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This study was to evaluate usefulness of the extract for the management of chronic inflammation in a murine model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Arthritis was induced in Sprague-Dawley rats using Complete Freund\u2019s Adjuvant. Anti-arthritic effect of the extract was evaluated in prophylactic and therapeutic treatment models at doses of 50, 200 and 500\u2009mg\/kg. Parameters assessed included oedema, serology of inflammatory response, bone tissue histology and haematology. Data were analysed by ANOVA and Tukey\u2019s multiple comparisons post hoc test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HFE at 50\u2013500\u2009mg\/kg dose-dependently [\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2265\u20090.0354 (prophylactic) and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2265\u20090.0001 (therapeutic) inhibited swelling of the injected paw upon prophylactic [\u2264 81.26% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001) or therapeutic [\u2264 67.92% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) administration \u2014 and prevented spread of arthritis to the contralateral paw. The inflammation alleviation activity was further demonstrated by decrease in arthritis score, radiologic score and erythrocyte sedimentation rate. HFE at all doses significantly reduced serum interleukin (IL)-1\u03b1 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0197), and 500\u2009mg\/kg HFE reduced IL-6 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0032). In contrast, serum concentrations of IL-10, protein kinase A and cyclic adenosine monophosphate were enhanced (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2264\u20090.0436). HFE consistently showed better prophylactic than therapeutic activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HFE strongly suppressed Complete Freund\u2019s Adjuvant-induced arthritis and modulated regulators of inflammation, including IL-1\u03b1, \u2212\u20096 and\u2009\u2212\u200910. Taken together, the data suggest that HFE has potential for use as an agent for modulation of the inflammatory response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12950-022-00301-2","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T08:02:43Z","timestamp":1646467363000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prophylactic or therapeutic administration of Holarrhena floribunda hydro ethanol extract suppresses complete Freund\u2019s adjuvant-induced arthritis in Sprague-Dawley rats"],"prefix":"10.1186","volume":"19","author":[{"given":"Stephen","family":"Antwi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4492-2202","authenticated-orcid":false,"given":"Daniel","family":"Oduro-Mensah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Asiedu-Larbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebenezer","family":"Oduro-Mensah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Quasie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Darko-Obiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augustine","family":"Ocloo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laud Kenneth","family":"Okine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,5]]},"reference":[{"issue":"1","key":"301_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jaci.2016.05.011","volume":"138","author":"PJ Barnes","year":"2016","unstructured":"Barnes PJ. 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