{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T05:45:13Z","timestamp":1773467113078,"version":"3.50.1"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T00:00:00Z","timestamp":1550880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T00:00:00Z","timestamp":1550880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR 1008189"],"award-info":[{"award-number":["DMR 1008189"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Colciencias","doi-asserted-by":"crossref","award":["Francisco Jos\u00e9 de Caldas 567"],"award-info":[{"award-number":["Francisco Jos\u00e9 de Caldas 567"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12951-019-0460-8","type":"journal-article","created":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T08:02:57Z","timestamp":1550908977000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Evaluation of the elastic Young\u2019s modulus and cytotoxicity variations in fibroblasts exposed to carbon-based nanomaterials"],"prefix":"10.1186","volume":"17","author":[{"given":"Homero F.","family":"Pastrana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander X.","family":"Cartagena-Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Raman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1241-2080","authenticated-orcid":false,"given":"Alba","family":"\u00c1vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,2,23]]},"reference":[{"key":"460_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s11051-016-3375-4","volume":"18","author":"V Subramanian","year":"2016","unstructured":"Subramanian V, Semenzin E, Hristozov D, Zabeo A, Malsch I, McAlea E, et al. Sustainable nanotechnology decision support system: bridging risk management, sustainable innovation and risk governance. J Nanoparticle Res. 2016;18:89. \n                    https:\/\/doi.org\/10.1007\/s11051-016-3375-4\n                    \n                  .","journal-title":"J Nanoparticle Res"},{"key":"460_CR2","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2217\/nnm.11.88","volume":"6","author":"C Hirsch","year":"2011","unstructured":"Hirsch C, Roesslein M, Krug HF, Wick P. Nanomaterial cell interactions: are current in vitro tests reliable? Nanomedicine. 2011;6:837\u201347. \n                    https:\/\/doi.org\/10.2217\/nnm.11.88\n                    \n                  .","journal-title":"Nanomedicine"},{"key":"460_CR3","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.ejpb.2008.08.009","volume":"72","author":"A Kroll","year":"2009","unstructured":"Kroll A, Pillukat MH, Hahn D, Schnekenburger J. Current in vitro methods in nanoparticle risk assessment: limitations and challenges. Eur J Pharm Biopharm. 2009;72:370\u20137. \n                    https:\/\/doi.org\/10.1016\/j.ejpb.2008.08.009\n                    \n                  .","journal-title":"Eur J Pharm Biopharm"},{"key":"460_CR4","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/j.carbon.2007.03.033","volume":"45","author":"A Casey","year":"2007","unstructured":"Casey A, Herzog E, Davoren M, Lyng FM, Byrne HJ, Chambers G. Spectroscopic analysis confirms the interactions between single walled carbon nanotubes and various dyes commonly used to assess cytotoxicity. Carbon. 2007;45:1425\u201332. \n                    https:\/\/doi.org\/10.1016\/j.carbon.2007.03.033\n                    \n                  .","journal-title":"Carbon"},{"key":"460_CR5","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1021\/nl060177c","volume":"6","author":"JM W\u00f6rle-Knirsch","year":"2006","unstructured":"W\u00f6rle-Knirsch JM, Pulskamp K, Krug HF. Oops they did it again! Carbon nanotubes hoax scientists in viability assays. Nano Lett. 2006;6:1261\u20138. \n                    https:\/\/doi.org\/10.1021\/nl060177c\n                    \n                  .","journal-title":"Nano Lett"},{"key":"460_CR6","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/ropr.12129","volume":"32","author":"G Miller","year":"2015","unstructured":"Miller G, Wickson F. Risk analysis of nanomaterials: exposing nanotechnology\u2019s naked emperor. Rev Policy Res. 2015;32:485\u2013512. \n                    https:\/\/doi.org\/10.1111\/ropr.12129\n                    \n                  .","journal-title":"Rev Policy Res"},{"key":"460_CR7","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.2217\/nnm.15.65","volume":"10","author":"FMP Tonelli","year":"2015","unstructured":"Tonelli FMP, Goulart VAM, Gomes KN, Ladeira MS, Santos AK, Loren\u00e7on E, et al. Graphene-based nanomaterials: biological and medical applications and toxicity. Nanomedicine. 