{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:11:05Z","timestamp":1792800665810,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant No.82172838"],"award-info":[{"award-number":["Grant No.82172838"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"333 Project Excellent Young Talents Project of Jiangsu Province"},{"name":"Key Medical Research Projects of Jiangsu Provincial Health Commission","id":[{"id":"https:\/\/ror.org\/03eqskn19","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Social Development Project of Zhenjiang, Jiangsu Province","award":["Grant No. SH2023057"],"award-info":[{"award-number":["Grant No. SH2023057"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Premature ovarian insufficiency (POI) is an important cause of female infertility and seriously impacts the physical and psychological health of patients. Human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exs, H-Exs) have exhibited protective effects on ovarian function with unclear mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive analysis of the Gene Expression Omnibus (GEO) database were used to identify POI-associated circRNAs and miRNAs. The relationship between HucMSC-derived exosomal circBRCA1\/miR-642a-5p\/FOXO1 axis and POI was examined by RT-qPCR, Western blotting, reactive oxygen species (ROS) staining, senescence-associated \u03b2-gal (SA-\u03b2-gal) staining, JC-1 staining, TEM, oxygen consumption rate (OCR) measurements and ATP assay in\n                      <jats:italic>vivo<\/jats:italic>\n                      and in\n                      <jats:italic>vitro<\/jats:italic>\n                      . RT-qPCR detected the expression of circBRCA1 in GCs and serum of patients with normal ovarian reserve function (n\u2009=\u200950) and patients with POI (n\u2009=\u200950); then, the correlation of circBRCA1 with ovarian reserve function indexes was analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Herein, we found that circBRCA1 was decreased in the serum and ovarian granulosa cells (GCs) of patients with POI and was associated with decreased ovarian reserve. H-Exs improved the disorder of the estrous cycles and reproductive hormone levels, reduced the number of atretic follicles, and alleviated the apoptosis and senescence of GCs in rats with POI. Moreover, H-Exs mitigated mitochondrial damage and reversed the reduced circBRCA1 expression induced by oxidative stress in GCs. Mechanistically, FTO served as an eraser to increase the stability and expression of circBRCA1 by mediating the m\n                      <jats:sup>6<\/jats:sup>\n                      A demethylation of circBRCA1, and exosomal circBRCA1 sponged miR-642a-5p to block its interaction with FOXO1. CircBRCA1 insufficiency aggravated mitochondrial dysfunction, mimicking FTO or FOXO1 depletion effects, which was counteracted by miR-642a-5p inhibition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      H-Exs secreted circBRCA1 regulated by m\n                      <jats:sup>6<\/jats:sup>\n                      A modification, directly sponged miR-642a-5p to upregulate FOXO1, resisted oxidative stress injuries in GCs and protected ovarian function in rats with POI. Exosomal circBRCA1 supplementation may be a general prospect for the prevention and treatment of POI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s12951-024-02583-5","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T02:02:09Z","timestamp":1719280929000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p\/FOXO1 axis"],"prefix":"10.1186","volume":"22","author":[{"given":"Xiaolan","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"2583_CR1","doi-asserted-by":"publisher","first-page":"5871","DOI":"10.1038\/s41467-022-33323-8","volume":"13","author":"F Wang","year":"2022","unstructured":"Wang F, Liu Y, Ni F, Jin J, Wu Y, Huang Y, Ye X, Shen X, Ying Y, Chen J, Chen R, Zhang Y, Sun X, Wang S, Xu X, Chen C, Guo J, Zhang D. BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency. Nat Commun. 