{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:33:05Z","timestamp":1788449585364,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Yunnan Province Department of Education","award":["2024J0286"],"award-info":[{"award-number":["2024J0286"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Ultrasound"],"DOI":"10.1186\/s12947-025-00359-x","type":"journal-article","created":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T23:02:41Z","timestamp":1759705361000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic value of adenosine stress echocardiography in chronic coronary syndromes with preserved left ventricular ejection fraction"],"prefix":"10.1186","volume":"23","author":[{"given":"Li","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Yi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Han","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Long","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Chuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"issue":"1","key":"359_CR1","first-page":"125","volume":"42","author":"S Pruthi","year":"2024","unstructured":"Pruthi S, Siddiqui E, Smilowitz NR. Beyond coronary artery disease: assessing the microcirculation. Cardiol Clin. 2024;42(1):125\u201335.","journal-title":"Cardiol Clin"},{"issue":"22","key":"359_CR2","first-page":"e368","volume":"144","author":"M Gulati","year":"2021","unstructured":"Gulati M, Levy P, Mukherjee D, et al. 2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR guideline for the evaluation and diagnosis of chest pain: executive summary: A report of the American college of cardiology\/american heart association joint committee on clinical practice guidelines. Circulation. 2021;144(22):e368\u2013454.","journal-title":"Circulation"},{"key":"359_CR3","doi-asserted-by":"crossref","unstructured":"Picano E, Pierard L, Peteiro J et al. The clinical use of stress echocardiography in chronic coronary syndromes and beyond coronary artery disease: A clinical consensus statement from the European association of cardiovascular imaging of the ESC. Eur Heart J Cardiovasc Imaging. 2024;25(2):e65-e90.","DOI":"10.1093\/ehjci\/jead250"},{"key":"359_CR4","doi-asserted-by":"publisher","first-page":"k504","DOI":"10.1136\/bmj.k504","volume":"360","author":"GC Siontis","year":"2018","unstructured":"Siontis GC, Mavridis D, Greenwood JP, et al. Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease: network meta-analysis of diagnostic randomised controlled trials. BMJ. 2018;360:k504.","journal-title":"BMJ"},{"key":"359_CR5","doi-asserted-by":"crossref","unstructured":"Woodward W, Johnson CL, Krasner S et al. Long-Term outcomes after stress echocardiography in real world practice: five-year follow-up of the UK evarest study. Eur Heart J Cardiovasc Imaging. 2025;26(2):187-196.","DOI":"10.1093\/ehjci\/jeae291"},{"issue":"2","key":"359_CR6","doi-asserted-by":"publisher","first-page":"e65","DOI":"10.1093\/ehjci\/jead250","volume":"25","author":"E Picano","year":"2024","unstructured":"Picano E, Pierard L, Peteiro J, et al. The clinical use of stress echocardiography in chronic coronary syndromes and beyond coronary artery disease: a clinical consensus statement from the European association of cardiovascular imaging of the ESC. Eur Heart J Cardiovasc Imaging. 2024;25(2):e65\u201390.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"10","key":"359_CR7","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.echo.2023.07.002","volume":"36","author":"A Moya","year":"2023","unstructured":"Moya A, Buytaert D, Penicka M, et al. State-of-the-Art: noninvasive assessment of left ventricular function through myocardial work. J Am Soc Echocardiogr. 2023;36(10):1027\u201342.","journal-title":"J Am Soc Echocardiogr"},{"issue":"8","key":"359_CR8","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.echo.2021.04.013","volume":"34","author":"S Roemer","year":"2021","unstructured":"Roemer S, Jaglan A, Santos D, et al. The utility of myocardial work in clinical practice. J Am Soc Echocardiogr. 