2015;10:2423\u201350. \n                    https:\/\/doi.org\/10.2217\/nnm.15.65\n                    \n                  .","journal-title":"Nanomedicine"},{"key":"460_CR8","doi-asserted-by":"publisher","DOI":"10.2788\/406937","author":"J Ponti","year":"2014","unstructured":"Ponti J, Kinsner-Ovaskainen A, Norlen H, Altmeyer S, Cristina A, Bogni A. Interlaboratory comparison study of the Colony Forming Efficiency assay for assessing cytotoxicity of nanomaterials. Ispra. 2014. \n                    https:\/\/doi.org\/10.2788\/406937\n                    \n                  .","journal-title":"Ispra"},{"key":"460_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1743-8977-8-9","volume":"8","author":"A Kroll","year":"2011","unstructured":"Kroll A, Dierker C, Rommel C, Hahn D, Wohlleben W, Schulze-Isfort C, et al. Cytotoxicity screening of 23 engineered nanomaterials using a test matrix of ten cell lines and three different assays. Part Fibre Toxicol. 2011;8:9. \n                    https:\/\/doi.org\/10.1186\/1743-8977-8-9\n                    \n                  .","journal-title":"Part Fibre Toxicol"},{"key":"460_CR10","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1007\/s11051-013-2153-9","volume":"16","author":"PA Schulte","year":"2014","unstructured":"Schulte PA, Geraci CL, Murashov V, Kuempel ED, Zumwalde RD, Castranova V, et al. Occupational safety and health criteria for responsible development of nanotechnology. J Nanoparticle Res. 2014;16:2153. \n                    https:\/\/doi.org\/10.1007\/s11051-013-2153-9\n                    \n                  .","journal-title":"J Nanoparticle Res"},{"key":"460_CR11","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.toxlet.2010.04.018","volume":"197","author":"J Ponti","year":"2010","unstructured":"Ponti J, Colognato R, Rauscher H, Gioria S, Broggi F, Franchini F, et al. Colony forming efficiency and microscopy analysis of multi-wall carbon nanotubes cell interaction. Toxicol Lett. 2010;197:29\u201337. \n                    https:\/\/doi.org\/10.1016\/j.toxlet.2010.04.018\n                    \n                  .","journal-title":"Toxicol Lett"},{"key":"460_CR12","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1016\/j.injury.2007.02.007","volume":"38","author":"R Bielby","year":"2007","unstructured":"Bielby R, Jones E, McGonagle D. The role of mesenchymal stem cells in maintenance and repair of bone. Injury. 2007;38:S26\u201332. \n                    https:\/\/doi.org\/10.1016\/j.injury.2007.02.007\n                    \n                  .","journal-title":"Injury"},{"key":"460_CR13","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1126\/science.1116995","volume":"310","author":"DE Discher","year":"2005","unstructured":"Discher DE, Janmey P, Wang Y-L. Tissue cells feel and respond to the stiffness of their substrate. Science. 2005;310:1139\u201343. \n                    https:\/\/doi.org\/10.1126\/science.1116995\n                    \n                  .","journal-title":"Science"},{"key":"460_CR14","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1586\/erc.09.184","volume":"8","author":"B Freestone","year":"2010","unstructured":"Freestone B, Krishnamoorthy S, Lip GY. Assessment of endothelial dysfunction. Expert Rev Cardiovasc Ther. 2010;8:557\u201371. \n                    https:\/\/doi.org\/10.1586\/erc.09.184\n                    \n                  .","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"460_CR15","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/lapl.201010087","volume":"8","author":"H Bai","year":"2011","unstructured":"Bai H, Chen P, Fang H, Lin L, Tang GQ, Mu GG, et al. Detecting viability transitions of umbilical cord mesenchymal stem cells by Raman micro-spectroscopy. Laser Phys Lett. 2011;8:78\u201384. \n                    https:\/\/doi.org\/10.1002\/lapl.201010087\n                    \n                  .","journal-title":"Laser Phys Lett"},{"key":"460_CR16","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1089\/ars.2011.4271","volume":"18","author":"A Lawen","year":"2013","unstructured":"Lawen A, Lane DJR. Mammalian iron homeostasis in health and disease: uptake, storage, transport, and molecular mechanisms of action. Antioxid Redox Signal. 