{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:42:41Z","timestamp":1790991761321,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["22007005"],"award-info":[{"award-number":["22007005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21804010"],"award-info":[{"award-number":["21804010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Initiation Fund of Binzhou Medical University","award":["BY2020KYQD01"],"award-info":[{"award-number":["BY2020KYQD01"]}]},{"name":"Research Initiation Fund of Binzhou Medical University","award":["BY2019KYQD39"],"award-info":[{"award-number":["BY2019KYQD39"]}]},{"name":"Research Initiation Fund of Binzhou Medical University","award":["50012304601"],"award-info":[{"award-number":["50012304601"]}]},{"name":"Taishan Scholar Project Special Funding","award":["ts20190962"],"award-info":[{"award-number":["ts20190962"]}]},{"name":"Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization","award":["2018LS014"],"award-info":[{"award-number":["2018LS014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-024-02878-7","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T12:02:29Z","timestamp":1727784149000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["NIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic\/gas therapy"],"prefix":"10.1186","volume":"22","author":[{"given":"Lili","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"2878_CR1","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1021\/jacs.0c10517","volume":"143","author":"J Sun","year":"2021","unstructured":"Sun J, Cai X, Wang C, Du K, Chen W, Feng F, Wang S. Cascade reactions by Nitric Oxide and Hydrogen Radical for Anti-hypoxia Photodynamic Therapy using an Activatable Photosensitizer. J Am Chem Soc. 2021;143:868\u201378.","journal-title":"J Am Chem Soc"},{"key":"2878_CR2","doi-asserted-by":"publisher","first-page":"2000189","DOI":"10.1002\/adfm.202000189","volume":"30","author":"C Zhang","year":"2020","unstructured":"Zhang C, Xia DL, Liu JH, Huo D, Jiang XQ, Hu Y. Bypassing the immunosuppression of myeloid-derived suppressor cells by reversing Tumor Hypoxia using a platelet-inspired platform. Adv Funct Mater. 2020;30:2000189\u2013200207.","journal-title":"Adv Funct Mater"},{"key":"2878_CR3","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1021\/acs.nanolett.1c04369","volume":"22","author":"C Zhang","year":"2022","unstructured":"Zhang C, Yuan YF, Wu KJ, Wang Y, Zhu ST, Shi JY, Wang LH, Li Q, Zuo XL, Fan CH, Chang C, Li J. Driving DNA Origami Assembly with a Terahertz Wave. Nano Lett. 2022;22:468\u201375.","journal-title":"Nano Lett"},{"key":"2878_CR4","first-page":"1","volume":"7","author":"L Li","year":"2024","unstructured":"Li L, He SH, Liao BY, Wang MC, Lin HM, Hu B, Lan XY, Shu ZL, Zhang C, Yu M, Zou ZW. Orally Administrated Hydrogel Harnessing Intratumoral Microbiome and Microbiota-Related Immune responses for Potentiated Colorectal Cancer Treatment. Research-China. 2024;7:1\u201321.","journal-title":"Research-China"},{"key":"2878_CR5","doi-asserted-by":"publisher","first-page":"4211","DOI":"10.1021\/acs.nanolett.0c00650","volume":"20","author":"H Huang","year":"2020","unstructured":"Huang H, Zhang C, Wang XL, Shao JS, Chen C, Li HM, Ju CM, He J, Gu HY, Xia DL. Overcoming hypoxia-restrained Radiotherapy using an erythrocyte-inspired and glucose-activatable platform. Nano Lett. 2020;20:4211\u20139.","journal-title":"Nano Lett"},{"key":"2878_CR6","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.actbio.2018.09.017","volume":"80","author":"HQ Zuo","year":"2018","unstructured":"Zuo HQ, Tao JX, Shi H, He J, Zhou ZY, Zhang C. Platelet-mimicking nanoparticles co-loaded with WO and metformin alleviate tumor hypoxia for enhanced photodynamic therapy and photothermal therapy. Acta Biomater. 