{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:36:06Z","timestamp":1787020566903,"version":"build-2736575974"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Mansoura Manchester Programme for Medical Education","award":["call #1"],"award-info":[{"award-number":["call #1"]}]},{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["#41873"],"award-info":[{"award-number":["#41873"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["22990"],"award-info":[{"award-number":["22990"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mansoura University competitive grant","award":["Mu-Med-20-31"],"award-info":[{"award-number":["Mu-Med-20-31"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Inflamm"],"DOI":"10.1186\/s12950-024-00396-9","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:03:14Z","timestamp":1722931394000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impairment of Nrf2 signaling in the hippocampus of P301S tauopathy mice model aligns with the cognitive impairment and the associated neuroinflammation"],"prefix":"10.1186","volume":"21","author":[{"given":"Ahmed Sabry","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"ElKaffas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Metwally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Abdelfattah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eslam Ashraf","family":"Elsery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elshazly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam Eldin","family":"Gomaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziza","family":"Alsayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"El-Desouky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randa","family":"El-Gamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Elfarrash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"396_CR1","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/369488a0","volume":"369","author":"A Harada","year":"1994","unstructured":"Harada A, Oguchi K, Okabe S, Kuno J, Terada S, Ohshima T, et al. Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 1994;369:488\u201391.","journal-title":"Nature"},{"key":"396_CR2","doi-asserted-by":"crossref","unstructured":"Spillantini MG, Goedert M. Tau protein pathology in neurodegenerative diseases. Trends Neurosci. 1998. p. 428\u201333.","DOI":"10.1016\/S0166-2236(98)01337-X"},{"key":"396_CR3","doi-asserted-by":"crossref","unstructured":"Tolnay M, Probst A. Tau protein pathology in Alzheimer\u2019s disease and related disorders. Neuropathol Appl Neurobiol. 1999. p. 171\u201387.","DOI":"10.1046\/j.1365-2990.1999.00182.x"},{"key":"396_CR4","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1098\/rstb.1999.0466","volume":"354","author":"M Goedert","year":"1999","unstructured":"Goedert M. Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and \u03b1-synucleinopathies. Philos Trans R Soc B Biol Sci. 1999;354:1101\u201318.","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"396_CR5","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/0896-6273(89)90210-9","volume":"3","author":"M Goedert","year":"1989","unstructured":"Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer\u2019s disease. Neuron. 1989;3:519\u201326.","journal-title":"Neuron"},{"key":"396_CR6","doi-asserted-by":"crossref","unstructured":"Bu\u00e9e L, Bussi\u00e8re T, Bu\u00e9e-Scherrer V, Delacourte A, Hof PR. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Rev. 2000. p. 95\u2013130.","DOI":"10.1016\/S0165-0173(00)00019-9"},{"key":"396_CR7","doi-asserted-by":"crossref","unstructured":"Lee VMY, Goedert M, Trojanowski JQ. Neurodegenerative tauopathies. Annu Rev Neurosci. 2001. p. 1121\u201359.","DOI":"10.1146\/annurev.neuro.24.1.1121"},{"key":"396_CR8","doi-asserted-by":"crossref","unstructured":"Strang KH, Golde TE, Giasson BI. MAPT mutations, tauopathy, and mechanisms of neurodegeneration. Lab Investig. 2019. p. 912\u201328.","DOI":"10.1038\/s41374-019-0197-x"},{"key":"396_CR9","doi-asserted-by":"publisher","first-page":"10637","DOI":"10.1523\/JNEUROSCI.3279-05.2005","volume":"25","author":"M Ramsden","year":"2005","unstructured":"Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, et al. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci. 2005;25:10637\u201347.","journal-title":"J Neurosci"},{"key":"396_CR10","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.bbr.2009.12.002","volume":"208","author":"ML Scattoni","year":"2010","unstructured":"Scattoni ML, Gasparini L, Alleva E, Goedert M, Calamandrei G, Spillantini MG. Early behavioural markers of disease in P301S tau transgenic mice. Behav Brain Res. 2010;208:250\u20137.","journal-title":"Behav Brain Res"},{"key":"396_CR11","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.2353\/ajpath.2006.050840","volume":"168","author":"TL Spires","year":"2006","unstructured":"Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson GA, Ashe KH, et al. Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am J Pathol. 2006;168:1598\u2013607.","journal-title":"Am J Pathol"},{"key":"396_CR12","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/nan.12160","volume":"40","author":"H Xu","year":"2014","unstructured":"Xu H, R\u00f6sler TW, Carlsson T, de Andrade A, Bruch J, H\u00f6llerhage M, et al. Memory deficits correlate with tau and spine pathology in P301S MAPT transgenic mice. Neuropathol Appl Neurobiol. 2014;40:833\u201343.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"396_CR13","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.neurobiolaging.2009.04.006","volume":"32","author":"M Yue","year":"2011","unstructured":"Yue M, Hanna A, Wilson J, Roder H, Janus C. Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy. Neurobiol Aging. 2011;32:590\u2013603.","journal-title":"Neurobiol Aging"},{"key":"396_CR14","doi-asserted-by":"crossref","unstructured":"Wenger K, Viode A, Schlaffner CN, van Zalm P, Cheng L, Dellovade T et al. Common mouse models of tauopathy reflect early but not late human disease. Mol Neurodegener. 2023;18.","DOI":"10.1186\/s13024-023-00601-y"},{"key":"396_CR15","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1126\/science.1113694","volume":"309","author":"K Santacruz","year":"2005","unstructured":"Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, et al. Medicine: tau suppression in a neurodegenerative mouse model improves memory function. Sci (80-). 2005;309:476\u201381.","journal-title":"Sci (80-)"},{"key":"396_CR16","doi-asserted-by":"publisher","first-page":"9973","DOI":"10.1523\/JNEUROSCI.0834-10.2010","volume":"30","author":"DW Hampton","year":"2010","unstructured":"Hampton DW, Webber DJ, Bilican B, Goedert M, Spillantini MG, Chandran S. Cell-mediated neuroprotection in a mouse model of human tauopathy. J Neurosci. 2010;30:9973\u201383.","journal-title":"J Neurosci"},{"key":"396_CR17","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s11011-017-0137-7","volume":"33","author":"M Salama","year":"2018","unstructured":"Salama M, Elhussiny M, Magdy A, Omran AG, Alsayed A, Ashry R, et al. Dual mTORC1\/mTORC2 blocker as a possible therapy for tauopathy in cellular model. Metab Brain Dis. 2018;33:583\u20137.","journal-title":"Metab Brain Dis"},{"key":"396_CR18","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s12640-018-9974-3","volume":"35","author":"M Salama","year":"2019","unstructured":"Salama M, El-Desouky S, Alsayed A, El-Hussiny M, Magdy K, Fekry E, et al. siRNA blocking of mammalian target of Rapamycin (mTOR) attenuates Pathology in Annonacin-Induced Tauopathy in mice. Neurotox Res. 2019;35:987\u201392.","journal-title":"Neurotox Res"},{"key":"396_CR19","doi-asserted-by":"crossref","unstructured":"Kwon HS, Koh SH. Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener. 2020.","DOI":"10.1186\/s40035-020-00221-2"},{"key":"396_CR20","doi-asserted-by":"crossref","unstructured":"Tansey MG, Wallings RL, Houser MC, Herrick MK, Keating CE, Joers V. Inflammation and immune dysfunction in Parkinson disease. Nat Rev Immunol. 2022. p. 657\u201373.","DOI":"10.1038\/s41577-022-00684-6"},{"key":"396_CR21","doi-asserted-by":"crossref","unstructured":"Zhang W, Xiao D, Mao Q, Xia H. Role of neuroinflammation in neurodegeneration development. Signal Transduct Target Ther. 2023.","DOI":"10.1038\/s41392-023-01486-5"},{"key":"396_CR22","doi-asserted-by":"crossref","unstructured":"Sun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y et al. The behavioural and neuropathologic sexual dimorphism and absence of MIP-3\u03b1 in tau P301S mouse model of Alzheimer\u2019s disease. J Neuroinflammation. 