\u20132013). The People\u2019s Republic of China health industry standard. 2013."},{"key":"2598_CR26","unstructured":"Hongmei Shen PL, Qingzhen Jia W, Li W, Jiang J, Ma HZ, Wang P. Yang Du, Lijun Fan Delineation of iodine-deficient and iodine-adequate areas (WS\/T 669\u20132020). The People\u2019s Republic of China health industry standard. 2020."},{"key":"2598_CR27","doi-asserted-by":"publisher","first-page":"911487","DOI":"10.3389\/fendo.2022.911487","volume":"13","author":"J Li","year":"2022","unstructured":"Li J, He Y, Ren B, Zhang Z, Meng F, Zhang X, et al. The thyroid condition and residual clinical signs in 31 existing endemic neurological cretins after 42 years of iodine supplementation in China. Front Endocrinol (Lausanne). 2022;13:911487.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2598_CR28","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jchromb.2014.05.022","volume":"962","author":"A Blazewicz","year":"2014","unstructured":"Blazewicz A, Klatka M, Dolliver W, Kocjan R. Determination of total iodine in serum and urine samples by ion chromatography with pulsed amperometric detection - studies on analyte loss, optimization of sample Preparation procedures, and validation of analytical method. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;962:141\u20136.","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"2598_CR29","unstructured":"Li JQHQ, Wei Z. Summary of Three Years\u2019 Effort on Prevention and Treatment of Endemic Goiter and Endemic Cretinism in Jixian Area. (1982) Heilongjiang Med Sci. 1982;4:40\u20135."},{"issue":"4","key":"2598_CR30","first-page":"353","volume":"22","author":"JY Xiaohui Su","year":"2003","unstructured":"Xiaohui Su JY, Li Y. Shubin Zhang,Weihuan Wang,Ming Su,Shoude Wang,Yongxiang Ye,Shoujun Liu. Epidemiologic survey of endemic goiter and endemic cretinism in Jixian village. Chin J Endemiology. 2003;22(4):353\u20134.","journal-title":"Chin J Endemiology"},{"issue":"2","key":"2598_CR31","first-page":"42","volume":"26","author":"EB Demko","year":"1967","unstructured":"Demko EB. [The effect of copper on the condition of the thyroid in albino rats against the background of a predominantly carbohydrate diet and iodine deficiency]. Vopr Pitan. 1967;26(2):42\u20137.","journal-title":"Vopr Pitan"},{"issue":"2","key":"2598_CR32","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1210\/jcem-47-2-354","volume":"47","author":"CH Thilly","year":"1978","unstructured":"Thilly CH, Delange F, Lagasse R, Bourdoux P, Ramioul L, Berquist H, et al. Fetal hypothyroidism and maternal thyroid status in severe endemic goiter. J Clin Endocrinol Metab. 1978;47(2):354\u201360.","journal-title":"J Clin Endocrinol Metab"},{"key":"2598_CR33","doi-asserted-by":"crossref","unstructured":"Taylor RM, Fealy SM, Bisquera A, Smith R, Collins CE, Evans TJ et al. Effects of nutritional interventions during pregnancy on infant and child cognitive outcomes: A systematic review and Meta-Analysis. Nutrients. 2017;9(11).","DOI":"10.3390\/nu9111265"},{"issue":"3","key":"2598_CR34","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.neuro.2005.03.003","volume":"26","author":"J Dong","year":"2005","unstructured":"Dong J, Yin H, Liu W, Wang P, Jiang Y, Chen J. Congenital iodine deficiency and hypothyroidism impair LTP and decrease C-fos and C-jun expression in rat hippocampus. Neurotoxicology. 2005;26(3):417\u201326.","journal-title":"Neurotoxicology"},{"issue":"2","key":"2598_CR35","doi-asserted-by":"publisher","first-page":"S668","DOI":"10.3945\/ajcn.2008.26811C","volume":"89","author":"MB Zimmermann","year":"2009","unstructured":"Zimmermann MB. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. Am J Clin Nutr. 2009;89(2):S668\u201372.","journal-title":"Am J Clin Nutr"},{"issue":"Suppl 3","key":"2598_CR36","doi-asserted-by":"publisher","first-page":"U25","DOI":"10.1530\/eje.0.151u025","volume":"151","author":"G Morreale de Escobar","year":"2004","unstructured":"Morreale de Escobar G, Obregon MJ, Escobar del Rey F. Role of thyroid hormone during early brain development. Eur J Endocrinol. 2004;151(Suppl 3):U25\u201337.","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"2598_CR37","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1001\/archinternmed.2012.1159","volume":"172","author":"S Razvi","year":"2012","unstructured":"Razvi S, Weaver JU, Butler TJ, Pearce SH. Levothyroxine treatment of subclinical hypothyroidism, fatal and nonfatal cardiovascular events, and mortality. Arch Intern Med. 2012;172(10):811\u20137.","journal-title":"Arch Intern Med"},{"issue":"4","key":"2598_CR38","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1001\/archinte.160.4.526","volume":"160","author":"GJ Canaris","year":"2000","unstructured":"Canaris GJ, Mayor NRMG, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160(4):526.","journal-title":"Arch Intern Med"},{"issue":"22","key":"2598_CR39","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1001\/jama.2010.1786","volume":"2481","author":"M Rotondi","year":"2010","unstructured":"Rotondi M, Magri F, Chiovato L. Risk of coronary heart disease and mortality for adults with subclinical hypothyroidism. JAMA: J Am Med Association. 