{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:11:45Z","timestamp":1793913105418,"version":"4.8.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL158926-04S1"],"award-info":[{"award-number":["R01HL158926-04S1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000850","name":"National Heart and Lung Institute","doi-asserted-by":"publisher","award":["R01HL158926"],"award-info":[{"award-number":["R01HL158926"]}],"id":[{"id":"10.13039\/501100000850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"DOI":"10.1186\/s12944-025-02651-1","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T07:01:43Z","timestamp":1751439703000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spectral immune cell profiling reveals modulations in immune cell response to repetitive inhaled organic dust exposure in a high omega-3 fatty acid mouse model"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8699-0513","authenticated-orcid":false,"given":"Logan S.","family":"Dean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eblis","family":"Wahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa N.","family":"Threatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Pauly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melea","family":"Barahona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel O.","family":"Oyewole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara M.","family":"Nordgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"2651_CR1","doi-asserted-by":"publisher","first-page":"G586","DOI":"10.1152\/ajpgi.00423.2020","volume":"320","author":"MS Crawford","year":"2021","unstructured":"Crawford MS, Nordgren TM, McCole DF. Every breath you take: impacts of environmental dust exposure on intestinal barrier function\u2013from the gut-lung axis to COVID-19. Am J Physiology-Gastrointestinal Liver Physiol. 2021;320:G586\u2013600.","journal-title":"Am J Physiology-Gastrointestinal Liver Physiol"},{"key":"2651_CR2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/MCP.0000000000000247","volume":"22","author":"TM Nordgren","year":"2016","unstructured":"Nordgren TM, Bailey KL. Pulmonary health effects of agriculture. Curr Opin Pulm Med. 2016;22:144\u20139.","journal-title":"Curr Opin Pulm Med"},{"key":"2651_CR3","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s11882-018-0820-8","volume":"18","author":"TM Nordgren","year":"2018","unstructured":"Nordgren TM, Charavaryamath C. Agriculture occupational exposures and factors affecting health effects. Curr Allergy Asthma Rep. 2018;18:65.","journal-title":"Curr Allergy Asthma Rep"},{"key":"2651_CR4","first-page":"78","volume":"2","author":"AJ Marcus","year":"1984","unstructured":"Marcus AJ, Broekman MJ, Safier LB, et al. Production of arachidonic acid Lipoxygenase products during platelet-neutrophil interactions. Clin Physiol Biochem. 1984;2:78\u201383.","journal-title":"Clin Physiol Biochem"},{"key":"2651_CR5","doi-asserted-by":"publisher","first-page":"5335","DOI":"10.1073\/pnas.81.17.5335","volume":"81","author":"CN Serhan","year":"1984","unstructured":"Serhan CN, Hamberg M, Samuelsson B. Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc Natl Acad Sci U S A. 1984;81:5335\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2651_CR6","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1084\/jem.20020760","volume":"196","author":"CN Serhan","year":"2002","unstructured":"Serhan CN, Hong S, Gronert K, et al. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med. 2002;196:1025\u201337.","journal-title":"J Exp Med"},{"key":"2651_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nri.2015.4","volume":"16","author":"MC Basil","year":"2016","unstructured":"Basil MC, Levy BD. Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nat Rev Immunol. 