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This autoimmune disease causes many severe disorders leading to organ failure, lower extremity amputations, and ultimately death. Modern delivery systems e.g., nanofiber (NF)-based systems fabricated by natural and synthetic or both materials to deliver therapeutics agents and cells, could be the harbinger of a new era to obviate DM complications. Such delivery systems can effectively deliver macromolecules (insulin) and small molecules. Besides, NF scaffolds can provide an ideal microenvironment to cell therapy for pancreatic \u03b2 cell transplantation and pancreatic tissue engineering. Numerous studies indicated the potential usage of therapeutics\/cells-incorporated NF mats to proliferate\/regenerate\/remodeling the structural and functional properties of diabetic skin ulcers. Thus, we intended to discuss the aforementioned features of the NF system for DM complications in detail.<\/jats:p>\n                <jats:p><jats:bold>Graphic abstract<\/jats:bold><\/jats:p>","DOI":"10.1186\/s12951-021-01065-2","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T01:07:06Z","timestamp":1634087226000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Nanofiber-based systems intended for diabetes"],"prefix":"10.1186","volume":"19","author":[{"given":"Hassan","family":"Maleki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-4292","authenticated-orcid":false,"given":"Kamyar","family":"Khoshnevisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed Mahmoud","family":"Sajjadi-Jazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Baharifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Doostan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazanin","family":"Khoshnevisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshad","family":"Sharifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"1065_CR1","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1039\/C3CS60436E","volume":"43","author":"R Mo","year":"2014","unstructured":"Mo R, Jiang T, Di J, Tai W, Gu Z. 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