{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:18:48Z","timestamp":1784859528061,"version":"3.55.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100003725","name":"The National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2014M3A7B4052192"],"award-info":[{"award-number":["2014M3A7B4052192"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12951-016-0229-2","type":"journal-article","created":{"date-parts":[[2016,11,26]],"date-time":"2016-11-26T01:58:32Z","timestamp":1480125512000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Generation of protective immunity against Orientia tsutsugamushi infection by immunization with a zinc oxide nanoparticle combined with ScaA antigen"],"prefix":"10.1186","volume":"14","author":[{"given":"Na-Young","family":"Ha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Mu","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ah","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Ki","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Hai","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Seung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik-Sang","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Sik","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Keun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam-Hyuk","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,26]]},"reference":[{"key":"229_CR1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.copbio.2015.03.014","volume":"34","author":"JD Smith","year":"2015","unstructured":"Smith JD, Morton LD, Ulery BD. Nanoparticles as synthetic vaccines. Curr Opin Biotechnol. 2015;34:217\u201324.","journal-title":"Curr Opin Biotechnol"},{"key":"229_CR2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nnano.2011.149","volume":"6","author":"NH Cho","year":"2011","unstructured":"Cho NH, Cheong TC, Min JH, Wu JH, Lee SJ, Kim D, Yang JS, Kim S, Kim YK, Seong SY. A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy. Nat Nanotechnol. 2011;6:675\u201382.","journal-title":"Nat Nanotechnol"},{"key":"229_CR3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/19440049.2013.865147","volume":"31","author":"LE Shi","year":"2014","unstructured":"Shi LE, Li ZH, Zheng W, Zhao YF, Jin YF, Tang ZX. Synthesis, antibacterial activity, antibacterial mechanism and food applications of ZnO nanoparticles: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31:173\u201386.","journal-title":"Food Addit Contam Part A Chem Anal Control Expo Risk Assess"},{"key":"229_CR4","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00204-012-0831-5","volume":"86","author":"GJ Nohynek","year":"2012","unstructured":"Nohynek GJ, Dufour EK. Nano-sized cosmetic formulations or solid nanoparticles in sunscreens: a risk to human health? Arch Toxicol. 2012;86:1063\u201375.","journal-title":"Arch Toxicol"},{"issue":"Suppl 1","key":"229_CR5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/17435390.2013.855831","volume":"8","author":"A Ivask","year":"2014","unstructured":"Ivask A, Juganson K, Bondarenko O, Mortimer M, Aruoja V, Kasemets K, Blinova I, Heinlaan M, Slaveykova V, Kahru A. Mechanisms of toxic action of Ag, ZnO and CuO nanoparticles to selected ecotoxicological test organisms and mammalian cells in vitro: a comparative review. Nanotoxicology. 2014;8(Suppl 1):57\u201371.","journal-title":"Nanotoxicology"},{"key":"229_CR6","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.1002\/adma.201301732","volume":"25","author":"HM Xiong","year":"2013","unstructured":"Xiong HM. ZnO nanoparticles applied to bioimaging and drug delivery. Adv Mater. 2013;25:5329\u201335.","journal-title":"Adv Mater"},{"key":"229_CR7","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1093\/bioinformatics\/btm436","volume":"23","author":"EE Oren","year":"2007","unstructured":"Oren EE, Tamerler C, Sahin D, Hnilova M, Seker UO, Sarikaya M, Samudrala R. A novel knowledge-based approach to design inorganic-binding peptides. Bioinformatics. 