2013;18:2473\u2013507. \n                    https:\/\/doi.org\/10.1089\/ars.2011.4271\n                    \n                  .","journal-title":"Antioxid Redox Signal"},{"key":"460_CR17","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/nature08908","volume":"463","author":"DA Fletcher","year":"2010","unstructured":"Fletcher DA, Mullins RD. Cell mechanics and the cytoskeleton. Nature. 2010;463:485\u201392. \n                    https:\/\/doi.org\/10.1038\/nature08908\n                    \n                  .","journal-title":"Nature"},{"key":"460_CR18","doi-asserted-by":"publisher","first-page":"4872","DOI":"10.1021\/nn101151x","volume":"4","author":"BD Holt","year":"2010","unstructured":"Holt BD, Short PA, Rape AD, Wang Y, Islam MF, Dahl KN. Carbon nanotubes reorganize actin structures in cells and ex vivo. ACS Nano. 2010;4:4872\u20138. \n                    https:\/\/doi.org\/10.1021\/nn101151x\n                    \n                  .","journal-title":"ACS Nano"},{"key":"460_CR19","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.immuni.2012.08.017","volume":"37","author":"J Sakai","year":"2012","unstructured":"Sakai J, Li J, Subramanian KK, Mondal S, Bajrami B, Hattori H, et al. Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils. Immunity. 2012;37:1037\u201349. \n                    https:\/\/doi.org\/10.1016\/j.immuni.2012.08.017\n                    \n                  .","journal-title":"Immunity"},{"key":"460_CR20","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/nrm1682","volume":"6","author":"CW Gourlay","year":"2005","unstructured":"Gourlay CW, Ayscough KR. The actin cytoskeleton: a key regulator of apoptosis and ageing? Nat Rev Mol Cell Biol. 2005;6:583\u20139. \n                    https:\/\/doi.org\/10.1038\/nrm1682\n                    \n                  .","journal-title":"Nat Rev Mol Cell Biol"},{"key":"460_CR21","doi-asserted-by":"publisher","first-page":"16027","DOI":"10.1073\/pnas.1306324110","volume":"110","author":"D Illner","year":"2013","unstructured":"Illner D, Scherthan H. Ionizing irradiation-induced radical stress stalls live meiotic chromosome movements by altering the actin cytoskeleton. Proc Natl Acad Sci USA. 2013;110:16027\u201332. \n                    https:\/\/doi.org\/10.1073\/pnas.1306324110\n                    \n                  .","journal-title":"Proc Natl Acad Sci USA"},{"key":"460_CR22","doi-asserted-by":"publisher","first-page":"C719","DOI":"10.1152\/ajpcell.2001.280.4.C719","volume":"280","author":"H Lum","year":"2001","unstructured":"Lum H, Roebuck KA. Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol. 2001;280:C719\u201341. \n                    https:\/\/doi.org\/10.1152\/ajpcell.2001.280.4.C719\n                    \n                  .","journal-title":"Am J Physiol Cell Physiol"},{"key":"460_CR23","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1166\/jbn.2014.1745","volume":"10","author":"I Dul\u00ednska-Molak","year":"2014","unstructured":"Dul\u00ednska-Molak I, Mao H, Kawazoe N, Chen G, Duli I, Mao H, et al. Variation of mechanical property of single-walled carbon nanotubes-treated cells explored by atomic force microscopy. J Biomed Nanotechnol. 2014;10:651\u20139. \n                    https:\/\/doi.org\/10.1166\/jbn.2014.1745\n                    \n                  .","journal-title":"J Biomed Nanotechnol"},{"key":"460_CR24","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1016\/j.bpj.2016.04.034","volume":"110","author":"AX Cartagena-Rivera","year":"2016","unstructured":"Cartagena-Rivera AX, Logue JS, Waterman CM, Chadwick RS. Actomyosin cortical mechanical properties in nonadherent cells determined by atomic force microscopy. Biophys J. 2016;110:2528\u201339. \n                    https:\/\/doi.org\/10.1016\/j.bpj.2016.04.034\n                    \n                  .","journal-title":"Biophys J"},{"key":"460_CR25","doi-asserted-by":"publisher","first-page":"4986","DOI":"10.1002\/anie.201209099","volume":"52","author":"A Bianco","year":"2013","unstructured":"Bianco A. Graphene: safe or toxic? The two faces of the medal. Angew Chem Int Ed Engl. 2013;52:4986\u201397. \n                    https:\/\/doi.org\/10.1002\/anie.201209099\n                    \n                  .","journal-title":"Angew Chem Int Ed Engl"},{"key":"460_CR26","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.toxlet.2006.11.001","volume":"168","author":"K Pulskamp","year":"2007","unstructured":"Pulskamp K, Diabat\u00e9 S, Krug HF. Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants. Toxicol Lett. 2007;168:58\u201374. \n                    https:\/\/doi.org\/10.1016\/j.toxlet.2006.11.001\n                    \n                  .","journal-title":"Toxicol Lett"},{"key":"460_CR27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1021\/tx200339h","volume":"25","author":"VC Sanchez","year":"2012","unstructured":"Sanchez VC, Jachak A, Hurt RH, Kane AB. Biological interactions of graphene-family nanomaterials: an interdisciplinary review. Chem Res Toxicol. 2012;25:15\u201334. \n                    https:\/\/doi.org\/10.1021\/tx200339h\n                    \n                  .","journal-title":"Chem Res Toxicol"},{"key":"460_CR28","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.taap.2012.03.023","volume":"261","author":"AA Shvedova","year":"2012","unstructured":"Shvedova AA, Pietroiusti A, Fadeel B, Kagan VE. Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress. Toxicol Appl Pharmacol. 2012;261:121\u201333. \n                    https:\/\/doi.org\/10.1016\/j.taap.2012.03.023\n                    \n                  .","journal-title":"Toxicol Appl Pharmacol"},{"key":"460_CR29","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12989-016-0168-y","volume":"13","author":"L Ou","year":"2016","unstructured":"Ou L, Song B, Liang H, Liu J, Feng X, Deng B, et al. Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms. Part Fibre Toxicol. 2016;13:57. \n                    https:\/\/doi.org\/10.1186\/s12989-016-0168-y\n                    \n                  .","journal-title":"Part Fibre Toxicol"},{"key":"460_CR30","doi-asserted-by":"publisher","first-page":"10886","DOI":"10.1038\/srep10886","volume":"5","author":"Z Gu","year":"2015","unstructured":"Gu Z, Yang Z, Chong Y, Ge C, Weber JK, Bell DR, et al. Surface curvature relation to protein adsorption for carbon-based nanomaterials. Sci Rep. 2015;5:10886. \n                    https:\/\/doi.org\/10.1038\/srep10886\n                    \n                  .","journal-title":"Sci Rep"},{"key":"460_CR31","doi-asserted-by":"publisher","first-page":"23323","DOI":"10.1021\/jp208967t","volume":"115","author":"G Zuo","year":"2011","unstructured":"Zuo G, Zhou X, Huang Q, Fang H, Zhou R. Adsorption of villin headpiece onto graphene, carbon nanotube, and C60: effect of contacting surface curvatures on binding affinity. J Phys Chem C. 2011;115:23323\u20138. \n                    https:\/\/doi.org\/10.1021\/jp208967t\n                    \n                  .","journal-title":"J Phys Chem C"},{"key":"460_CR32","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/joim.12247","volume":"276","author":"RJ Burgess","year":"2014","unstructured":"Burgess RJ, Agathocleous M, Morrison SJ. Metabolic regulation of stem cell function. J Intern Med. 2014;276:12\u201324. \n                    https:\/\/doi.org\/10.1111\/joim.12247\n                    \n                  .","journal-title":"J Intern Med"},{"key":"460_CR33","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.neuron.2011.05.011","volume":"70","author":"D Nakada","year":"2011","unstructured":"Nakada D, Levi BP, Morrison SJ. Integrating physiological regulation with stem cell and tissue homeostasis. Neuron. 2011;70:703\u201318. \n                    https:\/\/doi.org\/10.1016\/j.neuron.2011.05.011\n                    \n                  .","journal-title":"Neuron"},{"key":"460_CR34","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1743-8977-11-18","volume":"11","author":"HM Braakhuis","year":"2014","unstructured":"Braakhuis HM, Park MV, Gosens I, De Jong WH, Cassee FR. Physicochemical characteristics of nanomaterials that affect pulmonary inflammation. Part Fibre Toxicol. 2014;11:18. \n                    https:\/\/doi.org\/10.1186\/1743-8977-11-18\n                    \n                  .","journal-title":"Part Fibre Toxicol"},{"key":"460_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10616-010-9263-3","volume":"62","author":"GL Francis","year":"2010","unstructured":"Francis GL. Albumin and mammalian cell culture: implications for biotechnology applications. Cytotechnology. 