{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:03:40Z","timestamp":1794258220025,"version":"4.9.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Natural Science Research Foundation of Anhui Province","award":["1508085MH173"],"award-info":[{"award-number":["1508085MH173"]}]},{"name":"Natural Science Research Foundation of Anhui Province","award":["KJ2015A137"],"award-info":[{"award-number":["KJ2015A137"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Currently, systemic therapies for patients with advanced-stage hepatocellular carcinoma (HCC) rely mainly on systemic drugs. However, traditional systemic drugs have a high rate of serious adverse events, and the curative effects of some potential anticancer drugs, such as curcumin (CUR) and resveratrol (RSV), are less apparent due to their poor bioavailability. Therefore, it is urgent to develop a highly effective therapy to improve patient prognosis. Herein, an injectable HCC-targeted nanoparticle (NP) was designed to deliver CUR and RSV to hepatoma cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The molecular self-assembled NPs showed higher tumour retention through the enhanced permeability and retention (EPR) effect of the NPs and surface modification with the HCC-specific peptide moiety SP94 to effectively treat HCC. These HCC-targeted NPs led to a significant reduction in the drug dosage, delayed the rate of drug release and improved the bioavailability of the encapsulated drugs. The drug concentrations in the vicinity of the tumour increased, and a good therapeutic effect was observed without obvious side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These SP94-mediated NPs allowed large amounts of antitumor drugs to accumulate in tumours, providing a novel strategy for innovative HCC therapy. This nanoplatform also offers an idea for exploring other potential chemotherapeutics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s12951-022-01554-y","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T15:32:48Z","timestamp":1658331168000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Curcumin- and resveratrol-co-loaded nanoparticles in synergistic treatment of hepatocellular carcinoma"],"prefix":"10.1186","volume":"20","author":[{"given":"Yongshun","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohe","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeben","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"issue":"6","key":"1554_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394\u2013424.","journal-title":"CA Cancer J Clin"},{"issue":"10127","key":"1554_CR2","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","volume":"391","author":"A Forner","year":"2018","unstructured":"Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet. 2018;391(10127):1301\u201314.","journal-title":"Lancet"},{"issue":"15","key":"1554_CR3","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1056\/NEJMra1713263","volume":"380","author":"A Villanueva","year":"2019","unstructured":"Villanueva A. Hepatocellular carcinoma. N Engl J Med. 2019;380(15):1450\u201362.","journal-title":"N Engl J Med"},{"issue":"1","key":"1554_CR4","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","volume":"7","author":"JM Llovet","year":"2021","unstructured":"Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, et al. Hepatocellular carcinoma. Nat Rev Dis Prim. 2021;7(1):6.","journal-title":"Nat Rev Dis Prim"},{"issue":"6","key":"1554_CR5","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1200\/JCO.2013.53.7746","volume":"33","author":"AX Zhu","year":"2015","unstructured":"Zhu AX, Rosmorduc O, Evans TR, Ross PJ, Santoro A, Carrilho FJ, et al. SEARCH: a phase III, randomized, double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2015;33(6):559\u201366.","journal-title":"J Clin Oncol"},{"issue":"10126","key":"1554_CR6","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/S0140-6736(18)30207-1","volume":"391","author":"M Kudo","year":"2018","unstructured":"Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial. Lancet. 