2007;23:2816\u201322.","journal-title":"Bioinformatics"},{"key":"229_CR8","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nmat833","volume":"2","author":"S Wang","year":"2003","unstructured":"Wang S, Humphreys ES, Chung SY, Delduco DF, Lustig SR, Wang H, Parker KN, Rizzo NW, Subramoney S, Chiang YM, Jagota A. Peptides with selective affinity for carbon nanotubes. Nat Mater. 2003;2:196\u2013200.","journal-title":"Nat Mater"},{"key":"229_CR9","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1002\/anie.200900115","volume":"48","author":"J Chen","year":"2009","unstructured":"Chen J, Serizawa T, Komiyama M. Peptides recognize photoresponsive targets. Angew Chem Int Ed Engl. 2009;48:2917\u201320.","journal-title":"Angew Chem Int Ed Engl"},{"key":"229_CR10","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1007\/s11051-012-1218-5","volume":"14","author":"P Golec","year":"2012","unstructured":"Golec P, Karczewska-Golec J, Los M, Wegrzyn G. Novel ZnO-binding peptides obtained by the screening of a phage display peptide library. J Nanopart Res. 2012;14:1218.","journal-title":"J Nanopart Res"},{"key":"229_CR11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/bit.20149","volume":"87","author":"CK Thai","year":"2004","unstructured":"Thai CK, Dai H, Sastry MS, Sarikaya M, Schwartz DT, Baneyx F. Identification and characterization of Cu(2)O- and ZnO-binding polypeptides by Escherichia coli cell surface display: toward an understanding of metal oxide binding. Biotechnol Bioeng. 2004;87:129\u201337.","journal-title":"Biotechnol Bioeng"},{"key":"229_CR12","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/j.actbio.2009.12.025","volume":"6","author":"M Okochi","year":"2010","unstructured":"Okochi M, Ogawa M, Kaga C, Sugita T, Tomita Y, Kato R, Honda H. Screening of peptides with a high affinity for ZnO using spot-synthesized peptide arrays and computational analysis. Acta Biomater. 2010;6:2301\u20136.","journal-title":"Acta Biomater"},{"key":"229_CR13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/AEM.66.1.10-14.2000","volume":"66","author":"K Kjaergaard","year":"2000","unstructured":"Kjaergaard K, Sorensen JK, Schembri MA, Klemm P. Sequestration of zinc oxide by fimbrial designer chelators. Appl Environ Microbiol. 2000;66:10\u20134.","journal-title":"Appl Environ Microbiol"},{"key":"229_CR14","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1021\/jp907731b","volume":"114","author":"N Yokoo","year":"2010","unstructured":"Yokoo N, Togashi T, Umetsu M, Tsumoto K, Hattori T, Nakanishi T, Ohara S, Takami S, Naka T, Abe H, et al. Direct and selective immobilization of proteins by means of an inorganic material-binding peptide: discussion on functionalization in the elongation to material-binding peptide. J Phys Chem B. 2010;114:480\u20136.","journal-title":"J Phys Chem B"},{"key":"229_CR15","first-page":"143720","volume":"2015","author":"YH Luo","year":"2015","unstructured":"Luo YH, Chang LW, Lin P. Metal-based nanoparticles and the immune system: activation, inflammation, and potential applications. Biomed Res Int. 2015;2015:143720.","journal-title":"Biomed Res Int"},{"key":"229_CR16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/jat.3102","volume":"35","author":"JW Yun","year":"2015","unstructured":"Yun JW, Yoon JH, Kang BC, Cho NH, Seok SH, Min SK, Min JH, Che JH, Kim YK. The toxicity and distribution of iron oxide-zinc oxide core-shell nanoparticles in C57BL\/6 mice after repeated subcutaneous administration. J Appl Toxicol. 2015;35:593\u2013602.","journal-title":"J Appl Toxicol"},{"key":"229_CR17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12951-015-0067-7","volume":"13","author":"SR Saptarshi","year":"2015","unstructured":"Saptarshi SR, Feltis BN, Wright PFA, Lopata AL. Investigating the immunomodulatory nature of zinc oxide nanoparticles at sub-cytotoxic levels in vitro and after intranasal instillation in vivo. J Nanobiotechnol. 