2010;62:1\u201316. \n                    https:\/\/doi.org\/10.1007\/s10616-010-9263-3\n                    \n                  .","journal-title":"Cytotechnology"},{"key":"460_CR36","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.carbon.2013.05.060","volume":"62","author":"T Mesari\u010d","year":"2013","unstructured":"Mesari\u010d T, Baweja L, Dra\u0161ler B, Drobne D, Makovec D, Du\u0161ak P, et al. Effects of surface curvature and surface characteristics of carbon-based nanomaterials on the adsorption and activity of acetylcholinesterase. Carbon. 2013;62:222\u201332.","journal-title":"Carbon"},{"key":"460_CR37","doi-asserted-by":"publisher","first-page":"28443","DOI":"10.1038\/srep28443","volume":"6","author":"SS Nanda","year":"2016","unstructured":"Nanda SS, Yi DK, Kim K. Study of antibacterial mechanism of graphene oxide using Raman spectroscopy. Sci Rep. 2016;6:28443. \n                    https:\/\/doi.org\/10.1038\/srep28443\n                    \n                  .","journal-title":"Sci Rep"},{"key":"460_CR38","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1039\/C2IB20117H","volume":"5","author":"RM Crist","year":"2013","unstructured":"Crist RM, Grossman JH, Patri AK, Stern ST, Dobrovolskaia MA, Adiseshaiah PP, et al. Common pitfalls in nanotechnology: lessons learned from NCI\u2019s Nanotechnology Characterization Laboratory. Integr Biol. 2013;5:66\u201373. \n                    https:\/\/doi.org\/10.1039\/C2IB20117H\n                    \n                  .","journal-title":"Integr Biol"},{"key":"460_CR39","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1365-2796.2009.02187.x","volume":"267","author":"G Oberd\u00f6rster","year":"2010","unstructured":"Oberd\u00f6rster G. Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. J Intern Med. 2010;267:89\u2013105. \n                    https:\/\/doi.org\/10.1111\/j.1365-2796.2009.02187.x\n                    \n                  .","journal-title":"J Intern Med"},{"key":"460_CR40","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1743-8977-7-22","volume":"7","author":"SK Sohaebuddin","year":"2010","unstructured":"Sohaebuddin SK, Thevenot PT, Baker D, Eaton JW, Tang L. Nanomaterial cytotoxicity is composition, size, and cell type dependent. Part Fibre Toxicol. 2010;7:22. \n                    https:\/\/doi.org\/10.1186\/1743-8977-7-22\n                    \n                  .","journal-title":"Part Fibre Toxicol"},{"key":"460_CR41","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1111\/j.1539-6924.2010.01446.x","volume":"30","author":"LC Abbott","year":"2010","unstructured":"Abbott LC, Maynard AD. Exposure assessment approaches for engineered nanomaterials. Risk Anal. 2010;30:1634\u201344. \n                    https:\/\/doi.org\/10.1111\/j.1539-6924.2010.01446.x\n                    \n                  .","journal-title":"Risk Anal"},{"key":"460_CR42","doi-asserted-by":"publisher","first-page":"e9445","DOI":"10.1371\/journal.pone.0009445","volume":"5","author":"M Ochsner","year":"2010","unstructured":"Ochsner M, Textor M, Vogel V, Smith ML. Dimensionality controls cytoskeleton assembly and metabolism of fibroblast cells in response to rigidity and shape. PLoS ONE. 2010;5:e9445. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0009445\n                    \n                  .","journal-title":"PLoS ONE"},{"key":"460_CR43","doi-asserted-by":"publisher","first-page":"e1003360","DOI":"10.1371\/journal.pcbi.1003360","volume":"9","author":"N Todorova","year":"2013","unstructured":"Todorova N, Makarucha AJ, Hine NDM, Mostofi AA, Yarovsky I. Dimensionality of carbon nanomaterials determines the binding and dynamics of amyloidogenic peptides: multiscale theoretical simulations. PLoS Comput Biol. 2013;9:e1003360. \n                    https:\/\/doi.org\/10.1371\/journal.pcbi.1003360\n                    \n                  .","journal-title":"PLoS Comput Biol"},{"key":"460_CR44","doi-asserted-by":"publisher","first-page":"474204","DOI":"10.1088\/0953-8984\/20\/47\/474204","volume":"20","author":"Nicola M De","year":"2008","unstructured":"De Nicola M, Bellucci S, Traversa E, De Bellis G, Micciulla F, Ghibelli L. Carbon nanotubes on Jurkat cells: effects on cell viability and plasma membrane potential. J Phys Condens Matter. 