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The following indexes during atrial reservoir, conduit and pump phase were analyzed respectively: (1) peak atrial longitudinal strain (PALS) and strain rate (PALSR), (2) the standard deviation of time to PALS and PALSR of all LA segments (TpS-SD% and TpSR-SD%).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Compared with controls, PALS<jats:sub>res<\/jats:sub>, PALS<jats:sub>cond<\/jats:sub> and PALSR<jats:sub>cond<\/jats:sub> were significantly reduced in patients with isolated hypertension (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) but no significant differences were observed in PALS<jats:sub>pump<\/jats:sub>, PALSR<jats:sub>pump<\/jats:sub> and TpS<jats:sub>pump<\/jats:sub>-SD% between them (all <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). PALS<jats:sub>pump<\/jats:sub>, PALSR<jats:sub>pump<\/jats:sub> and PALSR<jats:sub>res<\/jats:sub> were significantly lower in patients with both hypertension and PAF than in those with isolated hypertension (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). PALS and PALSR were significantly decreased, and TpS-SD% was significantly increased during each phase in lone AF patients than in controls (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and PALSR<jats:sub>pump<\/jats:sub> was further depressed in patients with both hypertension and PAF (<jats:italic>P<\/jats:italic>\u2009=\u20090.029). PALSR<jats:sub>cond<\/jats:sub>\u2009\u2264\u20091.475\u2009s<jats:sup>\u2212\u20091<\/jats:sup> combined with TpS<jats:sub>pump<\/jats:sub>-SD%\u2009\u2265\u20093.25% (sensitivity, 85%; specificity, 71%; AUC\u2009=\u20090.845, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) could distinguish lone AF from healthy subjects effectively, while in hypertensive patients, PALS<jats:sub>pump<\/jats:sub>\u2009\u2264\u200914.2% was found to be an independent differentiator for occurrence of AF or not with sensitivity of 81% and specificity of 84% (AUC\u2009=\u20090.838, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). LAVI\u226529.3\u2009mL\/m<jats:sup>2<\/jats:sup> was an independent characteristic for reflecting different LA remodeling in lone AF or hypertension with AF.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The impairment of LA phasic functions was varied in patients with hypertension and\/or AF. The disturbed LA phasic functions were proved to have independent abilities of differential diagnosis in this heterogeneous population associated with hypertension or AF.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12947-019-0175-x","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T15:53:12Z","timestamp":1573573992000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical implication of disturbed left atrial phasic functions in the heterogeneous population associated with hypertension or atrial fibrillation"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1900-9609","authenticated-orcid":false,"given":"Mengruo","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianhong","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"issue":"12","key":"175_CR1","volume":"11","author":"A Chirinos Julio","year":"2018","unstructured":"Chirinos Julio A, Sardana M, Ansari B, et al. 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