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The underlying mechanisms of ischemia-reperfusion (I\/R) induced AKI is very complicated and needed for further research. Here, we sought to found out the functions of lncRNA TUG1 in I\/R-induced AKI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In vivo model was constructed by I\/R-induced mice and in vitro model was constructed by hypoxia\/reoxygenation (H\/R)-induced HK-2 cell. Kidney tissue damage was evaluated through H&amp;E staining in mice. Cell flow cytometry was used to detect the degree of apoptosis. TUG1, miR-494-3p and E-cadherin were determined both by RT-PCR and western blot. Dual luciferase assay was employed to validate the relationships between TUG1, miR-494-3p and E-cadherin. Inflammatory factors including IL-1\u03b2, TNF\u0251 and IL-6 were evaluated by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>lncRNA TUG1 was decreased while miR-494-3p was elevated in vivo and in vitro. Overexpression of TUG1 or transfection with miR-494-3p inhibitor significantly alleviated cell apoptosis. MiR-494-3p directly targeted E-cadherin and TUG1 suppressed cell apoptosis via serving as a miR-494-3p sponge to disinhibit E-cadherin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>lncRNA TUG1 alleviated I\/R-induced AKI through targeting miR-494-3p\/E-cadherin.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12950-021-00278-4","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T18:03:10Z","timestamp":1614880990000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["LncRNA TUG1 regulates the development of ischemia-reperfusion mediated acute kidney injury through miR-494-3p\/E-cadherin axis"],"prefix":"10.1186","volume":"18","author":[{"given":"Li","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0058-853X","authenticated-orcid":false,"given":"Hong-Bao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"issue":"2","key":"278_CR1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1681\/ASN.V102366","volume":"10","author":"ME Pagtalunan","year":"1999","unstructured":"Pagtalunan ME, Olson JL, Tilney NL, Meyer TW. 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