2018;80:296\u2013307.","journal-title":"Acta Biomater"},{"key":"2878_CR7","doi-asserted-by":"publisher","first-page":"3750","DOI":"10.1002\/smll.201400437","volume":"10","author":"J Xu","year":"2014","unstructured":"Xu J, Zeng F, Wu H, Hu C, Yu C, Wu S. Preparation of a mitochondria-targeted and NO-releasing nanoplatform and its enhanced pro-apoptotic effect on cancer cells. Small. 2014;10:3750\u201360.","journal-title":"Small"},{"key":"2878_CR8","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.biomaterials.2018.03.046","volume":"168","author":"C Hu","year":"2018","unstructured":"Hu C, Cun X, Ruan S, Liu R, Xiao W, Yang X, Yang Y, Yang C, Gao H. Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy. Biomaterials. 2018;168:64\u201375.","journal-title":"Biomaterials"},{"key":"2878_CR9","doi-asserted-by":"publisher","first-page":"119636","DOI":"10.1016\/j.biomaterials.2019.119636","volume":"230","author":"J An","year":"2020","unstructured":"An J, Hu YG, Li C, Hou XL, Cheng K, Zhang B, Zhang RY, Li DY, Liu SJ, Liu B, Zhu D, Zhao YD. A pH\/Ultrasound dual-response biomimetic nanoplatform for nitric oxide gas-sonodynamic combined therapy and repeated ultrasound for relieving hypoxia. Biomaterials. 2020;230:119636.","journal-title":"Biomaterials"},{"key":"2878_CR10","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.biomaterials.2018.09.043","volume":"187","author":"Y Deng","year":"2018","unstructured":"Deng Y, Jia F, Chen S, Shen Z, Jin Q, Fu G, Ji J. Nitric oxide as an all-rounder for enhanced photodynamic therapy: Hypoxia relief, glutathione depletion and reactive nitrogen species generation. Biomaterials. 2018;187:55\u201365.","journal-title":"Biomaterials"},{"key":"2878_CR11","doi-asserted-by":"publisher","first-page":"9393","DOI":"10.3390\/ijms21249393","volume":"21","author":"FH Khan","year":"2020","unstructured":"Khan FH, Dervan E, Bhattacharyya DD, McAuliffe JD, Miranda KM, Glynn SA. The role of nitric oxide in Cancer: Master Regulator or NOt? Int. J Mol Sci. 2020;21:9393.","journal-title":"J Mol Sci"},{"key":"2878_CR12","doi-asserted-by":"crossref","unstructured":"Nwahara N, Motaung M, Abrahams G, Mashazi P, Mack J, Prinsloo E, et al. Dual singlet oxygen and nitric oxide-releasing silicon phthalocyanine for augmented photodynamic therapy. Mater Today Chem. 2022;26:101201.","DOI":"10.1016\/j.mtchem.2022.101201"},{"key":"2878_CR13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1021\/acs.joc.8b02521","volume":"84","author":"J Gayton","year":"2019","unstructured":"Gayton J, Autry SA, Meador W, Parkin SR, Hill GJ, Hammer NI, Delcamp JH. Indolizine-cyanine dyes: Near Infrared Emissive Cyanine dyes with increased Stokes shifts. J Org Chem. 2019;84:687\u201397.","journal-title":"J Org Chem"},{"key":"2878_CR14","doi-asserted-by":"publisher","first-page":"e1900321","DOI":"10.1002\/adma.201900321","volume":"31","author":"S Zhu","year":"2019","unstructured":"Zhu S, Tian R, Antaris AL, Chen X, Dai H. Near-Infrared-II Molecular dyes for Cancer imaging and surgery. Adv Mater. 2019;31:e1900321.","journal-title":"Adv Mater"},{"key":"2878_CR15","doi-asserted-by":"publisher","first-page":"12220","DOI":"10.1039\/C9NR02296A","volume":"11","author":"Y Huang","year":"2019","unstructured":"Huang Y, Liu Q, Wang Y, He N, Zhao R, Choo J, Chen L. Gold nanorods functionalized by a glutathione response near-infrared fluorescent probe as a promising nanoplatform for fluorescence imaging guided precision therapy. Nanoscale. 