{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T19:10:52Z","timestamp":1788117052916,"version":"build-2803163510"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["10-082982\/FSS"],"award-info":[{"award-number":["10-082982\/FSS"]}],"id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006442","name":"Det Sundhedsvidenskabelige Fakultet, K\u00f8benhavns Universitet","doi-asserted-by":"publisher","award":["211-0730\/10-3012"],"award-info":[{"award-number":["211-0730\/10-3012"]}],"id":[{"id":"10.13039\/501100006442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","award":["10-04-R78-A2786-22613"],"award-info":[{"award-number":["10-04-R78-A2786-22613"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bispebjerg Hospital"},{"DOI":"10.13039\/501100009898","name":"Beckett Fonden","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009898","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Else og Mogens Wedell-Wedellsborgs Fond"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Ultrasound"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12947-016-0066-3","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T11:44:50Z","timestamp":1465299890000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Coronary flow velocity reserve by echocardiography: feasibility, reproducibility and agreement with PET in overweight and obese patients with stable and revascularized coronary artery disease"],"prefix":"10.1186","volume":"14","author":[{"given":"Rasmus Huan","family":"Olsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene R\u00f8rholm","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Snoer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Emil","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam Ali","family":"Ghotbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Hasbak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kjaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen B.","family":"Haugaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Prescott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,7]]},"reference":[{"key":"66_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0002-9149(74)90743-7","volume":"33","author":"KL Gould","year":"1974","unstructured":"Gould KL, Lipscomb K, Hamilton GW. Physiologic basis for assessing critical coronary stenosis. Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve. Am J Cardiol. 1974;33:87\u201394.","journal-title":"Am J Cardiol"},{"key":"66_CR2","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1093\/eurheartj\/eht513","volume":"35","author":"F Crea","year":"2014","unstructured":"Crea F, Camici PG, Bairey Merz CN. Coronary microvascular dysfunction: an update. Eur Heart J. 2014;35:1101\u201311.","journal-title":"Eur Heart J"},{"key":"66_CR3","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1007\/s12265-013-9497-5","volume":"6","author":"L-M Gan","year":"2013","unstructured":"Gan L-M, Wikstr\u00f6m J, Fritsche-Danielson R. Coronary flow reserve from mouse to man-from mechanistic understanding to future interventions. J Cardiovasc Transl Res. 2013;6:715\u201328.","journal-title":"J Cardiovasc Transl Res"},{"key":"66_CR4","doi-asserted-by":"publisher","unstructured":"Taqueti VR, Hachamovitch R, Murthy VL, Naya M, Foster CR, Hainer J, et al. Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization. Circulation. 2014;1\u20139. doi: 10.1161\/CIRCULATIONAHA.114.011939 .","DOI":"10.1161\/CIRCULATIONAHA.114.011939"},{"key":"66_CR5","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/0735-1097(93)90172-W","volume":"22","author":"NG Uren","year":"1993","unstructured":"Uren NG, Marraccini P, Gistri R, de Silva R, Camici PG. Altered coronary vasodilator reserve and metabolism in myocardium subtended by normal arteries in patients with coronary artery disease. J Am Coll Cardiol. 1993;22:650\u20138.","journal-title":"J Am Coll Cardiol"},{"key":"66_CR6","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.amjcard.2009.08.669","volume":"105","author":"L Cortigiani","year":"2010","unstructured":"Cortigiani L, Rigo F, Gherardi S, Bovenzi F, Picano E, Sicari R. Implication of the continuous prognostic spectrum of Doppler echocardiographic derived coronary flow reserve on left anterior descending artery. Am J Cardiol. 