{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:19:58Z","timestamp":1761167998891,"version":"build-2065373602"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Hospital level project of QingPu Branch of Zhongshan Hospital Affiliated to Fudan University","award":["QY2021-05","QY2021-05","QY2021-05","QY2021-05","QY2021-05"],"award-info":[{"award-number":["QY2021-05","QY2021-05","QY2021-05","QY2021-05","QY2021-05"]}]},{"name":"Shanghai Jiao Tong University \"Jiao Tong University Star\" Program Medical and Industrial Cross Research Fund","award":["YG2022QN068","YG2022QN068","YG2022QN068","YG2022QN068","YG2022QN068"],"award-info":[{"award-number":["YG2022QN068","YG2022QN068","YG2022QN068","YG2022QN068","YG2022QN068"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"DOI":"10.1186\/s12944-025-02758-5","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:29:53Z","timestamp":1761042593000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between elevated serum total cholesterol and increased risk of post-induction hypotension in elderly patients undergoing non-cardiac surgery: a retrospective cohort study"],"prefix":"10.1186","volume":"24","author":[{"given":"Yiying","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianhua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"2758_CR1","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1213\/ANE.0000000000005250","volume":"132","author":"A Gregory","year":"2021","unstructured":"Gregory A, Stapelfeldt WH, Khanna AK, Smischney NJ, Boero IJ, Chen Q, et al. Intraoperative hypotension is associated with adverse clinical outcomes after noncardiac surgery. Anesth Analg. 2021;132:1654\u201365.","journal-title":"Anesth Analg"},{"key":"2758_CR2","doi-asserted-by":"publisher","first-page":"e15997","DOI":"10.1016\/j.heliyon.2023.e15997","volume":"9","author":"J Cai","year":"2023","unstructured":"Cai J, Tang M, Wu H, Yuan J, Liang H, Wu X, et al. Association of intraoperative hypotension and severe postoperative complications during non-cardiac surgery in adult patients: a systematic review and meta-analysis. Heliyon. 2023;9:e15997.","journal-title":"Heliyon"},{"key":"2758_CR3","doi-asserted-by":"publisher","first-page":"e287","DOI":"10.1161\/CIR.0000000000001024","volume":"144","author":"K Ruetzler","year":"2021","unstructured":"Ruetzler K, Smilowitz NR, Berger JS, Devereaux PJ, Maron BA, Newby LK, et al. Diagnosis and management of patients with myocardial injury after noncardiac surgery: a scientific statement from the American Heart Association. Circulation. 2021;144:e287-305.","journal-title":"Circulation"},{"key":"2758_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/bja\/aex127","volume":"119","author":"S Sudfeld","year":"2017","unstructured":"Sudfeld S, Brechnitz S, Wagner JY, Reese PC, Pinnschmidt HO, Reuter DA, et al. Post-induction hypotension and early intraoperative hypotension associated with general anaesthesia. Br J Anaesth. 2017;119:57\u201364.","journal-title":"Br J Anaesth"},{"key":"2758_CR5","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1213\/01.ANE.0000175214.38450.91","volume":"101","author":"DL Reich","year":"2005","unstructured":"Reich DL, Hossain S, Krol M, Baez B, Patel P, Bernstein A, et al. Predictors of hypotension after induction of general anesthesia. Anesth Analg. 2005;101:622\u20138.","journal-title":"Anesth Analg"},{"key":"2758_CR6","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1097\/EJA.0000000000001192","volume":"37","author":"MH Choi","year":"2020","unstructured":"Choi MH, Chae JS, Lee HJ, Woo JH. Pre-anaesthesia ultrasonography of the subclavian\/infraclavicular axillary vein for predicting hypotension after inducing general anaesthesia: a prospective observational study. Eur J Anaesthesiol. 2020;37:474\u201381.","journal-title":"Eur J Anaesthesiol"},{"key":"2758_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2022.110846","volume":"80","author":"RB Schonberger","year":"2022","unstructured":"Schonberger RB, Dai F, Michel G, Vaughn MT, Burg MM, Mathis M, et al. Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65. J Clin Anesth. 2022;80:110846.","journal-title":"J Clin Anesth"},{"key":"2758_CR8","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/ALN.0000000000001002","volume":"124","author":"J Zhang","year":"2016","unstructured":"Zhang J, Critchley LA. Inferior vena cava ultrasonography before general anesthesia can predict hypotension after induction. Anesthesiology. 2016;124:580\u20139.","journal-title":"Anesthesiology"},{"key":"2758_CR9","unstructured":"Morimoto Y, Yamagata K, Hanamoto H, Boku A, Kudo C, Yokoe C et al. Arteriosclerosis can predict hypotension during anesthesia induction in patients 40 years and older. J Clin Anesth. 2014;S0952-8180(14):00329-8."},{"key":"2758_CR10","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1186\/s12877-017-0685-z","volume":"17","author":"Y Liang","year":"2017","unstructured":"Liang Y, Vetrano DL, Qiu C. Serum total cholesterol and risk of cardiovascular and non-cardiovascular mortality in old age: a population-based study. BMC Geriatr. 2017;17:294.","journal-title":"BMC Geriatr"},{"key":"2758_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19148272","author":"E Jung","year":"2022","unstructured":"Jung E, Kong SY, Ro YS, Ryu HH, Shin SD. Serum cholesterol levels and risk of cardiovascular death: a systematic review and a dose-response meta-analysis of prospective cohort studies. Int J Environ Res Public Health. 2022. https:\/\/doi.org\/10.3390\/ijerph19148272.","journal-title":"Int J Environ Res Public Health"},{"key":"2758_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2024.111573","volume":"98","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Zhong K, Zheng Y, Xia X, Lin X, Kowark A, et al. Postoperative delirium risk in patients with hyperlipidemia: a prospective cohort study. J Clin Anesth. 2024;98:111573.","journal-title":"J Clin Anesth"},{"key":"2758_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-01277-9","volume":"19","author":"A Rosada","year":"2020","unstructured":"Rosada A, Kassner U, Weidemann F, Konig M, Buchmann N, Steinhagen-Thiessen E, et al. Hyperlipidemias in elderly patients: results from the Berlin aging study II (BASEII), a cross-sectional study. Lipids Health Dis. 2020;19:92.","journal-title":"Lipids Health Dis"},{"key":"2758_CR14","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/01.anes.0000270724.40897.8e","volume":"107","author":"JB Bijker","year":"2007","unstructured":"Bijker JB, van Klei WA, Kappen TH, van Wolfswinkel L, Moons KG, Kalkman CJ. Incidence of intraoperative hypotension as a function of the chosen definition: literature definitions applied to a retrospective cohort using automated data collection. Anesthesiology. 2007;107:213\u201320.","journal-title":"Anesthesiology"},{"key":"2758_CR15","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1007\/s00540-019-02675-9","volume":"33","author":"K Okamura","year":"2019","unstructured":"Okamura K, Nomura T, Mizuno Y, Miyashita T, Goto T. Pre-anesthetic ultrasonographic assessment of the internal jugular vein for prediction of hypotension during the induction of general anesthesia. J Anesth. 2019;33:612\u20139.","journal-title":"J Anesth"},{"key":"2758_CR16","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1213\/ANE.0b013e3181f62a2b","volume":"111","author":"AP Morley","year":"2010","unstructured":"Morley AP, Nalla BP, Vamadevan S, Strandvik G, Natarajan A, Prevost AT, et al. The influence of duration of fluid abstinence on hypotension during propofol induction. Anesth Analg. 2010;111:1373\u20137.","journal-title":"Anesth Analg"},{"key":"2758_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2021.106066","volume":"139","author":"A Collado","year":"2021","unstructured":"Collado A, Domingo E, Piqueras L, Sanz MJ. Primary hypercholesterolemia and development of cardiovascular disorders: cellular and molecular mechanisms involved in low-grade systemic inflammation and endothelial dysfunction. Int J Biochem Cell Biol. 2021;139:106066.","journal-title":"Int J Biochem Cell Biol"},{"key":"2758_CR18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.atherosclerosis.2018.02.008","volume":"271","author":"B Vitverova","year":"2018","unstructured":"Vitverova B, Blazickova K, Najmanova I, Vicen M, Hyspler R, Dolezelova E, et al. Soluble endoglin and hypercholesterolemia aggravate endothelial and vessel wall dysfunction in mouse aorta. Atherosclerosis. 