2016;16:51\u201367.","journal-title":"Nat Rev Immunol"},{"key":"2651_CR8","doi-asserted-by":"publisher","unstructured":"Schebb NH, K\u00fchn H, Kahnt AS et al. Formation, signaling and occurrence of specialized Pro-Resolving lipid Mediators\u2014What is the evidence so far? Frontiers in Pharmacology;13. Epub ahead of print March 2, 2022. https:\/\/doi.org\/10.3389\/fphar.2022.838782","DOI":"10.3389\/fphar.2022.838782"},{"key":"2651_CR9","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0753-3322(02)00253-6","volume":"56","author":"AP Simopoulos","year":"2002","unstructured":"Simopoulos AP. The importance of the ratio of omega-6\/omega-3 essential fatty acids. Biomed Pharmacother. 2002;56:365\u201379.","journal-title":"Biomed Pharmacother"},{"key":"2651_CR10","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s42003-019-0521-4","volume":"2","author":"K Kaliannan","year":"2019","unstructured":"Kaliannan K, Li X-Y, Wang B, et al. Multi-omic analysis in Transgenic mice implicates omega-6\/omega-3 fatty acid imbalance as a risk factor for chronic disease. Commun Biol. 2019;2:276.","journal-title":"Commun Biol"},{"key":"2651_CR11","doi-asserted-by":"publisher","first-page":"5434","DOI":"10.3390\/nu6125434","volume":"6","author":"T Nordgren","year":"2014","unstructured":"Nordgren T, Friemel T, Heires A, et al. The Omega-3 fatty acid docosahexaenoic acid attenuates organic Dust-Induced airway inflammation. Nutrients. 2014;6:5434\u201352.","journal-title":"Nutrients"},{"key":"2651_CR12","doi-asserted-by":"publisher","unstructured":"Ulu A, Velazquez JV, Burr A et al. Sex-Specific Differences in Resolution of Airway Inflammation in Fat-1 Transgenic Mice Following Repetitive Agricultural Dust Exposure. Front Pharmacol; 12. Epub ahead of print January 13, 2022. https:\/\/doi.org\/10.3389\/fphar.2021.785193","DOI":"10.3389\/fphar.2021.785193"},{"key":"2651_CR13","doi-asserted-by":"publisher","unstructured":"Hanson C, Ponce J, Isaak M, et al. Fatty acids, Amphiregulin production, and lung function in a cohort of Midwestern veterans. Front Rehabilitation Sci. 2022;3. https:\/\/doi.org\/10.3389\/fresc.2022.773835. Epub ahead of print March.","DOI":"10.3389\/fresc.2022.773835"},{"key":"2651_CR14","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.3390\/nu12082334","volume":"12","author":"EC Dominguez","year":"2020","unstructured":"Dominguez EC, Heires AJ, Pavlik J, et al. A high docosahexaenoic acid diet alters the lung inflammatory response to acute dust exposure. Nutrients. 2020;12:2334.","journal-title":"Nutrients"},{"key":"2651_CR15","doi-asserted-by":"publisher","unstructured":"Ulu A, Burr A, Heires AJ et al. A high docosahexaenoic acid diters lung inflammation and recovery following repetitive exposure to aqueous organic dust extracts. Journal of Nutritional Biochemistry; 97. Epub ahead of print 2021. https:\/\/doi.org\/10.1016\/j.jnutbio.2021.108797","DOI":"10.1016\/j.jnutbio.2021.108797"},{"key":"2651_CR16","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.3390\/cancers14081900","volume":"14","author":"EC Dominguez","year":"2022","unstructured":"Dominguez EC, Phandthong R, Nguyen M, et al. Aspirin-Triggered resolvin D1 reduces chronic Dust-Induced lung pathology without altering susceptibility to Dust-Enhanced carcinogenesis. Cancers (Basel). 2022;14:1900.","journal-title":"Cancers (Basel)"},{"key":"2651_CR17","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1465-9921-14-51","volume":"14","author":"TM Nordgren","year":"2013","unstructured":"Nordgren TM, Heires AJ, Wyatt TA, et al. Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. Respir Res. 2013;14:51.","journal-title":"Respir Res"},{"key":"2651_CR18","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.trsl.2015.01.001","volume":"166","author":"TM Nordgren","year":"2015","unstructured":"Nordgren TM, Bauer CD, Heires AJ, et al. Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. Translational Res. 2015;166:57\u201369.","journal-title":"Translational Res"},{"key":"2651_CR19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/safety3010010","volume":"3","author":"K Warren","year":"2017","unstructured":"Warren K, Wyatt T, Romberger D, et al. Post-Injury and resolution response to repetitive inhalation exposure to agricultural organic dust in mice. Safety. 2017;3:10.","journal-title":"Safety"},{"key":"2651_CR20","doi-asserted-by":"publisher","first-page":"L180","DOI":"10.1152\/ajplung.00039.2019","volume":"318","author":"JA Poole","year":"2020","unstructured":"Poole JA, Nordgren TM, Heires AJ, et al. Amphiregulin modulates murine lung recovery and fibroblast function following exposure to agriculture organic dust. Am J Physiology-Lung Cell Mol Physiol. 2020;318:L180\u201391.","journal-title":"Am J Physiology-Lung Cell Mol Physiol"},{"key":"2651_CR21","doi-asserted-by":"publisher","first-page":"L421","DOI":"10.1152\/ajplung.00273.2017","volume":"314","author":"TM Nordgren","year":"2018","unstructured":"Nordgren TM, Heires AJ, Bailey KL, et al. Docosahexaenoic acid enhances amphiregulin-mediated bronchial epithelial cell repair processes following organic dust exposure. Am J Physiology-Lung Cell Mol Physiol. 2018;314:L421\u201331.","journal-title":"Am J Physiology-Lung Cell Mol Physiol"},{"key":"2651_CR22","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/s41423-019-0217-1","volume":"16","author":"C Seillet","year":"2019","unstructured":"Seillet C, Jacquelot N. Sensing of physiological regulators by innate lymphoid cells. Cell Mol Immunol. 2019;16:442\u201351.","journal-title":"Cell Mol Immunol"},{"key":"2651_CR23","doi-asserted-by":"publisher","unstructured":"Panda SK, Colonna M. Innate lymphoid cells in mucosal immunity. Frontiers in Immunology; 10. Epub ahead of print 2019. https:\/\/doi.org\/10.3389\/fimmu.2019.00861","DOI":"10.3389\/fimmu.2019.00861"},{"key":"2651_CR24","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nm.3892","volume":"21","author":"GF Sonnenberg","year":"2015","unstructured":"Sonnenberg GF, Artis D. Innate lymphoid cells in the initiation, regulation and resolution of inflammation. Nat Med. 2015;21:698\u2013708.","journal-title":"Nat Med"},{"key":"2651_CR25","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/s41422-020-0323-8","volume":"30","author":"CSN Klose","year":"2020","unstructured":"Klose CSN, Artis D. Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity. Cell Res. 2020;30:475\u201391.","journal-title":"Cell Res"},{"key":"2651_CR26","first-page":"e30","volume":"39","author":"EPC van der Vorst","year":"2019","unstructured":"van der Vorst EPC, Weber C. Novel features of monocytes and macrophages in cardiovascular biology and disease. Arterioscler Thromb Vasc Biol. 2019;39:e30\u20137.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2651_CR27","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.1038\/s41467-019-11843-0","volume":"10","author":"J Schyns","year":"2019","unstructured":"Schyns J, Bai Q, Ruscitti C, et al. Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung. Nat Commun. 2019;10:3964.","journal-title":"Nat Commun"},{"key":"2651_CR28","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/imm.13154","volume":"160","author":"E Evren","year":"2020","unstructured":"Evren E, Ringqvist E, Willinger T. Origin and ontogeny of lung macrophages: from mice to humans. Immunology. 