2010;105:158\u201362.","journal-title":"Am J Cardiol"},{"key":"66_CR7","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.jacc.2007.06.027","volume":"50","author":"L Cortigiani","year":"2007","unstructured":"Cortigiani L, Rigo F, Gherardi S, Sicari R, Galderisi M, Bovenzi F, et al. Additional prognostic value of coronary flow reserve in diabetic and nondiabetic patients with negative dipyridamole stress echocardiography by wall motion criteria. J Am Coll Cardiol. 2007;50:1354\u201361.","journal-title":"J Am Coll Cardiol"},{"key":"66_CR8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.ijcard.2015.03.118","volume":"185","author":"RH Olsen","year":"2015","unstructured":"Olsen RH, Pedersen LR, J\u00fcrs A, Snoer M, Haugaard SB, Prescott E. A randomised trial comparing the effect of exercise training and weight loss on microvascular function in coronary artery disease. Int J Cardiol. 2015;185:229\u201335.","journal-title":"Int J Cardiol"},{"key":"66_CR9","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.echo.2012.04.022","volume":"25","author":"M Ruscazio","year":"2012","unstructured":"Ruscazio M, Montisci R, Bezante G, Caiati C, Balbi M, Tona F, et al. Early noninvasive evaluation of coronary flow reserve after angioplasty in the left anterior descending coronary artery identifies patients at high risk of restenosis at follow-up. J Am Soc Echocardiogr. 2012;25:902\u201310.","journal-title":"J Am Soc Echocardiogr"},{"key":"66_CR10","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12872-015-0151-9","volume":"15","author":"A J\u00fcrs","year":"2015","unstructured":"J\u00fcrs A, Pedersen LR, Olsen RH, Snoer M, Chabanova E, Haugaard SB, et al. Coronary microvascular function, insulin sensitivity and body composition in predicting exercise capacity in overweight patients with coronary artery disease. BMC Cardiovasc Disord. 2015;15:159.","journal-title":"BMC Cardiovasc Disord"},{"key":"66_CR11","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1476-7120-7-58","volume":"7","author":"J Vegsundv\u00e5g","year":"2009","unstructured":"Vegsundv\u00e5g J, Holte E, Wiseth R, Hegbom K, Hole T. Transthoracic echocardiography for imaging of the different coronary artery segments: a feasibility study. Cardiovasc Ultrasound. 2009;7:58.","journal-title":"Cardiovasc Ultrasound"},{"key":"66_CR12","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/S0735-1097(99)00342-3","volume":"34","author":"C Caiati","year":"1999","unstructured":"Caiati C, Montaldo C, Zedda N, Montisci R, Ruscazio M, Lai G, et al. Validation of a new noninvasive method (contrast-enhanced transthoracic second harmonic echo Doppler) for the evaluation of coronary flow reserve: comparison with intracoronary Doppler flow wire. J Am Coll Cardiol. 1999;34:1193\u2013200.","journal-title":"J Am Coll Cardiol"},{"key":"66_CR13","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/S0735-1097(98)00389-1","volume":"32","author":"T Hozumi","year":"1998","unstructured":"Hozumi T, Yoshida K, Akasaka T, Asami Y, Ogata Y, Takagi T, et al. Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique. J Am Coll Cardiol. 1998;32:1251\u20139.","journal-title":"J Am Coll Cardiol"},{"key":"66_CR14","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1161\/01.CIR.99.6.771","volume":"99","author":"C Caiati","year":"1999","unstructured":"Caiati C, Montaldo C, Zedda N, Bina A, Iliceto S. New noninvasive method for coronary flow reserve assessment contrast-enhanced transthoracic second harmonic echo Doppler. Circulation. 1999;99:771\u20138.","journal-title":"Circulation"},{"key":"66_CR15","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1067\/mje.2002.120982","volume":"15","author":"DJR Hildick-Smith","year":"2002","unstructured":"Hildick-Smith DJR, Maryan R, Shapiro LM. Assessment of coronary flow reserve by adenosine transthoracic echocardiography: validation with intracoronary doppler. J Am Soc Echocardiogr. 