{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:50:57Z","timestamp":1792900257715,"version":"4.5.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82171893"],"award-info":[{"award-number":["82171893"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82271943"],"award-info":[{"award-number":["82271943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Medical Joint Fund of Jinan University","award":["YXJC2022008"],"award-info":[{"award-number":["YXJC2022008"]}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012660"],"award-info":[{"award-number":["2023A1515012660"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012660"],"award-info":[{"award-number":["2023A1515012660"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Clinical Frontier Technology Program of the First Affiliated Hospital of Jinan University, China","award":["JNU1AF-CFTP-2022-a01233"],"award-info":[{"award-number":["JNU1AF-CFTP-2022-a01233"]}],"id":[{"id":"https:\/\/ror.org\/05d5vvz89","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Guangzhou Science and Technology Plan Project","award":["2023A03J1037"],"award-info":[{"award-number":["2023A03J1037"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-024-03011-4","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T22:38:49Z","timestamp":1734561529000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Synergistic enhancement of low-dose radiation therapy via cuproptosis and metabolic reprogramming for radiosensitization in in situ hepatocellular carcinoma"],"prefix":"10.1186","volume":"22","author":[{"given":"Ni","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genwen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianlan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangping","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"issue":"3","key":"3011_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J Clin. 2024;74(3):229\u201363.","journal-title":"Cancer J Clin"},{"issue":"1","key":"3011_CR2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. Cancer J Clin. 2024;74(1):12\u201349.","journal-title":"Cancer J Clin"},{"issue":"9","key":"3011_CR3","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/nrclinonc.2015.120","volume":"12","author":"D Schaue","year":"2015","unstructured":"Schaue D, McBride WH. Opportunities and challenges of radiotherapy for treating cancer. Nat Rev Clin Oncol. 2015;12(9):527\u201340.","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"3011_CR4","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/nrclinonc.2012.203","volume":"10","author":"J Thariat","year":"2013","unstructured":"Thariat J, Hannoun-Levi J-M, Sun Myint A, Vuong T, G\u00e9rard J-P. Past, present, and future of radiotherapy for the benefit of patients. Nat Rev Clin Oncol. 2013;10(1):52\u201360.","journal-title":"Nat Rev Clin Oncol"},{"key":"3011_CR5","doi-asserted-by":"crossref","unstructured":"Allen C, Her S, Jaffray DA. Radiotherapy for cancer: present and future. In; 2017. pp. 1\u20132.","DOI":"10.1016\/j.addr.2017.01.004"},{"issue":"32","key":"3011_CR6","doi-asserted-by":"publisher","first-page":"1700996","DOI":"10.1002\/adma.201700996","volume":"29","author":"G Song","year":"2017","unstructured":"Song G, Cheng L, Chao Y, Yang K, Liu Z. Emerging nanotechnology and advanced materials for cancer radiation therapy. Adv Mater. 2017;29(32):1700996.","journal-title":"Adv Mater"},{"issue":"37","key":"3011_CR7","doi-asserted-by":"publisher","first-page":"62742","DOI":"10.18632\/oncotarget.18409","volume":"8","author":"HH Chen","year":"2017","unstructured":"Chen HH, Kuo MT. Improving radiotherapy in cancer treatment: promises and challenges. Oncotarget. 