{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:48:08Z","timestamp":1788317288497,"version":"build-2803163510"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"postgraduate research and innovation projects of Chong Municipal Education Commission","award":["CYB21180"],"award-info":[{"award-number":["CYB21180"]}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81972439"],"award-info":[{"award-number":["81972439"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The hypoimmunogenicity of tumors is one of the main bottlenecks of cancer immunotherapy. Enhancing tumor immunogenicity can improve the efficacy of tumor immunotherapy by increasing antigen exposure and presentation, and establishing an inflammatory microenvironment. Here, a multifunctional antigen trapping nanoparticle with indocyanine green (ICG), aluminum hydroxide (Al(OH)<jats:sub>3<\/jats:sub>) and oxaliplatin (OXA) (PPIAO) has been developed for tumor photoacoustic\/ultrasound dual-modality imaging and therapy. The combination of photothermal\/photodynamic therapy and chemotherapy induced tumor antigen exposure and release through immunogenic death of tumor cells. A timely capture and storage of antigens by aluminum hydroxide enabled dendritic cells to recognize and present those antigens spatiotemporally. In an ovarian tumor model, the photoacoustic-mediated PPIAO NPs combination therapy achieved a transition from \u201ccold tumor\u201d to \u201chot tumor\u201d that promoted more CD8<jats:sup>+<\/jats:sup> T lymphocytes activation in vivo and intratumoral infiltration, and successfully inhibited the growth of primary and metastatic tumors. An in situ tumor vaccine effect was produced from the treated tumor tissue, assisting mice against the recurrence of tumor cells. This study provided a simple and effective personalized tumor vaccine strategy for better treatment of metastatic and recurrent tumors. The developed multifunctional tumor antigen trapping nanoparticles may be a promising nanoplatform for integrating multimodal imaging monitoring, tumor treatment, and tumor vaccine immunotherapy.<\/jats:p>","DOI":"10.1186\/s12951-022-01682-5","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T12:03:01Z","timestamp":1667476981000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Photoacoustic mediated multifunctional tumor antigen trapping nanoparticles inhibit the recurrence and metastasis of ovarian cancer by enhancing tumor immunogenicity"],"prefix":"10.1186","volume":"20","author":[{"given":"Xiaowen","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuning","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangchuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenyin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"1682_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clinicians. 2022;72:7\u201333.","journal-title":"CA Cancer J Clinicians"},{"key":"1682_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209\u201349.","journal-title":"CA Cancer J Clin"},{"key":"1682_CR3","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.3390\/cancers13071661","volume":"13","author":"K Ksi\u0105\u017cek","year":"2021","unstructured":"Ksi\u0105\u017cek K. Molecular biology of ovarian cancer: from mechanisms of intraperitoneal metastasis to therapeutic opportunities. Cancers (Basel). 2021;13:1661.","journal-title":"Cancers (Basel)"},{"key":"1682_CR4","doi-asserted-by":"publisher","first-page":"5840","DOI":"10.1038\/onc.2017.171","volume":"36","author":"Y Klymenko","year":"2017","unstructured":"Klymenko Y, Kim O, Loughran E, Yang J, Lombard R, Alber M, Stack MS. Cadherin composition and multicellular aggregate invasion in organotypic models of epithelial ovarian cancer intraperitoneal metastasis. Oncogene. 