2015;13:6.","journal-title":"J Nanobiotechnol"},{"key":"229_CR18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/intimm\/dxt053","volume":"26","author":"R Roy","year":"2014","unstructured":"Roy R, Kumar S, Verma AK, Sharma A, Chaudhari BP, Tripathi A, Das M, Dwivedi PD. Zinc oxide nanoparticles provide an adjuvant effect to ovalbumin via a Th2 response in Balb\/c mice. Int Immunol. 2014;26:159\u201372.","journal-title":"Int Immunol"},{"key":"229_CR19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3109\/08830185.2013.773326","volume":"32","author":"E Kuroda","year":"2013","unstructured":"Kuroda E, Coban C, Ishii KJ. Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects. Int Rev Immunol. 2013;32:209\u201320.","journal-title":"Int Rev Immunol"},{"key":"229_CR20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1286-4579(00)01352-6","volume":"3","author":"SY Seong","year":"2001","unstructured":"Seong SY, Choi MS, Kim IS. Orientia tsutsugamushi infection: overview and immune responses. Microbes Infect. 2001;3:11\u201321.","journal-title":"Microbes Infect"},{"key":"229_CR21","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3201\/eid1507.080399","volume":"15","author":"SS Kweon","year":"2009","unstructured":"Kweon SS, Choi JS, Lim HS, Kim JR, Kim KY, Ryu SY, Yoo HS, Park O. Rapid increase of scrub typhus, South Korea, 2001\u20132006. Emerg Infect Dis. 2009;15:1127\u20139.","journal-title":"Emerg Infect Dis"},{"key":"229_CR22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4269\/ajtmh.13-0064","volume":"89","author":"DH Paris","year":"2013","unstructured":"Paris DH, Shelite TR, Day NP, Walker DH. Unresolved problems related to scrub typhus: a seriously neglected life-threatening disease. Am J Trop Med Hyg. 2013;89:301\u20137.","journal-title":"Am J Trop Med Hyg"},{"key":"229_CR23","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.phrp.2013.04.007","volume":"4","author":"MA Jeong","year":"2013","unstructured":"Jeong MA, Youn SK, Kim YK, Lee H, Kim SJ, Sohn A. Trends in the incidence of scrub typhus: the fastest growing vector-borne disease in Korea. Osong Public Health Res Perspect. 2013;4:166\u20139.","journal-title":"Osong Public Health Res Perspect"},{"key":"229_CR24","doi-asserted-by":"crossref","first-page":"e2493","DOI":"10.1371\/journal.pntd.0002493","volume":"7","author":"WY Zhang","year":"2013","unstructured":"Zhang WY, Wang LY, Ding F, Hu WB, Soares Magalhaes RJ, Sun HL, Liu YX, Liu QY, Huang LY, Clements AC, et al. Scrub typhus in mainland China, 2006\u20132012: the need for targeted public health interventions. PLoS Negl Trop Dis. 2013;7:e2493.","journal-title":"PLoS Negl Trop Dis"},{"key":"229_CR25","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s12098-014-1664-4","volume":"82","author":"MR Krishna","year":"2015","unstructured":"Krishna MR, Vasuki B, Nagaraju K. Scrub typhus: audit of an outbreak. Indian J Pediatr. 2015;82:537\u201340.","journal-title":"Indian J Pediatr"},{"key":"229_CR26","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3201\/eid1905.121445","volume":"19","author":"W Rodkvamtook","year":"2013","unstructured":"Rodkvamtook W, Gaywee J, Kanjanavanit S, Ruangareerate T, Richards AL, Sangjun N, Jeamwattanalert P, Sirisopana N. Scrub typhus outbreak, northern Thailand, 2006\u20132007. Emerg Infect Dis. 2013;19:774\u20137.","journal-title":"Emerg Infect Dis"},{"issue":"Suppl 3","key":"229_CR27","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1086\/596576","volume":"48","author":"DJ Kelly","year":"2009","unstructured":"Kelly DJ, Fuerst PA, Ching WM, Richards AL. Scrub typhus: the geographic distribution of phenotypic and genotypic