2019;11:12220\u20139.","journal-title":"Nanoscale"},{"key":"2878_CR16","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.addr.2021.04.023","volume":"174","author":"K Thananukul","year":"2021","unstructured":"Thananukul K, Kaewsaneha C, Opaprakasit P, Lebaz N, Errachid A, Elaissari A. Smart gating porous particles as new carriers for drug delivery. Adv Drug Deliv Rev. 2021;174:425\u201346.","journal-title":"Adv Drug Deliv Rev"},{"key":"2878_CR17","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s11426-016-0409-4","volume":"60","author":"J Wen","year":"2017","unstructured":"Wen J, Yan H, Xia PY, Xu YQ, Li HJ, Sun SG. Mesoporous silica nanoparticles-assisted ruthenium(II) complexes for live cell staining. Sci China Chem. 2017;60:799\u2013805.","journal-title":"Sci China Chem"},{"key":"2878_CR18","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3389\/fchem.2017.00118","volume":"5","author":"T Zhao","year":"2017","unstructured":"Zhao T, Nguyen NT, Xie Y, Sun X, Li Q, Li X. Inorganic nanocrystals functionalized mesoporous silica nanoparticles: fabrication and enhanced bio-applications. Front Chem. 2017;5:118.","journal-title":"Front Chem"},{"key":"2878_CR19","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1177\/0748233715622307","volume":"33","author":"N Rawat","year":"2017","unstructured":"Rawat N, Sandhya K, Subaharan M, Eswaramoorthy G, Kaul. Comparative in vivo toxicity assessment places multiwalled carbon nanotubes at a higher level than mesoporous silica nanoparticles. Toxicol Ind Health. 2017;33:182\u201392.","journal-title":"Toxicol Ind Health"},{"key":"2878_CR20","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1002\/smll.201000538","volume":"6","author":"J Lu","year":"2010","unstructured":"Lu J, Liong M, Li Z, Zink JI, Tamanoi F. Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals. Small. 2010;6:1794\u2013805.","journal-title":"Small"},{"key":"2878_CR21","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1039\/C5CS00798D","volume":"45","author":"M Karimi","year":"2016","unstructured":"Karimi M, Ghasemi A, Sahandi ZP, Rahighi R, Moosavi BS, Mirshekari H, Amiri M, Shafaei PZ, Aslani A, Bozorgomid M, Ghosh D, Beyzavi A, Vaseghi A, Aref AR, Haghani L, Bahrami S, Hamblin MR. Smart micro\/nanoparticles in stimulus-responsive drug\/gene delivery systems. Chem Soc Rev. 2016;45:1457\u2013501.","journal-title":"Chem Soc Rev"},{"key":"2878_CR22","doi-asserted-by":"crossref","unstructured":"Chang MY, Wang M, Liu YH, Liu M, Al Kheraif AA, Ma PA, Zhao YL, Lin J. Dendritic plasmonic CuPt alloys for closed-Loop Multimode Cancer Therapy with remarkably enhanced efficacy. Small 19 (2023).","DOI":"10.1002\/smll.202206423"},{"key":"2878_CR23","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1517\/17425247.2014.953051","volume":"12","author":"A Baeza","year":"2015","unstructured":"Baeza A, Colilla M, Vallet-Regi M. Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery. Expert Opin Drug Deliv. 2015;12:319\u201337.","journal-title":"Expert Opin Drug Deliv"},{"key":"2878_CR24","doi-asserted-by":"publisher","first-page":"e202103642","DOI":"10.1002\/chem.202103642","volume":"28","author":"C Xing","year":"2022","unstructured":"Xing C, Deng J, Fu W, Li J, Xu L, Sun R, Wang D, Li C, Liang K, Gao M, Kong B. Interfacially Super-assembled Benzimidazole Derivative-based mesoporous silica nanoprobe for sensitive copper (II) detection and Biosensing in living cells. Chemistry. 2022;28:e202103642.","journal-title":"Chemistry"},{"key":"2878_CR25","doi-asserted-by":"publisher","first-page":"2002525","DOI":"10.1002\/advs.202002525","volume":"8","author":"MM Wan","year":"2021","unstructured":"Wan MM, Chen H, Da WZ, Liu ZY, Yu YQ, Li L, Miao ZY, Wang XW, Wang Q, Mao C, Shen J, Wei J. Nitric oxide-driven Nanomotor for Deep tissue penetration and Multidrug Resistance reversal in Cancer Therapy. Adv Sci (Weinh). 