2017;36:5840\u201351.","journal-title":"Oncogene"},{"key":"1682_CR5","doi-asserted-by":"publisher","first-page":"eaaw2614","DOI":"10.1126\/scitranslmed.aaw2614","volume":"11","author":"N Momin","year":"2019","unstructured":"Momin N, Mehta NK, Bennett NR, Ma L, Palmeri JR, Chinn MM, Lutz EA, Kang B, Irvine DJ, Spranger S, Wittrup KD. Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy. Sci Transl Med. 2019;11:eaaw2614.","journal-title":"Sci Transl Med"},{"key":"1682_CR6","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41572-020-0160-6","volume":"6","author":"M Ramos-Casals","year":"2020","unstructured":"Ramos-Casals M, Brahmer JR, Callahan MK, Flores-Ch\u00e1vez A, Keegan N, Khamashta MA, Lambotte O, Mariette X, Prat A, Su\u00e1rez-Almazor ME. Immune-related adverse events of checkpoint inhibitors. Nat Rev Dis Primers. 2020;6:38.","journal-title":"Nat Rev Dis Primers"},{"key":"1682_CR7","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.3389\/fimmu.2020.01965","volume":"11","author":"MA Morgan","year":"2020","unstructured":"Morgan MA, B\u00fcning H, Sauer M, Schambach A. Use of cell and genome modification technologies to generate improved \u201cOff-the-Shelf\u201d CAR T and CAR NK cells. Front Immunol. 2020;11:1965.","journal-title":"Front Immunol"},{"key":"1682_CR8","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.immuni.2019.12.011","volume":"52","author":"PS Hegde","year":"2020","unstructured":"Hegde PS, Chen DS. Top 10 challenges in cancer immunotherapy. Immunity. 2020;52:17\u201335.","journal-title":"Immunity"},{"key":"1682_CR9","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1126\/science.aar7112","volume":"359","author":"U Sahin","year":"2018","unstructured":"Sahin U, T\u00fcreci \u00d6. Personalized vaccines for cancer immunotherapy. Science. 2018;359:1355\u201360.","journal-title":"Science"},{"key":"1682_CR10","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.ejca.2017.01.035","volume":"81","author":"LA Emens","year":"2017","unstructured":"Emens LA, Ascierto PA, Darcy PK, Demaria S, Eggermont AMM, Redmond WL, Seliger B, Marincola FM. Cancer immunotherapy: opportunities and challenges in the rapidly evolving clinical landscape. Eur J Cancer. 2017;81:116\u201329.","journal-title":"Eur J Cancer"},{"key":"1682_CR11","doi-asserted-by":"publisher","first-page":"5483","DOI":"10.1002\/smll.201501284","volume":"11","author":"RH Fang","year":"2015","unstructured":"Fang RH, Kroll AV, Zhang L. Nanoparticle-based manipulation of antigen-presenting cells for cancer immunotherapy. Small. 2015;11:5483\u201396.","journal-title":"Small"},{"key":"1682_CR12","doi-asserted-by":"publisher","first-page":"e2102611118","DOI":"10.1073\/pnas.2102611118","volume":"118","author":"DM Lussier","year":"2021","unstructured":"Lussier DM, Alspach E, Ward JP, Miceli AP, Runci D, White JM, Mpoy C, Arthur CD, Kohlmiller HN, Jacks T, Artyomov MN, Rogers BE, Schreiber RD. Radiation-induced neoantigens broaden the immunotherapeutic window of cancers with low mutational loads. Proc Natl Acad Sci USA. 2021;118:e2102611118.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1682_CR13","doi-asserted-by":"publisher","first-page":"110640","DOI":"10.1016\/j.biopha.2020.110640","volume":"131","author":"P Xu","year":"2020","unstructured":"Xu P, Luo H, Kong Y, Lai WF, Cui L, Zhu X. Cancer neoantigen: boosting immunotherapy. Biomed Pharmacother. 2020;131:110640.","journal-title":"Biomed Pharmacother"},{"key":"1682_CR14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev-immunol-032712-100008","volume":"31","author":"G Kroemer","year":"2013","unstructured":"Kroemer G, Galluzzi L, Kepp O, Zitvogel L. Immunogenic cell death in cancer therapy. Annu Rev Immunol. 