2002;15:984\u201390.","journal-title":"J Am Soc Echocardiogr"},{"key":"66_CR16","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1097\/HJR.0b013e328336a05f","volume":"17","author":"D Bacquer De","year":"2010","unstructured":"De Bacquer D, Dallongeville J, Heidrich J, Kotseva K, Reiner Z, Gaita D, et al. Management of overweight and obese patients with coronary heart disease across Europe. Eur J Cardiovasc Prev Rehabil. 2010;17:447\u201354.","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"66_CR17","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1001\/jama.2014.732","volume":"311","author":"CL Ogden","year":"2014","unstructured":"Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011\u20132012. JAMA. 2014;311:806\u201314.","journal-title":"JAMA"},{"key":"66_CR18","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1046\/j.1365-2281.2001.00296.x","volume":"21","author":"M Saraste","year":"2001","unstructured":"Saraste M, Koskenvuo J, Knuuti J, Toikka J, Laine H, Niemi P, et al. Coronary flow reserve: measurement with transthoracic Doppler echocardiography is reproducible and comparable with positron emission tomography. Clin Physiol. 2001;21:114\u201322.","journal-title":"Clin Physiol"},{"key":"66_CR19","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/1471-2261-13-106","volume":"13","author":"LR Pedersen","year":"2013","unstructured":"Pedersen LR, Olsen RH, Frederiksen M, Astrup A, Chabanova E, Hasbak P, et al. Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol. BMC Cardiovasc Disord. 2013;13:106.","journal-title":"BMC Cardiovasc Disord"},{"key":"66_CR20","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1111\/echo.12445","volume":"31","author":"M Snoer","year":"2014","unstructured":"Snoer M, Olsen RH, Monk-Hansen T, Pedersen LR, Haugaard SB, Dela F, et al. Coronary flow reserve predicts cardiopulmonary fitness in patients with coronary artery disease independently of systolic and diastolic function. Echocardiography. 2014;31:654\u201362.","journal-title":"Echocardiography"},{"key":"66_CR21","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S0735-1097(99)00164-3","volume":"34","author":"C Caiati","year":"1999","unstructured":"Caiati C, Zedda N, Montaldo C, Montisci R, Iliceto S. Contrast-enhanced transthoracic second harmonic echo Doppler with adenosine: a noninvasive, rapid and effective method for coronary flow reserve assessment. J Am Coll Cardiol. 1999;34:122\u201330.","journal-title":"J Am Coll Cardiol"},{"key":"66_CR22","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1476-7120-1-16","volume":"1","author":"M Krzanowski","year":"2003","unstructured":"Krzanowski M, Bodzo\u0144 W, Dimitrow PP. Imaging of all three coronary arteries by transthoracic echocardiography. An illustrated guide. Cardiovasc Ultrasound. 2003;1:16.","journal-title":"Cardiovasc Ultrasound"},{"key":"66_CR23","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1067\/mje.2000.103508","volume":"13","author":"HE Lim","year":"2000","unstructured":"Lim HE, Shim WJ, Rhee H, Kim SM, Hwang GS, Kim YH, et al. Assessment of coronary flow reserve with transthoracic Doppler echocardiography: comparison among adenosine, standard-dose dipyridamole, and high-dose dipyridamole. J Am Soc Echocardiogr. 2000;13:264\u201370.","journal-title":"J Am Soc Echocardiogr"},{"key":"66_CR24","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1093\/ehjci\/jes269","volume":"14","author":"M Snoer","year":"2013","unstructured":"Snoer M, Monk-Hansen T, Olsen RH, Pedersen LR, Nielsen OW, Rasmusen H, et al. Coronary flow reserve as a link between diastolic and systolic function and exercise capacity in heart failure. Eur Heart J Cardiovasc Imaging. 2013;14:677\u201383.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"66_CR25","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s12350-009-9170-1","volume":"17","author":"FP Esteves","year":"2010","unstructured":"Esteves FP, Nye JA, Khan A, Folks RD, Halkar RK, Garcia EV, et al. Prompt-gamma compensation in Rb-82 myocardial perfusion 3D PET\/CT. J Nucl Cardiol. 