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Hence, the construction of a highly sensitive detection method for RBP4 is the key to early prevention and multidisciplinary intervention of T2DM. In this work, a dual-quenched electrochemiluminescence (ECL) immunosensor has been fabricated for ultrasensitive detection of RBP4 by combining zeolitic imidazolate framework-67\/AuPt-supported luminol (luminol@AuPt\/ZIF-67) with MnO<jats:sub>2<\/jats:sub> nanosheets-grown on carbon nanotubes (MnO<jats:sub>2<\/jats:sub>@CNTs).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>AuPt\/ZIF-67 hybrids with high-efficiency peroxidase-like activity could provide multipoint binding sites for luminol and antibodies and significantly boost the amplified initial signal of the ECL immunosensor. Upon glutathione\/H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> coreactants system, MnO<jats:sub>2<\/jats:sub>@CNTs composites could quench the initial signal by inhibiting mimic peroxidase activity of luminol@AuPt\/ZIF-67. Moreover, the absorption spectrum of the MnO<jats:sub>2<\/jats:sub>@CNTs composites completely overlaps with the emission spectrum of luminol, which can further reduce initial signal by ECL resonance energy transfer (ECL-RET).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Benefiting from the above-mentioned properties, the designed immunoassay sensitivity exhibited excellent sensitivity and relative stability for RBP4 detection range from 0.0001 to 100\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup> with a low detection limit of 43\u00a0fg\u00a0mL<jats:sup>\u22121<\/jats:sup>. Therefore, our ECL immunosensor provides an alternative assaying strategy for early diagnosis of T2DM.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphic abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s12951-021-01020-1","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T08:03:03Z","timestamp":1631088183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["A dual-quenched ECL immunosensor for ultrasensitive detection of retinol binding protein 4 based on luminol@AuPt\/ZIF-67 and MnO2@CNTs"],"prefix":"10.1186","volume":"19","author":[{"given":"Wei","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengshun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junman","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijia","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"1020_CR1","doi-asserted-by":"publisher","first-page":"m2206","DOI":"10.1136\/bmj.m2206","volume":"370","author":"Y Hu","year":"2020","unstructured":"Hu Y, Ding M, Sampson L, Willett WC, Manson JE, Wang M, Rosner B, Hu FB, Sun Q. 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