2010;2481(22):2481.","journal-title":"JAMA: J Am Med Association"},{"issue":"4","key":"2598_CR40","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1370\/afm.79","volume":"2","author":"WJ Hueston","year":"2004","unstructured":"Hueston WJ, Pearson WS. Subclinical hypothyroidism and the risk of hypercholesterolemia. Ann Fam Med. 2004;2(4):351\u20135.","journal-title":"Ann Fam Med"},{"issue":"2","key":"2598_CR41","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1530\/eje.1.02333","volume":"156","author":"BO Asvold","year":"2007","unstructured":"Asvold BO, Vatten LJ, Nilsen TI, Bjoro T. The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT study. Eur J Endocrinol. 2007;156(2):181\u20136.","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2598_CR42","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1046\/j.1365-2265.1996.739560.x","volume":"44","author":"BC Tanis","year":"1996","unstructured":"Tanis BC, Westendorp RGJ, Smelt AHM. Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: a reanalysis of intervention studies. Clin Endocrinol. 1996;44(6):643\u20139.","journal-title":"Clin Endocrinol"},{"issue":"9","key":"2598_CR43","first-page":"2993","volume":"85","author":"MD Danese","year":"2000","unstructured":"Danese MD, Ladenson PW, Meinert CL, Powe NR. Effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: A quantitative review of the literature. J Clin Endocrinol Metabolism. 2000;85(9):2993\u20133001.","journal-title":"J Clin Endocrinol Metabolism"},{"issue":"12","key":"2598_CR44","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1001\/jama.2010.1361","volume":"304","author":"WPJE Nicolas Rodondi","year":"2010","unstructured":"Nicolas Rodondi WPJE, Bauer DC, Cappola AR, Razvi S, Walsh JP, Bj\u00f8rn O, Asvold G, Iervasi M, Imaizumi T-H, Collet A, Bremner P, Maisonneuve Jos\u00e9A, Sgarbi K-T, Khaw, Mark PJ, Vanderpump AB, Newman J, Cornuz, Jayne A, Franklyn, Rudi GJ, Westendorp. Eric Vittinghoff, Jacobijn Gussekloo; thyroid studies collaboration. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA: J Am Med Association. 2010;304(12):1365.","journal-title":"JAMA: J Am Med Association"},{"key":"2598_CR45","doi-asserted-by":"publisher","first-page":"4711275","DOI":"10.1155\/2023\/4711275","volume":"2023","author":"M Heidarpour","year":"2023","unstructured":"Heidarpour M, Rezvanian P, Sadri MA, Keshavarzrad P, Zakeri R, Vakilbashi O, et al. The association of Thyroid-Stimulating hormone (TSH) levels and lipid profile in euthyroid patients with Familial hypercholesterolemia. Biomed Res Int. 2023;2023:4711275.","journal-title":"Biomed Res Int"},{"issue":"4","key":"2598_CR46","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1002\/hep.23800","volume":"52","author":"L Tian","year":"2010","unstructured":"Tian L, Song Y, Xing M, Zhang W, Ning G, Li X, et al. A novel role for thyroid-stimulating hormone: up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the Cyclic adenosine monophosphate\/protein kinase A\/cyclic adenosine monophosphate-responsive element binding protein pathway. Hepatology. 2010;52(4):1401\u20139.","journal-title":"Hepatology"},{"key":"2598_CR47","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.metabol.2017.07.006","volume":"76","author":"Y Gong","year":"2017","unstructured":"Gong Y, Ma Y, Ye Z, Fu Z, Yang P, Gao B, et al. Thyroid stimulating hormone exhibits the impact on LDLR\/LDL-c via up-regulating hepatic PCSK9 expression. Metabolism. 2017;76:32\u201341.","journal-title":"Metabolism"},{"issue":"5","key":"2598_CR48","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/j.1365-2265.1992.tb02351.x","volume":"37","author":"JV Parle","year":"1992","unstructured":"Parle JV, Franklyn JA, Cross KW, Jones SR, Sheppard MC. Circulating lipids and minor abnormalities of thyroid function. Clin Endocrinol. 