2018;391(10126):1163\u201373.","journal-title":"Lancet"},{"key":"1554_CR7","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.ejpb.2015.04.002","volume":"93","author":"S Zupancic","year":"2015","unstructured":"Zupancic S, Lavric Z, Kristl J. Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature. Eur J Pharm Biopharm. 2015;93:196\u2013204.","journal-title":"Eur J Pharm Biopharm"},{"issue":"3","key":"1554_CR8","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.jep.2013.07.030","volume":"149","author":"Y Hu","year":"2013","unstructured":"Hu Y, Wang S, Wu X, Zhang J, Chen R, Chen M, et al. Chinese herbal medicine-derived compounds for cancer therapy: a focus on hepatocellular carcinoma. J Ethnopharmacol. 2013;149(3):601\u201312.","journal-title":"J Ethnopharmacol"},{"issue":"1\u20132","key":"1554_CR9","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ijpharm.2018.05.007","volume":"545","author":"Y Cheng","year":"2018","unstructured":"Cheng Y, Zhao P, Wu S, Yang T, Chen Y, Zhang X, et al. Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma. Int J Pharm. 2018;545(1\u20132):261\u201373.","journal-title":"Int J Pharm"},{"key":"1554_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118051","volume":"257","author":"M Najafi","year":"2020","unstructured":"Najafi M, Mortezaee K, Rahimifard M, Farhood B, Haghi-Aminjan H. The role of curcumin\/curcuminoids during gastric cancer chemotherapy: a systematic review of non-clinical study. Life Sci. 2020;257: 118051.","journal-title":"Life Sci"},{"issue":"3","key":"1554_CR11","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1021\/acsabm.1c01311","volume":"5","author":"M Ramezani Farani","year":"2022","unstructured":"Ramezani Farani M, Azarian M, Heydari Sheikh Hossein H, Abdolvahabi Z, Mohammadi Abgarmi Z, Moradi A, et al. Folic acid-adorned curcumin-loaded iron oxide nanoparticles for cervical cancer. ACS Appl Bio Mater. 2022;5(3):1305\u201318.","journal-title":"ACS Appl Bio Mater"},{"key":"1554_CR12","doi-asserted-by":"publisher","first-page":"2892917","DOI":"10.1155\/2020\/2892917","volume":"2020","author":"J Li","year":"2020","unstructured":"Li J, Wei H, Liu Y, Li Q, Guo H, Guo Y, et al. Curcumin inhibits hepatocellular carcinoma via regulating miR-21\/TIMP3 axis. Evid Based Complement Altern Med. 2020;2020:2892917.","journal-title":"Evid Based Complement Altern Med"},{"issue":"1","key":"1554_CR13","doi-asserted-by":"publisher","first-page":"218","DOI":"10.2174\/138920112798868791","volume":"13","author":"AS Darvesh","year":"2012","unstructured":"Darvesh AS, Aggarwal BB, Bishayee A. Curcumin and liver cancer: a review. Curr Pharm Biotechnol. 2012;13(1):218\u201328.","journal-title":"Curr Pharm Biotechnol"},{"key":"1554_CR14","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/765832","volume":"2014","author":"YQ Xue","year":"2014","unstructured":"Xue YQ, Di JM, Luo Y, Cheng KJ, Wei X, Shi Z. Resveratrol oligomers for the prevention and treatment of cancers. Oxid Med Cell Longev. 2014;2014: 765832.","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"1554_CR15","doi-asserted-by":"publisher","first-page":"142","DOI":"10.2174\/18755666MTA2pODE0z","volume":"21","author":"P Amini","year":"2021","unstructured":"Amini P, Nodooshan SJ, Ashrafizadeh M, Eftekhari SM, Aryafar T, Khalafi L, et al. Resveratrol induces apoptosis and attenuates proliferation of MCF-7 cells in combination with radiation and hyperthermia. Curr Mol Med. 2021;21(2):142\u201350.","journal-title":"Curr Mol Med"},{"issue":"29","key":"1554_CR16","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.2174\/1568026621666211105093658","volume":"21","author":"EK Vernousfaderani","year":"2021","unstructured":"Vernousfaderani EK, Akhtari N, Rezaei S, Rezaee Y, Shiranirad S, Mashhadi M, et al. Resveratrol and colorectal cancer: a molecular approach to clinical researches. Curr Top Med Chem. 2021;21(29):2634\u201346.","journal-title":"Curr Top Med Chem"},{"key":"1554_CR17","doi-asserted-by":"publisher","first-page":"110116","DOI":"10.1016\/j.biopha.2020.110116","volume":"127","author":"W Qian","year":"2020","unstructured":"Qian W, Xiao Q, Wang L, Qin T, Xiao Y, Li J, et al. Resveratrol slows the tumourigenesis of pancreatic cancer by inhibiting NFkappaB activation. Biomed Pharmacother. 