{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:31:47Z","timestamp":1788629507272,"version":"build-2803163510"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP190103486"],"award-info":[{"award-number":["DP190103486"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multi-modal therapy has attracted increasing attention as it provides enhanced effectiveness and potential stimulation of the immune community. However, low accumulation at the tumor sites and quick immune clearance of the anti-tumor agents are still insurmountable challenges. Hypothetically, cancer cell membrane (CCM) can homologously target the tumor whereas multi-modal therapy can complement the disadvantages of singular therapies. Meanwhile, moderate\u00a0hyperthermia induced by photothermal therapy can boost the cellular uptake of therapeutic agents by cancer cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CCM-cloaked indocyanine green (ICG)-incorporated and abraxane (PTX-BSA)-loaded layered double hydroxide (LDH) nanosheets (LIPC NSs) were fabricated for target efficient photo-chemotherapy of colorectal carcinoma (CRC). The CCM-cloaked LDH delivery system showed efficient homologous targeting\u00a0and cytotoxicity, which was further enhanced under laser irradiation to synergize CRC apoptosis. On the other hand, CCM-cloaking remarkably reduced the uptake of LDH NSs by HEK 293T cells and macrophages, implying mitigation of the side effects and the immune clearance, respectively. In vivo data further exhibited that LIPC NSs enhanced the drug accumulation in tumor tissues and significantly retarded tumor progression under laser irradiation at very low therapeutic doses (1.2 and 0.6\u00a0mg\/kg of ICG and PTX-BSA), without observed side effects on other organs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This research has demonstrated that targeting delivery efficiency and immune-escaping ability of LIPC NSs are tremendously enhanced by CCM cloaking for efficient tumor accumulation and in situ generated hyperthermia boosts the uptake of LIPC NSs by cancer cells, a potential effective way to improve the multi-modal cancer therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s12951-021-01096-9","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T14:03:09Z","timestamp":1635602589000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Biomimetic 2D layered double hydroxide nanocomposites for hyperthermia-facilitated homologous targeting cancer photo-chemotherapy"],"prefix":"10.1186","volume":"19","author":[{"given":"Jingjing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6070-5035","authenticated-orcid":false,"given":"Zhi Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"1096_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-020-01184-8","volume":"19","author":"K Han","year":"2020","unstructured":"Han K, Wang F, Cao CH, Ling H, Chen J, Chen R, Feng Z, Luo J, Jin X, Duan J. CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17. Mol Cancer. 2020;19:1\u201318.","journal-title":"Mol Cancer"},{"key":"1096_CR2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3390\/ijms18010197","volume":"18","author":"I M\u00e1rmol","year":"2017","unstructured":"M\u00e1rmol I, S\u00e1nchez-de-Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi MJ. Colorectal carcinoma: a general overview and future perspectives in colorectal cancer. Int J Mol Sci. 2017;18:197.","journal-title":"Int J Mol Sci"},{"key":"1096_CR3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.7150\/ijbs.36955","volume":"16","author":"N Zhang","year":"2020","unstructured":"Zhang N, Peng F, Wang Y, Yang L, Wu F, Wang X, Ye C, Han B, He G. Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1\/JNK signaling axis. Int J Biol Sci. 2020;16:147.","journal-title":"Int J Biol Sci"},{"key":"1096_CR4","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1039\/C8CS00618K","volume":"48","author":"Y Liu","year":"2019","unstructured":"Liu Y, Bhattarai P, Dai Z, Chen X. Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem Soc Rev. 2019;48:2053\u2013108.","journal-title":"Chem Soc Rev"},{"key":"1096_CR5","doi-asserted-by":"publisher","first-page":"1910301","DOI":"10.1002\/adfm.201910301","volume":"30","author":"Z He","year":"2020","unstructured":"He Z, Zhao L, Zhang Q, Chang M, Li C, Zhang H, Lu Y, Chen Y. An acceptor-donor-acceptor structured small molecule for effective NIR triggered dual phototherapy of cancer. Adv Funct Mater. 2020;30:1910301.","journal-title":"Adv Funct Mater"},{"key":"1096_CR6","doi-asserted-by":"publisher","first-page":"23248","DOI":"10.1021\/acsami.5b07316","volume":"7","author":"J Wang","year":"2015","unstructured":"Wang J, Zhang L, Chen M, Gao S, Zhu L. Activatable ferritin nanocomplex for real-time monitoring of caspase-3 activation during photodynamic therapy. ACS Appl Mater Interfaces. 2015;7:23248\u201356.","journal-title":"ACS Appl Mater Interfaces"},{"key":"1096_CR7","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3390\/nano11020394","volume":"11","author":"R Liu","year":"2021","unstructured":"Liu R, Xu F, Wang L, Liu M, Cao X, Shi X, Guo R. Polydopamine-coated laponite nanoplatforms for photoacoustic imaging-guided chemo-phototherapy of breast cancer. Nanomaterials. 2021;11:394.","journal-title":"Nanomaterials"},{"key":"1096_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.coph.2016.11.005","volume":"31","author":"G Gu","year":"2016","unstructured":"Gu G, Dustin D, Fuqua SA. Targeted therapy for breast cancer and molecular mechanisms of resistance to treatment. Curr Opin Pharmacol. 2016;31:97\u2013103.","journal-title":"Curr Opin Pharmacol"},{"key":"1096_CR9","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.4254\/wjh.v7.i15.1964","volume":"7","author":"C Chen","year":"2015","unstructured":"Chen C, Wang G. Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy. World J Hepatol. 2015;7:1964\u201370.","journal-title":"World J Hepatol"},{"key":"1096_CR10","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.jconrel.2020.09.012","volume":"327","author":"P Dash","year":"2020","unstructured":"Dash P, Piras AM, Dash M. Cell membrane coated nanocarriers-an efficient biomimetic platform for targeted therapy. J Control Release. 2020;327:546\u201370.","journal-title":"J Control Release"},{"key":"1096_CR11","doi-asserted-by":"publisher","first-page":"7006","DOI":"10.1021\/acsnano.7b02533","volume":"11","author":"S Li","year":"2017","unstructured":"Li S, Cheng H, Xie B, Qiu W, Zeng J, Li C, Wan S, Zhang L, Liu W, Zhang X. Cancer cell membrane camouflaged cascade bioreactor for cancer targeted starvation and photodynamic therapy. ACS Nano. 2017;11:7006\u201318.","journal-title":"ACS Nano"},{"key":"1096_CR12","doi-asserted-by":"publisher","first-page":"32729","DOI":"10.1021\/acsami.9b10948","volume":"11","author":"Q Feng","year":"2019","unstructured":"Feng Q, Yang X, Hao Y, Wang N, Feng X, Hou L, Zhang Z. Cancer cell membrane-biomimetic nanoplatform for enhanced sonodynamic therapy on breast cancer via autophagy regulation strategy. ACS Appl Mater Interfaces. 