2022;13:5871.","journal-title":"Nat Commun"},{"key":"2583_CR2","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1210\/en.2019-00441","volume":"160","author":"D Tiosano","year":"2019","unstructured":"Tiosano D, Mears JA, Buchner DA. Mitochondrial dysfunction in primary ovarian insufficiency. Endocrinology. 2019;160:2353\u201366.","journal-title":"Endocrinology"},{"key":"2583_CR3","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1111\/jcmm.17264","volume":"26","author":"L Lin","year":"2022","unstructured":"Lin L, Gao W, Chen Y, Li T, Sha C, Chen L, Yang M, Wei H, Chen Y, Zhu X. Reactive oxygen species-induced SIAH1 promotes granulosa cells\u2019 senescence in premature ovarian failure. J Cell Mol Med. 2022;26:2417\u201327.","journal-title":"J Cell Mol Med"},{"key":"2583_CR4","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.redox.2015.09.005","volume":"6","author":"J Dan Dunn","year":"2015","unstructured":"Dan Dunn J, Alvarez LA, Zhang X, Soldati T. Reactive oxygen species and mitochondria: a nexus of cellular homeostasis. Redox Biol. 2015;6:472\u201385.","journal-title":"Redox Biol"},{"key":"2583_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102684","volume":"62","author":"X Wang","year":"2023","unstructured":"Wang X, Yang J, Li H, Mu H, Zeng L, Cai S, Su P, Li H, Zhang L, Xiang W. miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation. Redox Biol. 2023;62: 102684.","journal-title":"Redox Biol"},{"key":"2583_CR6","doi-asserted-by":"publisher","first-page":"4217","DOI":"10.1002\/jcp.29376","volume":"235","author":"M Ghahremani-Nasab","year":"2020","unstructured":"Ghahremani-Nasab M, Ghanbari E, Jahanbani Y, Mehdizadeh A, Yousefi M. Premature ovarian failure and tissue engineering. J Cell Physiol. 2020;235:4217\u201326.","journal-title":"J Cell Physiol"},{"key":"2583_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2023.503651","volume":"889","author":"X Hu","year":"2023","unstructured":"Hu X, He C, Zhang L, Zhang Y, Chen L, Sun C, Wei J, Yang L, Tan X, Yang J, Zhang Y. Mesenchymal stem cell-derived exosomes attenuate DNA damage response induced by cisplatin and bleomycin. Mutat Res Genet Toxicol Environ Mutagen. 2023;889: 503651.","journal-title":"Mutat Res Genet Toxicol Environ Mutagen"},{"key":"2583_CR8","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s13287-021-02255-3","volume":"12","author":"S Zhang","year":"2021","unstructured":"Zhang S, Huang B, Su P, Chang Q, Li P, Song A, Zhao X, Yuan Z, Tan J. Concentrated exosomes from menstrual blood-derived stromal cells improves ovarian activity in a rat model of premature ovarian insufficiency. Stem Cell Res Ther. 2021;12:178.","journal-title":"Stem Cell Res Ther"},{"key":"2583_CR9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.omtn.2020.05.013","volume":"21","author":"C Ding","year":"2020","unstructured":"Ding C, Qian C, Hou S, Lu J, Zou Q, Li H, Huang B. Exosomal miRNA-320a is released from hAMSCs and regulates SIRT4 to prevent reactive oxygen species generation in POI. Mol Ther Nucleic Acids. 2020;21:37\u201350.","journal-title":"Mol Ther Nucleic Acids"},{"key":"2583_CR10","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1186\/s13287-022-03056-y","volume":"13","author":"Q Qu","year":"2022","unstructured":"Qu Q, Liu L, Cui Y, Liu H, Yi J, Bing W, Liu C, Jiang D, Bi Y. miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis in a preclinical rat model of premature ovarian failure. Stem Cell Res Ther. 2022;13:352.","journal-title":"Stem Cell Res Ther"},{"key":"2583_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/php.13801","author":"W Gao","year":"2023","unstructured":"Gao W, Zhang Y, Yuan L, Huang F, Wang Y-S. Long non-coding RNA H19-overexpressing exosomes ameliorate UVB-induced photoaging by upregulating SIRT1 Via sponging miR-138. Photochem Photobiol. 