2010;17:247\u201353.","journal-title":"J Nucl Cardiol"},{"key":"66_CR26","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1007\/s00259-007-0478-2","volume":"34","author":"M Lortie","year":"2007","unstructured":"Lortie M, Beanlands RSB, Yoshinaga K, Klein R, Dasilva JN, DeKemp RA. Quantification of myocardial blood flow with 82Rb dynamic PET imaging. Eur J Nucl Med Mol Imaging. 2007;34:1765\u201374.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"66_CR27","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.2967\/jnumed.110.077669","volume":"51","author":"S Senthamizhchelvan","year":"2010","unstructured":"Senthamizhchelvan S, Bravo PE, Esaias C, Lodge MA, Merrill J, Hobbs RF, et al. Human biodistribution and radiation dosimetry of 82Rb. J Nucl Med. 2010;51:1592\u20139.","journal-title":"J Nucl Med"},{"key":"66_CR28","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1161\/hc0402.102975","volume":"105","author":"MD Cerqueira","year":"2002","unstructured":"Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002;105:539\u201342.","journal-title":"Circulation"},{"key":"66_CR29","doi-asserted-by":"publisher","DOI":"10.1007\/978-88-470-5367-0","volume-title":"Coronary microvascular dysfunction","author":"F Crea","year":"2014","unstructured":"Crea F, Lanza GA, Camici PG. Coronary microvascular dysfunction. Milano: Springer Milan; 2014."},{"key":"66_CR30","first-page":"1848","volume":"40","author":"PA Kaufmann","year":"1999","unstructured":"Kaufmann PA, Gnecchi-Ruscone T, Yap JT, Rimoldi O, Camici PG. Assessment of the reproducibility of baseline and hyperemic myocardial blood flow measurements with 15O-labeled water and PET. J Nucl Med. 1999;40:1848\u201356.","journal-title":"J Nucl Med"},{"key":"66_CR31","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","volume":"1","author":"JM Bland","year":"1986","unstructured":"Bland JM, Altman D. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;1:307\u201310.","journal-title":"Lancet"},{"key":"66_CR32","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1191\/096228099673819272","volume":"8","author":"JM Bland","year":"1999","unstructured":"Bland JM, Altman DG. Measuring agreement in method comparison studies. Stat Methods Med Res. 1999;8:135\u201360.","journal-title":"Stat Methods Med Res"},{"key":"66_CR33","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/uog.5256","volume":"31","author":"JW Bartlett","year":"2008","unstructured":"Bartlett JW, Frost C. Reliability, repeatability and reproducibility: analysis of measurement errors in continuous variables. Ultrasound Obstet Gynecol. 2008;31:466\u201375.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"66_CR34","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1191\/1740774504cn057oa","volume":"1","author":"JM Lachin","year":"2004","unstructured":"Lachin JM. The role of measurement reliability in clinical trials. Clin Trials. 2004;1:553\u201366.","journal-title":"Clin Trials"},{"key":"66_CR35","doi-asserted-by":"publisher","first-page":"255","DOI":"10.2307\/2532051","volume":"45","author":"LI Lin","year":"1989","unstructured":"Lin LI. A concordance correlation coefficient to evaluate reproducibility. Biometrics. 1989;45:255\u201368.","journal-title":"Biometrics"},{"key":"66_CR36","doi-asserted-by":"publisher","first-page":"599","DOI":"10.2307\/2532314","volume":"48","author":"LI-K Lin","year":"1992","unstructured":"Lin LI-K. Assay validation using the concordance correlation coefficient. Biometrics. 1992;48:599\u2013604.","journal-title":"Biometrics"},{"key":"66_CR37","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/j.0006-341X.2000.00324.x","volume":"56","author":"LI Lin","year":"2000","unstructured":"Lin LI. Correction: a note on the concordance correlation coefficient. Biometrics. 2000;56:324\u20135.","journal-title":"Biometrics"},{"key":"66_CR38","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.echo.2004.03.014","volume":"17","author":"P Pellikka","year":"2004","unstructured":"Pellikka P. Going for the money: transthoracic assessment of coronary artery flow reserve. J Am Soc Echocardiogr. 