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The triglyceride\u2013total cholesterol\u2013body weight index (TCBI) is a novel nutritional indicator derived from routine clinical measures. However, its association with edentulism remains unclear. This study was designed to assess the association between TCBI and edentulism risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study utilized survey data provided by the China Health and Retirement Longitudinal Study (CHARLS). Three analyses were performed: cross-sectional (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099,686), prospective (participants without baseline edentulism,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098,568), and trajectory analyses (TCBI trajectories and incident edentulism,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094,921). Logistic regression, Cox proportional hazards models, group-based trajectory modeling, and restricted cubic spline analyses were applied. Sensitivity analyses using cumulative TCBI during follow-up were also conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the cross-sectional analysis, individuals in the highest TCBI tertile demonstrated a significantly lower risk of prevalent edentulism (adjusted OR\u2009=\u20090.80, 95% CI: 0.65\u20130.97). In the prospective analysis, higher TCBI levels were independently associated with a reduced risk of incident edentulism (adjusted HR\u2009=\u20090.85, 95% CI: 0.77\u20130.92). Trajectory modeling demonstrated that individuals with persistently high TCBI had the lowest risk of incident edentulism (adjusted HR\u2009=\u20090.59, 95% CI: 0.40\u20130.89). These associations remained robust in sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TCBI was consistently and inversely associated with edentulism across cross-sectional, prospective, and trajectory analyses. As a readily obtainable nutritional index, TCBI may have clinical utility for the early identification and risk prediction of edentulism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12944-026-02860-2","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T06:34:17Z","timestamp":1768372457000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel nutritional index and risk of edentulism: evidence from cross-sectional, prospective, and trajectory analyses"],"prefix":"10.1186","volume":"25","author":[{"given":"Qi","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"issue":"1","key":"2860_CR1","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1186\/s12903-022-02595-3","volume":"22","author":"Z Tang","year":"2022","unstructured":"Tang Z, Huang C, Li Y, Sun Y, Chen X. 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