2023. https:\/\/doi.org\/10.1111\/php.13801.","journal-title":"Photochem Photobiol"},{"key":"2583_CR12","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","volume":"20","author":"LS Kristensen","year":"2019","unstructured":"Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20:675\u201391.","journal-title":"Nat Rev Genet"},{"key":"2583_CR13","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","volume":"495","author":"S Memczak","year":"2013","unstructured":"Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495:333\u20138.","journal-title":"Nature"},{"key":"2583_CR14","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature11993","volume":"495","author":"TB Hansen","year":"2013","unstructured":"Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, Kjems J. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495:384\u20138.","journal-title":"Nature"},{"key":"2583_CR15","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3389\/fcell.2020.00050","volume":"8","author":"AM Tran","year":"2020","unstructured":"Tran AM, Chalbatani GM, Berland L, Cruz De los Santos M, Raj P, Jalali SA, Gharagouzloo E, Ivan C, Dragomir MP, Calin GA. A new world of biomarkers and therapeutics for female reproductive system and breast cancers: circular RNAs. Front Cell Dev Biol. 2020;8:50.","journal-title":"Front Cell Dev Biol"},{"key":"2583_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177888","volume":"12","author":"J Cheng","year":"2017","unstructured":"Cheng J, Huang J, Yuan S, Zhou S, Yan W, Shen W, Chen Y, Xia X, Luo A, Zhu D, Wang S. Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. PLoS ONE. 2017;12: e0177888.","journal-title":"PLoS ONE"},{"key":"2583_CR17","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature12730","volume":"505","author":"X Wang","year":"2014","unstructured":"Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014;505:117\u201320.","journal-title":"Nature"},{"key":"2583_CR18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12943-020-01224-3","volume":"19","author":"L Zhang","year":"2020","unstructured":"Zhang L, Hou C, Chen C, Guo Y, Yuan W, Yin D, Liu J, Sun Z. The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs. Mol Cancer. 2020;19:105.","journal-title":"Mol Cancer"},{"key":"2583_CR19","doi-asserted-by":"publisher","first-page":"7055","DOI":"10.1002\/jcp.26507","volume":"233","author":"C Ding","year":"2018","unstructured":"Ding C, Zou Q, Ding J, Ling M, Wang W, Li H, Huang B. Increased N6-methyladenosine causes infertility is associated with FTO expression. J Cell Physiol. 2018;233:7055\u201366.","journal-title":"J Cell Physiol"},{"key":"2583_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.884295","volume":"10","author":"X Sun","year":"2022","unstructured":"Sun X, Lu J, Li H, Huang B. The role of m6A on female reproduction and fertility: from gonad development to ovarian aging. Front Cell Dev Biol. 2022;10: 884295.","journal-title":"Front Cell Dev Biol"},{"key":"2583_CR21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nchembio.1432","volume":"10","author":"J Liu","year":"2014","unstructured":"Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol. 2014;10:93\u20135.","journal-title":"Nat Chem Biol"},{"key":"2583_CR22","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nchembio.687","volume":"7","author":"G Jia","year":"2011","unstructured":"Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang Y-G, He C. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. 2011;7:885\u20137.","journal-title":"Nat Chem Biol"},{"key":"2583_CR23","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","volume":"49","author":"G Zheng","year":"2013","unstructured":"Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang C-M, Li CJ, V\u00e5gb\u00f8 CB, Shi Y, Wang W-L, Song S-H, Lu Z, Bosmans RPG, Dai Q, Hao Y-J, Yang X, Zhao W-M, Tong W-M, Wang X-J, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang Y-G, He C. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013;49:18\u201329.","journal-title":"Mol Cell"},{"key":"2583_CR24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12958-022-00911-8","volume":"20","author":"R Wang","year":"2022","unstructured":"Wang R, Wang W, Wang L, Yuan L, Cheng F, Guan X, Zheng N, Yang X. FTO protects human granulosa cells from chemotherapy-induced cytotoxicity. Reprod Biol Endocrinol RBE. 2022;20:39.","journal-title":"Reprod Biol Endocrinol RBE"},{"key":"2583_CR25","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/s41419-021-04016-9","volume":"12","author":"Z-X Jiang","year":"2021","unstructured":"Jiang Z-X, Wang Y-N, Li Z-Y, Dai Z-H, He Y, Chu K, Gu J-Y, Ji Y-X, Sun N-X, Yang F, Li W. The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging. Cell Death Dis. 2021;12:744.","journal-title":"Cell Death Dis"},{"key":"2583_CR26","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12943-022-01575-z","volume":"21","author":"A Du","year":"2022","unstructured":"Du A, Li S, Zhou Y, Disoma C, Liao Y, Zhang Y, Chen Z, Yang Q, Liu P, Liu S, Dong Z, Razzaq A, Tao S, Chen X, Liu Y, Xu L, Zhang Q, Li S, Peng J, Xia Z. M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma. Mol Cancer. 2022;21:109.","journal-title":"Mol Cancer"},{"key":"2583_CR27","doi-asserted-by":"publisher","first-page":"4695","DOI":"10.1038\/s41467-019-12651-2","volume":"10","author":"R-X Chen","year":"2019","unstructured":"Chen R-X, Chen X, Xia L-P, Zhang J-X, Pan Z-Z, Ma X-D, Han K, Chen J-W, Judde J-G, Deas O, Wang F, Ma N-F, Guan X, Yun J-P, Wang F-W, Xu R-H, Xie D. N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. Nat Commun. 2019;10:4695.","journal-title":"Nat Commun"},{"key":"2583_CR28","first-page":"356","volume":"29","author":"Y Yan","year":"2009","unstructured":"Yan Y, Xu W, Qian H, Si Y, Zhu W, Cao H, Zhou H, Mao F. Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver Int Off J Int Assoc Study Liver. 2009;29:356\u201365.","journal-title":"Liver Int Off J Int Assoc Study Liver"},{"key":"2583_CR29","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13287-019-1136-x","volume":"10","author":"L Ling","year":"2019","unstructured":"Ling L, Feng X, Wei T, Wang Y, Wang Y, Wang Z, Tang D, Luo Y, Xiong Z. Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly through a paracrine mechanism. Stem Cell Res Ther. 2019;10:46.","journal-title":"Stem Cell Res Ther"},{"key":"2583_CR30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13287-016-0458-1","volume":"8","author":"Z Wang","year":"2017","unstructured":"Wang Z, Wang Y, Yang T, Li J, Yang X. Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice. Stem Cell Res Ther. 2017;8:11.","journal-title":"Stem Cell Res Ther"},{"key":"2583_CR31","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/s41374-019-0321-y","volume":"100","author":"M Yang","year":"2020","unstructured":"Yang M, Lin L, Sha C, Li T, Zhao D, Wei H, Chen Q, Liu Y, Chen X, Xu W, Li Y, Zhu X. Bone marrow mesenchymal stem cell-derived exosomal miR-144-5p improves rat ovarian function after chemotherapy-induced ovarian failure by targeting PTEN. Lab Investig J Tech Methods Pathol. 2020;100:342\u201352.","journal-title":"Lab Investig J Tech Methods Pathol"},{"key":"2583_CR32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158447","volume":"132","author":"S Miwa","year":"2022","unstructured":"Miwa S, Kashyap S, Chini E, von Zglinicki T. Mitochondrial dysfunction in cell senescence and aging. J Clin Invest. 2022;132: e158447.","journal-title":"J Clin Invest"},{"key":"2583_CR33","first-page":"1903616","volume":"7","author":"Q Chen","year":"2020","unstructured":"Chen Q, Lei JH, Bao J, Wang H, Hao W, Li L, Peng C, Masuda T, Miao K, Xu J, Xu X, Deng C-X. BRCA1 Deficiency impairs mitophagy and promotes inflammasome activation and mammary tumor metastasis. Adv Sci Weinh Baden-Wurtt Ger. 2020;7:1903616.","journal-title":"Adv Sci Weinh Baden-Wurtt Ger"},{"key":"2583_CR34","doi-asserted-by":"publisher","first-page":"5920","DOI":"10.1158\/0008-5472.CAN-19-1405","volume":"79","author":"A Kanakkanthara","year":"2019","unstructured":"Kanakkanthara A, Kurmi K, Ekstrom TL, Hou X, Purfeerst ER, Heinzen EP, Correia C, Huntoon CJ, O\u2019Brien D, Wahner Hendrickson AE, Dowdy SC, Li H, Oberg AL, Hitosugi T, Kaufmann SH, Weroha SJ, Karnitz LM. BRCA1 deficiency upregulates NNMT, which reprograms metabolism and sensitizes ovarian cancer cells to