2018;271:15\u201325.","journal-title":"Atherosclerosis"},{"key":"2758_CR19","unstructured":"Landmesser U, Hornig B, Drexler H. Endothelial dysfunction in hypercholesterolemia: mechanisms, pathophysiological importance, and therapeutic interventions. In: Seminars in thrombosis and hemostasis: 2000: Copyright\u00a9 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New. 9\u2009-38."},{"key":"2758_CR20","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1097\/00000542-199701000-00010","volume":"86","author":"BJ Robinson","year":"1997","unstructured":"Robinson BJ, Ebert TJ, O\u2019Brien TJ, Colinco MD, Muzi M. Mechanisms whereby propofol mediates peripheral vasodilation in humans. Sympathoinhibition or direct vascular relaxation? Anesthesiology. 1997;86:64\u201372.","journal-title":"Anesthesiology"},{"key":"2758_CR21","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1097\/ALN.0b013e31818e435c","volume":"109","author":"M Neukirchen","year":"2008","unstructured":"Neukirchen M, Kienbaum P. Sympathetic nervous system: evaluation and importance for clinical general anesthesia. Anesthesiology. 2008;109:1113\u201331.","journal-title":"Anesthesiology"},{"key":"2758_CR22","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00021.2024","volume":"40","author":"M Cifuentes","year":"2025","unstructured":"Cifuentes M, Verdejo HE, Castro PF, Corvalan AH, Ferreccio C, Quest AFG, et al. Low-grade chronic inflammation: a shared mechanism for chronic diseases. Physiology. 2025;40:0.","journal-title":"Physiology"},{"key":"2758_CR23","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1007\/s11357-022-00616-1","volume":"44","author":"Y Jiang","year":"2022","unstructured":"Jiang Y, Yabluchanskiy A, Deng J, Amil FA, Po SS, Dasari TW. The role of age-associated autonomic dysfunction in inflammation and endothelial dysfunction. Geroscience. 2022;44:2655\u201370.","journal-title":"Geroscience"},{"key":"2758_CR24","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12933-024-02208-z","volume":"23","author":"J Liu","year":"2024","unstructured":"Liu J, Li J, Xia C, He W, Li X, Shen S, et al. The effect of hyperlipidemia and body fat distribution on subclinical left ventricular function in obesity: a cardiovascular magnetic resonance study. Cardiovasc Diabetol. 2024;23:120.","journal-title":"Cardiovasc Diabetol"},{"key":"2758_CR25","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jjcc.2021.03.010","volume":"78","author":"K Tarao","year":"2021","unstructured":"Tarao K, Daimon M, Son K, Nakanishi K, Nakao T, Suwazono Y, et al. Risk factors including preoperative echocardiographic parameters for post-induction hypotension in general anesthesia. J Cardiol. 2021;78:230\u20136.","journal-title":"J Cardiol"},{"key":"2758_CR26","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1016\/j.jbiomech.2004.09.030","volume":"38","author":"YS Li","year":"2005","unstructured":"Li YS, Haga JH, Chien S. Molecular basis of the effects of shear stress on vascular endothelial cells. J Biomech. 2005;38:1949\u201371.","journal-title":"J Biomech"},{"key":"2758_CR27","doi-asserted-by":"publisher","first-page":"25717","DOI":"10.1038\/s41598-024-76279-z","volume":"14","author":"K Son","year":"2024","unstructured":"Son K, Tarao K, Daimon M, Yoshii T, Nakagomi A, Hasegawa-Moriyama M. Preoperative echocardiography and anesthetic drugs as predictors of post-induction hypotension during general anesthesia: a prospective observational study. Sci Rep. 2024;14:25717.","journal-title":"Sci Rep"},{"key":"2758_CR28","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1007\/s00228-020-02965-2","volume":"76","author":"J Alghamdi","year":"2020","unstructured":"Alghamdi J, Alqadi A, Alharf A, Almuzzaini B, Mahmud A, Barhoumi T, et al. Blood pressure-lowering activity of statins: a systematic literature review and meta-analysis of placebo-randomized controlled trials. Eur J Clin Pharmacol. 