2019;11:32729\u201338.","journal-title":"ACS Appl Mater Interfaces"},{"key":"1096_CR13","doi-asserted-by":"publisher","first-page":"1604300","DOI":"10.1002\/adfm.201604300","volume":"27","author":"H Sun","year":"2017","unstructured":"Sun H, Su J, Meng Q, Yin Q, Chen L, Gu W, Zhang Z, Yu H, Zhang P, Wang S. Cancer cell membrane coated gold nanocages with hyperthermia-triggered drug release and homotypic target inhibit growth and metastasis of breast cancer. Adv Funct Mater. 2017;27:1604300.","journal-title":"Adv Funct Mater"},{"key":"1096_CR14","doi-asserted-by":"publisher","first-page":"8520","DOI":"10.1021\/acsnano.8b04066","volume":"12","author":"J Li","year":"2018","unstructured":"Li J, Zhen X, Lyu Y, Jiang Y, Huang J, Pu K. Cell membrane coated semiconducting polymer nanoparticles for enhanced multimodal cancer phototheranostics. ACS Nano. 2018;12:8520\u201330.","journal-title":"ACS Nano"},{"key":"1096_CR15","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1002\/adma.201506086","volume":"28","author":"L Rao","year":"2016","unstructured":"Rao L, Bu L, Cai B, Xu J, Li A, Zhang W, Sun Z, Guo S, Liu W, Wang T. Cancer cell membrane-coated upconversion nanoprobes for highly specific tumor imaging. Adv Mater. 2016;28:3460\u20136.","journal-title":"Adv Mater"},{"key":"1096_CR16","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.1021\/acsnano.8b03788","volume":"13","author":"W Xie","year":"2019","unstructured":"Xie W, Deng W, Zan M, Rao L, Yu G, Zhu D, Wu W, Chen B, Ji L, Chen L. Cancer cell membrane camouflaged nanoparticles to realize starvation therapy together with checkpoint blockades for enhancing cancer therapy. ACS Nano. 2019;13:2849\u201357.","journal-title":"ACS Nano"},{"key":"1096_CR17","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1038\/nm.2554","volume":"17","author":"M Mitsunaga","year":"2011","unstructured":"Mitsunaga M, Ogawa M, Kosaka N, Rosenblum LT, Choyke PL, Kobayashi H. Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules. Nat Med. 2011;17:1685\u201391.","journal-title":"Nat Med"},{"key":"1096_CR18","doi-asserted-by":"publisher","first-page":"2003834","DOI":"10.1002\/smll.202003834","volume":"16","author":"M Zhou","year":"2020","unstructured":"Zhou M, Xing Y, Li X, Du X, Xu T, Zhang X. Cancer cell membrane camouflaged semi-yolk @ spiky-shell nanomotor for enhanced cell adhesion and synergistic therapy. Small. 2020;16:2003834.","journal-title":"Small"},{"key":"1096_CR19","doi-asserted-by":"publisher","first-page":"35566","DOI":"10.1021\/acsami.9b11746","volume":"11","author":"L Zhang","year":"2019","unstructured":"Zhang L, Sun X, Xu ZP, Liu R. Development of multifunctional clay-based nanomedicine for elimination of primary invasive breast cancer and prevention of its lung metastasis and distant inoculation. ACS Appl Mater Interfaces. 2019;11:35566\u201376.","journal-title":"ACS Appl Mater Interfaces"},{"key":"1096_CR20","doi-asserted-by":"publisher","first-page":"14299","DOI":"10.1002\/chem.201702835","volume":"23","author":"H Zuo","year":"2017","unstructured":"Zuo H, Chen W, Li B, Xu K, Cooper H, Gu Z, Xu ZP. MnAl layered double hydroxide nanoparticles as a dual-functional platform for magnetic resonance imaging and siRNA delivery. Chem Eur J. 2017;23:14299\u2013306.","journal-title":"Chem Eur J"},{"issue":"6","key":"1096_CR21","doi-asserted-by":"publisher","first-page":"7115","DOI":"10.1021\/acsami.0c23143","volume":"13","author":"J Liu","year":"2021","unstructured":"Liu J, Sun L, Li L, Zhang R, Xu ZP. Synergistic cancer photochemotherapy via layered double hydroxide-based trimodal nanomedicine at very low therapeutic doses. ACS Appl Mater Interfaces. 