2020;160:126\u201338.","journal-title":"Immunology"},{"key":"2651_CR29","doi-asserted-by":"publisher","unstructured":"Neehus A-L, Carey B, Landekic M et al. Human inherited CCR2 deficiency underlies progressive polycystic lung disease. Cell Epub ahead Print Dec 2023. https:\/\/doi.org\/10.1016\/j.cell.2023.11.036","DOI":"10.1016\/j.cell.2023.11.036"},{"key":"2651_CR30","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1152\/japplphysiol.00815.2001","volume":"93","author":"DJ Romberger","year":"2002","unstructured":"Romberger DJ, Bodlak V, Von Essen SG, et al. Hog barn dust extract stimulates IL-8 and IL-6 release in human bronchial epithelial cells via PKC activation. J Appl Physiol. 2002;93:289\u201396.","journal-title":"J Appl Physiol"},{"key":"2651_CR31","doi-asserted-by":"publisher","first-page":"L829","DOI":"10.1152\/ajplung.00364.2013","volume":"306","author":"TM Nordgren","year":"2014","unstructured":"Nordgren TM, Wyatt TA, Sweeter J, et al. Motile cilia harbor serum response factor as a mechanism of environment sensing and injury response in the airway. Am J Physiology-Lung Cell Mol Physiol. 2014;306:L829\u201339.","journal-title":"Am J Physiology-Lung Cell Mol Physiol"},{"key":"2651_CR32","doi-asserted-by":"publisher","first-page":"L388","DOI":"10.1152\/ajplung.00025.2015","volume":"309","author":"DJ Romberger","year":"2015","unstructured":"Romberger DJ, Heires AJ, Nordgren TM, et al. Proteases in agricultural dust induce lung inflammation through PAR-1 and PAR-2 activation. Am J Physiology-Lung Cell Mol Physiol. 2015;309:L388\u201399.","journal-title":"Am J Physiology-Lung Cell Mol Physiol"},{"key":"2651_CR33","doi-asserted-by":"publisher","first-page":"L1085","DOI":"10.1152\/ajplung.90622.2008","volume":"296","author":"JA Poole","year":"2009","unstructured":"Poole JA, Wyatt TA, Oldenburg PJ, et al. Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice. Am J Physiology-Lung Cell Mol Physiol. 2009;296:L1085\u201395.","journal-title":"Am J Physiology-Lung Cell Mol Physiol"},{"key":"2651_CR34","doi-asserted-by":"publisher","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","volume":"7","author":"P Bankhead","year":"2017","unstructured":"Bankhead P, Loughrey MB, Fern\u00e1ndez JA, et al. QuPath: open source software for digital pathology image analysis. Sci Rep. 2017;7:16878.","journal-title":"Sci Rep"},{"key":"2651_CR35","doi-asserted-by":"publisher","first-page":"4035","DOI":"10.2147\/JIR.S320096","volume":"14","author":"AC Burr","year":"2021","unstructured":"Burr AC, Velazquez JV, Ulu A, et al. Lung inflammatory response to environmental dust exposure in mice suggests a link to regional respiratory disease risk. J Inflamm Res. 2021;14:4035\u201352.","journal-title":"J Inflamm Res"},{"key":"2651_CR36","doi-asserted-by":"publisher","first-page":"108937","DOI":"10.1016\/j.intimp.2022.108937","volume":"110","author":"G Yin","year":"2022","unstructured":"Yin G, Zhao C, Pei W. Crosstalk between macrophages and innate lymphoid cells (ILCs) in diseases. Int Immunopharmacol. 2022;110:108937.","journal-title":"Int Immunopharmacol"},{"key":"2651_CR37","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.stem.2017.03.024","volume":"21","author":"AJ Lechner","year":"2017","unstructured":"Lechner AJ, Driver IH, Lee J, et al. Recruited monocytes and type 2 immunity promote lung regeneration following pneumonectomy. Cell Stem Cell. 2017;21:120\u2013e1347.","journal-title":"Cell Stem Cell"},{"key":"2651_CR38","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3389\/fimmu.2019.00092","volume":"10","author":"A Ardain","year":"2019","unstructured":"Ardain A, Porterfield JZ, Kl\u00f8verpris HN, et al. Type 3 ILCs in lung disease. Front Immunol. 