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Due to its antimicrobial and wound healing-promoting activity, metal nanoparticles have attracted attention for dermatological applications. This study is designed to investigate the scope and bactericidal potential of zinc ferrite nanoparticles (ZnFe\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      NPs), and the mechanism of anti-bacterial action along with cytocompatibility, hemocompatibility, and wound healing properties.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ZnFe\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      NPs were synthesized via a modified co-precipitation method. Structure, size, morphology, and elemental compositions of ZnFe\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      NPs were analyzed using X-ray diffraction pattern, Fourier transform infrared spectroscopy, and field emission scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy. In PrestoBlue and live\/dead assays, ZnFe\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      NPs exhibited dose-dependent cytotoxic effects on human dermal fibroblasts. In addition, the hemocompatibility assay revealed that the NPs do not significantly rupture red blood cells up to a dose of 1000\u00a0\u00b5g\/mL. Bacterial live\/dead imaging and zone of inhibition analysis demonstrated that ZnFe\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      NPs showed dose-dependent bactericidal activities in various strains of Gram-negative and Gram-positive bacteria. Interestingly, NPs showed antimicrobial activity through multiple mechanisms, such as cell membrane damage, protein leakage, and reactive oxygen species generation, and were more effective against gram-positive bacteria. Furthermore, in vitro scratch assay revealed that ZnFe\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      NPs improved cell migration and proliferation of cells, with noticeable shrinkage of the artificial wound model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study indicated that ZnFe\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>4<\/jats:sub>\n                      NPs have the potential to be used as a future antimicrobial and wound healing drug.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12951-021-00776-w","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T08:08:27Z","timestamp":1612512507000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":203,"title":["Anti\u2010bacterial and wound healing\u2010promoting effects of zinc ferrite nanoparticles"],"prefix":"10.1186","volume":"19","author":[{"given":"Reihaneh","family":"Haghniaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atiya","family":"Rabbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Vajhadin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taous","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozina","family":"Kousar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rehman","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Montazerian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Libanori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-7238","authenticated-orcid":false,"given":"Han-Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazli","family":"Wahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"issue":"1","key":"776_CR1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nrmicro3380","volume":"13","author":"JM Blair","year":"2015","unstructured":"Blair JM, et al. 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