2020;127:110116.","journal-title":"Biomed Pharmacother"},{"issue":"24","key":"1554_CR18","doi-asserted-by":"publisher","first-page":"4845","DOI":"10.2174\/0929867328666201228124038","volume":"28","author":"N Zaffaroni","year":"2021","unstructured":"Zaffaroni N, Beretta GL. Resveratrol and prostate cancer: the power of phytochemicals. Curr Med Chem. 2021;28(24):4845\u201362.","journal-title":"Curr Med Chem"},{"issue":"5","key":"1554_CR19","first-page":"582","volume":"50","author":"F Song","year":"2021","unstructured":"Song F, Zhang Y, Pan Z, Zhang Q, Lu X, Huang P. Resveratrol inhibits the migration, invasion and epithelial-mesenchymal transition in liver cancer cells through up- miR-186\u20135p expression. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2021;50(5):582\u201390.","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"1","key":"1554_CR20","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1186\/s12935-021-02179-1","volume":"21","author":"Z Kohandel","year":"2021","unstructured":"Kohandel Z, Farkhondeh T, Aschner M, Pourbagher-Shahri AM, Samarghandian S. STAT3 pathway as a molecular target for resveratrol in breast cancer treatment. Cancer Cell Int. 2021;21(1):468.","journal-title":"Cancer Cell Int"},{"issue":"9","key":"1554_CR21","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1080\/10408398.2016.1263597","volume":"58","author":"A Rauf","year":"2018","unstructured":"Rauf A, Imran M, Butt MS, Nadeem M, Peters DG, Mubarak MS. Resveratrol as an anti-cancer agent: a review. Crit Rev Food Sci Nutr. 2018;58(9):1428\u201347.","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"5","key":"1554_CR22","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1007\/s12094-021-02731-5","volume":"24","author":"IW Cheuk","year":"2022","unstructured":"Cheuk IW, Chen J, Siu M, Ho JC, Lam SS, Shin VY, et al. Resveratrol enhanced chemosensitivity by reversing macrophage polarization in breast cancer. Clin Transl Oncol. 2022;24(5):854\u201363.","journal-title":"Clin Transl Oncol"},{"key":"1554_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126322","author":"M Bostan","year":"2021","unstructured":"Bostan M, Mihaila M, Petrica-Matei GG, Radu N, Hainarosie R, Stefanescu CD, et al. Resveratrol modulation of apoptosis and cell cycle response to cisplatin in head and neck cancer cell lines. Int J Mol Sci. 2021. https:\/\/doi.org\/10.3390\/ijms22126322.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1554_CR24","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/ptr.7305","volume":"36","author":"AJ Abadi","year":"2022","unstructured":"Abadi AJ, Mirzaei S, Mahabady MK, Hashemi F, Zabolian A, Hashemi F, et al. Curcumin and its derivatives in cancer therapy: potentiating antitumor activity of cisplatin and reducing side effects. Phytother Res. 2022;36(1):189\u2013213.","journal-title":"Phytother Res"},{"issue":"12_suppl","key":"1554_CR25","doi-asserted-by":"publisher","first-page":"S861","DOI":"10.1177\/09603271211052985","volume":"40","author":"Y Muhanmode","year":"2021","unstructured":"Muhanmode Y, Wen MK, Maitinuri A, Shen G. Curcumin and resveratrol inhibit chemoresistance in cisplatin-resistant epithelial ovarian cancer cells via targeting P13K pathway. Hum Exp Toxicol. 2021;40(12_suppl):S861\u20138.","journal-title":"Hum Exp Toxicol"},{"issue":"1","key":"1554_CR26","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1080\/1061186X.2019.1601199","volume":"28","author":"W Guo","year":"2020","unstructured":"Guo W, Wu X, Li Y, Gao J, Wang F, Jin Y, et al. Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer. J Drug Target. 2020;28(1):41\u20135.","journal-title":"J Drug Target"},{"issue":"8","key":"1554_CR27","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1002\/jps.24042","volume":"103","author":"LJ Carlson","year":"2014","unstructured":"Carlson LJ, Cote B, Alani AW, Rao DA. Polymeric micellar co-delivery of resveratrol and curcumin to mitigate in vitro doxorubicin-induced cardiotoxicity. J Pharm Sci. 2014;103(8):2315\u201322.","journal-title":"J Pharm Sci"},{"key":"1554_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/ph14111068","author":"A Arena","year":"2021","unstructured":"Arena A, Romeo MA, Benedetti R, Masuelli L, Bei R, Gilardini Montani MS, et al. New Insights into curcumin- and resveratrol-mediated anti-cancer effects. Pharmaceuticals. 