2019;10:92.","journal-title":"Front Immunol"},{"key":"2651_CR39","doi-asserted-by":"publisher","first-page":"111797","DOI":"10.1016\/j.celrep.2022.111797","volume":"41","author":"HH \u00d6z","year":"2022","unstructured":"\u00d6z HH, Cheng E-C, Di Pietro C, et al. Recruited monocytes\/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis. Cell Rep. 2022;41:111797.","journal-title":"Cell Rep"},{"key":"2651_CR40","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1183\/13993003.00153-2015","volume":"47","author":"A Guillien","year":"2016","unstructured":"Guillien A, Puyraveau M, Soumagne T, et al. Prevalence and risk factors for COPD in farmers: a cross-sectional controlled study. Eur Respir J. 2016;47:95\u2013103.","journal-title":"Eur Respir J"},{"key":"2651_CR41","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.anai.2014.07.029","volume":"113","author":"CK Reeb-Whitaker","year":"2014","unstructured":"Reeb-Whitaker CK, Bonauto DK. Respiratory disease associated with occupational inhalation to hop (Humulus lupulus) during harvest and processing. Ann Allergy Asthma Immunol. 2014;113:534\u20138.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2651_CR42","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1021\/acs.est.9b04295","volume":"54","author":"DP Croft","year":"2020","unstructured":"Croft DP, Zhang W, Lin S, et al. Associations between Source-Specific particulate matter and respiratory infections in new York state adults. Environ Sci Technol. 2020;54:975\u201384.","journal-title":"Environ Sci Technol"},{"key":"2651_CR43","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.pupt.2006.04.003","volume":"20","author":"NA Molfino","year":"2007","unstructured":"Molfino NA, Jeffery PK. Chronic obstructive pulmonary disease: histopathology, inflammation and potential therapies. Pulm Pharmacol Ther. 2007;20:462\u201372.","journal-title":"Pulm Pharmacol Ther"},{"key":"2651_CR44","doi-asserted-by":"publisher","first-page":"2297559","DOI":"10.1155\/2023\/2297559","volume":"2023","author":"I Shakeel","year":"2023","unstructured":"Shakeel I, Ashraf A, Afzal M, et al. The molecular blueprint for chronic obstructive pulmonary disease (COPD): A new paradigm for diagnosis and therapeutics. Oxid Med Cell Longev. 2023;2023:2297559.","journal-title":"Oxid Med Cell Longev"},{"key":"2651_CR45","doi-asserted-by":"publisher","unstructured":"Kapellos TS, Bonaguro L, Gem\u00fcnd I et al. Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases. Front Immunol; 10. Epub ahead of print August 30, 2019. https:\/\/doi.org\/10.3389\/fimmu.2019.02035","DOI":"10.3389\/fimmu.2019.02035"},{"key":"2651_CR46","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1084\/jem.128.3.415","volume":"128","author":"R van Furth","year":"1968","unstructured":"van Furth R, Cohn ZA. THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES. J Exp Med. 1968;128:415\u201335.","journal-title":"J Exp Med"},{"key":"2651_CR47","doi-asserted-by":"publisher","unstructured":"Wolf AA, Y\u00e1\u00f1ez A, Barman PK et al. The Ontogeny of Monocyte Subsets. Front Immunol; 10. Epub ahead of print July 17, 2019. https:\/\/doi.org\/10.3389\/fimmu.2019.01642","DOI":"10.3389\/fimmu.2019.01642"},{"key":"2651_CR48","doi-asserted-by":"publisher","first-page":"e50","DOI":"10.1182\/blood-2011-01-326827","volume":"118","author":"AM Zawada","year":"2011","unstructured":"Zawada AM, Rogacev KS, Rotter B, et al. SuperSAGE evidence for CD14\u2009+\u2009+\u2009CD16\u2009+\u2009monocytes as a third monocyte subset. Blood. 2011;118:e50\u201361.","journal-title":"Blood"},{"key":"2651_CR49","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1182\/blood.V74.7.2527.2527","volume":"74","author":"B Passlick","year":"1989","unstructured":"Passlick B, Flieger D, Ziegler-Heitbrock H. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood. 1989;74:2527\u201334.","journal-title":"Blood"},{"key":"2651_CR50","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1182\/blood-2010-02-258558","volume":"116","author":"L Ziegler-Heitbrock","year":"2010","unstructured":"Ziegler-Heitbrock L, Ancuta P, Crowe S, et al. Nomenclature of monocytes and dendritic cells in blood. Blood. 