{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:15:45Z","timestamp":1788318945742,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"DOI":"10.1186\/s12944-025-02780-7","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T14:15:03Z","timestamp":1765289703000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Relationship of admission uric acid to high density lipoprotein cholesterol ratio with unfavorable prognosis among acute ischemic stroke patients"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiangqi","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haobo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"issue":"1","key":"2780_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/17474930211065917","volume":"17","author":"VL Feigin","year":"2022","unstructured":"Feigin VL, Brainin M, Norrving B, Martins S, Sacco RL, Hacke W, et al. World stroke organization (WSO): global stroke fact sheet 2022. Int J Stroke. 2022;17(1):18\u201329.","journal-title":"Int J Stroke"},{"issue":"10","key":"2780_CR2","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S1474-4422(24)00369-7","volume":"23","author":"GBD 2021 Stroke Risk Factor Collaborators","year":"2024","unstructured":"GBD 2021 Stroke Risk Factor Collaborators. Global, regional, and National burden of stroke and its risk factors, 1990\u20132021: a systematic analysis for the global burden of disease study 2021. Lancet Neurol. 2024;23(10):973\u20131003.","journal-title":"Lancet Neurol"},{"issue":"12","key":"2780_CR3","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","volume":"50","author":"WJ Powers","year":"2019","unstructured":"Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke. 2019;50(12):e344-418.","journal-title":"Stroke"},{"issue":"6","key":"2780_CR4","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1080\/15257770802138558","volume":"27","author":"YY Sautin","year":"2008","unstructured":"Sautin YY, Johnson RJ. Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids. 2008;27(6):608\u201319.","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"issue":"5","key":"2780_CR5","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1002\/(SICI)1097-4547(19980901)53:5<613::AID-JNR11>3.0.CO;2-1","volume":"53","author":"ZF Yu","year":"1998","unstructured":"Yu ZF, Bruce-Keller AJ, Goodman Y, Mattson MP. Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo. J Neurosci Res. 1998;53(5):613\u201325.","journal-title":"J Neurosci Res"},{"issue":"4","key":"2780_CR6","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1161\/hs0402.105927","volume":"33","author":"A Chamorro","year":"2002","unstructured":"Chamorro A, Obach V, Cervera A, Revilla M, Deulofeu R, Aponte JH. Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke. Stroke. 2002;33(4):1048\u201352.","journal-title":"Stroke"},{"issue":"20","key":"2780_CR7","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.21037\/atm-22-4494","volume":"10","author":"H Bai","year":"2022","unstructured":"Bai H, Nie X, Leng X, Wang D, Pan Y, Yan H, et al. Increased serum uric acid level is associated with better outcome after endovascular treatment for acute ischemic stroke-a prospective cohort study. Ann Transl Med. 2022;10(20):1111.","journal-title":"Ann Transl Med"},{"issue":"1","key":"2780_CR8","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s12640-015-9561-9","volume":"29","author":"X Zhang","year":"2016","unstructured":"Zhang X, Huang ZC, Lu TS, You SJ, Cao YJ, Liu CF. Prognostic significance of uric acid levels in ischemic stroke patients. Neurotox Res. 2016;29(1):10\u201320.","journal-title":"Neurotox Res"},{"issue":"10","key":"2780_CR9","volume":"11","author":"MA Tariq","year":"2019","unstructured":"Tariq MA, Shamim SA, Rana KF, Saeed A, Malik BH. Serum uric acid - risk factor for acute ischemic stroke and poor outcomes. Cureus. 2019;11(10):e6007.","journal-title":"Cureus"},{"issue":"3","key":"2780_CR10","first-page":"677","volume":"31","author":"MM Rahman","year":"2022","unstructured":"Rahman MM, Kamrul-Hasan AB, Jasmine T, Hossain MS, Rahman MM, Saha PK, et al. Relationship of serum uric acid level with acute ischemic stroke: A Single-Center, Hospital-Based study from Bangladesh. Mymensingh Med Journal: MMJ. 2022;31(3):677\u201382.","journal-title":"Mymensingh Med Journal: MMJ"},{"issue":"9943","key":"2780_CR11","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/S0140-6736(14)61217-4","volume":"384","author":"DJ Rader","year":"2014","unstructured":"Rader DJ, Hovingh GK. HDL and cardiovascular disease. Lancet. 2014;384(9943):618\u201325.","journal-title":"Lancet"},{"key":"2780_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9121947","author":"G Hu","year":"2021","unstructured":"Hu G, Pan Y, Wang M, Meng X, Jiang Y, Li Z, et al. Inverse association between High-Density lipoprotein cholesterol and adverse outcomes among acute ischemic stroke patients with diabetes mellitus. Biomedicines. 2021. https:\/\/doi.org\/10.3390\/biomedicines9121947.","journal-title":"Biomedicines"},{"issue":"4","key":"2780_CR13","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s12325-008-0045-7","volume":"25","author":"W Li","year":"2008","unstructured":"Li W, Liu M, Wu B, Liu H, Wang LC, Tan S. Serum lipid levels and 3-month prognosis in Chinese patients with acute stroke. Adv Ther. 2008;25(4):329\u201341.","journal-title":"Adv Ther"},{"issue":"1","key":"2780_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-53613-z","volume":"14","author":"A Ali","year":"2024","unstructured":"Ali A, Obaid O, Akhtar N, Rao R, Tora SH, Shuaib A. Association between HDL levels and stroke outcomes in the Arab population. Sci Rep. 2024;14(1):3071.","journal-title":"Sci Rep"},{"issue":"12","key":"2780_CR15","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1007\/s10067-013-2339-7","volume":"32","author":"A Onat","year":"2013","unstructured":"Onat A, Can G, \u00d6rnek E, Altay S, Y\u00fcksel M, Ademo\u011flu E. Elevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently predicts coronary disease. Clin Rheumatol. 