2008;20:474204. \n                    https:\/\/doi.org\/10.1088\/0953-8984\/20\/47\/474204\n                    \n                  .","journal-title":"J Phys Condens Matter"},{"key":"460_CR45","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jtemb.2017.01.005","volume":"43","author":"G Visalli","year":"2017","unstructured":"Visalli G, Facciol\u00e0 A, Iannazzo D, Piperno A, Pistone A, Di Pietro A. The role of the iron catalyst in the toxicity of multi-walled carbon nanotubes (MWCNTs). J Trace Elem Med Biol. 2017;43:153\u201360. \n                    https:\/\/doi.org\/10.1016\/j.jtemb.2017.01.005\n                    \n                  .","journal-title":"J Trace Elem Med Biol"},{"key":"460_CR46","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1042\/BJ20100208","volume":"428","author":"M Karlsson","year":"2010","unstructured":"Karlsson M, Kurz T, Brunk UT, Nilsson SE, Frennesson CI. What does the commonly used DCF test for oxidative stress really show? Biochem J. 2010;428:183\u201390. \n                    https:\/\/doi.org\/10.1042\/BJ20100208\n                    \n                  .","journal-title":"Biochem J"},{"key":"460_CR47","doi-asserted-by":"publisher","first-page":"1603830","DOI":"10.1002\/smll.201603830","volume":"13","author":"J Ma","year":"2017","unstructured":"Ma J, Li R, Liu Y, Qu G, Liu J, Guo W, et al. Carbon nanotubes disrupt iron homeostasis and induce anemia of inflammation through inflammatory pathway as a secondary effect distant to their portal-of-entry. Small. 2017;13:1603830. \n                    https:\/\/doi.org\/10.1002\/smll.201603830\n                    \n                  .","journal-title":"Small"},{"key":"460_CR48","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1111\/risa.12394","volume":"35","author":"J Nakanishi","year":"2015","unstructured":"Nakanishi J, Morimoto Y, Ogura I, Kobayashi N, Naya M, Ema M, et al. Risk assessment of the carbon nanotube group. Risk Anal. 2015;35:1940\u201356. \n                    https:\/\/doi.org\/10.1111\/risa.12394\n                    \n                  .","journal-title":"Risk Anal"},{"key":"460_CR49","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/978-94-017-8739-0_5","volume":"811","author":"IM Adjei","year":"2014","unstructured":"Adjei IM, Sharma B, Labhasetwar V. Nanoparticles: cellular uptake and cytotoxicity. Adv Exp Med Biol. 2014;811:73\u201391. \n                    https:\/\/doi.org\/10.1007\/978-94-017-8739-0_5\n                    \n                  .","journal-title":"Adv Exp Med Biol"},{"key":"460_CR50","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/jcp.1041190110","volume":"119","author":"F Grinnell","year":"1984","unstructured":"Grinnell F. Fibroblast spreading and phagocytosis: similar cell responses to different-sized substrata. J Cell Physiol. 1984;119:58\u201364. \n                    https:\/\/doi.org\/10.1002\/jcp.1041190110\n                    \n                  .","journal-title":"J Cell Physiol"},{"key":"460_CR51","doi-asserted-by":"publisher","first-page":"4013","DOI":"10.1016\/j.biomaterials.2012.02.021","volume":"33","author":"H Yue","year":"2012","unstructured":"Yue H, Wei W, Yue Z, Wang B, Luo N, Gao Y, et al. The role of the lateral dimension of graphene oxide in the regulation of cellular responses. Biomaterials. 2012;33:4013\u201321. \n                    https:\/\/doi.org\/10.1016\/j.biomaterials.2012.02.021\n                    \n                  .","journal-title":"Biomaterials"},{"key":"460_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.23","author":"E Owusu-Ansah","year":"2008","unstructured":"Owusu-Ansah E, Yavari A, Banerjee U. A protocol for in vivo detection of reactive oxygen species. Protoc Exch. 2008. \n                    https:\/\/doi.org\/10.1038\/nprot.2008.23\n                    \n                  .","journal-title":"Protoc Exch"},{"key":"460_CR53","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s10439-012-0653-x","volume":"41","author":"J Chen","year":"2013","unstructured":"Chen J, Rogers SC, Kavdia M. Analysis of kinetics of dihydroethidium fluorescence with superoxide using xanthine oxidase and hypoxanthine assay. Ann Biomed Eng. 2013;41:327\u201337. \n                    https:\/\/doi.org\/10.1007\/s10439-012-0653-x\n                    \n                  .","journal-title":"Ann Biomed Eng"},{"key":"460_CR54","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3390\/jfb3020398","volume":"3","author":"BD Holt","year":"2012","unstructured":"Holt BD, Shams H, Horst TA, Basu S, Rape AD, Wang Y-L, et al. Altered cell mechanics from the inside: dispersed single wall carbon nanotubes integrate with and restructure actin. J Funct Biomater. 