2017;8(37):62742.","journal-title":"Oncotarget"},{"issue":"1","key":"3011_CR8","doi-asserted-by":"publisher","first-page":"7709","DOI":"10.1038\/s41467-023-43462-1","volume":"14","author":"S Li","year":"2023","unstructured":"Li S, Li K, Wang K, Yu H, Wang X, Shi M, et al. Low-dose radiotherapy combined with dual PD-L1 and VEGFA blockade elicits antitumor response in hepatocellular carcinoma mediated by activated intratumoral CD8(+) exhausted-like T cells. Nat Commun. 2023;14(1):7709.","journal-title":"Nat Commun"},{"issue":"6","key":"3011_CR9","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/s12276-021-00640-9","volume":"53","author":"T Suwa","year":"2021","unstructured":"Suwa T, Kobayashi M, Nam J-M, Harada H. Tumor microenvironment and radioresistance. Exp Mol Med. 2021;53(6):1029\u201335.","journal-title":"Exp Mol Med"},{"issue":"1","key":"3011_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2020.100905","volume":"14","author":"E McCann","year":"2021","unstructured":"McCann E, O\u2019Sullivan J, Marcone S. Targeting cancer-cell mitochondria and metabolism to improve radiotherapy response. Transl Oncol. 2021;14(1): 100905.","journal-title":"Transl Oncol"},{"issue":"5","key":"3011_CR11","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.molcel.2016.02.011","volume":"61","author":"WX Zong","year":"2016","unstructured":"Zong WX, Rabinowitz JD, White E. Mitochondria and cancer. Mol Cell. 2016;61(5):667\u201376.","journal-title":"Mol Cell"},{"issue":"12","key":"3011_CR12","doi-asserted-by":"publisher","first-page":"13398","DOI":"10.1096\/fj.201901366R","volume":"33","author":"Y Wang","year":"2019","unstructured":"Wang Y, Agarwal E, Bertolini I, Ghosh JC, Seo JH, Altieri DC. IDH2 reprograms mitochondrial dynamics in cancer through a HIF-1\u03b1-regulated pseudohypoxic state. Faseb J. 2019;33(12):13398\u2013411.","journal-title":"Faseb J"},{"issue":"2","key":"3011_CR13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/s41419-021-03505-1","volume":"12","author":"X Bao","year":"2021","unstructured":"Bao X, Zhang J, Huang G, Yan J, Xu C, Dou Z, et al. The crosstalk between HIFs and mitochondrial dysfunctions in cancer development. Cell Death Dis. 2021;12(2):215.","journal-title":"Cell Death Dis"},{"issue":"4","key":"3011_CR14","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.ccr.2013.02.005","volume":"23","author":"D Zhao","year":"2013","unstructured":"Zhao D, Zou SW, Liu Y, Zhou X, Mo Y, Wang P, et al. Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell. 2013;23(4):464\u201376.","journal-title":"Cancer Cell"},{"issue":"19","key":"3011_CR15","doi-asserted-by":"publisher","first-page":"11343","DOI":"10.3390\/ijms231911343","volume":"23","author":"M Zaffaroni","year":"2022","unstructured":"Zaffaroni M, Vincini MG, Corrao G, Marvaso G, Pepa M, Viglietto G, et al. Unraveling mitochondrial determinants of tumor response to radiation therapy. Int J Mol Sci. 2022;23(19):11343.","journal-title":"Int J Mol Sci"},{"key":"3011_CR16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1741-7015-7-68","volume":"7","author":"SP Pitroda","year":"2009","unstructured":"Pitroda SP, Wakim BT, Sood RF, Beveridge MG, Beckett MA, MacDermed DM, et al. STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect. BMC Med. 2009;7:68.","journal-title":"BMC Med"},{"issue":"2","key":"3011_CR17","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s41556-022-00843-w","volume":"24","author":"P Romani","year":"2022","unstructured":"Romani P, Nirchio N, Arboit M, Barbieri V, Tosi A, Michielin F, et al. Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance. Nat Cell Biol. 2022;24(2):168\u201380.","journal-title":"Nat Cell Biol"},{"issue":"5","key":"3011_CR18","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646\u201374.","journal-title":"Cell"},{"issue":"18","key":"3011_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300437","volume":"35","author":"Q Truong Hoang","year":"2023","unstructured":"Truong Hoang Q, Huynh KA, Nguyen Cao TG, Kang JH, Dang XN, Ravichandran V, et al. Piezocatalytic 2D WS(2) nanosheets for ultrasound-triggered and mitochondria-targeted piezodynamic cancer therapy synergized with energy metabolism-targeted chemotherapy. Adv Mater. 2023;35(18): e2300437.","journal-title":"Adv Mater"},{"key":"3011_CR20","doi-asserted-by":"publisher","first-page":"0335","DOI":"10.34133\/research.0335","volume":"7","author":"C Xiao","year":"2024","unstructured":"Xiao C, Li J, Hua A, Wang X, Li S, Li Z, et al. Hyperbaric oxygen boosts antitumor efficacy of copper-diethyldithiocarbamate nanoparticles against pancreatic ductal adenocarcinoma by regulating cancer stem cell metabolism. Research. 2024;7:0335.","journal-title":"Research"},{"issue":"23","key":"3011_CR21","doi-asserted-by":"publisher","first-page":"2401738","DOI":"10.1002\/advs.202401738","volume":"11","author":"X Wei","year":"2024","unstructured":"Wei X, Han R, Gao Y, Song P, Guo Z, Hou Y, et al. Boosting energy deprivation by synchronous interventions of glycolysis and oxidative phosphorylation for bioenergetic therapy synergetic with chemodynamic\/photothermal therapy. Advanced Science. 2024;11(23):2401738.","journal-title":"Advanced Science"},{"key":"3011_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122223","volume":"334","author":"Z Tian","year":"2023","unstructured":"Tian Z, Jiang S, Zhou J, Zhang W. Copper homeostasis and cuproptosis in mitochondria. Life Sci. 2023;334: 122223.","journal-title":"Life Sci"},{"issue":"43","key":"3011_CR23","doi-asserted-by":"publisher","first-page":"2204733","DOI":"10.1002\/adma.202204733","volume":"34","author":"Y Xu","year":"2022","unstructured":"Xu Y, Liu SY, Zeng L, Ma H, Zhang Y, Yang H, et al. An enzyme-engineered nonporous copper (I) coordination polymer nanoplatform for cuproptosis-based synergistic cancer therapy. Adv Mater. 2022;34(43):2204733.","journal-title":"Adv Mater"},{"key":"3011_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.06.002","volume":"62","author":"X Cao","year":"2019","unstructured":"Cao X, Wen P, Fu Y, Gao Y, Qi X, Chen B, et al. Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells. Cell Signal. 2019;62: 109337.","journal-title":"Cell Signal"},{"issue":"6586","key":"3011_CR25","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.abf0529","volume":"375","author":"P Tsvetkov","year":"2022","unstructured":"Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022;375(6586):1254\u201361.","journal-title":"Science"},{"issue":"5","key":"3011_CR26","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1038\/s41571-024-00876-0","volume":"21","author":"D Tang","year":"2024","unstructured":"Tang D, Kroemer G, Kang R. Targeting cuproplasia and cuproptosis in cancer. Nat Rev Clin Oncol. 2024;21(5):370\u201388.","journal-title":"Nat Rev Clin Oncol"},{"key":"3011_CR27","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.mattod.2023.06.024","volume":"68","author":"X-K Jin","year":"2023","unstructured":"Jin X-K, Liang J-L, Zhang S-M, Huang Q-X, Zhang S-K, Liu C-J, et al. Orchestrated copper-based nanoreactor for remodeling tumor microenvironment to amplify cuproptosis-mediated anti-tumor immunity in colorectal cancer. Mater Today. 2023;68:108\u201324.","journal-title":"Mater Today"},{"issue":"40","key":"3011_CR28","doi-asserted-by":"publisher","first-page":"2205013","DOI":"10.1002\/adfm.202205013","volume":"32","author":"W Xu","year":"2022","unstructured":"Xu W, Qian J, Hou G, Wang T, Wang J, Wang Y, et al. A hollow amorphous bimetal organic framework for synergistic cuproptosis\/ferroptosis\/apoptosis anticancer therapy via disrupting intracellular redox homeostasis and copper\/iron metabolisms. Adv Func Mater. 