2020;17.","DOI":"10.1186\/s12974-020-01749-w"},{"key":"396_CR23","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s40478-019-0695-5","volume":"7","author":"JA Macdonald","year":"2019","unstructured":"Macdonald JA, Bronner IF, Drynan L, Fan J, Curry A, Fraser G, et al. Assembly of transgenic human P301S tau is necessary for neurodegeneration in murine spinal cord. Acta Neuropathol Commun. 2019;7:44.","journal-title":"Acta Neuropathol Commun"},{"key":"396_CR24","doi-asserted-by":"crossref","unstructured":"Perea JR, Garc\u00eda E, Vall\u00e9s-Saiz L, Cuadros R, Hern\u00e1ndez F, Bol\u00f3s M et al. p38 activation occurs mainly in microglia in the P301S tauopathy mouse model. Sci Rep. 2022;12.","DOI":"10.1038\/s41598-022-05980-8"},{"key":"396_CR25","doi-asserted-by":"crossref","unstructured":"Xie J, Zhang Y, Li S, Wei H, Yu H, Zhou Q et al. P301S-hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2\/ARE pathway: a novel mechanism underlying Htau\u2010induced synaptic toxicities. Clin Transl Med. 2022;12.","DOI":"10.1002\/ctm2.1003"},{"key":"396_CR26","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1159\/000322228","volume":"8","author":"A Bellucci","year":"2011","unstructured":"Bellucci A, Bugiani O, Ghetti B, Spillantini MG. Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation. Neurodegener Dis. 2011;8:221\u20139.","journal-title":"Neurodegener Dis"},{"key":"396_CR27","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1016\/S0002-9440(10)63421-9","volume":"165","author":"A Bellucci","year":"2004","unstructured":"Bellucci A, Westwood AJ, Ingram E, Casamenti F, Goedert M, Spillantini MG. Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. Am J Pathol. 2004;165:1643\u201352.","journal-title":"Am J Pathol"},{"key":"396_CR28","doi-asserted-by":"publisher","first-page":"371","DOI":"10.15252\/emmm.201606664","volume":"9","author":"J Bruch","year":"2017","unstructured":"Bruch J, Xu H, R\u00f6sler TW, De Andrade A, Kuhn P, Lichtenthaler SF, et al. PERK activation mitigates tau pathology in vitro and in vivo. EMBO Mol Med. 2017;9:371\u201384.","journal-title":"EMBO Mol Med"},{"key":"396_CR29","doi-asserted-by":"publisher","first-page":"9340","DOI":"10.1523\/JNEUROSCI.22-21-09340.2002","volume":"22","author":"B Allen","year":"2002","unstructured":"Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K, et al. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301s tau protein. J Neurosci. 2002;22:9340\u201351.","journal-title":"J Neurosci"},{"key":"396_CR30","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","volume":"11","author":"R Morris","year":"1984","unstructured":"Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods. 1984;11:47\u201360.","journal-title":"J Neurosci Methods"},{"key":"396_CR31","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/297681a0","volume":"297","author":"RGM Morris","year":"1982","unstructured":"Morris RGM, Garrud P, Rawlins JNP, O\u2019Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature. 1982;297:681\u20133.","journal-title":"Nature"},{"key":"396_CR32","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nprot.2006.2","volume":"1","author":"RMJ Deacon","year":"2006","unstructured":"Deacon RMJ, Rawlins JNP. T-maze alternation in the rodent. Nat Protoc. 2006;1:7\u201312.","journal-title":"Nat Protoc"},{"key":"396_CR33","doi-asserted-by":"crossref","unstructured":"Fouad S, Elfarrash S, Rizk A, Rezk S, Mosbah E, Saad MA et al. Cerebrolysin recovers diaphragmatic function and reduces injury-associated astrogliosis following a cervical spinal cord hemi-section injury in rats. Egypt J Neurol Psychiatry Neurosurg. 2023;59.","DOI":"10.1186\/s41983-023-00707-6"},{"key":"396_CR34","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u2206\u2206CT method. Methods. 2001;25:402\u20138.","journal-title":"Methods"},{"key":"396_CR35","doi-asserted-by":"crossref","unstructured":"Crowe A, Yue W. Semi-quantitative determination of protein expression using immunohistochemistry staining and analysis: an Integrated Protocol. Bio-Protocol. 