2012;3:398\u2013417. \n                    https:\/\/doi.org\/10.3390\/jfb3020398\n                    \n                  .","journal-title":"J Funct Biomater"},{"key":"460_CR55","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00424-007-0419-8","volume":"456","author":"JC Martens","year":"2008","unstructured":"Martens JC, Radmacher M. Softening of the actin cytoskeleton by inhibition of myosin II. Pflugers Arch. 2008;456:95\u2013100. \n                    https:\/\/doi.org\/10.1007\/s00424-007-0419-8\n                    \n                  .","journal-title":"Pflugers Arch"},{"key":"460_CR56","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1205\/cherd05053","volume":"84","author":"N Hilal","year":"2006","unstructured":"Hilal N, Bowen WR, Alkhatib L, Ogunbiyi O. A review of atomic force microscopy applied to cell interactions with membranes. Chem Eng Res Des. 2006;84:282\u201392. \n                    https:\/\/doi.org\/10.1205\/cherd05053\n                    \n                  .","journal-title":"Chem Eng Res Des"},{"key":"460_CR57","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ymeth.2013.03.037","volume":"60","author":"I Sokolov","year":"2013","unstructured":"Sokolov I, Dokukin ME, Guz NV. Method for quantitative measurements of the elastic modulus of biological cells in AFM indentation experiments. Methods. 2013;60:202\u201313. \n                    https:\/\/doi.org\/10.1016\/j.ymeth.2013.03.037\n                    \n                  .","journal-title":"Methods"},{"key":"460_CR58","doi-asserted-by":"publisher","first-page":"15118","DOI":"10.1021\/acs.jpcb.5b07656","volume":"119","author":"YX Liu","year":"2015","unstructured":"Liu YX, Karsai A, Anderson DS, Silva RM, Uyeminami DL, Van Winkle LS, et al. Single-cell mechanics provides an effective means to probe in vivo interactions between alveolar macrophages and silver nanoparticles. J Phys Chem B. 2015;119:15118\u201329. \n                    https:\/\/doi.org\/10.1021\/acs.jpcb.5b07656\n                    \n                  .","journal-title":"J Phys Chem B"},{"key":"460_CR59","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1021\/jp410764f","volume":"118","author":"CC Zimmer","year":"2014","unstructured":"Zimmer CC, Liu YX, Morgan JT, Yang G, Wang K-H, Kennedy IM, et al. New approach to investigate the cytotoxicity of nanomaterials using single cell mechanics. J Phys Chem B. 2014;118:1246\u201355. \n                    https:\/\/doi.org\/10.1021\/jp410764f\n                    \n                  .","journal-title":"J Phys Chem B"},{"key":"460_CR60","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.bpj.2013.12.037","volume":"106","author":"A Cartagena","year":"2014","unstructured":"Cartagena A, Raman A. Local viscoelastic properties of live cells investigated using dynamic and quasi-static atomic force microscopy methods. Biophys J. 2014;106:1033\u201343. \n                    https:\/\/doi.org\/10.1016\/j.bpj.2013.12.037\n                    \n                  .","journal-title":"Biophys J"},{"key":"460_CR61","doi-asserted-by":"publisher","first-page":"11692","DOI":"10.1038\/srep11692","volume":"5","author":"AX Cartagena-Rivera","year":"2015","unstructured":"Cartagena-Rivera AX, Wang W-H, Geahlen RL, Raman A. Fast, multi-frequency, and quantitative nanomechanical mapping of live cells using the atomic force microscope. Sci Rep. 2015;5:11692. \n                    https:\/\/doi.org\/10.1038\/srep11692\n                    \n                  .","journal-title":"Sci Rep"},{"key":"460_CR62","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nnano.2012.163","volume":"7","author":"N Gavara","year":"2012","unstructured":"Gavara N, Chadwick RS. Determination of the elastic moduli of thin samples and adherent cells using conical atomic force microscope tips. Nat Nanotechnol. 2012;7:733\u20136. \n                    https:\/\/doi.org\/10.1038\/nnano.2012.163\n                    \n                  .","journal-title":"Nat Nanotechnol"},{"key":"460_CR63","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1039\/C5TB00179J","volume":"3","author":"C Dong","year":"2015","unstructured":"Dong C, Eldawud R, Sargent LM, Kashon ML, Lowry D, Rojanasakul Y, et al. Carbon nanotube uptake changes the biomechanical properties of human lung epithelial cells in a time-dependent manner. J Mater Chem B. 2015;3:3983\u201392. \n                    https:\/\/doi.org\/10.1039\/C5TB00179J\n                    \n                  .","journal-title":"J Mater Chem B"},{"key":"460_CR64","doi-asserted-by":"publisher","first-page":"20130694","DOI":"10.1098\/rsif.2013.0694","volume":"10","author":"R Subbiah","year":"2013","unstructured":"Subbiah R, Ramasundaram S, Du P, Hyojin K, Sung D, Lee N, et al. Evaluation of cytotoxicity, biophysics and biomechanics of cells treated with functionalized hybrid nanomaterials. J R Soc Interface. 