2013;31:51\u201372.","journal-title":"Annu Rev Immunol"},{"key":"1682_CR15","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nrc3380","volume":"12","author":"DV Krysko","year":"2012","unstructured":"Krysko DV, Garg AD, Kaczmarek A, Krysko O, Agostinis P, Vandenabeele P. Immunogenic cell death and DAMPs in cancer therapy. Nat Rev Cancer. 2012;12:860\u201375.","journal-title":"Nat Rev Cancer"},{"key":"1682_CR16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/bs.acr.2018.05.003","volume":"139","author":"CT Hagan","year":"2018","unstructured":"Hagan CT, Medik YB, Wang AZ. Nanotechnology approaches to improving cancer immunotherapy. Adv Cancer Res. 2018;139:35\u201356.","journal-title":"Adv Cancer Res"},{"key":"1682_CR17","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1021\/acs.accounts.0c00518","volume":"53","author":"H Cabral","year":"2020","unstructured":"Cabral H, Kinoh H, Kataoka K. Tumor-targeted nanomedicine for immunotherapy. Acc Chem Res. 2020;53:2765\u201376.","journal-title":"Acc Chem Res"},{"key":"1682_CR18","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.1121\/1.5136611","volume":"146.4","author":"M Aliabouzar","year":"2019","unstructured":"Aliabouzar M, Kumar KN, Sarkar K. Acoustic droplet vaporization threshold of perfluorocarbon droplets as a function of frequency: effects of droplet cores and size. J Acoust Soc Am. 2019;146.4:2774\u20134.","journal-title":"J Acoust Soc Am"},{"key":"1682_CR19","doi-asserted-by":"publisher","first-page":"100196","DOI":"10.1016\/j.pacs.2020.100196","volume":"19","author":"S Manohar","year":"2020","unstructured":"Manohar S, Gambhir SS. Clinical photoacoustic imaging. Photoacoustics. 2020;19:100196.","journal-title":"Photoacoustics"},{"key":"1682_CR20","first-page":"249","volume":"45","author":"H Aza\u00efs","year":"2017","unstructured":"Aza\u00efs H, Mordon S, Collinet P. Intraperitoneal photodynamic therapy for peritoneal metastasis of epithelial ovarian cancer. Limits and future prospects. Gynecol Obstet Fertil Senol. 2017;45:249\u201356.","journal-title":"Gynecol Obstet Fertil Senol"},{"key":"1682_CR21","doi-asserted-by":"publisher","first-page":"9377","DOI":"10.2147\/IJN.S208404","volume":"14","author":"W Xie","year":"2019","unstructured":"Xie W, Zhu S, Yang B, Chen C, Chen S, Liu Y, Nie C, Hao L, Wang Z, Sun J, Chang S. The destruction of laser-induced phase-transition nanoparticles triggered by low-intensity ultrasound: an innovative modality to enhance the immunological treatment of ovarian cancer cells. Int J Nanomed. 2019;14:9377\u201393.","journal-title":"Int J Nanomed"},{"key":"1682_CR22","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.jconrel.2021.02.032","volume":"332","author":"J Zheng","year":"2021","unstructured":"Zheng J, Sun J, Chen J, Zhu S, Chen S, Liu Y, Hao L, Wang Z, Chang S. Oxygen and oxaliplatin-loaded nanoparticles combined with photo-sonodynamic inducing enhanced immunogenic cell death in syngeneic mouse models of ovarian cancer. J Control Release. 2021;332:448\u201359.","journal-title":"J Control Release"},{"key":"1682_CR23","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/nnano.2017.113","volume":"9","author":"Y Min","year":"2017","unstructured":"Min Y, Roche KC, Tian S, Eblan MJ, McKinnon KP, Caster JM, Chai S, Herring LE, Zhang L, Zhang T, DeSimone JM, Tepper JE, Vincent BG, Serody JS, Wang AZ. Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy. Nat Nanotechnol. 