variants of Orientia tsutsugamushi. Clin Infect Dis. 2009;48(Suppl 3):S203\u201330.","journal-title":"Clin Infect Dis"},{"key":"229_CR28","doi-asserted-by":"crossref","first-page":"e0003585","DOI":"10.1371\/journal.pntd.0003585","volume":"9","author":"NY Ha","year":"2015","unstructured":"Ha NY, Sharma P, Kim G, Kim Y, Min CK, Choi MS, Kim IS, Cho NH. Immunization with an autotransporter protein of Orientia tsutsugamushi provides protective immunity against scrub typhus. Plos Negl Trop Dis. 2015;9:e0003585.","journal-title":"Plos Negl Trop Dis"},{"key":"229_CR29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4167\/jbv.2013.43.2.155","volume":"43","author":"NY Ha","year":"2013","unstructured":"Ha NY, Choi MS, Cho NH. Molecular characterization of sca genes found in Orientia tsutsugamushi genome. J Bacteriol Virol. 2013;43:155\u20138.","journal-title":"J Bacteriol Virol"},{"key":"229_CR30","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.radmeas.2004.05.001","volume":"38","author":"D Millers","year":"2004","unstructured":"Millers D, Grigorjeva L, Lojkowski W, Strachowski T. Luminescence of ZnO nanopowders. Radiat Meas. 2004;38:589\u201391.","journal-title":"Radiat Meas"},{"key":"229_CR31","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.3390\/molecules16021426","volume":"16","author":"UO Seker","year":"2011","unstructured":"Seker UO, Demir HV. Material binding peptides for nanotechnology. Molecules. 2011;16:1426\u201351.","journal-title":"Molecules"},{"key":"229_CR32","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jinorgbio.2015.08.029","volume":"153","author":"AM Abdelmonem","year":"2015","unstructured":"Abdelmonem AM, Pelaz B, Kantner K, Bigall NC, Del Pino P, Parak WJ. Charge and agglomeration dependent in vitro uptake and cytotoxicity of zinc oxide nanoparticles. J Inorg Biochem. 2015;153:334\u20138.","journal-title":"J Inorg Biochem"},{"key":"229_CR33","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1021\/nn300415x","volume":"6","author":"AA Shemetov","year":"2012","unstructured":"Shemetov AA, Nabiev I, Sukhanova A. Molecular interaction of proteins and peptides with nanoparticles. ACS Nano. 2012;6:4585\u2013602.","journal-title":"ACS Nano"},{"key":"229_CR34","doi-asserted-by":"crossref","first-page":"455101","DOI":"10.1088\/0957-4484\/20\/45\/455101","volume":"20","author":"ZJ Deng","year":"2009","unstructured":"Deng ZJ, Mortimer G, Schiller T, Musumeci A, Martin D, Minchin RF. Differential plasma protein binding to metal oxide nanoparticles. Nanotechnology. 2009;20:455101.","journal-title":"Nanotechnology"},{"key":"229_CR35","doi-asserted-by":"crossref","first-page":"11142","DOI":"10.1021\/la3007603","volume":"28","author":"S Chakraborti","year":"2012","unstructured":"Chakraborti S, Joshi P, Chakravarty D, Shanker V, Ansari ZA, Singh SP, Chakrabarti P. Interaction of polyethyleneimine-functionalized ZnO nanoparticles with bovine serum albumin. Langmuir. 2012;28:11142\u201352.","journal-title":"Langmuir"},{"key":"229_CR36","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ijpharm.2005.03.035","volume":"298","author":"C Foged","year":"2005","unstructured":"Foged C, Brodin B, Frokjaer S, Sundblad A. Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model. Int J Pharm. 2005;298:315\u201322.","journal-title":"Int J Pharm"},{"key":"229_CR37","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.molimm.2014.08.001","volume":"63","author":"R Roy","year":"2015","unstructured":"Roy R, Das M, Dwivedi PD. Toxicological mode of action of ZnO nanoparticles: impact on immune cells. Mol Immunol. 2015;63:184\u201392.","journal-title":"Mol Immunol"},{"key":"229_CR38","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.2217\/nnm.15.44","volume":"10","author":"SR Saptarshi","year":"2015","unstructured":"Saptarshi SR, Duschl A, Lopata AL. Biological reactivity of zinc oxide nanoparticles with mammalian test systems: an overview. Nanomedicine (Lond). 