2020;76:1745\u201354.","journal-title":"Eur J Clin Pharmacol"},{"key":"2758_CR29","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1097\/ALN.0000000000000765","volume":"123","author":"LY Sun","year":"2015","unstructured":"Sun LY, Wijeysundera DN, Tait GA, Beattie WS. Association of intraoperative hypotension with acute kidney injury after elective noncardiac surgery. Anesthesiology. 2015;123:515\u201323.","journal-title":"Anesthesiology"},{"key":"2758_CR30","doi-asserted-by":"publisher","first-page":"690","DOI":"10.4103\/aer.AER_102_18","volume":"12","author":"U Prathapadas","year":"2018","unstructured":"Prathapadas U, Gomathiamma M, Arulvelan A, Lionel KR, Hrishi AP. A study comparing propofol auto-coinduction and standard propofol induction in patients undergoing general anesthesia without midazolam pretreatment: a prospective randomized control trial. Anesth Essays Res. 2018;12:690\u20134.","journal-title":"Anesth Essays Res"},{"key":"2758_CR31","first-page":"103270","volume":"84","author":"DKW Yow","year":"2025","unstructured":"Yow DKW, Ang WJ, Yap HJ, Ito S, Liu J, Ko J, et al. Interventions to improve adherence to lipid-lowering drugs: a systematic review and meta-analysis. EClinMed. 2025;84:103270.","journal-title":"EClinMed"},{"key":"2758_CR32","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1161\/ATVBAHA.122.318247","volume":"43","author":"DM Conlon","year":"2023","unstructured":"Conlon DM, Welty FK, Reyes-Soffer G, Amengual J. Sex-specific differences in lipoprotein production and clearance. Arterioscler Thromb Vasc Biol. 2023;43:1617\u201325.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2758_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/nu15153433","author":"R Song","year":"2023","unstructured":"Song R, Hu M, Qin X, Qiu L, Wang P, Zhang X, et al. The roles of lipid metabolism in the pathogenesis of chronic diseases in the elderly. Nutrients. 2023. https:\/\/doi.org\/10.3390\/nu15153433.","journal-title":"Nutrients"},{"key":"2758_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040880","author":"KW Chung","year":"2021","unstructured":"Chung KW. Advances in understanding of the role of lipid metabolism in aging. Cells. 2021. https:\/\/doi.org\/10.3390\/cells10040880.","journal-title":"Cells"},{"key":"2758_CR35","doi-asserted-by":"publisher","first-page":"e238","DOI":"10.3346\/jkms.2023.38.e238","volume":"38","author":"J Park","year":"2023","unstructured":"Park J, Son MK, Park HY. Substantial lipid increases during menopausal transition in Korean middle-aged women. J Korean Med Sci. 2023;38:e238.","journal-title":"J Korean Med Sci"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02758-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12944-025-02758-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02758-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T23:05:12Z","timestamp":1761087912000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/s12944-025-02758-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2758"],"URL":"https:\/\/doi.org\/10.1186\/s12944-025-02758-5","relation":{},"ISSN":["1476-511X"],"issn-type":[{"type":"electronic","value":"1476-511X"}],"subject":[],"published":{"date-parts":[[2025,10,21]]},"assertion":[{"value":"20 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Research Ethics Committee and registered at Chinese Clinical Trial Registry. Ethical approval for this study (IRB Number: 2021-32) was provided by Ethics Committee of QingPu Branch of Zhongshan Hospital Affiliated to Fudan University (Chairperson: Bing Zhu), on 22 December 2021. Informed consent was waived due to the retrospective collection of data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"338"}}