2013;32(12):1767\u201375.","journal-title":"Clin Rheumatol"},{"issue":"7","key":"2780_CR16","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1016\/j.numecd.2022.03.026","volume":"32","author":"X Hu","year":"2022","unstructured":"Hu X, Liu J, Li W, Wang C, Li G, Zhou Y, et al. Elevated serum uric acid was associated with pre-inflammatory state and impacted the role of HDL-C on carotid atherosclerosis. Nutr Metab Cardiovasc Dis. 2022;32(7):1661\u20139.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2780_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1577077","volume":"16","author":"T Zhu","year":"2025","unstructured":"Zhu T, He Y, Bei E. Increased uric acid to high-density lipoprotein ratio positively correlated with stroke risk. Front Neurol. 2025;16:1577077.","journal-title":"Front Neurol"},{"issue":"1","key":"2780_CR18","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1212\/WNL.59.1.26","volume":"59","author":"D Leys","year":"2002","unstructured":"Leys D, Bandu L, H\u00e9non H, Lucas C, Mounier-Vehier F, Rondepierre P, et al. Clinical outcome in 287 consecutive young adults (15 to 45 years) with ischemic stroke. Neurology. 2002;59(1):26\u201333.","journal-title":"Neurology"},{"issue":"1","key":"2780_CR19","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jphys.2013.12.012","volume":"60","author":"LK Kwah","year":"2014","unstructured":"Kwah LK, Diong J. National institutes of health stroke scale (NIHSS). J Physiother. 2014;60(1):61.","journal-title":"J Physiother"},{"issue":"31","key":"2780_CR20","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000034182","volume":"102","author":"H Wang","year":"2023","unstructured":"Wang H, Ba Y, Gao X, Zhuo J, Li Y, Sun J, et al. Association between serum uric acid to high density lipoprotein-cholesterol ratio and arterial stiffness in a Japanese population. Medicine. 2023;102(31):e34182.","journal-title":"Medicine"},{"issue":"1","key":"2780_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-024-03824-z","volume":"24","author":"F Deng","year":"2024","unstructured":"Deng F, Jia F, Sun Y, Zhang L, Han J, Li D, et al. Predictive value of the serum uric acid to high-density lipoprotein cholesterol ratio for culprit plaques in patients with acute coronary syndrome. BMC Cardiovasc Disord. 2024;24(1):155.","journal-title":"BMC Cardiovasc Disord"},{"issue":"1","key":"2780_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-99205-3","volume":"15","author":"Y Cui","year":"2025","unstructured":"Cui Y, Zhang W. Long-term cardiovascular risk and mortality associated with uric acid to HDL-C ratio: a 20-year cohort study in adults over 40. Sci Rep. 2025;15(1):14242.","journal-title":"Sci Rep"},{"issue":"7","key":"2780_CR23","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300393R","volume":"37","author":"X Wei","year":"2023","unstructured":"Wei X, Zhang M, Huang S, Lan X, Zheng J, Luo H, et al. Hyperuricemia: a key contributor to endothelial dysfunction in cardiovascular diseases. FASEB J. 2023;37(7):e23012.","journal-title":"FASEB J"},{"issue":"6","key":"2780_CR24","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1097\/HJH.0b013e328337da1d","volume":"28","author":"MA Yu","year":"2010","unstructured":"Yu MA, S\u00e1nchez-Lozada LG, Johnson RJ, Kang DH. Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. J Hypertens. 2010;28(6):1234\u201342.","journal-title":"J Hypertens"},{"key":"2780_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112622","volume":"138","author":"H Kang","year":"2024","unstructured":"Kang H, Song J, Cheng Y. HDL regulates the risk of cardiometabolic and inflammatory-related diseases: focusing on cholesterol efflux capacity. Int Immunopharmacol. 2024;138:112622.","journal-title":"Int Immunopharmacol"},{"key":"2780_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1226108","volume":"10","author":"Y Yang","year":"2023","unstructured":"Yang Y, Zhang J, Jia L, Su J, Ma M, Lin X. The interaction between uric acid and high-density lipoprotein cholesterol on the prognosis of patients with acute myocardial infarction. Front Cardiovasc Med. 2023;10:1226108.","journal-title":"Front Cardiovasc Med"},{"issue":"1","key":"2780_CR27","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1212\/WNL.0b013e31827b1ace","volume":"80","author":"G Saposnik","year":"2013","unstructured":"Saposnik G, Guzik AK, Reeves M, Ovbiagele B, Johnston SC. Stroke prognostication using age and NIH stroke scale: SPAN-100. Neurology. 2013;80(1):21\u20138.","journal-title":"Neurology"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02780-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12944-025-02780-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-025-02780-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T14:15:04Z","timestamp":1765289704000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/s12944-025-02780-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2780"],"URL":"https:\/\/doi.org\/10.1186\/s12944-025-02780-7","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]},"assertion":[{"value":"21 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethics Committee of Shanxi Bethune Hospital (YXLL-2025-230). Written informed consent was waived.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"381"}}