2013;10:20130694. \n                    https:\/\/doi.org\/10.1098\/rsif.2013.0694\n                    \n                  .","journal-title":"J R Soc Interface"},{"key":"460_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-0-387-98161-1_1","volume-title":"Biological interactions on materials surfaces","author":"DR Schmidt","year":"2009","unstructured":"Schmidt DR, Waldeck H, Kao WJ. Protein adsorption to biomaterials. In: Puleo D, Bizios R, editors. Biological interactions on materials surfaces. New York: Springer; 2009. p. 1\u201318. \n                    https:\/\/doi.org\/10.1007\/978-0-387-98161-1_1\n                    \n                  ."},{"key":"460_CR66","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1743-8977-9-10","volume":"9","author":"AR Murray","year":"2012","unstructured":"Murray AR, Kisin ER, Tkach AV, Yanamala N, Mercer R, Young S-H, et al. Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos. Part Fibre Toxicol. 2012;9:10. \n                    https:\/\/doi.org\/10.1186\/1743-8977-9-10\n                    \n                  .","journal-title":"Part Fibre Toxicol"},{"key":"460_CR67","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fcell.2017.00041","volume":"5","author":"AR Kay","year":"2017","unstructured":"Kay AR. How cells can control their size by pumping ions. Front Cell Dev Biol. 2017;5:41. \n                    https:\/\/doi.org\/10.3389\/fcell.2017.00041\n                    \n                  .","journal-title":"Front Cell Dev Biol"},{"key":"460_CR68","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1088\/0957-4484\/13\/1\/307","volume":"13","author":"R L\u00e9vy","year":"2002","unstructured":"L\u00e9vy R, Maaloum M. Measuring the spring constant of atomic force microscope cantilevers: thermal fluctuations and other methods. Nanotechnology. 2002;13:33\u20137. \n                    https:\/\/doi.org\/10.1088\/0957-4484\/13\/1\/307\n                    \n                  .","journal-title":"Nanotechnology"},{"key":"460_CR69","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1063\/1.103950","volume":"57","author":"G Meyer","year":"1990","unstructured":"Meyer G, Amer NM. Simultaneous measurement of lateral and normal forces with an optical-beam-deflection atomic force microscope. Appl Phys Lett. 1990;57:2089. \n                    https:\/\/doi.org\/10.1063\/1.103950\n                    \n                  .","journal-title":"Appl Phys Lett"},{"key":"460_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1115\/1.3261297","volume":"37","author":"KL Johnson","year":"2003","unstructured":"Johnson KL. Contact mechanics. J Am Chem Soc. 2003;37:1\u201317. \n                    https:\/\/doi.org\/10.1115\/1.3261297\n                    \n                  .","journal-title":"J Am Chem Soc"},{"key":"460_CR71","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1016\/S0006-3495(02)75620-8","volume":"82","author":"EK Dimitriadis","year":"2002","unstructured":"Dimitriadis EK, Horkay F, Maresca J, Kachar B, Chadwick RS. Determination of elastic moduli of thin layers of soft material using the atomic force microscope. Biophys J. 2002;82:2798\u2013810. \n                    https:\/\/doi.org\/10.1016\/S0006-3495(02)75620-8\n                    \n                  .","journal-title":"Biophys J"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-019-0460-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12951-019-0460-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-019-0460-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T18:33:06Z","timestamp":1589481186000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-019-0460-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,23]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["460"],"URL":"https:\/\/doi.org\/10.1186\/s12951-019-0460-8","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,23]]},"assertion":[{"value":"7 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"32"}}