2015;10:2075\u201392.","journal-title":"Nanomedicine (Lond)"},{"key":"229_CR39","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/17435390.2014.886740","volume":"9","author":"JK Chen","year":"2015","unstructured":"Chen JK, Ho CC, Chang H, Lin JF, Yang CS, Tsai MH, Tsai HT, Lin P. Particulate nature of inhaled zinc oxide nanoparticles determines systemic effects and mechanisms of pulmonary inflammation in mice. Nanotoxicology. 2015;9:43\u201353.","journal-title":"Nanotoxicology"},{"key":"229_CR40","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/imm.12276","volume":"142","author":"R Roy","year":"2014","unstructured":"Roy R, Singh SK, Das M, Tripathi A, Dwivedi PD. Toll-like receptor 6 mediated inflammatory and functional responses of zinc oxide nanoparticles primed macrophages. Immunology. 2014;142:453\u201364.","journal-title":"Immunology"},{"key":"229_CR41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tox.2009.10.034","volume":"267","author":"J Palomaki","year":"2010","unstructured":"Palomaki J, Karisola P, Pylkkanen L, Savolainen K, Alenius H. Engineered nanomaterials cause cytotoxicity and activation on mouse antigen presenting cells. Toxicology. 2010;267:125\u201331.","journal-title":"Toxicology"},{"key":"229_CR42","first-page":"406","volume":"3","author":"H Hogenesch","year":"2012","unstructured":"Hogenesch H. Mechanism of immunopotentiation and safety of aluminum adjuvants. Front Immunol. 2012;3:406.","journal-title":"Front Immunol"},{"key":"229_CR43","doi-asserted-by":"crossref","unstructured":"Sruthi S, Mohanan PV. Engineered zinc oxide nanoparticles; biological interactions at the organ level. Curr Med Chem 2016.","DOI":"10.2174\/0929867323666160607224628"},{"issue":"Suppl 2","key":"229_CR44","first-page":"137","volume":"9","author":"HJ Ryu","year":"2014","unstructured":"Ryu HJ, Seo MY, Jung SK, Maeng EH, Lee SY, Jang DH, Lee TJ, Jo KY, Kim YR, Cho KB, et al. Zinc oxide nanoparticles: a 90-day repeated-dose dermal toxicity study in rats. Int J Nanomed. 2014;9(Suppl 2):137\u201344.","journal-title":"Int J Nanomed"},{"key":"229_CR45","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1080\/15287394.2014.949949","volume":"78","author":"J Choi","year":"2015","unstructured":"Choi J, Kim H, Kim P, Jo E, Kim HM, Lee MY, Jin SM, Park K. Toxicity of zinc oxide nanoparticles in rats treated by two different routes: single intravenous injection and single oral administration. J Toxicol Environ Health A. 2015;78:226\u201343.","journal-title":"J Toxicol Environ Health A"},{"key":"229_CR46","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1086\/589284","volume":"198","author":"JH Lee","year":"2008","unstructured":"Lee JH, Cho NH, Kim SY, Bang SY, Chu H, Choi MS, Kim IS. Fibronectin facilitates the invasion of Orientia tsutsugamushi into host cells through interaction with a 56-kDa type-specific antigen. J Infect Dis. 2008;198:250\u20137.","journal-title":"J Infect Dis"},{"key":"229_CR47","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1128\/IAI.01239-10","volume":"79","author":"NY Ha","year":"2011","unstructured":"Ha NY, Cho NH, Kim YS, Choi MS, Kim IS. An autotransporter protein from Orientia tsutsugamushi mediates adherence to nonphagocytic host cells. Infect Immun. 2011;79:1718\u201327.","journal-title":"Infect Immun"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-016-0229-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T04:32:23Z","timestamp":1498365143000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-016-0229-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,26]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["229"],"URL":"https:\/\/doi.org\/10.1186\/s12951-016-0229-2","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,26]]},"article-number":"76"}}