2004;17:700\u20133.","journal-title":"J Am Soc Echocardiogr"},{"key":"66_CR39","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.0742-2822.2005.04004.x","volume":"22","author":"M Takeuchi","year":"2005","unstructured":"Takeuchi M, Lodato JA, Furlong KT, Lang RM, Yoshikawa J. Feasibility of measuring coronary flow velocity and reserve in the left anterior descending coronary artery by transthoracic Doppler echocardiography in a relatively obese American population. Echocardiography. 2005;22:225\u201332.","journal-title":"Echocardiography"},{"key":"66_CR40","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1016\/j.echo.2009.08.004","volume":"22","author":"BM Dalen van","year":"2009","unstructured":"van Dalen BM, Bosch JG, Kauer F, Soliman OII, Vletter WB, ten Cate FJ, et al. Assessment of mitral annular velocities by speckle tracking echocardiography versus tissue doppler imaging: validation, feasibility, and reproducibility. J Am Soc Echocardiogr. 2009;22:1302\u20138.","journal-title":"J Am Soc Echocardiogr"},{"key":"66_CR41","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1097\/00004872-200411000-00024","volume":"22","author":"M Galderisi","year":"2004","unstructured":"Galderisi M, Cicala S, D\u2019Errico A, de Divitiis O, de Simone G. Nebivolol improves coronary flow reserve in hypertensive patients without coronary heart disease. J Hypertens. 2004;22:2201\u20138.","journal-title":"J Hypertens"},{"key":"66_CR42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/ejechocard\/jep188","volume":"11","author":"A Thorstensen","year":"2010","unstructured":"Thorstensen A, Dalen H, Amundsen BH, Aase SA, Stoylen A. Reproducibility in echocardiographic assessment of the left ventricular global and regional function, the HUNT study. Eur J Echocardiogr. 2010;11:149\u201356.","journal-title":"Eur J Echocardiogr"},{"key":"66_CR43","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1111\/echo.12832","volume":"32","author":"AC Armstrong","year":"2015","unstructured":"Armstrong AC, Ricketts EP, Cox C, Adler P, Arynchyn A, Liu K, et al. Quality control and reproducibility in M-mode, two-dimensional, and speckle tracking echocardiography acquisition and analysis: the CARDIA study, year 25 examination experience. Echocardiography. 2015;32:1233\u201340.","journal-title":"Echocardiography"},{"key":"66_CR44","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.jcmg.2011.02.008","volume":"4","author":"S Sdringola","year":"2011","unstructured":"Sdringola S, Johnson NP, Kirkeeide RL, Cid E, Gould KL. Impact of unexpected factors on quantitative myocardial perfusion and coronary flow reserve in young, asymptomatic volunteers. JACC Cardiovasc Imaging. 2011;4:402\u201312.","journal-title":"JACC Cardiovasc Imaging"},{"key":"66_CR45","first-page":"146","volume":"44","author":"CA Wyss","year":"2003","unstructured":"Wyss CA, Koepfli P, Mikolajczyk K, Burger C, von Schulthess GK, Kaufmann PA. Bicycle exercise stress in PET for assessment of coronary flow reserve: repeatability and comparison with adenosine stress. J Nucl Med. 2003;44:146\u201354.","journal-title":"J Nucl Med"},{"key":"66_CR46","doi-asserted-by":"publisher","first-page":"68","DOI":"10.2967\/jnumed.108.055673","volume":"50","author":"O Manabe","year":"2009","unstructured":"Manabe O, Yoshinaga K, Katoh C, Naya M, DeKemp RA, Tamaki N. Repeatability of rest and hyperemic myocardial blood flow measurements with 82Rb dynamic PET. J Nucl Med. 2009;50:68\u201371.","journal-title":"J Nucl Med"},{"key":"66_CR47","doi-asserted-by":"crossref","unstructured":"Machac J. Radiopharmaceuticals for Clinical Cardiac PET Imaging. In: Di Carli MF, Lipton MJ, editors. Cardiac PET and PET\/CT Imaging. New York, NY, USA: Springer Science\u2009+\u2009Business Media, LLC; 2007. p. 73\u201382.","DOI":"10.1007\/978-0-387-38295-1_5"},{"key":"66_CR48","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S1071-3581(05)80029-7","volume":"2","author":"S Sawada","year":"1995","unstructured":"Sawada S, Muzik O, Beanlands RS, Wolfe E, Hutchins GD, Schwaiger M. Interobserver and interstudy variability of myocardial blood flow and flow-reserve measurements with nitrogen 13 ammonia-labeled positron emission tomography. J Nucl Cardiol. 