mitochondrial metabolic targeting agents. Cancer Res. 2019;79:5920\u20139.","journal-title":"Cancer Res"},{"key":"2583_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102356","volume":"54","author":"Y Kong","year":"2022","unstructured":"Kong Y, Akatsuka S, Motooka Y, Zheng H, Cheng Z, Shiraki Y, Mashimo T, Imaoka T, Toyokuni S. BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance. Redox Biol. 2022;54: 102356.","journal-title":"Redox Biol"},{"key":"2583_CR36","doi-asserted-by":"publisher","first-page":"1172481","DOI":"10.3389\/fendo.2023.1172481","volume":"14","author":"Y-Q Shi","year":"2023","unstructured":"Shi Y-Q, Zhu X-T, Zhang S-N, Ma Y-F, Han Y-H, Jiang Y, Zhang Y-H. Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants. Front Endocrinol. 2023;14:1172481.","journal-title":"Front Endocrinol"},{"key":"2583_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108123","volume":"234","author":"H Wang","year":"2022","unstructured":"Wang H, Meng Q, Qian J, Li M, Gu C, Yang Y. Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer. Pharmacol Ther. 2022;234: 108123.","journal-title":"Pharmacol Ther"},{"key":"2583_CR38","doi-asserted-by":"publisher","first-page":"933","DOI":"10.3892\/or.2020.7905","volume":"45","author":"X Wang","year":"2021","unstructured":"Wang X, Song Z, Hu B, Chen Z, Chen F, Cao C. MicroRNA-642a-5p inhibits colon cancer cell migration and invasion by targeting collagen type I \u03b11. Oncol Rep. 2021;45:933\u201344.","journal-title":"Oncol Rep"},{"key":"2583_CR39","doi-asserted-by":"publisher","first-page":"18003","DOI":"10.1038\/s41598-021-97190-x","volume":"11","author":"DJ Beveridge","year":"2021","unstructured":"Beveridge DJ, Richardson KL, Epis MR, Brown RAM, Stuart LM, Woo AJ, Leedman PJ. The tumor suppressor miR-642a-5p targets Wilms Tumor 1 gene and cell-cycle progression in prostate cancer. Sci Rep. 2021;11:18003.","journal-title":"Sci Rep"},{"key":"2583_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2020.106604","volume":"221","author":"Q Han","year":"2020","unstructured":"Han Q, Guo X, Jia K, Jing J, Dang W, Li Y, Qin X, Li P, Ren Y, Liu W, Kebreab E, Lyu L. Effects of FOXO1 on the proliferation and cell cycle-, apoptosis- and steroidogenesis-related genes expression in sheep granulosa cells. Anim Reprod Sci. 2020;221: 106604.","journal-title":"Anim Reprod Sci"},{"key":"2583_CR41","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.molcel.2018.02.015","volume":"69","author":"J Wen","year":"2018","unstructured":"Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, Shi YG, He C, Shi Y, Diao J. Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal. Mol Cell. 2018;69:1028-1038.e6.","journal-title":"Mol Cell"},{"key":"2583_CR42","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13046-022-02254-z","volume":"41","author":"J Huang","year":"2022","unstructured":"Huang J, Sun W, Wang Z, Lv C, Zhang T, Zhang D, Dong W, Shao L, He L, Ji X, Zhang P, Zhang H. FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner. J Exp Clin Cancer Res CR. 2022;41:42.","journal-title":"J Exp Clin Cancer Res CR"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-024-02583-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-024-02583-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-024-02583-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T03:06:18Z","timestamp":1719284778000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-024-02583-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2583"],"URL":"https:\/\/doi.org\/10.1186\/s12951-024-02583-5","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]},"assertion":[{"value":"24 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The collection of patients' GCs and serum samples was approved by the Ethics Committee of The Fourth Affiliated Hospital of Jiangsu University (Zhenjiang Maternal and Child Health Hospital), which was in accordance with the ethical requirements, and all subjects participated voluntarily and signed a written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"367"}}