2022;32(40):2205013.","journal-title":"Adv Func Mater"},{"issue":"33","key":"3011_CR29","doi-asserted-by":"publisher","first-page":"2302054","DOI":"10.1002\/adfm.202302054","volume":"33","author":"L Chan","year":"2023","unstructured":"Chan L, Liu Y, Chen M, Su Y, Guo J, Zhu L, et al. Cuproptosis-driven enhancement of thermotherapy by sequentially response Cu2-xSe via copper chemical transition. Adv Func Mater. 2023;33(33):2302054.","journal-title":"Adv Func Mater"},{"issue":"3","key":"3011_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.484","volume":"5","author":"P Pei","year":"2024","unstructured":"Pei P, Wang Y, Shen W, He Q, Han X, Zhang C, et al. Oxygen-driven cuproptosis synergizes with radiotherapy to potentiate tumor immunotherapy. Aggregate. 2024;5(3): e484.","journal-title":"Aggregate"},{"issue":"19","key":"3011_CR31","doi-asserted-by":"publisher","first-page":"2308850","DOI":"10.1002\/advs.202308850","volume":"11","author":"Z Luo","year":"2024","unstructured":"Luo Z, Lu R, Shi T, Ruan Z, Wang W, Guo Z, et al. Enhanced bacterial cuproptosis-like death via reversal of hypoxia microenvironment for biofilm infection treatment. Advanced Science. 2024;11(19):2308850.","journal-title":"Advanced Science"},{"issue":"12","key":"3011_CR32","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/nrd4002","volume":"12","author":"C Gorrini","year":"2013","unstructured":"Gorrini C, Harris IS, Mak TW. Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 2013;12(12):931\u201347.","journal-title":"Nat Rev Drug Discov"},{"issue":"18","key":"3011_CR33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202402397","volume":"63","author":"W Zhang","year":"2024","unstructured":"Zhang W, Wang M, Liu B, Chen H, Tan J, Meng Q, et al. Glutathione induced in situ synthesis of Cu single-atom nanozymes with anaerobic glycolysis metabolism interference for boosting cuproptosis. Angew Chem Int Ed. 2024;63(18): e202402397.","journal-title":"Angew Chem Int Ed"},{"key":"3011_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.103007","volume":"69","author":"P Zhang","year":"2024","unstructured":"Zhang P, Zhou C, Ren X, Jing Q, Gao Y, Yang C, et al. Inhibiting the compensatory elevation of xCT collaborates with disulfiram\/copper-induced GSH consumption for cascade ferroptosis and cuproptosis. Redox Biol. 2024;69: 103007.","journal-title":"Redox Biol"},{"issue":"14","key":"3011_CR35","doi-asserted-by":"publisher","first-page":"10288","DOI":"10.1021\/acsnano.4c01625","volume":"18","author":"Z Wang","year":"2024","unstructured":"Wang Z, Ren X, Li Y, Qiu L, Wang D, Liu A, et al. Reactive oxygen species amplifier for apoptosis-ferroptosis mediated high-efficiency radiosensitization of tumors. ACS Nano. 2024;18(14):10288\u2013301.","journal-title":"ACS Nano"},{"key":"3011_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2023.101710","volume":"35","author":"L Gao","year":"2023","unstructured":"Gao L, Zhang A. Low-dose radiotherapy effects the progression of anti-tumor response. Transl Oncol. 2023;35: 101710.","journal-title":"Transl Oncol"},{"issue":"25","key":"3011_CR37","doi-asserted-by":"publisher","first-page":"9937","DOI":"10.1021\/jacs.9b03457","volume":"141","author":"LS Lin","year":"2019","unstructured":"Lin LS, Huang T, Song J, Ou XY, Wang Z, Deng H, et al. Synthesis of copper peroxide nanodots for H(2)O(2) self-supplying chemodynamic therapy. J Am Chem Soc. 2019;141(25):9937\u201345.","journal-title":"J Am Chem Soc"},{"issue":"20","key":"3011_CR38","doi-asserted-by":"publisher","first-page":"2300153","DOI":"10.1002\/adhm.202300153","volume":"12","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Ding C, Sun T, Wang L, Chen C. Tumor therapy strategies based on microenvironment-specific responsive nanomaterials. Adv Healthcare Mater. 