2017;9:877.","journal-title":"Nat Nanotechnol"},{"key":"1682_CR24","doi-asserted-by":"publisher","first-page":"1802157","DOI":"10.1002\/advs.201802157","volume":"10","author":"M Wang","year":"2019","unstructured":"Wang M, Song J, Zhou F, Hoover AR, Murray C, Zhou B, Wang L, Qu J, Chen WR. NIR-triggered phototherapy and immunotherapy via an antigen-capturing nanoplatform for metastatic cancer treatment. Adv Sci (Weinh). 2019;10:1802157.","journal-title":"Adv Sci (Weinh)"},{"key":"1682_CR25","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1080\/21645515.2014.1004026","volume":"11","author":"P He","year":"2015","unstructured":"He P, Zou Y, Hu Z. Advances in aluminum hydroxide-based adjuvant research and its mechanism. Hum Vaccines Immunother. 2015;11:477\u201388.","journal-title":"Hum Vaccines Immunother"},{"key":"1682_CR26","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13223-018-0305-2","volume":"14","author":"E Shardlow","year":"2018","unstructured":"Shardlow E, Mold M, Exley C. Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminum-based adjuvants and their immunological mechanisms of action. Allergy Asthma Clin Immunol. 2018;14:80.","journal-title":"Allergy Asthma Clin Immunol"},{"key":"1682_CR27","doi-asserted-by":"publisher","first-page":"3600","DOI":"10.1016\/j.vaccine.2020.02.001","volume":"38","author":"A Colaprico","year":"2020","unstructured":"Colaprico A, Senesi S, Ferlicca F, Brunelli B, Ugozzoli M, Pallaoro M, O\u2019Hagan DT. Adsorption onto aluminum hydroxide adjuvant protects antigens from degradation. Vaccine. 2020;38:3600\u20139.","journal-title":"Vaccine"},{"key":"1682_CR28","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41578-021-00372-2","volume":"7","author":"GA Roth","year":"2021","unstructured":"Roth GA, Picece VCTM, Ou BS, Luo W, Pulendran B, Appel EA. Designing spatial and temporal control of vaccine responses. Nat Rev Mater. 2021;7:174\u201395.","journal-title":"Nat Rev Mater."},{"key":"1682_CR29","doi-asserted-by":"publisher","first-page":"6597","DOI":"10.1016\/j.vaccine.2010.07.056","volume":"28","author":"M de Veer","year":"2010","unstructured":"de Veer M, Kemp J, Chatelier J, Elhay MJ, Meeusen EN. The kinetics of soluble and particulate antigen trafficking in the afferent lymph, and its modulation by aluminum-based adjuvant. Vaccine. 2010;28:6597\u2013602.","journal-title":"Vaccine"},{"key":"1682_CR30","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jconrel.2013.10.032","volume":"173","author":"X Li","year":"2014","unstructured":"Li X, Aldayel AM, Cui Z. Aluminum hydroxide nanoparticles show a stronger vaccine adjuvant activity than traditional aluminum hydroxide microparticles. J Control Release. 2014;173:148\u201357.","journal-title":"J Control Release"},{"key":"1682_CR31","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1021\/acs.molpharmaceut.0c00114","volume":"17","author":"Y Liu","year":"2020","unstructured":"Liu Y, Chen S, Sun J, Zhu S, Chen C, Xie W, Zheng J, Zhu Y, Xiao L, Hao L, Wang Z, Chang S. Folate-targeted and oxygen\/indocyanine green loaded lipid nanoparticles for dual-mode imaging and photo-sonodynamic\/photothermal therapy of ovarian cancer in vitro and in vivo. Mol Pharm. 