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Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) with appropriate concentration can reverse the Warburg effect in cancer cells. The combination of PTT with H<jats:sub>2<\/jats:sub>S gas therapy is expected to achieve synergistic tumor treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Here, sulourea (Su) is developed as a thermosensitive\/hydrolysable H<jats:sub>2<\/jats:sub>S donor to be loaded into Pd nanocubes through in-depth coordination for construction of the Pd-Su nanomedicine for the first time to achieve photo-controlled H<jats:sub>2<\/jats:sub>S release, realizing the effective combination of photothermal therapy and H<jats:sub>2<\/jats:sub>S gas therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The Pd-Su nanomedicine shows a high Su loading capacity (85\u00a0mg\u00a0g<jats:sup>\u22121<\/jats:sup>), a high near-infrared (NIR) photothermal conversion efficiency (69.4%), and NIR-controlled H<jats:sub>2<\/jats:sub>S release by the photothermal-triggered hydrolysis of Su. The combination of photothermal heating and H<jats:sub>2<\/jats:sub>S produces a strong synergetic effect by H<jats:sub>2<\/jats:sub>S-induced inhibition of heat shock response, thereby effectively inhibiting tumor growth. Moreover, high intratumoral accumulation of the Pd-Su nanomedicine after intravenous injection also enables photothermal\/photoacoustic dual-mode imaging-guided tumor treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The proposed NIR-responsive heat\/H<jats:sub>2<\/jats:sub>S release strategy provides a new approach for effective cancer therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphic abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s12951-021-01042-9","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T09:40:38Z","timestamp":1634204438000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Sulourea-coordinated Pd nanocubes for NIR-responsive photothermal\/H2S therapy of cancer"],"prefix":"10.1186","volume":"19","author":[{"given":"Xiaoyang","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingdong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0689-8838","authenticated-orcid":false,"given":"Qianjun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"1042_CR1","doi-asserted-by":"publisher","first-page":"10887","DOI":"10.1021\/acsnano.9b04954","volume":"13","author":"LC Chen","year":"2019","unstructured":"Chen LC, Zhou SF, Su LC, Song JB. 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