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The corresponding authors are Xinqiao Chu, Muqing Zhang and Zhen Liu.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":9,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":10,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12944-026-02933-2","URL":"https:\/\/doi.org\/10.1186\/s12944-026-02933-2","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All GWAS and eQTL studies contributing summary data adhered to the ethical principles of the Declaration of Helsinki. The cross-sectional observational study was approved by the Ethics Review Board of the National Center for Health Statistics (NCHS), with participants providing documented consent (Protocol #98\u201312, Continuation of Protocol #2005\u201306). The cross-sectional study was approved by the Ethics Committee of Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences (Approval No. 2022\u2013071-KY). The animal experiments were approved by the Animal Ethics Committee of Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences (Approval No. IACUC-GAMH-2025\u2013015). 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