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This study aims to describe the normal Doppler hemodynamic profile of MPVP using Doppler echocardiography.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The current prospective, single center observational study enrolled 108 patients who underwent pulmonary valve replacement (PVR) surgery for the first time and had a normally functioning prosthesis post-operation. The hemodynamic performance of MPVPs, considering flow dependent and flow independent parameters, was evaluated at two follow-up points, at week one and week four post-operation. All assessments were conducted by an experienced echocardiographer.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The mean age (\u00b1SD) of the participants was 26.4 (\u00b18.98). Tetralogy of Fallot (ToF) was the most common underlying disease leading to PVR, with a prevalence of 88%. At first week post-operation, measurement of indices reported the following values (\u00b1SD): peak pressure gradient (PPG): 18.51(\u00b17.64) mm Hg; mean pressure gradient (MPG): 10.88(\u00b15.62) mm Hg; peak velocity (PV): 1.97(\u00b10.43)m\/s; doppler velocity index (DVI): 0.61(\u00b118); pulmonary velocity acceleration time (PVAT): 87.35(\u00b115.16) ms; effective orifice area (EOA): 2.98(\u00b11.02) cm<jats:sup>2<\/jats:sup>;and effective orifice area to body surface area ratio (EOA\/ BSA): 1.81(\u00b10.62) cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>. Comparing these measurements with those obtained from the second follow-up (at week four post-op) failed to hold significant difference in all values except for PVAT, which had increased from its primary value (<jats:italic>p<\/jats:italic>\u2009=\u20090.038). Also, right ventricular (RV) function showed significant improvement throughout the follow up period.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The findings of this study help strengthen the previously scarce data pool and better establish the normal values for Doppler hemodynamics in mechanical pulmonary prosthesis.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12947-020-00196-0","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T16:04:54Z","timestamp":1589558694000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of normal hemodynamic profile of mechanical pulmonary prosthesis by doppler echocardiography: a prospective cross-sectional study"],"prefix":"10.1186","volume":"18","author":[{"given":"Maryam","family":"Shojaeifard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Daryanavard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-2371","authenticated-orcid":false,"given":"Arman","family":"Karimi Behnagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Moradian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajjad","family":"Erami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Dehghani Mohammad Abadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"issue":"4","key":"196_CR1","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.jtcvs.2017.04.072","volume":"154","author":"H Pragt","year":"2017","unstructured":"Pragt H, van Melle JP, Javadikasgari H, Seo DM, Stulak JM, Knez I, Horer J, Munoz-Guijosa C, Dehaki MG, Shin HJ, et al. 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