2021. https:\/\/doi.org\/10.3390\/ph14111068.","journal-title":"Pharmaceuticals"},{"key":"1554_CR29","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.semcancer.2020.10.010","volume":"73","author":"S Patra","year":"2021","unstructured":"Patra S, Pradhan B, Nayak R, Behera C, Rout L, Jena M, et al. Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics. Semin Cancer Biol. 2021;73:310\u201320.","journal-title":"Semin Cancer Biol"},{"key":"1554_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118485","volume":"567","author":"L Meng","year":"2019","unstructured":"Meng L, Chu X, Xing H, Liu X, Xin X, Chen L, et al. Improving glioblastoma therapeutic outcomes via doxorubicin-loaded nanomicelles modified with borneol. Int J Pharm. 2019;567: 118485.","journal-title":"Int J Pharm"},{"issue":"1\u20132","key":"1554_CR31","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ijpharm.2017.03.090","volume":"524","author":"X Huang","year":"2017","unstructured":"Huang X, Li M, Bruni R, Messa P, Cellesi F. The effect of thermosensitive liposomal formulations on loading and release of high molecular weight biomolecules. Int J Pharm. 2017;524(1\u20132):279\u201389.","journal-title":"Int J Pharm"},{"issue":"1","key":"1554_CR32","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.apsb.2017.11.009","volume":"8","author":"R Li","year":"2018","unstructured":"Li R, He Y, Zhang S, Qin J, Wang J. Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment. Acta Pharmaceut Sin B. 2018;8(1):14\u201322.","journal-title":"Acta Pharmaceut Sin B"},{"key":"1554_CR33","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.foodchem.2017.03.021","volume":"230","author":"W Liu","year":"2017","unstructured":"Liu W, Wei F, Ye A, Tian M, Han J. Kinetic stability and membrane structure of liposomes during in vitro infant intestinal digestion: effect of cholesterol and lactoferrin. Food Chem. 2017;230:6\u201313.","journal-title":"Food Chem"},{"issue":"6","key":"1554_CR34","doi-asserted-by":"publisher","first-page":"4009","DOI":"10.1166\/jnn.2015.9713","volume":"15","author":"BP Reddy","year":"2015","unstructured":"Reddy BP, Yadav HK, Nagesha DK, Raizaday A, Karim A. Polymeric micelles as novel carriers for poorly soluble drugs\u2013a review. J Nanosci Nanotechnol. 2015;15(6):4009\u201318.","journal-title":"J Nanosci Nanotechnol"},{"key":"1554_CR35","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.colsurfb.2015.06.028","volume":"134","author":"A de Ghellinck","year":"2015","unstructured":"de Ghellinck A, Shen C, Fragneto G, Klosgen B. Probing the position of resveratrol in lipid bilayers: a neutron reflectivity study. Colloids Surf B. 2015;134:65\u201372.","journal-title":"Colloids Surf B"},{"issue":"1","key":"1554_CR36","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.colsurfb.2011.06.037","volume":"88","author":"A Karewicz","year":"2011","unstructured":"Karewicz A, Bielska D, Gzyl-Malcher B, Kepczynski M, Lach R, Nowakowska M. Interaction of curcumin with lipid monolayers and liposomal bilayers. Colloids Surf B. 2011;88(1):231\u20139.","journal-title":"Colloids Surf B"},{"issue":"43","key":"1554_CR37","doi-asserted-by":"publisher","first-page":"11532","DOI":"10.1002\/anie.201406685","volume":"53","author":"H Wang","year":"2014","unstructured":"Wang H, Xie H, Wu J, Wei X, Zhou L, Xu X, et al. Structure-based rational design of prodrugs to enable their combination with polymeric nanoparticle delivery platforms for enhanced antitumor efficacy. Angew Chem. 2014;53(43):11532\u20137.","journal-title":"Angew Chem"},{"key":"1554_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2019.101665","volume":"181","author":"KB Johnsen","year":"2019","unstructured":"Johnsen KB, Burkhart A, Thomsen LB, Andresen TL, Moos T. Targeting the transferrin receptor for brain drug delivery. Prog Neurobiol. 