2019;9.","DOI":"10.21769\/BioProtoc.3465"},{"key":"396_CR36","doi-asserted-by":"crossref","unstructured":"Takeuchi H, Iba M, Inoue H, Higuchi M, Takao K, Tsukita K et al. P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS ONE. 2011;6.","DOI":"10.1371\/journal.pone.0021050"},{"key":"396_CR37","doi-asserted-by":"crossref","unstructured":"Brigas HC, Ribeiro M, Coelho JE, Gomes R, Gomez-Murcia V, Carvalho K et al. IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer\u2019s disease. Cell Rep. 2021;36.","DOI":"10.1016\/j.celrep.2021.109574"},{"key":"396_CR38","doi-asserted-by":"publisher","unstructured":"Heikal SA, Fawi G, Moustafa SA, Barakat M, Ragab G, Hegazy MT et al. Serum Alpha-Synuclein and Inammatory Markers prole in an Egyptian Alzheimer\u2019s and Parkinson\u2019s Diseases patients: A Pilot Study. 2024; https:\/\/doi.org\/10.21203\/rs.3.rs-3893418\/v1.","DOI":"10.21203\/rs.3.rs-3893418\/v1"},{"key":"396_CR39","doi-asserted-by":"crossref","unstructured":"Ransohoff RM. How neuroinflammation contributes to neurodegeneration. Science (80-.). 2016. p. 777\u201383.","DOI":"10.1126\/science.aag2590"},{"key":"396_CR40","doi-asserted-by":"crossref","unstructured":"Ferreira SA, Romero-Ramos M. Microglia response during Parkinson\u2019s disease: alpha-synuclein intervention. Front Cell Neurosci. 2018;12.","DOI":"10.3389\/fncel.2018.00247"},{"key":"396_CR41","doi-asserted-by":"crossref","unstructured":"Haukedal H, Freude K. Implications of Microglia in Amyotrophic lateral sclerosis and Frontotemporal Dementia. J Mol Biol. 2019. p. 1818\u201329.","DOI":"10.1016\/j.jmb.2019.02.004"},{"key":"396_CR42","doi-asserted-by":"crossref","unstructured":"Guzman-Martinez L, Maccioni RB, Andrade V, Navarrete LP, Pastor MG, Ramos-Escobar N. Neuroinflammation as a common feature of neurodegenerative disorders. Front Pharmacol. 2019.","DOI":"10.3389\/fphar.2019.01008"},{"key":"396_CR43","doi-asserted-by":"crossref","unstructured":"Parhizkar S, Holtzman DM. APOE mediated neuroinflammation and neurodegeneration in Alzheimer\u2019s disease. Semin Immunol. 2022.","DOI":"10.1016\/j.smim.2022.101594"},{"key":"396_CR44","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/nen.0b013e31802d6da9","volume":"66","author":"CP Ramsey","year":"2007","unstructured":"Ramsey CP, Glass CA, Montgomery MB, Lindl KA, Ritson GP, Chia LA, et al. Expression of Nrf2 in neurodegenerative diseases. J Neuropathol Exp Neurol. 2007;66:75\u201385.","journal-title":"J Neuropathol Exp Neurol"},{"key":"396_CR45","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.redox.2017.07.006","volume":"13","author":"AI Rojo","year":"2017","unstructured":"Rojo AI, Pajares M, Rada P, Nu\u00f1ez A, Nevado-Holgado AJ, Killik R, et al. NRF2 deficiency replicates transcriptomic changes in Alzheimer\u2019s patients and worsens APP and TAU pathology. Redox Biol. 2017;13:444\u201351.","journal-title":"Redox Biol"},{"key":"396_CR46","doi-asserted-by":"crossref","unstructured":"Zhang H, Davies KJA, Forman HJ. Oxidative stress response and Nrf2 signaling in aging. Free Radic Biol Med. 2015.","DOI":"10.1016\/j.freeradbiomed.2015.05.036"},{"key":"396_CR47","doi-asserted-by":"crossref","unstructured":"Yang Y, Jiang S, Yan J, Li Y, Xin Z, Lin Y et al. An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders. Cytokine Growth Factor Rev. 2015.","DOI":"10.1016\/j.cytogfr.2014.09.002"},{"key":"396_CR48","doi-asserted-by":"crossref","unstructured":"Volonte D, Liu Z, Musille PM, Stoppani E, Wakabayashi N, Di YP et al. Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence. Mol Biol Cell. 2013.","DOI":"10.1091\/mbc.e12-09-0666"},{"key":"396_CR49","first-page":"853","volume":"73","author":"S Tarantini","year":"2018","unstructured":"Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, et al. Nrf2 Deficiency exacerbates obesity-Induced oxidative stress, neurovascular dysfunction, blood-brain barrier disruption, Neuroinflammation, Amyloidogenic Gene expression, and Cognitive decline in mice, mimicking the aging phenotype. Journals Gerontol - Ser Biol Sci Med Sci. 2018;73:853\u201363.","journal-title":"Journals Gerontol - Ser Biol Sci Med Sci"},{"key":"396_CR50","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.neurobiolaging.2014.09.004","volume":"36","author":"G Joshi","year":"2015","unstructured":"Joshi G, Gan KA, Johnson DA, Johnson JA. Increased Alzheimer\u2019s disease-like pathology in the APP\/ PS1\u03b4E9 mouse model lacking Nrf2 through modulation of autophagy. Neurobiol Aging. 