2010;116:e74\u201380.","journal-title":"Blood"},{"key":"2651_CR51","doi-asserted-by":"publisher","unstructured":"Shahid F, Lip GYH, Shantsila E. Role of monocytes in heart failure and atrial fibrillation. J Am Heart Assoc. 2018;7. https:\/\/doi.org\/10.1161\/JAHA.117.007849. Epub ahead of print.","DOI":"10.1161\/JAHA.117.007849"},{"key":"2651_CR52","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1161\/ATVBAHA.116.308198","volume":"37","author":"RM Kratofil","year":"2017","unstructured":"Kratofil RM, Kubes P, Deniset JF. Monocyte conversion during inflammation and injury. Arterioscler Thromb Vasc Biol. 2017;37:35\u201342.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2651_CR53","doi-asserted-by":"publisher","first-page":"8757","DOI":"10.3390\/ijms24108757","volume":"24","author":"H Williams","year":"2023","unstructured":"Williams H, Mack C, Baraz R, et al. Monocyte differentiation and heterogeneity: Inter-Subset and interindividual differences. Int J Mol Sci. 2023;24:8757.","journal-title":"Int J Mol Sci"},{"key":"2651_CR54","doi-asserted-by":"publisher","first-page":"e07847","DOI":"10.7554\/eLife.07847","volume":"4","author":"MP Rodero","year":"2015","unstructured":"Rodero MP, Poupel L, Loyher P-L, et al. Immune surveillance of the lung by migrating tissue monocytes. Elife. 2015;4:e07847.","journal-title":"Elife"},{"key":"2651_CR55","doi-asserted-by":"publisher","unstructured":"Mildner A, Marinkovic G, Jung S. Murine Monocytes: Origins, Subsets, Fates, and Functions. Microbiol Spectr; 4. Epub ahead of print October 14, 2016. https:\/\/doi.org\/10.1128\/microbiolspec.MCHD-0033-2016","DOI":"10.1128\/microbiolspec.MCHD-0033-2016"},{"key":"2651_CR56","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1002\/eji.201040760","volume":"41","author":"A H\u00e4nninen","year":"2011","unstructured":"H\u00e4nninen A, Maksimow M, Alam C, et al. Ly6C supports Preferential homing of central memory CD8 + T cells into lymph nodes. Eur J Immunol. 2011;41:634\u201344.","journal-title":"Eur J Immunol"},{"key":"2651_CR57","doi-asserted-by":"publisher","unstructured":"Cui TX, Brady AE, Fulton CT et al. CCR2 Mediates Chronic LPS-Induced Pulmonary Inflammation and Hypoalveolarization in a Murine Model of Bronchopulmonary Dysplasia. Front Immunol; 11. Epub ahead of print October 6, 2020. https:\/\/doi.org\/10.3389\/fimmu.2020.579628","DOI":"10.3389\/fimmu.2020.579628"},{"key":"2651_CR58","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12931-024-02804-3","volume":"25","author":"AD Schwab","year":"2024","unstructured":"Schwab AD, Wyatt TA, Moravec G, et al. Targeting transitioning lung monocytes\/macrophages as treatment strategies in lung disease related to environmental exposures. Respir Res. 2024;25:157.","journal-title":"Respir Res"},{"key":"2651_CR59","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1038\/s41598-023-29781-9","volume":"13","author":"AJ Heires","year":"2023","unstructured":"Heires AJ, Samuelson D, Villageliu D, et al. Agricultural dust derived bacterial extracellular vesicle mediated inflammation is attenuated by DHA. Sci Rep. 2023;13:2767.","journal-title":"Sci Rep"},{"key":"2651_CR60","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.plefa.2007.10.010","volume":"77","author":"JX Kang","year":"2007","unstructured":"Kang JX. Fat-1 Transgenic mice: a new model for omega-3 research. Prostaglandins Leukot Essent Fat Acids. 2007;77:263\u20137.","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"key":"2651_CR61","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/427504a","volume":"427","author":"JX Kang","year":"2004","unstructured":"Kang JX, Wang J, Wu L, et al. Fat-1 mice convert n-6 to n-3 fatty acids. Nature. 