2021;34(8):807\u201318.","journal-title":"J Am Soc Echocardiogr"},{"issue":"3","key":"359_CR9","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","volume":"41","author":"J Knuuti","year":"2020","unstructured":"Knuuti J, Wijns W, Saraste A, et al. 2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020;41(3):407\u201377.","journal-title":"Eur Heart J"},{"issue":"1","key":"359_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2018.06.004","volume":"32","author":"C Mitchell","year":"2019","unstructured":"Mitchell C, Rahko PS, Blauwet LA, et al. Guidelines for performing a comprehensive transthoracic echocardiographic examination in adults: recommendations from the American society of echocardiography. J Am Soc Echocardiogr. 2019;32(1):1\u201364.","journal-title":"J Am Soc Echocardiogr"},{"issue":"44","key":"359_CR11","doi-asserted-by":"publisher","first-page":"4592","DOI":"10.1093\/eurheartj\/ehab282","volume":"42","author":"H Shimokawa","year":"2021","unstructured":"Shimokawa H, Suda A, Takahashi J, et al. Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the coronary vasomotor disorders international study (COVADIS) group. Eur Heart J. 2021;42(44):4592\u2013600.","journal-title":"Eur Heart J"},{"issue":"2","key":"359_CR12","doi-asserted-by":"publisher","first-page":"41","DOI":"10.4103\/ajm.AJM_209_17","volume":"8","author":"RM Abazid","year":"2018","unstructured":"Abazid RM, Abohamr SI, Smettei OA, et al. Visual versus fully automated assessment of left ventricular ejection fraction. Avicenna J Med. 2018;8(2):41\u20135.","journal-title":"Avicenna J Med"},{"issue":"11","key":"359_CR13","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1093\/ehjci\/jex182","volume":"18","author":"R Senior","year":"2017","unstructured":"Senior R, Becher H, Monaghan M, et al. Clinical practice of contrast echocardiography: recommendation by the European association of cardiovascular imaging (EACVI) 2017. Eur Heart J Cardiovasc Imaging. 2017;18(11):1205\u2013af1205.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"37","key":"359_CR14","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1093\/eurheartj\/ehab493","volume":"42","author":"Q Ciampi","year":"2021","unstructured":"Ciampi Q, Zagatina A, Cortigiani L, et al. Prognostic value of stress echocardiography assessed by the ABCDE protocol. Eur Heart J. 2021;42(37):3869\u201378.","journal-title":"Eur Heart J"},{"key":"359_CR15","unstructured":"Gaibazzi N, Ciampi Q, Cortigiani L et al. Multiple Phenotypes of Chronic Coronary Syndromes Identified by ABCDE Stress Echocardiography. Journal of the American Society of Echocardiography: official publication of the American Society of Echocardiography. 2023."},{"issue":"1","key":"359_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2019.07.001","volume":"33","author":"PA Pellikka","year":"2020","unstructured":"Pellikka PA, Arruda-Olson A, Chaudhry FA, et al. Guidelines for performance, interpretation, and application of stress echocardiography in ischemic heart disease: from the American society of echocardiography. J Am Soc Echocardiogr. 2020;33(1):1\u2013e4148.","journal-title":"J Am Soc Echocardiogr"},{"issue":"10","key":"359_CR17","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.echo.2022.05.012","volume":"35","author":"N Gaibazzi","year":"2022","unstructured":"Gaibazzi N, Lorenzoni V, Tuttolomondo D, et al. Association between resting global longitudinal strain and clinical outcome of patients undergoing stress echocardiography. J Am Soc Echocardiogr. 2022;35(10):1018\u201327. e1016.","journal-title":"J Am Soc Echocardiogr"},{"key":"359_CR18","doi-asserted-by":"crossref","unstructured":"Biering-S\u00f8rensen T, Biering-S\u00f8rensen SR, Olsen FJ et al. Global longitudinal strain by echocardiography predicts Long-Term risk of cardiovascular morbidity and mortality in a Low-Risk general population: the Copenhagen City heart study. Circ Cardiovasc Imaging. 2017;10(3):e005521.","DOI":"10.1161\/CIRCIMAGING.116.005521"},{"issue":"8","key":"359_CR19","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1111\/echo.13222","volume":"33","author":"A Kataoka","year":"2016","unstructured":"Kataoka A, Scherrer-Crosbie M, Senior R, et al. Transient ischemic dilatation during stress echocardiography: an additional marker of significant myocardial ischemia. Echocardiography. 2016;33(8):1202\u20138.","journal-title":"Echocardiography"},{"key":"359_CR20","unstructured":"Bombardini TZ, Ciampi A. Q;. Feasibility and value of two-dimensional volumetric stress echocardiography. Minerva Cardioangiol. 