2020;17:1442\u20133.","journal-title":"Mol Pharm"},{"key":"1682_CR32","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1186\/s11671-019-3219-0","volume":"14","author":"X Zhong","year":"2019","unstructured":"Zhong X, Zhang M, Tian Z, Wang Q, Wang Z. The study of enhanced high-intensity focused ultrasound therapy by sonodynamic N2O microbubbles. Nanoscale Res Lett. 2019;14:381.","journal-title":"Nanoscale Res Lett"},{"key":"1682_CR33","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.canlet.2021.02.023","volume":"506","author":"Y Wang","year":"2021","unstructured":"Wang Y, Shi T, Song X, Liu B, Wei J. Gene fusion neoantigens: emerging targets for cancer immunotherapy. Cancer Lett. 2021;506:45\u201354.","journal-title":"Cancer Lett"},{"key":"1682_CR34","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/nature14426","volume":"520","author":"S Kreiter","year":"2015","unstructured":"Kreiter S, Vormehr M, van de Roemer N, Diken M, L\u00f6wer M, Diekmann J, Boegel S, Schr\u00f6rs B, Vascotto F, Castle JC, Tadmor AD, Schoenberger SP, Huber C, T\u00fcreci \u00d6, Sahin U. Mutant MHC class II epitopes drive therapeutic immune responses to cancer. Nature. 2015;520:692\u20136.","journal-title":"Nature"},{"key":"1682_CR35","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12943-019-1055-6","volume":"18","author":"M Peng","year":"2019","unstructured":"Peng M, Mo Y, Wang Y, Wu P, Zhang Y, Xiong F, Guo C, Wu X, Li Y, Li X, Li G, Xiong W, Zeng Z. Neoantigen vaccine: an emerging tumor immunotherapy. Mol Cancer. 2019;18:128.","journal-title":"Mol Cancer"},{"key":"1682_CR36","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1126\/science.aaa4971","volume":"348","author":"TN Schumacher","year":"2015","unstructured":"Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science. 2015;348:69\u201374.","journal-title":"Science"},{"key":"1682_CR37","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.canlet.2016.12.039","volume":"392","author":"Z Sun","year":"2017","unstructured":"Sun Z, Chen F, Meng F, Wei J, Liu B. MHC class II restricted neoantigen: a promising target in tumor immunotherapy. Cancer Lett. 2017;392:17\u201325.","journal-title":"Cancer Lett"},{"key":"1682_CR38","unstructured":"EUROPEAN PHARMACOPOEIA\u201410th EDITION, European Directorate for the Quality of Medicines & HealthCare (edqm.eu).\u00a02020;1:1. https:\/\/www.edqm.eu\/en\/web\/edqm\/european-pharmacopoeia-ph-eur-10th-edition\u00a0"},{"key":"1682_CR39","unstructured":"Code of Federal Regulation Title 21\u2014Food and Drugs. pp. 48\u201339.\u00a0https:\/\/www.fda.gov."},{"key":"1682_CR40","volume-title":"Pharmacopoeia of the People\u2019s Republic of China (3)","author":"State Pharmacopoeia Commission","year":"2015","unstructured":"State Pharmacopoeia Commission. Pharmacopoeia of the People\u2019s Republic of China (3). Beijing: China Pharmaceutical Science and Technology Press; 2015."},{"key":"1682_CR41","doi-asserted-by":"publisher","first-page":"120502","DOI":"10.1016\/j.ijpharm.2021.120502","volume":"600","author":"T Cui","year":"2021","unstructured":"Cui T, Li S, Chen S, Liang Y, Sun H, Wang L. \u201cStealth\u201d dendrimers with encapsulation of indocyanine green for photothermal and photodynamic therapy of cancer. Int J Pharm. 2021;600:120502.","journal-title":"Int J Pharm"},{"key":"1682_CR42","doi-asserted-by":"publisher","first-page":"e2001300","DOI":"10.1002\/adhm.202001300","volume":"10","author":"G Liang","year":"2021","unstructured":"Liang G, Han J, Xing D. Precise tumor photothermal therapy guided and monitored by magnetic resonance\/photoacoustic imaging using a safe and pH-responsive Fe(III) complex. Adv Healthc Mater. 2021;10:e2001300.","journal-title":"Adv Healthc Mater"},{"key":"1682_CR43","doi-asserted-by":"publisher","first-page":"5158","DOI":"10.1021\/acs.nanolett.2c00854","volume":"13","author":"Z Li","year":"2022","unstructured":"Li Z, Meng Z, Tian F, Ye Z, Zhou X, Zhong X, Chen Q, Yang M, Liu Z, Yin Y. Fast Fourier transform-weighted photoacoustic imaging by in vivo magnetic alignment of hybrid nanorods. Nano Lett. 2022;13:5158\u201366.","journal-title":"Nano Lett"},{"key":"1682_CR44","doi-asserted-by":"publisher","first-page":"121687","DOI":"10.1016\/j.biomaterials.2022.121687","volume":"287","author":"JE Cun","year":"2022","unstructured":"Cun JE, Pan Y, Zhang Z, Lu Y, Li J, Pan Q, Gao W, Luo K, He B, Pu Y. Photo-enhanced upcycling H2O2 into hydroxyl radicals by IR780-embedded Fe3O4@MIL-100 for intense nanocatalytic tumor therapy. Biomaterials. 