1992;37(5):411\u20134.","journal-title":"Clin Endocrinol"},{"issue":"2","key":"2598_CR49","doi-asserted-by":"publisher","first-page":"96","DOI":"10.5144\/0256-4947.2008.96","volume":"28","author":"SS Serpil Turhan","year":"2008","unstructured":"Serpil Turhan SS, Gonul Erden A, Guctekin F, Ucar Z, Ginis O, Ozturk, Sezin Bingol. Plasma homocysteine concentrations and serum lipid profile as atherosclerotic risk factors in subclinical hypothyroidism. Ann Saudi Med. 2008;28(2):96\u2013101.","journal-title":"Ann Saudi Med"},{"issue":"8","key":"2598_CR50","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1210\/jc.2012-1133","volume":"97","author":"F Wang","year":"2012","unstructured":"Wang F, Tan Y, Wang C, Zhang X, Zhao Y, Song X, et al. Thyroid-stimulating hormone levels within the reference range are associated with serum lipid profiles independent of thyroid hormones. J Clin Endocrinol Metab. 2012;97(8):2724\u201331.","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2598_CR51","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1210\/jc.2014-3987","volume":"100","author":"M Zhao","year":"2015","unstructured":"Zhao M, Tang X, Yang T, Zhang B, Guan Q, Shao S, et al. Lipotoxicity, a potential risk factor for the increasing prevalence of subclinical hypothyroidism? J Clin Endocrinol Metab. 2015;100(5):1887\u201394.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2598_CR52","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1743-7075-9-44","volume":"9","author":"XY Chao Xu","year":"2012","unstructured":"Chao Xu XY, Wenhui Liu H, Yuan C, Yu L, Gao J, Zhao. Thyroid stimulating hormone, independent of thyroid hormone, can elevate the serum total cholesterol level in patients with coronary heart disease: a cross-sectional design. Nutr Metabolism. 2012;9(1):44.","journal-title":"Nutr Metabolism"},{"issue":"11","key":"2598_CR53","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1038\/aps.2014.82","volume":"35","author":"SS Shao","year":"2014","unstructured":"Shao SS, Zhao YF, Song YF, Xu C, Yang JM, Xuan SM, et al. Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats. Acta Pharmacol Sin. 2014;35(11):1411\u201320.","journal-title":"Acta Pharmacol Sin"},{"key":"2598_CR54","doi-asserted-by":"crossref","unstructured":"Jianmei Yang XZ, Xu Z, Hu J, Song LGY, Yu C, Yuan SSZ, Sun Y, Li HYG. Jiajun Zhao. Analysis of the correlation between lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats. Oncotarget. 2016;7(26):39332-44.","DOI":"10.18632\/oncotarget.10045"},{"key":"2598_CR55","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3389\/fendo.2020.00252","volume":"11","author":"CJ Packard","year":"2020","unstructured":"Packard CJ, Boren J, Taskinen MR. Causes and consequences of hypertriglyceridemia. Front Endocrinol (Lausanne). 2020;11:252.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"2598_CR56","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1210\/jc.2011-2532","volume":"97","author":"EN Pearce","year":"2012","unstructured":"Pearce EN. Update in lipid alterations in subclinical hypothyroidism. J Clin Endocrinol Metab. 2012;97(2):326\u201333.","journal-title":"J Clin Endocrinol Metab"},{"key":"2598_CR57","doi-asserted-by":"crossref","unstructured":"Iacoviello M, Guastamacchia PGE, Triggiani V, Forleo C, Catanzaro R, Cicala M, Basile1 M. Sorrentino1 and S. Favale. Prognostic role of Sub-Clinical hypothyroidism in chronic heart failure outpatients. Curr Pharm Design. 2008;14(26):2686\u2013092.","DOI":"10.2174\/138161208786264142"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02598-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12944-025-02598-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02598-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T19:03:48Z","timestamp":1749323028000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/s12944-025-02598-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,7]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2598"],"URL":"https:\/\/doi.org\/10.1186\/s12944-025-02598-3","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,7]]},"assertion":[{"value":"2 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were by the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study protocol was approved by the Ethics Review Committee of Harbin Medical University (No. hrbmuecdc20201201).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was provided by all control participants and guardians of all patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Consent to publish from the participant was obtained to report individual participant data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors hereby confirm that no part of this manuscript has been published or is under consideration for publication elsewhere. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure statement"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"208"}}