2020;70(2):148-159."},{"issue":"11","key":"359_CR21","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s11886-023-01970-y","volume":"25","author":"S Capdeville","year":"2023","unstructured":"Capdeville S, Gholson BA, Lindner JR. Contrast echocardiography for assessing myocardial perfusion. Curr Cardiol Rep. 2023;25(11):1581\u20137.","journal-title":"Curr Cardiol Rep"},{"issue":"5","key":"359_CR22","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1093\/ehjci\/jeaa026","volume":"22","author":"L Qian","year":"2021","unstructured":"Qian L, Xie F, Xu D, et al. Long-term prognostic value of stress myocardial perfusion echocardiography in patients with coronary artery disease: a meta-analysis. Eur Heart J Cardiovasc Imaging. 2021;22(5):553\u201362.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"18","key":"359_CR23","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1016\/j.jacc.2019.08.1042","volume":"74","author":"SL Mulvagh","year":"2019","unstructured":"Mulvagh SL, Mokhtar AT. Coronary flow velocity reserve in stress echocardiography: time to go with the global flow? J Am Coll Cardiol. 2019;74(18):2292\u20134.","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"359_CR24","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.echo.2020.01.007","volume":"33","author":"N Gaibazzi","year":"2020","unstructured":"Gaibazzi N, Picano E, Suma S, et al. Coronary flow velocity reserve reduction is associated with cardiovascular, cancer, and noncancer, noncardiovascular mortality. J Am Soc Echocardiogr. 2020;33(5):594\u2013603.","journal-title":"J Am Soc Echocardiogr"},{"issue":"4","key":"359_CR25","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1093\/ehjci\/jead304","volume":"25","author":"N Gaibazzi","year":"2024","unstructured":"Gaibazzi N, Cortigiani L, Rigo F, et al. Reversible ischaemia and outcome after adjustment for coronary artery disease severity: a multicentre stress-echocardiography registry. Eur Heart J Cardiovasc Imaging. 2024;25(4):510\u20139.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"1","key":"359_CR26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.echo.2024.09.011","volume":"38","author":"L Cortigiani","year":"2025","unstructured":"Cortigiani L, Gaibazzi N, Ciampi Q, et al. Reduction of coronary flow velocity reserve as the main driver of prognostically beneficial coronary revascularization. J Am Soc Echocardiogr. 2025;38(1):24\u201332.","journal-title":"J Am Soc Echocardiogr"},{"issue":"4","key":"359_CR27","doi-asserted-by":"publisher","first-page":"e031270","DOI":"10.1161\/JAHA.123.031270","volume":"13","author":"L Cortigiani","year":"2024","unstructured":"Cortigiani L, Gaibazzi N, Ciampi Q, et al. High resting coronary flow velocity by echocardiography is associated with worse survival in patients with chronic coronary syndromes. J Am Heart Assoc. 2024;13(4):e031270.","journal-title":"J Am Heart Assoc"},{"key":"359_CR28","doi-asserted-by":"crossref","unstructured":"Fri\u0219an AC, Morno\u0219 C, Laz\u0103r MA et al. Echocardiographic myocardial work: A novel method to assess left ventricular function in patients with coronary artery disease and diabetes mellitus. Med (Kaunas). 2024;60(2):199.","DOI":"10.3390\/medicina60020199"},{"issue":"8","key":"359_CR29","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.echo.2019.02.014","volume":"32","author":"NFA Edwards","year":"2019","unstructured":"Edwards NFA, Scalia GM, Shiino K, et al. Global myocardial work is superior to global longitudinal strain to predict significant coronary artery disease in patients with normal left ventricular function and wall motion. J Am Soc Echocardiogr. 2019;32(8):947\u201357.","journal-title":"J Am Soc Echocardiogr"},{"issue":"12","key":"359_CR30","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1007\/s10554-023-02951-6","volume":"39","author":"H Lv","year":"2023","unstructured":"Lv H, Jiang Y, Tan X, et al. Global and regional myocardial function assessment in symptomatic patients with chronic coronary syndrome using longitudinal strain and noninvasive myocardial work. Int J Cardiovasc Imaging. 