2004;427:504\u2013504.","journal-title":"Nature"},{"key":"2651_CR62","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.bbrc.2006.08.093","volume":"349","author":"A Bhattacharya","year":"2006","unstructured":"Bhattacharya A, Chandrasekar B, Rahman MM, et al. Inhibition of inflammatory response in Transgenic fat-1 mice on a calorie-restricted diet. Biochem Biophys Res Commun. 2006;349:925\u201330.","journal-title":"Biochem Biophys Res Commun"},{"key":"2651_CR63","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1080\/15287390903578539","volume":"73","author":"JA Poole","year":"2010","unstructured":"Poole JA, Dooley GP, Saito R, et al. Muramic acid, endotoxin, 3-Hydroxy fatty acids, and ergosterol content explain monocyte and epithelial cell inflammatory responses to agricultural dusts. J Toxicol Environ Health A. 2010;73:684\u2013700.","journal-title":"J Toxicol Environ Health A"},{"key":"2651_CR64","doi-asserted-by":"publisher","unstructured":"Boissy RJ, Romberger DJ, Roughead WA et al. Shotgun pyrosequencing metagenomic analyses of dusts from swine confinement and grain facilities. PLoS One; 9. Epub ahead of print April 18, 2014. https:\/\/doi.org\/10.1371\/journal.pone.0095578","DOI":"10.1371\/journal.pone.0095578"},{"key":"2651_CR65","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/nri.2016.90","volume":"16","author":"SL Klein","year":"2016","unstructured":"Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16:626\u201338.","journal-title":"Nat Rev Immunol"},{"key":"2651_CR66","doi-asserted-by":"publisher","unstructured":"Varghese M, Clemente J, Lerner A et al. Monocyte Trafficking and Polarization Contribute to Sex Differences in Meta-Inflammation. Front Endocrinol (Lausanne); 13. Epub ahead of print March 28, 2022. https:\/\/doi.org\/10.3389\/fendo.2022.826320","DOI":"10.3389\/fendo.2022.826320"},{"key":"2651_CR67","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13293-021-00387-y","volume":"12","author":"J So","year":"2021","unstructured":"So J, Tai AK, Lichtenstein AH, et al. Sexual dimorphism of monocyte transcriptome in individuals with chronic low-grade inflammation. Biol Sex Differ. 2021;12:43.","journal-title":"Biol Sex Differ"},{"key":"2651_CR68","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12931-017-0703-x","volume":"18","author":"JA Poole","year":"2017","unstructured":"Poole JA, Mikuls TR, Duryee MJ, et al. A role for B cells in organic dust induced lung inflammation. Respir Res. 2017;18:214.","journal-title":"Respir Res"},{"key":"2651_CR69","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jim.2011.09.013","volume":"375","author":"KE Barletta","year":"2012","unstructured":"Barletta KE, Cagnina RE, Wallace KL, et al. Leukocyte compartments in the mouse lung: distinguishing between marginated, interstitial, and alveolar cells in response to injury. J Immunol Methods. 2012;375:100\u201310.","journal-title":"J Immunol Methods"},{"key":"2651_CR70","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1165\/rcmb.2012-0366MA","volume":"49","author":"R Zaynagetdinov","year":"2013","unstructured":"Zaynagetdinov R, Sherrill TP, Kendall PL, et al. Identification of myeloid cell subsets in murine lungs using flow cytometry. Am J Respir Cell Mol Biol. 2013;49:180\u20139.","journal-title":"Am J Respir Cell Mol Biol"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02651-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12944-025-02651-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02651-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T08:03:28Z","timestamp":1751443408000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/s12944-025-02651-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":70,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2651"],"URL":"https:\/\/doi.org\/10.1186\/s12944-025-02651-1","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"assertion":[{"value":"26 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"227"}}