2023;12(20):2300153.","journal-title":"Adv Healthcare Mater"},{"key":"3011_CR39","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jconrel.2021.02.030","volume":"332","author":"M Chen","year":"2021","unstructured":"Chen M, Liu D, Liu F, Wu Y, Peng X, Song F. Recent advances of redox-responsive nanoplatforms for tumor theranostics. J Control Release. 2021;332:269\u201384.","journal-title":"J Control Release"},{"key":"3011_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122056","volume":"295","author":"L Wang","year":"2023","unstructured":"Wang L, Liu C, Wang X, Ma S, Liu F, Zhang Y, et al. Tumor-specific activated nano-domino-CRISPR to amplify intrinsic oxidative and activate endogenous apoptosis for spatiotemporally specific therapy. Biomaterials. 2023;295: 122056.","journal-title":"Biomaterials"},{"issue":"26","key":"3011_CR41","doi-asserted-by":"publisher","first-page":"17267","DOI":"10.1021\/acsnano.4c04901","volume":"18","author":"W Cao","year":"2024","unstructured":"Cao W, Zhang X, Feng Y, Li R, Lu A, Li Z, et al. Lipid nanoparticular codelivery system for enhanced antitumor effects by ferroptosis-apoptosis synergistic with programmed cell death-ligand 1 downregulation. ACS Nano. 2024;18(26):17267\u201381.","journal-title":"ACS Nano"},{"key":"3011_CR42","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.jconrel.2024.01.049","volume":"367","author":"XY Zhu","year":"2024","unstructured":"Zhu XY, Wang TY, Jia HR, Wu SY, Gao CZ, Li YH, et al. A ferroptosis-reinforced nanocatalyst enhances chemodynamic therapy through dual H(2)O(2) production and oxidative stress amplification. J Control Release. 2024;367:892\u2013904.","journal-title":"J Control Release"},{"issue":"24","key":"3011_CR43","doi-asserted-by":"publisher","first-page":"7970","DOI":"10.1111\/febs.16179","volume":"289","author":"Q Guo","year":"2022","unstructured":"Guo Q, Yang C, Gao F. The state of CD44 activation in cancer progression and therapeutic targeting. Febs j. 2022;289(24):7970\u201386.","journal-title":"Febs j"},{"issue":"24","key":"3011_CR44","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202306738","volume":"20","author":"S Kim","year":"2024","unstructured":"Kim S, Li S, Jangid AK, Park HW, Lee DJ, Jung HS, et al. Surface engineering of natural killer cells with CD44-targeting ligands for augmented cancer immunotherapy. Small. 2024;20(24): e2306738.","journal-title":"Small"},{"key":"3011_CR45","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.jconrel.2021.07.002","volume":"336","author":"NG Kotla","year":"2021","unstructured":"Kotla NG, Bonam SR, Rasala S, Wankar J, Bohara RA, Bayry J, et al. Recent advances and prospects of hyaluronan as a multifunctional therapeutic system. J Control Release. 2021;336:598\u2013620.","journal-title":"J Control Release"},{"key":"3011_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121257","volume":"320","author":"MC de Paula","year":"2023","unstructured":"de Paula MC, Carvalho SG, Silvestre ALP, Dos Santos AM, Meneguin AB, Chorilli M. The role of hyaluronic acid in the design and functionalization of nanoparticles for the treatment of colorectal cancer. Carbohyd Polym. 