2023;39(12):2465\u201374.","journal-title":"Int J Cardiovasc Imaging"},{"issue":"3","key":"359_CR31","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.echo.2021.10.009","volume":"35","author":"J Lin","year":"2022","unstructured":"Lin J, Wu W, Gao L, et al. Global myocardial work combined with treadmill exercise stress to detect significant coronary artery disease. J Am Soc Echocardiogr. 2022;35(3):247\u201357.","journal-title":"J Am Soc Echocardiogr"},{"issue":"9","key":"359_CR32","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1161\/CIRCULATIONAHA.122.063642","volume":"148","author":"T Kondo","year":"2023","unstructured":"Kondo T, Dewan P, Anand IS, et al. Clinical characteristics and outcomes in patients with heart failure: are there thresholds and inflection points in left ventricular ejection fraction and thresholds justifying a clinical classification?? Circulation. 2023;148(9):732\u201349.","journal-title":"Circulation"},{"issue":"2 Pt 1","key":"359_CR33","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.jcmg.2017.11.017","volume":"11","author":"E Potter","year":"2018","unstructured":"Potter E, Marwick TH. Assessment of left ventricular function by echocardiography: the case for routinely adding global longitudinal strain to ejection fraction. JACC Cardiovasc Imaging. 2018;11(2 Pt 1):260\u201374.","journal-title":"JACC Cardiovasc Imaging"},{"issue":"21","key":"359_CR34","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1136\/heartjnl-2014-305538","volume":"100","author":"K Kalam","year":"2014","unstructured":"Kalam K, Otahal P, Marwick TH. Prognostic implications of global LV dysfunction: a systematic review and meta-analysis of global longitudinal strain and ejection fraction. Heart. 2014;100(21):1673\u201380.","journal-title":"Heart"},{"issue":"1","key":"359_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4070\/kcj.2024.0264","volume":"55","author":"N Miaris","year":"2025","unstructured":"Miaris N. Is any ABCDE stress echocardiography score equivalent to stress-Induced ischaemia?? Reply with a modified 2-Stage approach. Korean Circ J. 2025;55(1):1\u20134.","journal-title":"Korean Circ J"},{"issue":"6","key":"359_CR36","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.echo.2017.11.019","volume":"31","author":"L Cortigiani","year":"2018","unstructured":"Cortigiani L, Huqi A, Ciampi Q, et al. Integration of wall motion, coronary flow velocity, and left ventricular contractile reserve in a single test: prognostic value of vasodilator stress echocardiography in patients with diabetes. J Am Soc Echocardiogr. 2018;31(6):692\u2013701.","journal-title":"J Am Soc Echocardiogr"},{"key":"359_CR37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ijcard.2016.08.313","volume":"224","author":"C Carpeggiani","year":"2016","unstructured":"Carpeggiani C, Landi P, Michelassi C, et al. The declining frequency of inducible myocardial ischemia during stress echocardiography over 27 consecutive years (1983\u20132009). Int J Cardiol. 2016;224:57\u201361.","journal-title":"Int J Cardiol"}],"container-title":["Cardiovascular Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12947-025-00359-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12947-025-00359-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12947-025-00359-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T23:02:46Z","timestamp":1759705366000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiovascularultrasound.biomedcentral.com\/articles\/10.1186\/s12947-025-00359-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["359"],"URL":"https:\/\/doi.org\/10.1186\/s12947-025-00359-x","relation":{},"ISSN":["1476-7120"],"issn-type":[{"value":"1476-7120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,6]]},"assertion":[{"value":"25 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in accordance with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Yan\u2019an Hospital Affiliated to Kunming Medical University (approval No: 2023-179-01).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"All the participants gave their consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All authors declare no conflicts of interest associated with this manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"21"}}