2021;13(6):7115\u201326.","journal-title":"ACS Appl Mater Interfaces"},{"key":"1096_CR22","doi-asserted-by":"publisher","first-page":"1700373","DOI":"10.1002\/adma.201700373","volume":"29","author":"B Li","year":"2017","unstructured":"Li B, Gu Z, Kurniawan N, Chen W, Xu ZP. Manganese-based layered double hydroxide nanoparticles as a T1-MRI contrast agent with ultrasensitive pH response and high relaxivity. Adv Mater. 2017;29:1700373.","journal-title":"Adv Mater"},{"key":"1096_CR23","doi-asserted-by":"publisher","first-page":"1909745","DOI":"10.1002\/adfm.201909745","volume":"30","author":"B Li","year":"2020","unstructured":"Li B, Hao G, Sun B, Gu Z, Xu ZP. Engineering a therapy-induced \u201cimmunogenic cancer cell death\u201d amplifier to boost systemic tumor elimination. Adv Funct Mater. 2020;30:1909745.","journal-title":"Adv Funct Mater"},{"key":"1096_CR24","doi-asserted-by":"publisher","first-page":"2000112","DOI":"10.1002\/sstr.202000112","volume":"2","author":"L Sun","year":"2021","unstructured":"Sun L, Wang J, Liu J, Li L, Xu ZP. Creating structural defects of drug-free copper-containing layered double hydroxide nanoparticles to synergize photothermal\/photodynamic\/chemodynamic cancer therapy. Small Struct. 2021;2:2000112.","journal-title":"Small Struct"},{"key":"1096_CR25","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1039\/C9BM01394F","volume":"8","author":"Y Xu","year":"2020","unstructured":"Xu Y, Kong Y, Xu J, Li X, Gou J, Yin T, He H, Zhang Y, Tang X. Doxorubicin intercalated copper diethyldithiocarbamate functionalized layered double hydroxide hybrid nanoparticles for targeted therapy of hepatocellular carcinoma. Biomater Sci. 2020;8:897\u2013911.","journal-title":"Biomater Sci"},{"key":"1096_CR26","doi-asserted-by":"publisher","first-page":"102369","DOI":"10.1016\/j.nano.2021.102369","volume":"34","author":"L Li","year":"2021","unstructured":"Li L, Qian Y, Sun L, Han FY, Zhang R, Wang P, Xu ZP. Albumin-stabilized layered double hydroxide nanoparticles synergized combination chemotherapy for colorectal cancer treatment. Nanomedicine. 2021;34:102369.","journal-title":"Nanomedicine"},{"key":"1096_CR27","doi-asserted-by":"publisher","first-page":"20326","DOI":"10.1021\/acsami.8b04613","volume":"10","author":"W Chen","year":"2018","unstructured":"Chen W, Zuo H, Zhang E, Li L, Henrich-Noack P, Cooper H, Qian Y, Xu ZP. Brain targeting delivery facilitated by ligand-functionalized layered double hydroxide nanoparticles. ACS Appl Mater Interfaces. 2018;10:20326\u201333.","journal-title":"ACS Appl Mater Interfaces"},{"key":"1096_CR28","doi-asserted-by":"publisher","first-page":"95518","DOI":"10.1039\/C6RA19225D","volume":"6","author":"L Li","year":"2016","unstructured":"Li L, Gu Z, Gu W, Xu Z. Direct synthesis of layered double hydroxide nanosheets for efficient siRNA delivery. RSC Adv. 2016;6:95518\u201326.","journal-title":"RSC Adv"},{"key":"1096_CR29","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.jconrel.2018.11.008","volume":"292","author":"W Chen","year":"2018","unstructured":"Chen W, Zuo H, Rolfe B, Schembri MA, Cobbold RN, Zhang B, Mahony TJ, Xu ZP. Clay nanoparticles co-deliver three antigens to promote potent immune responses against pathogenic Escherichia coli. J Control Release. 2018;292:196\u2013209.","journal-title":"J Control Release"},{"key":"1096_CR30","doi-asserted-by":"publisher","first-page":"57290","DOI":"10.1021\/acsami.0c13865","volume":"12","author":"S Li","year":"2020","unstructured":"Li S, Jiang W, Yuan Y, Sui M, Yang Y, Huang L, Jiang L, Liu M, Chen S, Zhou X. Delicately designed cancer cell membrane-camouflaged nanoparticles for targeted 19F MR\/PA\/FL imaging-guided photothermal therapy. ACS Appl Mater Interfaces. 