2021;8:2002525.","journal-title":"Adv Sci (Weinh)"},{"key":"2878_CR26","doi-asserted-by":"publisher","first-page":"5323","DOI":"10.1039\/c3cs35531d","volume":"42","author":"J Zhao","year":"2013","unstructured":"Zhao J, Wu W, Sun J, Guo S. Triplet photosensitizers: from molecular design to applications. Chem Soc Rev. 2013;42:5323\u201351.","journal-title":"Chem Soc Rev"},{"key":"2878_CR27","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1021\/acscatal.7b03423","volume":"8","author":"WT Wu","year":"2018","unstructured":"Wu WT, Zhang QG, Wang RQ, Zhao YF, Li ZT, Ning H, Zhao QS, Wiederrecht GP, Qiu JS, Wu MB. Synergies between Unsaturated Zn\/Cu Doping sites in Carbon dots provide New pathways for Photocatalytic Oxidation. Acs Catal. 2018;8:747\u201353.","journal-title":"Acs Catal"},{"key":"2878_CR28","doi-asserted-by":"publisher","first-page":"1900037","DOI":"10.1002\/advs.201900037","volume":"6","author":"M Yu","year":"2019","unstructured":"Yu M, Duan X, Cai Y, Zhang F, Jiang S, Han S, Shen J, Shuai X. Multifunctional Nanoregulator reshapes Immune Microenvironment and enhances Immune Memory for Tumor Immunotherapy. Adv Sci (Weinh). 2019;6:1900037.","journal-title":"Adv Sci (Weinh)"},{"key":"2878_CR29","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1124\/mol.106.027029","volume":"70","author":"Q Ke","year":"2006","unstructured":"Ke Q, Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol. 2006;70:1469\u201380.","journal-title":"Mol Pharmacol"},{"key":"2878_CR30","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrc1187","volume":"3","author":"GL Semenza","year":"2003","unstructured":"Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;3:721\u201332.","journal-title":"Nat Rev Cancer"},{"key":"2878_CR31","doi-asserted-by":"publisher","first-page":"3664","DOI":"10.1172\/JCI67230","volume":"123","author":"GL Semenza","year":"2013","unstructured":"Semenza GL. HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J Clin Invest. 2013;123:3664\u201371.","journal-title":"J Clin Invest"},{"key":"2878_CR32","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.jacc.2008.01.048","volume":"51","author":"R Vogel","year":"2008","unstructured":"Vogel R. Listening to the endothelium: a story of signal and noise. J Am Coll Cardiol. 2008;51:1965\u20136.","journal-title":"J Am Coll Cardiol"},{"key":"2878_CR33","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1021\/nn700191f","volume":"2","author":"EM Hetrick","year":"2008","unstructured":"Hetrick EM, Shin JH, Stasko NA, Johnson CB, Wespe DA, Holmuhamedov E, Schoenfisch MH. Bactericidal efficacy of nitric oxide-releasing silica nanoparticles. ACS Nano. 2008;2:235\u201346.","journal-title":"ACS Nano"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-024-02878-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-024-02878-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-024-02878-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T12:06:25Z","timestamp":1727784385000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-024-02878-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2878"],"URL":"https:\/\/doi.org\/10.1186\/s12951-024-02878-7","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]},"assertion":[{"value":"12 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were performed in accordance with the Guidelines for Care and Use of Laboratory Animals of Binzhou Medical University and approved by the Institutional Animal Care and Use Committee of Binzhou Medical University (Yantai, China) (Approval Number: 2023\u2009\u2212\u2009125).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"595"}}