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Global longitudinal strain (GLS) predicts poor prognosis in various cardiac diseases, but it has not been evaluated in a cohort of exclusively NI-DCM. Although deformation parameters have been shown to reflect diastolic function, their association with other hemodynamic parameters needs further elucidation. We aimed to evaluate the association between GLS and E\/GLS and invasive hemodynamic parameters and assess the prognostic value of GLS and E\/GLS in a prospective well-defined pure NI-DCM cohort.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and results<\/jats:title>\n                <jats:p>Forty-one patients with NI-DCM were enrolled in the study. They underwent a standard diagnostic workup, including transthoracic echocardiography and right heart catheterization. During a five-year follow-up, 20 (49%) patients reached the composite outcome measure: LV assist device implantation, heart transplantation, or cardiovascular death.<\/jats:p>\n                <jats:p>Pulmonary capillary wedge pressure (PCWP), mean pulmonary artery pressure, pulmonary vascular resistance (PVR) correlated with GLS and E\/GLS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). ROC analysis revealed that GLS and E\/GLS could identify elevated PCWP (\u2265\u200915\u00a0mmHg) and PVR (&gt;\u20093 Wood units). Survival analysis showed GLS and E\/GLS to be associated with short- and long-term adverse cardiac events (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). GLS values above thresholds of \u20135.34% and -5.96% indicated 18- and 12-fold higher risk of poor clinical outcomes at one and five years, respectively. Multivariate Cox regression analysis revealed that GLS is an independent long-term outcome predictor.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>GLS and E\/GLS correlate with invasive hemodynamics parameters and identify patients with elevated PCWP and high PVR. GLS and E\/GLS predict short- and long-term adverse cardiac events in patients with NI-DCM. Worsening GLS is associated with incremental risk of long-term adverse cardiac events and might be used to identify high-risk patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12947-021-00254-1","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T14:03:01Z","timestamp":1622901781000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Left ventricular global longitudinal strain predicts elevated cardiac pressures and poor clinical outcomes in patients with non-ischemic dilated cardiomyopathy"],"prefix":"10.1186","volume":"19","author":[{"given":"Ieva","family":"Ka\u017eukauskien\u0117","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giedr\u0117","family":"Bal\u010di\u016bnait\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaida","family":"Baltr\u016bnien\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"\u010celutkien\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vyt\u0117 Valerija","family":"Maneikien\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigitas","family":"\u010cibiras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u0119stutis","family":"Ru\u010dinskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginija","family":"Grabauskien\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,5]]},"reference":[{"key":"254_CR1","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.healun.2016.08.017","volume":"35","author":"LH Lund","year":"2016","unstructured":"Lund LH, Edwards LB, Dipchand AI, Goldfarb S, Kucheryavaya AY, Levvey BJ, Meiser B, Rossano JW, Yusen RD, Stehlik J. 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