2015;36:664\u201379.","journal-title":"Neurobiol Aging"},{"key":"396_CR51","doi-asserted-by":"crossref","unstructured":"Syapin PJ. Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders. Br J Pharmacol. 2008. p. 623\u201340.","DOI":"10.1038\/bjp.2008.342"},{"key":"396_CR52","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.2174\/1389450111009011517","volume":"11","author":"A Jazwa","year":"2012","unstructured":"Jazwa A, Cuadrado A. Targeting Heme Oxygenase-1 for Neuroprotection and Neuroinflammation in neurodegenerative diseases. Curr Drug Targets. 2012;11:1517\u201331.","journal-title":"Curr Drug Targets"},{"key":"396_CR53","doi-asserted-by":"crossref","unstructured":"Wong SY, Tan MGK, Wong PTH, Herr DR, Lai MKP. Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK. J Neuroinflammation. 2016;13.","DOI":"10.1186\/s12974-016-0723-3"},{"key":"396_CR54","doi-asserted-by":"crossref","unstructured":"Delaidelli A, Richner M, Jiang L, van der Laan A, Bergholdt Jul Christiansen I, Ferreira N et al. \u03b1-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response. Acta Neuropathol Commun. 2021;9.","DOI":"10.1186\/s40478-021-01209-3"},{"key":"396_CR55","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.1007\/s12035-022-02923-2","volume":"59","author":"MH Yousef","year":"2022","unstructured":"Yousef MH, Salama M, El-Fawal HAN, Abdelnaser A. Selective GSK3\u03b2 inhibition mediates an Nrf2-Independent anti-inflammatory microglial response. Mol Neurobiol. 2022;59:5591\u2013611.","journal-title":"Mol Neurobiol"},{"key":"396_CR56","doi-asserted-by":"crossref","unstructured":"Wang Y, Tian Y, Ding Y, Wang J, Yan S, Zhou L et al. MiR-152 may silence translation of camk ii and induce spontaneous immune tolerance in mouse liver transplantation. PLoS ONE. 2014;9.","DOI":"10.1371\/journal.pone.0105096"},{"key":"396_CR57","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.4049\/jimmunol.181.2.1357","volume":"181","author":"E Smith","year":"2008","unstructured":"Smith E, Stark MA, Zarbock A, Burcin TL, Bruce AC, Vaswani D, et al. IL-17A inhibits the expansion of IL-17A-Producing T cells in mice through short-Loop Inhibition via IL-17 receptor. J Immunol. 2008;181:1357\u201364.","journal-title":"J Immunol"},{"key":"396_CR58","doi-asserted-by":"crossref","unstructured":"Bolpetti A, Silva JS, Villa LL, Lepique AP. Interleukin-10 production by tumor infiltrating macrophages plays a role in human papillomavirus 16 tumor growth. BMC Immunol. 2010;11.","DOI":"10.1186\/1471-2172-11-27"},{"key":"396_CR59","doi-asserted-by":"crossref","unstructured":"Dai Y, Zhang Z, Cao Y, Mehta JL, Li J. MiR-590-5p inhibits Oxidized-LDL Induced Angiogenesis by Targeting LOX-1. Sci Rep. 2016;6.","DOI":"10.1038\/srep22607"}],"container-title":["Journal of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12950-024-00396-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12950-024-00396-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12950-024-00396-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:08:21Z","timestamp":1722931701000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal-inflammation.biomedcentral.com\/articles\/10.1186\/s12950-024-00396-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,6]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["396"],"URL":"https:\/\/doi.org\/10.1186\/s12950-024-00396-9","relation":{},"ISSN":["1476-9255"],"issn-type":[{"value":"1476-9255","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,6]]},"assertion":[{"value":"3 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experimental animal protocol of this work was approved by the Institutional research board Committee of Faculty of Medicine, Mansoura University (approval code: R.21.02.1220) and conformed complying with ARRIVE guidelines and were conducted in accordance with U.K. Animals ACT, 1986.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"29"}}