2023;320: 121257.","journal-title":"Carbohyd Polym"},{"key":"3011_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2024.04.002","author":"CH Lin","year":"2024","unstructured":"Lin CH, Chin Y, Zhou M, Sobol RW, Hung MC, Tan M. Protein lipoylation: mitochondria, cuproptosis, and beyond. Trends Biochem Sci. 2024. https:\/\/doi.org\/10.1016\/j.tibs.2024.04.002.","journal-title":"Trends Biochem Sci"},{"issue":"23","key":"3011_CR48","doi-asserted-by":"publisher","first-page":"23998","DOI":"10.1021\/acsnano.3c08875","volume":"17","author":"W Shen","year":"2023","unstructured":"Shen W, Pei P, Zhang C, Li J, Han X, Liu T, et al. A polymeric hydrogel to eliminate programmed death-ligand 1 for enhanced tumor radio-immunotherapy. ACS Nano. 2023;17(23):23998\u20134011.","journal-title":"ACS Nano"},{"issue":"1","key":"3011_CR49","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12943-023-01732-y","volume":"22","author":"J Xie","year":"2023","unstructured":"Xie J, Yang Y, Gao Y, He J. Cuproptosis: mechanisms and links with cancers. Mol Cancer. 2023;22(1):46.","journal-title":"Mol Cancer"},{"key":"3011_CR50","volume":"19","author":"X Sun","year":"2024","unstructured":"Sun X, Wu L, Du L, Xu W, Han M. Targeting the organelle for radiosensitization in cancer radiotherapy. Asian J Pharmaceutical Sci. 2024;19: 100903.","journal-title":"Asian J Pharmaceutical Sci"},{"issue":"43","key":"3011_CR51","doi-asserted-by":"publisher","first-page":"2007778","DOI":"10.1002\/adma.202007778","volume":"33","author":"X Guo","year":"2021","unstructured":"Guo X, Yang N, Ji W, Zhang H, Dong X, Zhou Z, et al. Mito-bomb: targeting mitochondria for cancer therapy. Adv Mater. 2021;33(43):2007778.","journal-title":"Adv Mater"},{"issue":"11","key":"3011_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101264","volume":"4","author":"T Xing","year":"2023","unstructured":"Xing T, Li L, Chen Y, Ju G, Li G, Zhu X, et al. Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma. Cell Rep Med. 2023;4(11): 101264.","journal-title":"Cell Rep Med"},{"key":"3011_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216101","volume":"518","author":"S Shi","year":"2024","unstructured":"Shi S, Zhong H, Zhang Y, Mei Q. Targeted delivery of nano-radiosensitizers for tumor radiotherapy. Coord Chem Rev. 2024;518: 216101.","journal-title":"Coord Chem Rev"},{"key":"3011_CR54","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.actbio.2023.01.022","volume":"159","author":"Y Lin","year":"2023","unstructured":"Lin Y, Chen X, Yu C, Xu G, Nie X, Cheng Y, et al. Radiotherapy-mediated redox homeostasis-controllable nanomedicine for enhanced ferroptosis sensitivity in tumor therapy. Acta Biomater. 2023;159:300\u201311.","journal-title":"Acta Biomater"},{"issue":"1","key":"3011_CR55","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13046-017-0580-7","volume":"36","author":"L Yu","year":"2017","unstructured":"Yu L, Sun Y, Li J, Wang Y, Zhu Y, Shi Y, et al. Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism. J Exp Clin Cancer Res. 2017;36(1):110.","journal-title":"J Exp Clin Cancer Res"},{"key":"3011_CR56","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.semcancer.2021.03.010","volume":"85","author":"Y Liu","year":"2022","unstructured":"Liu Y, Gu W. The complexity of p53-mediated metabolic regulation in tumor suppression. Semin Cancer Biol. 2022;85:4\u201332.","journal-title":"Semin Cancer Biol"},{"key":"3011_CR57","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.cbpa.2021.01.013","volume":"61","author":"CS Bonnet","year":"2021","unstructured":"Bonnet CS, T\u00f3th \u00c9. Metal-based environment-sensitive MRI contrast agents. Curr Opin Chem Biol. 2021;61:154\u201369.","journal-title":"Curr Opin Chem Biol"},{"issue":"1","key":"3011_CR58","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s12951-022-01479-6","volume":"20","author":"D Zhuang","year":"2022","unstructured":"Zhuang D, Zhang H, Hu G, Guo B. Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma. J Nanobiotechnol. 2022;20(1):284.","journal-title":"J Nanobiotechnol"},{"key":"3011_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101156","volume":"38","author":"X Meng","year":"2021","unstructured":"Meng X, Yang F, Dong H, Dou L, Zhang X. Recent advances in optical imaging of biomarkers in vivo. Nano Today. 2021;38: 101156.","journal-title":"Nano Today"},{"issue":"28","key":"3011_CR60","doi-asserted-by":"publisher","first-page":"15426","DOI":"10.1002\/anie.202101730","volume":"60","author":"G Yang","year":"2021","unstructured":"Yang G, Liu Y, Hui Y, Tengjisi, Chen D, Weitz DA, et al. Implications of quenching-to-dequenching switch in quantitative cell uptake and biodistribution of dye-labeled nanoparticles. Angewandte Chemie Int Edition. 2021;60(28):15426\u201335.","journal-title":"Angewandte Chemie Int Edition"},{"issue":"2","key":"3011_CR61","doi-asserted-by":"publisher","first-page":"612","DOI":"10.3390\/pharmaceutics15020612","volume":"15","author":"RP Pandey","year":"2023","unstructured":"Pandey RP, Vidic J, Mukherjee R, Chang C-M. Experimental methods for the biological evaluation of nanoparticle-based drug delivery risks. Pharmaceutics. 2023;15(2):612.","journal-title":"Pharmaceutics"},{"key":"3011_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100839","volume":"23","author":"C Huang","year":"2023","unstructured":"Huang C, Shao N, Huang Y, Chen J, Wang D, Hu G, et al. Overcoming challenges in the delivery of STING agonists for cancer immunotherapy: a comprehensive review of strategies and future perspectives. Mater Today Biol. 2023;23: 100839.","journal-title":"Mater Today Biol"},{"key":"3011_CR63","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.jconrel.2024.06.052","volume":"372","author":"D Wang","year":"2024","unstructured":"Wang D, Deng X, Wang J, Che S, Ma X, Zhang S, et al. Environmentally responsive hydrogel promotes vascular normalization to enhance STING anti-tumor immunity. J Control Release. 2024;372:403\u201316.","journal-title":"J Control Release"},{"issue":"1","key":"3011_CR64","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s12951-022-01316-w","volume":"20","author":"R Gao","year":"2022","unstructured":"Gao R, Gu Y, Yang Y, He Y, Huang W, Sun T, et al. Robust radiosensitization of hemoglobin-curcumin nanoparticles suppresses hypoxic hepatocellular carcinoma. J Nanobiotechnol. 2022;20(1):115.","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"3011_CR65","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/s12951-022-01494-7","volume":"20","author":"L Chen","year":"2022","unstructured":"Chen L, Zhang J, Xu L, Zhu L, Jing J, Feng Y, et al. Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy. J Nanobiotechnol. 2022;20(1):293.","journal-title":"J Nanobiotechnol"},{"key":"3011_CR66","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202409966","author":"C He","year":"2024","unstructured":"He C, Zhu N, Chen Y, Zheng Y, Chen S, Wu Z, et al. Reshaping immunosuppressive tumor microenvironment using ferroptosis\/cuproptosis nanosensitizers for enhanced radioimmunotherapy. Adv Funct Mater. 2024. https:\/\/doi.org\/10.1002\/adfm.202409966.","journal-title":"Adv Funct Mater"},{"key":"3011_CR67","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-024-01784-1","author":"Y Liao","year":"2024","unstructured":"Liao Y, Wang D, Gu C, Wang X, Zhu S, Zheng Z, et al. A cuproptosis nanocapsule for cancer radiotherapy. Nat Nanotechnol. 2024. https:\/\/doi.org\/10.1038\/s41565-024-01784-1.","journal-title":"Nat Nanotechnol"},{"issue":"25","key":"3011_CR68","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202306263","volume":"20","author":"R Li","year":"2024","unstructured":"Li R, Zhao W, Han Z, Feng N, Wu T, Xiong H, et al. Self-cascade nanozyme reactor as a cuproptosis inducer synergistic inhibition of cellular respiration boosting radioimmunotherapy. Small. 