2019;181: 101665.","journal-title":"Prog Neurobiol"},{"issue":"sup2","key":"1554_CR39","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/21691401.2018.1453829","volume":"46","author":"R Rastegar","year":"2018","unstructured":"Rastegar R, Akbari Javar H, Khoobi M, Dehghan Kelishadi P, Hossein Yousefi G, Doosti M, et al. Evaluation of a novel biocompatible magnetic nanomedicine based on beta-cyclodextrin, loaded doxorubicin-curcumin for overcoming chemoresistance in breast cancer. Artif Cells Nanomed Biotechnol. 2018;46(sup2):207\u201316.","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"2","key":"1554_CR40","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3892\/ijo.2020.5067","volume":"57","author":"Z Yang","year":"2020","unstructured":"Yang Z, Liu J, Lu Y. Doxorubicin and CDCUR inclusion complex coloaded in thermosensitive hydrogel PLGAPEGPLGA localized administration for osteosarcoma. Int J Oncol. 2020;57(2):433\u201344.","journal-title":"Int J Oncol"},{"issue":"8","key":"1554_CR41","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1080\/02652048.2019.1669728","volume":"36","author":"N Rafati","year":"2019","unstructured":"Rafati N, Zarrabi A, Caldera F, Trotta F, Ghias N. Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations. J Microencapsul. 2019;36(8):715\u201327.","journal-title":"J Microencapsul"},{"key":"1554_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119580","volume":"229","author":"Z Yang","year":"2020","unstructured":"Yang Z, Wang J, Liu S, Li X, Miao L, Yang B, et al. Defeating relapsed and refractory malignancies through a nano-enabled mitochondria-mediated respiratory inhibition and damage pathway. Biomaterials. 2020;229: 119580.","journal-title":"Biomaterials"},{"key":"1554_CR43","doi-asserted-by":"publisher","first-page":"33511","DOI":"10.1038\/srep33511","volume":"6","author":"Y Li","year":"2016","unstructured":"Li Y, Hu Y, Xiao J, Liu G, Li X, Zhao Y, et al. Investigation of SP94 peptide as a specific probe for hepatocellular carcinoma imaging and therapy. Sci Rep. 2016;6:33511.","journal-title":"Sci Rep"},{"issue":"5","key":"1554_CR44","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nmat2992","volume":"10","author":"CE Ashley","year":"2011","unstructured":"Ashley CE, Carnes EC, Phillips GK, Padilla D, Durfee PN, Brown PA, et al. The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. Nat Mater. 2011;10(5):389\u201397.","journal-title":"Nat Mater"},{"issue":"7","key":"1554_CR45","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1021\/bc300015f","volume":"23","author":"R Toita","year":"2012","unstructured":"Toita R, Murata M, Tabata S, Abe K, Narahara S, Piao JS, et al. Development of human hepatocellular carcinoma cell-targeted protein cages. Bioconjug Chem. 2012;23(7):1494\u2013501.","journal-title":"Bioconjug Chem"},{"issue":"5","key":"1554_CR46","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/nrclinonc.2011.30","volume":"8","author":"AX Zhu","year":"2011","unstructured":"Zhu AX, Duda DG, Sahani DV, Jain RK. HCC and angiogenesis: possible targets and future directions. Nat Rev Clin Oncol. 2011;8(5):292\u2013301.","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"1554_CR47","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jconrel.2013.06.039","volume":"172","author":"CP Hollis","year":"2013","unstructured":"Hollis CP, Weiss HL, Leggas M, Evers BM, Gemeinhart RA, Li T. Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery. J Control Release. 2013;172(1):12\u201321.","journal-title":"J Control Release"},{"key":"1554_CR48","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.fct.2018.12.002","volume":"124","author":"H Khan","year":"2019","unstructured":"Khan H, Ullah H, Nabavi SM. Mechanistic insights of hepatoprotective effects of curcumin: therapeutic updates and future prospects. Food Chem Toxicol. 2019;124:182\u201391.","journal-title":"Food Chem Toxicol"},{"issue":"6","key":"1554_CR49","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","volume":"48","author":"ML Circu","year":"2010","unstructured":"Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radical Biol Med. 2010;48(6):749\u201362.","journal-title":"Free Radical Biol Med"},{"issue":"1","key":"1554_CR50","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ctrv.2009.10.002","volume":"36","author":"A Bishayee","year":"2010","unstructured":"Bishayee A, Politis T, Darvesh AS. Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma. Cancer Treat Rev. 2010;36(1):43\u201353.","journal-title":"Cancer Treat Rev"},{"issue":"14","key":"1554_CR51","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1158\/1078-0432.CCR-16-1464","volume":"23","author":"F Fornari","year":"2017","unstructured":"Fornari F, Pollutri D, Patrizi C, La Bella T, Marinelli S, Casadei Gardini A, et al. In hepatocellular carcinoma miR-221 modulates sorafenib resistance through inhibition of caspase-3-mediated apoptosis. Clin Cancer Res. 2017;23(14):3953\u201365.","journal-title":"Clin Cancer Res"},{"issue":"10","key":"1554_CR52","doi-asserted-by":"publisher","first-page":"12679","DOI":"10.1021\/acsnano.0c01453","volume":"14","author":"T Zhou","year":"2020","unstructured":"Zhou T, Liang X, Wang P, Hu Y, Qi Y, Jin Y, et al. A hepatocellular carcinoma targeting nanostrategy with hypoxia-ameliorating and photothermal abilities that, combined with immunotherapy, inhibits metastasis and recurrence. ACS Nano. 2020;14(10):12679\u201396.","journal-title":"ACS Nano"},{"key":"1554_CR53","volume-title":"CompuSyn software for drug combinations and for general dose-effect analysis, and user\u2019s guide","author":"T-C Chou","year":"2007","unstructured":"Chou T-C, Martin N. CompuSyn software for drug combinations and for general dose-effect analysis, and user\u2019s guide. Paramus: ComboSyn, Inc.; 2007."},{"key":"1554_CR54","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jconrel.2015.06.040","volume":"213","author":"B Cote","year":"2015","unstructured":"Cote B, Carlson LJ, Rao DA, Alani AWG. Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo. J Control Release. 2015;213:128\u201333.","journal-title":"J Control Release"},{"key":"1554_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107916","volume":"228","author":"B Pedre","year":"2021","unstructured":"Pedre B, Barayeu U, Ezerina D, Dick TP. The mechanism of action of N-acetylcysteine (NAC): the emerging role of H2S and sulfane sulfur species. Pharmacol Ther. 2021;228: 107916.","journal-title":"Pharmacol Ther"},{"issue":"5","key":"1554_CR56","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1002\/jcp.22906","volume":"227","author":"L Zhu","year":"2012","unstructured":"Zhu L, Yuan H, Guo C, Lu Y, Deng S, Yang Y, et al. Zearalenone induces apoptosis and necrosis in porcine granulosa cells via a caspase-3- and caspase-9-dependent mitochondrial signaling pathway. J Cell Physiol. 2012;227(5):1814\u201320.","journal-title":"J Cell Physiol"},{"issue":"2","key":"1554_CR57","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101946","volume":"11","author":"C Zhang","year":"2022","unstructured":"Zhang C, Xin L, Li J, Cao J, Sun Y, Wang X, et al. Metal-organic framework (MOF)-based ultrasound-responsive dual-sonosensitizer nanoplatform for hypoxic cancer therapy. Adv Healthc Mater. 2022;11(2): e2101946.","journal-title":"Adv Healthc Mater"}],"updated-by":[{"DOI":"10.1186\/s12951-025-03361-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000}}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-022-01554-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-022-01554-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-022-01554-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T01:02:40Z","timestamp":1744246960000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-022-01554-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1554"],"URL":"https:\/\/doi.org\/10.1186\/s12951-022-01554-y","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,20]]},"assertion":[{"value":"3 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12951-025-03361-7","URL":"https:\/\/doi.org\/10.1186\/s12951-025-03361-7","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal studies were reviewed and approved by the Institutional Animal Care and Use Committee of Anhui University (Serial Number: 2021-065) based on the National Standard of China GB\/T35892-2018 guidelines for Ethical Review of Experimental Animal Welfare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have approved the submitted manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"339"}}