2020;12:57290\u2013301.","journal-title":"ACS Appl Mater Interfaces"},{"key":"1096_CR31","doi-asserted-by":"publisher","first-page":"3331","DOI":"10.1039\/C5TB00248F","volume":"3","author":"Z Gu","year":"2015","unstructured":"Gu Z, Zuo H, Li L, Wu A, Xu ZP. Pre-coating layered double hydroxide nanoparticles with albumin to improve colloidal stability and cellular uptake. J Mater Chem B. 2015;3:3331\u20139.","journal-title":"J Mater Chem B"},{"key":"1096_CR32","doi-asserted-by":"publisher","first-page":"39594","DOI":"10.1021\/acsami.9b14084","volume":"11","author":"D Zhang","year":"2019","unstructured":"Zhang D, Ye Z, Wei L, Luo H, Xiao L. Cell membrane-coated porphyrin metal-organic frameworks for cancer cell targeting and o2-evolving photodynamic therapy. ACS Appl Mater Interfaces. 2019;11:39594\u2013602.","journal-title":"ACS Appl Mater Interfaces"},{"key":"1096_CR33","doi-asserted-by":"publisher","first-page":"2004385","DOI":"10.1002\/adma.202004385","volume":"32","author":"D Shao","year":"2020","unstructured":"Shao D, Zhang F, Chen F, Zheng X, Hu H, Yang C, Tu Z, Wang Z, Chang Z, Lu J. Biomimetic diselenide-bridged mesoporous organosilica nanoparticles as an X-ray-responsive biodegradable carrier for chemo-immunotherapy. Adv Mater. 2020;32:2004385.","journal-title":"Adv Mater"},{"key":"1096_CR34","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jconrel.2008.05.021","volume":"130","author":"ZP Xu","year":"2008","unstructured":"Xu ZP, Niebert M, Porazik K, Walker TL, Cooper HM, Middelberg AP, Gray PP, Bartlett PF, Lu GQM. Subcellular compartment targeting of layered double hydroxide nanoparticles. J Control Release. 2008;130:86\u201394.","journal-title":"J Control Release"},{"key":"1096_CR35","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1039\/C8BM00104A","volume":"6","author":"J Chen","year":"2018","unstructured":"Chen J, Li X, Liu X, Yan H, Xie Z, Sheng Z, Gong X, Wang L, Liu X, Zhang P. Hybrid MoSe2-indocyanine green nanosheets as a highly efficient phototheranostic agent for photoacoustic imaging guided photothermal cancer therapy. Biomater Sci. 2018;6:1503\u201316.","journal-title":"Biomater Sci"},{"key":"1096_CR36","doi-asserted-by":"publisher","first-page":"35086","DOI":"10.1039\/C7RA06119F","volume":"7","author":"X Ding","year":"2017","unstructured":"Ding X, Xu X, Zhao Y, Zhang L, Yu Y, Huang F, Yin D, Huang H. Tumor targeted nanostructured lipid carrier co-delivering paclitaxel and indocyanine green for laser triggered synergetic therapy of cancer. RSC Adv. 2017;7:35086\u201395.","journal-title":"RSC Adv"},{"key":"1096_CR37","doi-asserted-by":"publisher","first-page":"6865","DOI":"10.1021\/acsami.6b15505","volume":"9","author":"N Li","year":"2017","unstructured":"Li N, Cai H, Jiang L, Hu J, Bains A, Hu J, Gong Q, Luo K, Gu Z. Enzyme-sensitive and amphiphilic PEGylated dendrimer-paclitaxel prodrug-based nanoparticles for enhanced stability and anticancer efficacy. ACS Appl Mater Interfaces. 2017;9:6865\u201377.","journal-title":"ACS Appl Mater Interfaces"},{"key":"1096_CR38","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.biomaterials.2017.07.026","volume":"142","author":"S Li","year":"2017","unstructured":"Li S, Cheng H, Qiu W, Zhang L, Wan S, Zeng J, Zhang X. Cancer cell membrane-coated biomimetic platform for tumor targeted photodynamic therapy and hypoxia-amplified bioreductive therapy. Biomaterials. 