2024;20(25): e2306263.","journal-title":"Small"},{"issue":"7986","key":"3011_CR69","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/s41586-023-06537-z","volume":"623","author":"N Borcherding","year":"2023","unstructured":"Borcherding N, Brestoff JR. The power and potential of mitochondria transfer. Nature. 2023;623(7986):283\u201391.","journal-title":"Nature"},{"issue":"4","key":"3011_CR70","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1152\/physrev.00058.2021","volume":"103","author":"JS Harrington","year":"2023","unstructured":"Harrington JS, Ryter SW, Plataki M, Price DR, Choi AMK. Mitochondria in health, disease, and aging. Physiol Rev. 2023;103(4):2349\u2013422.","journal-title":"Physiol Rev"},{"key":"3011_CR71","doi-asserted-by":"crossref","unstructured":"Feng Y, Wang J, Ning X, Li A, You Q, Su W, et al. BaTiO3@Au nanoheterostructure suppresses triple-negative breast cancer by persistently disrupting mitochondrial energy metabolism. Nano Res. 2023;16(2):2775\u201385.","DOI":"10.1007\/s12274-022-4927-9"},{"issue":"5","key":"3011_CR72","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41422-022-00653-7","volume":"32","author":"D Tang","year":"2022","unstructured":"Tang D, Chen X, Kroemer G. Cuproptosis: a copper-triggered modality of mitochondrial cell death. Cell Res. 2022;32(5):417\u20138.","journal-title":"Cell Res"},{"issue":"4","key":"3011_CR73","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1080\/02652048.2022.2094487","volume":"39","author":"S Mohaghegh","year":"2022","unstructured":"Mohaghegh S, Tarighatnia A, Omidi Y, Barar J, Aghanejad A, Adibkia K. Multifunctional magnetic nanoparticles for MRI-guided co-delivery of erlotinib and L-asparaginase to ovarian cancer. J Microencapsul. 2022;39(4):394\u2013408.","journal-title":"J Microencapsul"},{"key":"3011_CR74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102895","volume":"66","author":"A Tarighatnia","year":"2021","unstructured":"Tarighatnia A, Fouladi MR, Tohidkia MR, Johal G, Nader ND, Aghanejad A, et al. Engineering and quantification of bismuth nanoparticles as targeted contrast agent for computed tomography imaging in cellular and animal models. J Drug Delivery Sci Technol. 2021;66: 102895.","journal-title":"J Drug Delivery Sci Technol"},{"key":"3011_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102954","volume":"67","author":"J Kadkhoda","year":"2022","unstructured":"Kadkhoda J, Aghanejad A, Safari B, Barar J, Rasta SH, Davaran S. Aptamer-conjugated gold nanoparticles for targeted paclitaxel delivery and photothermal therapy in breast cancer. J Drug Delivery Sci Technol. 2022;67: 102954.","journal-title":"J Drug Delivery Sci Technol"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-024-03011-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-024-03011-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-024-03011-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T01:03:20Z","timestamp":1734570200000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-024-03011-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3011"],"URL":"https:\/\/doi.org\/10.1186\/s12951-024-03011-4","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"23 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were conducted in accordance with procedures approved by the Laboratory Animal Welfare and Ethics Committee of Jinan University (IACUC- 20240104\u201306). Figures were created with BioRender.com.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"772"}}