2022;287:121687.","journal-title":"Biomaterials"},{"key":"1682_CR45","doi-asserted-by":"publisher","first-page":"100398","DOI":"10.1016\/j.mtbio.2022.100398","volume":"16","author":"S Shi","year":"2022","unstructured":"Shi S, Li H, Zheng X, Lv L, Liao S, Lu P, Liu M, Zhao H, Mei Z. Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma. Mater Today Bio. 2022;16:100398.","journal-title":"Mater Today Bio"},{"key":"1682_CR46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c03333","author":"F Zhang","year":"2022","unstructured":"Zhang F, Wang Z, Peijnenburg WJGM, Vijver MG. Review and prospects on the ecotoxicity of mixtures of nanoparticles and hybrid nanomaterials. Environ Sci Technol. 2022. https:\/\/doi.org\/10.1021\/acs.est.2c03333.","journal-title":"Environ Sci Technol"},{"key":"1682_CR47","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1038\/s41596-022-00701-x","volume":"9","author":"MF Abdolahpur","year":"2022","unstructured":"Abdolahpur MF, Guo Z, Zhang P, Vijver MG, Lynch I, Valsami JE, Peijnenburg WJGM. An analytical workflow for dynamic characterization and quantification of metal-bearing nanomaterials in biological matrices. Nat Protoc. 2022;9:1926\u201352.","journal-title":"Nat Protoc"},{"key":"1682_CR48","doi-asserted-by":"publisher","first-page":"e2100574","DOI":"10.1002\/adhm.202100574","volume":"16","author":"JC Cortez","year":"2021","unstructured":"Cortez JC, Czuba WE, Tan A, Caruso F. A focus on \u201cbio\u201d in bio-nanoscience: the impact of biological factors on nanomaterial interactions. Adv Healthc Mater. 2021;16:e2100574.","journal-title":"Adv Healthc Mater"},{"key":"1682_CR49","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1051\/medsci\/2007233257","volume":"m23","author":"L Apetoh","year":"2007","unstructured":"Apetoh L, Ghiringhelli F, Zitvogel L. Calreticulin exposure dictates the immunogenicity of cancer cell death. m\u00e9decine\/sciences. 2007;m23:257\u20138.","journal-title":"m\u00e9decine\/sciences"},{"key":"1682_CR50","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1600-065X.2007.00574.x","volume":"220","author":"ME Bianchi","year":"2007","unstructured":"Bianchi ME, Manfredi AA. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev. 2007;220:35\u201346.","journal-title":"Immunol Rev"},{"key":"1682_CR51","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/nature08296","volume":"461","author":"MR Elliott","year":"2009","unstructured":"Elliott MR, Chekeni FB, Trampont PC, Lazarowski ER, Kadl A, Walk SF, Park D, Woodson RI, Ostankovich M, Sharma P, Lysiak JJ, Harden TK, Leitinger N, Ravichandran KS. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature. 2009;461:282\u20136.","journal-title":"Nature"},{"key":"1682_CR52","doi-asserted-by":"publisher","first-page":"924","DOI":"10.3389\/fimmu.2020.00924","volume":"11","author":"A Gardner","year":"2020","unstructured":"Gardner A, de Mingo Pulido \u00c1, Ruffell B. Dendritic cells and their role in immunotherapy. Front Immunol. 2020;11:924.","journal-title":"Front Immunol"},{"key":"1682_CR53","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1126\/science.aaa3828","volume":"348","author":"BM Carreno","year":"2015","unstructured":"Carreno BM, Magrini V, Becker-Hapak M, Kaabinejadian S, Hundal J, Petti AA, Ly A, Lie WR, Hildebrand WH, Mardis ER, Linette GP. Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells. Science. 2015;348:803\u20138.","journal-title":"Science"},{"key":"1682_CR54","doi-asserted-by":"publisher","first-page":"102753","DOI":"10.1016\/j.cis.2022.102753","volume":"308","author":"Y Ren","year":"2022","unstructured":"Ren Y, Yan Y, Qi H. Photothermal conversion and transfer in photothermal therapy: from macroscale to nanoscale. Adv Colloid Interface Sci. 2022;308:102753.","journal-title":"Adv Colloid Interface Sci"},{"key":"1682_CR55","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.canlet.2015.02.052","volume":"361","author":"L Liu","year":"2015","unstructured":"Liu L, Chang S, Sun J, Zhu S, Yin M, Zhu Y, Wang Z, Xu X. Ultrasound-mediated destruction of paclitaxel and oxygen loaded lipid microbubbles for combination therapy in ovarian cancer xenografts. Cancer Lett. 2015;361:147\u201354.","journal-title":"Cancer Lett"},{"key":"1682_CR56","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/s41419-020-03221-2","volume":"11","author":"J Fucikova","year":"2020","unstructured":"Fucikova J, Kepp O, Kasikova L, Petroni G, Yamazaki T, Liu P, Zhao L, Spisek R, Kroemer G, Galluzzi L. Detection of immunogenic cell death and its relevance for cancer therapy. Cell Death Dis. 2020;11:1013.","journal-title":"Cell Death Dis"},{"key":"1682_CR57","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/imr.12432","volume":"272","author":"A Alloatti","year":"2016","unstructured":"Alloatti A, Kotsias F, Magalhaes JG, Amigorena S. Dendritic cell maturation and cross-presentation: timing matters! Immunol Rev. 2016;272:97\u2013108.","journal-title":"Immunol Rev"},{"key":"1682_CR58","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41568-021-00346-0","volume":"21","author":"M Saxena","year":"2021","unstructured":"Saxena M, van der Burg SH, Melief CJM, Bhardwaj N. Therapeutic cancer vaccines. Nat Rev Cancer. 2021;21:360\u201378.","journal-title":"Nat Rev Cancer"},{"key":"1682_CR59","doi-asserted-by":"publisher","first-page":"eaal2094","DOI":"10.1126\/scitranslmed.aal2094","volume":"9","author":"F Liang","year":"2017","unstructured":"Liang F, Lindgren G, Sandgren KJ, Thompson EA, Francica JR, Seubert A, De Gregorio E, Barnett S, O\u2019Hagan DT, Sullivan NJ, Koup RA, Seder RA, Lor\u00e9 K. Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake. Sci Transl Med. 2017;9:eaal2094.","journal-title":"Sci Transl Med"},{"key":"1682_CR60","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nri.2015.3","volume":"16","author":"SN Mueller","year":"2016","unstructured":"Mueller SN, Mackay LK. Tissue-resident memory T cells: local specialists in immune defense. Nat Rev Immunol. 2016;16:79\u201389.","journal-title":"Nat Rev Immunol"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-022-01682-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-022-01682-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-022-01682-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T17:18:55Z","timestamp":1667668735000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-022-01682-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,3]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1682"],"URL":"https:\/\/doi.org\/10.1186\/s12951-022-01682-5","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,3]]},"assertion":[{"value":"5 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study is approved by the Animal Ethics Committee of Chongqing Medical University. Zhejiang University School of Medicine. All animals were treated under the Guidelines for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors agree to submit the manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"468"}}