2017;142:149\u201361.","journal-title":"Biomaterials"},{"key":"1096_CR39","doi-asserted-by":"publisher","first-page":"5270","DOI":"10.1039\/C9BM01192G","volume":"7","author":"Y Wang","year":"2019","unstructured":"Wang Y, Xie D, Pan J, Xia C, Fan L, Pu Y, Zhang Q, Hong Ni Y, Wang J, Hu Q. A near infrared light-triggered human serum albumin drug delivery system with coordination bonding of indocyanine green and cisplatin for targeting photochemistry therapy against oral squamous cell cancer. Biomater Sci. 2019;7:5270\u201382.","journal-title":"Biomater Sci"},{"key":"1096_CR40","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.biomaterials.2018.05.055","volume":"177","author":"B Li","year":"2018","unstructured":"Li B, Tang J, Chen W, Hao G, Kurniawan N, Gu Z, Xu ZP. Novel theranostic nanoplatform for complete mice tumor elimination via MR imaging-guided acid-enhanced photothermo-\/chemo-therapy. Biomaterials. 2018;177:40\u201351.","journal-title":"Biomaterials"},{"key":"1096_CR41","doi-asserted-by":"publisher","first-page":"1805544","DOI":"10.1002\/smll.201805544","volume":"15","author":"L Zhang","year":"2019","unstructured":"Zhang L, Zhang X, Lu G, Li F, Bao W, Song C, Wei W, Ma G. Cell membrane camouflaged hydrophobic drug nanoflake sandwiched with photosensitizer for orchestration of chemo-photothermal combination therapy. Small. 2019;15:1805544.","journal-title":"Small"},{"key":"1096_CR42","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.apsb.2017.11.009","volume":"8","author":"R Li","year":"2018","unstructured":"Li R, He Y, Zhang S, Qin J, Wang J. Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment. Acta Pharm Sin B. 2018;8:14\u201322.","journal-title":"Acta Pharm Sin B"},{"key":"1096_CR43","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1021\/acs.bioconjchem.7b00407","volume":"28","author":"L Lin","year":"2017","unstructured":"Lin L, Liang X, Xu Y, Yang Y, Li X, Dai Z. Doxorubicin and indocyanine green loaded hybrid bicelles for fluorescence imaging guided synergetic chemo\/photothermal therapy. Bioconjug Chem. 2017;28:2410\u20139.","journal-title":"Bioconjug Chem"},{"key":"1096_CR44","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jconrel.2017.05.015","volume":"258","author":"W Li","year":"2017","unstructured":"Li W, Guo X, Kong F, Zhang H, Luo L, Li Q, Zhu C, Yang J, Du Y, You J. Overcoming photodynamic resistance and tumor targeting dual-therapy mediated by indocyanine green conjugated gold nanospheres. J Control Release. 2017;258:171\u201381.","journal-title":"J Control Release"},{"key":"1096_CR45","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1080\/02652048.2017.1339739","volume":"34","author":"M Xiong","year":"2017","unstructured":"Xiong M, Lei Q, You X, Gao T, Song X, Xia Y, Ye T, Zhang L, Wang N, Yu L. Mannosylated liposomes improve therapeutic effects of paclitaxel in colon cancer models. J Microencapsul. 2017;34:513\u201321.","journal-title":"J Microencapsul"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-021-01096-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-021-01096-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-021-01096-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:21:09Z","timestamp":1675815669000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-021-01096-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,30]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["1096"],"URL":"https:\/\/doi.org\/10.1186\/s12951-021-01096-9","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,30]]},"assertion":[{"value":"24 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were conducted under the guideline of The University of Queensland Animal Care and Use Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors accept the submission conditions.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Completing interests"}}],"article-number":"351"}}