1995;2:413\u201322.","journal-title":"J Nucl Cardiol"},{"key":"66_CR49","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.2967\/jnumed.104.007831","volume":"50","author":"G Fakhri El","year":"2009","unstructured":"El Fakhri G, Kardan A, Sitek A, Dorbala S, Abi-Hatem N, Lahoud Y, et al. Reproducibility and accuracy of quantitative myocardial blood flow assessment with (82)Rb PET: comparison with (13)N-ammonia PET. J Nucl Med. 2009;50:1062\u201371.","journal-title":"J Nucl Med"},{"key":"66_CR50","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1093\/ehjci\/jeu059","volume":"15","author":"V Varho","year":"2014","unstructured":"Varho V, Karjalainen PP, Ylitalo A, Airaksinen JK, Mikkelsson J, Sia J, et al. Transthoracic echocardiography for non-invasive assessment of coronary vasodilator function after DES implantation. Eur Heart J Cardiovasc Imaging. 2014;15:1029.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"66_CR51","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0894-7317(03)00116-0","volume":"16","author":"JM Tsutsui","year":"2003","unstructured":"Tsutsui JM, Mathias W, Frimm CC, Lemos PA, Leal SMB, de Andrade JL. Coronary blood flow reserve response to left anterior descending coronary artery stenting and its value in predicting coronary restenosis. J Am Soc Echocardiogr. 2003;16:469\u201375.","journal-title":"J Am Soc Echocardiogr"},{"key":"66_CR52","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.echo.2011.01.004","volume":"24","author":"A Djordjevic-Dikic","year":"2011","unstructured":"Djordjevic-Dikic A, Beleslin B, Stepanovic J, Giga V, Tesic M, Dobric M, et al. Prediction of myocardial functional recovery by noninvasive evaluation of Basal and hyperemic coronary flow in patients with previous myocardial infarction. J Am Soc Echocardiogr. 2011;24:573\u201381.","journal-title":"J Am Soc Echocardiogr"},{"key":"66_CR53","doi-asserted-by":"crossref","first-page":"H2634","DOI":"10.1152\/ajpheart.2000.279.6.H2634","volume":"279","author":"N Spyrou","year":"2000","unstructured":"Spyrou N, Khan MA, Rosen SD, Foale R, Davies DW, Sogliani F, et al. Persistent but reversible coronary microvascular dysfunction after bypass grafting. Am J Physiol Heart Circ Physiol. 2000;279:H2634\u201340.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"66_CR54","first-page":"966","volume":"16","author":"J Knuuti","year":"2015","unstructured":"Knuuti J, Saraste A. Perfusion imaging and coronary anatomy. Eur Hear J Cardiovasc Imaging. 2015;16:966\u20137.","journal-title":"Eur Hear J Cardiovasc Imaging"},{"key":"66_CR55","doi-asserted-by":"publisher","first-page":"571","DOI":"10.2967\/jnumed.112.112219","volume":"54","author":"RA DeKemp","year":"2013","unstructured":"DeKemp RA, Declerck J, Klein R, Pan X-B, Nakazato R, Tonge C, et al. Multisoftware reproducibility study of stress and rest myocardial blood flow assessed with 3D dynamic PET\/CT and a 1-tissue-compartment model of 82Rb kinetics. J Nucl Med. 2013;54:571\u20137.","journal-title":"J Nucl Med"},{"key":"66_CR56","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1007\/s12350-010-9225-3","volume":"17","author":"R Klein","year":"2010","unstructured":"Klein R, Renaud JM, Ziadi MC, Thorn SL, Adler A, Beanlands RS, et al. Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program. J Nucl Cardiol. 2010;17:600\u201316.","journal-title":"J Nucl Cardiol"}],"container-title":["Cardiovascular Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12947-016-0066-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12947-016-0066-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12947-016-0066-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12947-016-0066-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T22:49:54Z","timestamp":1589669394000},"score":1,"resource":{"primary":{"URL":"http:\/\/cardiovascularultrasound.biomedcentral.com\/articles\/10.1186\/s12947-016-0066-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["66"],"URL":"https:\/\/doi.org\/10.1186\/s12947-016-0066-3","relation":{},"ISSN":["1476-7120"],"issn-type":[{"value":"1476-7120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"article-number":"22"}}