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It has become an urgent need to seek new therapeutic strategies without or with low toxicity and side effects. At present, more and more researchers has been attracting attention by nanotheranostic platform. Therefore, our team synthesized the polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X (USPIO-PEG-sLe<jats:sup>x<\/jats:sup>) nanotheranostic platform with high temperature pyrolysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The USPIO-PEG-sLe<jats:sup>x<\/jats:sup> nanoparticles had excellent photothermal conversion property, and the temperature of USPIO-PEG-sLe<jats:sup>x<\/jats:sup> nanoparticles solution increased with its concentration and power density of near-infrared (NIR) on 808\u00a0nm wavelengths. Five USPIO-PEG-sLe<jats:sup>x<\/jats:sup> nanoparticles with different concentrations of 0\u00a0mg\/ml, 0.025\u00a0mg\/ml, 0.05\u00a0mg\/ml, 0.1\u00a0mg\/ml and 0.2\u00a0mg\/ml were prepared. The biological toxicity results showed that the viability of NPC 5-8F cells is related to the concentration of USPIO-PEG-sLe<jats:sup>x<\/jats:sup> nanoparticles and the culture time (P\u2009&lt;\u20090.001). The results of photothermal therapy (PTT) in vitro indicated that the viability of 5-8F cells decreased significantly with the concentration of USPIO-PEG-sLe<jats:sup>x<\/jats:sup> nanoparticles increases (P\u2009&lt;\u20090.001), and the viability of NPC 5-8F cells were 91.04%\u2009\u00b1\u20095.20%, 77.83%\u2009\u00b1\u20093.01%, 73.48%\u2009\u00b1\u20095.55%, 59.50%\u2009\u00b1\u200910.98%, 17.11%\u2009\u00b1\u20093.14%, respectively. The USPIO-PEG-sLe<jats:sup>x<\/jats:sup> nanoparticles could target the tumor area, and reduce the T2* value of tumor tissue. The T2* values of tumor pre- and post-injection were 30.870\u2009\u00b1\u20095.604 and 18.335\u2009\u00b1\u20094.351, respectively (P\u2009&lt;\u20090.001). In addition, USPIO-PEG-sLe<jats:sup>x<\/jats:sup> nanoparticles as a photothermal agent for PTT could effectively inhibit tumor progression. The ratio of volume change between tail vein injection group, control group, nanoparticles without laser irradiation group and blank group after 5 treatments were 3.04\u2009\u00b1\u20090.57, 5.80\u2009\u00b1\u20091.06, 8.09\u2009\u00b1\u20091.96, 7.89\u2009\u00b1\u20092.20, respectively (P &lt; 0.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our synthesized USPIO-PEG-sLe<jats:sup>x<\/jats:sup> nanotheranostic platform, and it may be become a new strategy for the treatment of NPC.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphic Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s12951-021-00918-0","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T09:05:30Z","timestamp":1623143130000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X nanotheranostic platform for nasopharyngeal carcinoma imaging and photothermal therapy"],"prefix":"10.1186","volume":"19","author":[{"given":"Qinmin","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunwei","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2142-9001","authenticated-orcid":false,"given":"Guanqiao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"issue":"6","key":"918_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. 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