{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:37:24Z","timestamp":1787020644845,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Ultrasound"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Left atrial (LA) volume and strain parameters have been associated with cardiovascular outcomes in several cardiac pathologies, yet their role in predicting major adverse cardiovascular events (MACE) in kidney transplant (KT) recipients has not been explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the records of adult KT recipients from our institution (2015\u20132024). We utilized baseline echocardiograms routinely acquired during KT workup to measure LA volumetrics and strain. MACE was the study\u2019s primary endpoint, defined as cardiovascular death, nonfatal myocardial infarction, stroke, major arrhythmias or heart failure hospitalization. Logistic regression, Kaplan-Meier and Cox proportional hazards regression were performed to evaluate the association between LA parameters and MACE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 518 patients who underwent kidney transplant, 377 were in sinus rhythm with an acceptable quality echocardiogram (male, 56.7%; mean age 53.7\u2009\u00b1\u200913.1 years). Over a median follow up duration of 5.3\u2009\u00b1\u20092.3 years from KT, 82 patients reached the study endpoint. Kaplan-Meier analysis showed significantly lower MACE-free survival in patients with abnormal LA strain. After adjusting for confounding variables in the Cox Proportional Hazards model, of all LA parameters, lower LAScd (HR 0.94, 95% CI 0.89\u20130.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), and LASr (HR 0.97, 95% CI 0.94\u20130.995,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) were independently associated with MACE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this retrospective single center study, LA strain parameters particularly LASr and LAScd were independently associated with MACE after KT. LA strain might have a role in risk stratification in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12947-026-00369-3","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:01:15Z","timestamp":1772409675000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of left atrial volume and function parameters with cardiovascular outcomes following kidney transplantation"],"prefix":"10.1186","volume":"24","author":[{"given":"Ava R.","family":"DeLonais-Parker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer H.","family":"Hobbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor R.","family":"Coffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Kanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa J.","family":"Treiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rushda F.","family":"Mansuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara C.","family":"Okeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista L.","family":"Lentine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9076-2321","authenticated-orcid":false,"given":"Mina M.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"issue":"4","key":"369_CR1","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1681\/ASN.2021111517","volume":"33","author":"AJ Vinson","year":"2022","unstructured":"Vinson AJ, Singh S, Chadban S, Cherney D, Gaber O, Gill JS, et al. Premature death in kidney transplant recipients: the time for trials is now. J Am Soc Nephrol. 2022;33(4):665\u201373.","journal-title":"J Am Soc Nephrol"},{"key":"369_CR2","doi-asserted-by":"crossref","unstructured":"Shroff GR, Benjamin MM, Rangaswami J et al. Risk and management of cardiac disease in kidney and liver transplant recipients. Heart. 2025.","DOI":"10.1136\/heartjnl-2024-324796"},{"issue":"2S1","key":"369_CR3","doi-asserted-by":"publisher","first-page":"S22","DOI":"10.1016\/j.ajt.2025.01.020","volume":"25","author":"KL Lentine","year":"2025","unstructured":"Lentine KL, Smith JM, Lyden GR, et al. OPTN\/SRTR 2023 annual data report: kidney. Am J Transpl. 2025;25(2S1):S22\u2013137.","journal-title":"Am J Transpl"},{"key":"369_CR4","unstructured":"Services USDoHH. 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Echocardiography. 2025;42(2):e70088.","journal-title":"Echocardiography"},{"issue":"1","key":"369_CR11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.echo.2016.09.007","volume":"30","author":"F Pathan","year":"2017","unstructured":"Pathan F, D\u2019Elia N, Nolan MT, et al. Normal ranges of left atrial strain by Speckle-Tracking echocardiography: A systematic review and Meta-Analysis. J Am Soc Echocardiogr. 2017;30(1):59\u201370. e8.","journal-title":"J Am Soc Echocardiogr"},{"issue":"3","key":"369_CR12","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1007\/s00330-023-10142-z","volume":"34","author":"JF Cheng","year":"2024","unstructured":"Cheng JF, Huang PS, Chen ZW, et al. Post-exercise left atrial conduit strain predicted hemodynamic change in heart failure with preserved ejection fraction. 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Impact of different approaches to kidney transplant with and without chronic Hemodialysis on cardiac function and morphology: A Case-Control study. J Clin Med. 2021;10(17).","DOI":"10.3390\/jcm10173913"},{"issue":"5","key":"369_CR18","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1161\/HYPERTENSIONAHA.111.176594","volume":"58","author":"F Verbeke","year":"2011","unstructured":"Verbeke F, Marechal C, Van Laecke S, Van Biesen W, et al. Aortic stiffness and central wave reflections predict outcome in renal transplant recipients. Hypertension. 2011;58(5):833\u20138.","journal-title":"Hypertension"},{"issue":"8","key":"369_CR19","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1016\/j.transproceed.2020.01.132","volume":"52","author":"P Olczyk","year":"2020","unstructured":"Olczyk P, Malyszczak A, Golebiowski T, et al. Arterial stiffness assessed by oscillometric method in kidney Transplant, Predialysis, and Dialysis patients. 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The study protocol was approved by the Saint Louis University Institutional Review Board (IRB protocol number 34091). The requirement for informed consent was waived as the study was determined to be minimal risk.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7"}}