{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:16:31Z","timestamp":1781190991036,"version":"3.54.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Mol Allergy"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Egg allergy is the second most prevalent form of food allergy in childhood. In spite of the evidence accumulated, inoculating egg allergy children with attenuated vaccines grown on chick embryo cell cultures, such as the measles, mumps, and rubella (MMR) vaccine, is regarded (erroneously) as potentially dangerous or even anaphylactogenic, by many. An issue perceived as particularly conflicting also by Health Professionals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 15-year-old boy, with a history of severe egg allergy in early infancy, who was still sensitized to egg allergens, including baked egg, had never received MMR vaccination, in fear of possible anaphylaxis, in spite of the fact that this vaccination is mandatory in the first year of life, in Italy. Because of that, he was not allowed to attend school, longer, and was referred to us in order to assess the potential risk of MMR vaccination. Upon thorough allergologic workup, sensitization to MMR vaccine components was excluded by an in vivo approach, consisting in skin prick tests, intradermal tests, and subcutaneous injection test, corroborated by vaccine-specific B-lymphocyte proliferation assay, ex vivo. T-cell proliferation in response to MMR vaccine was also excluded. Eventually, the boy was inoculated with MMR vaccine and was readmitted to school.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The diagnostic strategy adopted appears feasible and easy-to-perform and may be adopted in controversial cases (as the one reported), characterized by previous severe allergic reactions to egg. The B-lymphocyte proliferation assay we developed may represent a useful and reliable tool not only in research but also in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12948-020-00136-3","type":"journal-article","created":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T14:02:37Z","timestamp":1605448957000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Safety of measles, mumps, and rubella vaccine in egg allergy: in vivo and in vitro management"],"prefix":"10.1186","volume":"18","author":[{"given":"Stefania","family":"Magist\u00e0","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Albanesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Chaoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Di Bona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Di Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eustachio","family":"Nettis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Filomena","family":"Caiaffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5896-086X","authenticated-orcid":false,"given":"Luigi","family":"Macchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"key":"136_CR1","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.jaci.2010.11.044","volume":"127","author":"SH Sicherer","year":"2011","unstructured":"Sicherer SH. Epidemiology of food allergy. J Allergy Clin Immunol. 2011;127:594\u2013602.","journal-title":"J Allergy Clin Immunol"},{"key":"136_CR2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s12393-011-9033-9","volume":"3","author":"SK Shriver","year":"2011","unstructured":"Shriver SK, Yang WW. Thermal and nonthermal methods for food allergen control. Food Eng Rev. 2011;3:26\u201343.","journal-title":"Food Eng Rev"},{"key":"136_CR3","first-page":"486","volume":"73","author":"B Freigang","year":"1994","unstructured":"Freigang B, Jadavji TP, Freigang DW. Lack of adverse reactions to measles, mumps, and rubella vaccine in egg-allergic children. Ann Allergy. 1994;73:486\u20138.","journal-title":"Ann Allergy"},{"key":"136_CR4","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1111\/j.1365-2222.2010.03557.x","volume":"40","author":"AT Clark","year":"2010","unstructured":"Clark AT, Skypala I, Leech SC, Ewan PW, Dugu\u00e9 P, Brathwaite N, et al. British Society for Allergy and Clinical Immunology guidelines for the managment of egg allergy. Clin Exp Allergy. 2010;40:1116\u201329.","journal-title":"Clin Exp Allergy"},{"key":"136_CR5","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1111\/j.1399-3038.2004.00188.x","volume":"15","author":"DJ Hill","year":"2004","unstructured":"Hill DJ, Heine RG, Hosking CS. The diagnostic value of skin prick testing in children with food allergy. Pediatr Allergy Immunol. 2004;15:435\u201341.","journal-title":"Pediatr Allergy Immunol"},{"key":"136_CR6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.5114\/ada.2019.82829","volume":"36","author":"M Albanesi","year":"2019","unstructured":"Albanesi M, Pasculli C, Giliberti L, Rossi MP, Di Bona D, Caiaffa MF, Macchia L. Immunological characterization of onion (Allium cepa) allergy. 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