{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:39:04Z","timestamp":1793569144431,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92168203"],"award-info":[{"award-number":["92168203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070363"],"award-info":[{"award-number":["82070363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Cardiovascular Medicine Innovation Center","award":["CXZX202210"],"award-info":[{"award-number":["CXZX202210"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFA1104300"],"award-info":[{"award-number":["2022YFA1104300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ischemic diseases are major contributors to global morbidity and mortality, posing a substantial threat to human health. Extracellular vesicles (EVs) play an essential role in enhancing neovascularization in ischemic tissues, thereby facilitating tissue repair and regeneration. However, the utilization of EVs is hindered by their rapid uptake and clearance by the mononuclear phagocyte system (MPS), which markedly impedes their therapeutic efficacy and organ-specific accumulation. Notably, CD47, upon binding to signal regulatory protein alpha, initiates a \u201cdon\u2019t eat me\u201d signal, enabling immune evasion from the MPS. Our research has demonstrated that phagocytes predominantly engulf CD47\n                    <jats:sup>low<\/jats:sup>\n                    dendritic DC2.4 cell-derived EVs (DV), while engineered CD47\n                    <jats:sup>high<\/jats:sup>\n                    EVs (MV\n                    <jats:sup>47<\/jats:sup>\n                    ) experience minimal ingestion. Leveraging these findings, we have developed a dual-faceted \u201cEngage &amp; Evasion\u201d strategy. Initially, DVs were employed to saturate the MPS, serving as the \u201cengage\u201d component. Subsequently, MV\n                    <jats:sup>47<\/jats:sup>\n                    , fortified with CD47, was introduced for \u201cevasion\u201d purposes. This approach effectively minimized entrapment by the liver and spleen, boosted serum concentration, and enhanced final accumulation in non-MPS organs. In summary, our \u201cEngage &amp; Evasion\u201d therapeutic strategy offers a promising avenue to enhance EV therapeutic potential against ischemic challenges through improved systemic distribution.\n                  <\/jats:p>","DOI":"10.1186\/s12951-024-03032-z","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T22:38:49Z","timestamp":1734561529000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["An integrated \u201cEngage &amp; Evasion\u201d approach for mononuclear phagocyte system escape and efficient extracellular vesicle therapy"],"prefix":"10.1186","volume":"22","author":[{"given":"Hongman","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenya","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"3032_CR1","doi-asserted-by":"publisher","first-page":"108025","DOI":"10.1016\/j.pharmthera.2021.108025","volume":"233","author":"C Han","year":"2022","unstructured":"Han C, Yang J, Sun J, Qin G. Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implications. Pharmacol Ther. 2022;233:108025.","journal-title":"Pharmacol Ther"},{"issue":"7","key":"3032_CR2","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1161\/CIRCRESAHA.111.253286","volume":"109","author":"S Sahoo","year":"2011","unstructured":"Sahoo S, Klychko E, Thorne T, Misener S, Schultz KM, Millay M, Ito A, Liu T, Kamide C, Agrawal H, et al. Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activity. Circ Res. 2011;109(7):724\u20138.","journal-title":"Circ Res"},{"issue":"4","key":"3032_CR3","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.7150\/thno.30853","volume":"9","author":"C Liu","year":"2019","unstructured":"Liu C, Su C. Design strategies and application progress of therapeutic exosomes. Theranostics. 2019;9(4):1015\u201328.","journal-title":"Theranostics"},{"issue":"46","key":"3032_CR4","doi-asserted-by":"publisher","first-page":"6225","DOI":"10.1002\/smll.201502388","volume":"11","author":"L Rao","year":"2015","unstructured":"Rao L, Bu LL, Xu JH, Cai B, Yu GT, Yu X, He Z, Huang Q, Li A, Guo SS, et al. Red blood cell membrane as a biomimetic nanocoating for prolonged circulation time and reduced accelerated blood clearance. Small. 2015;11(46):6225\u201336.","journal-title":"Small"},{"key":"3032_CR5","doi-asserted-by":"publisher","first-page":"26238","DOI":"10.3402\/jev.v4.26238","volume":"4","author":"T Imai","year":"2015","unstructured":"Imai T, Takahashi Y, Nishikawa M, Kato K, Morishita M, Yamashita T, Matsumoto A, Charoenviriyakul C, Takakura Y. Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice. J Extracell Vesicles. 2015;4:26238.","journal-title":"J Extracell Vesicles"},{"key":"3032_CR6","doi-asserted-by":"publisher","first-page":"121000","DOI":"10.1016\/j.biomaterials.2021.121000","volume":"275","author":"Z Wei","year":"2021","unstructured":"Wei Z, Chen Z, Zhao Y, Fan F, Xiong W, Song S, Yin Y, Hu J, Yang K, Yang L, et al. Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment. Biomaterials. 2021;275:121000.","journal-title":"Biomaterials"},{"issue":"6122","key":"3032_CR7","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1126\/science.1229568","volume":"339","author":"PL Rodriguez","year":"2013","unstructured":"Rodriguez PL, Harada T, Christian DA, Pantano DA, Tsai RK, Discher DE. Minimal self peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science. 2013;339(6122):971\u20135.","journal-title":"Science"},{"issue":"4","key":"3032_CR8","doi-asserted-by":"publisher","first-page":"787","DOI":"10.3390\/nano10040787","volume":"10","author":"SY Fam","year":"2020","unstructured":"Fam SY, Chee CF, Yong CY, Ho KL, Mariatulqabtiah AR, Tan WS. Stealth coating of nanoparticles in drug-delivery systems. Nanomaterials (Basel). 2020;10(4):787.","journal-title":"Nanomaterials (Basel)"},{"issue":"1","key":"3032_CR9","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41565-018-0319-4","volume":"14","author":"Q Chen","year":"2019","unstructured":"Chen Q, Wang C, Zhang X, Chen G, Hu Q, Li H, Wang J, Wen D, Zhang Y, Lu Y, et al. In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment. Nat Nanotechnol. 2019;14(1):89\u201397.","journal-title":"Nat Nanotechnol"},{"issue":"5","key":"3032_CR10","doi-asserted-by":"publisher","first-page":"e12222","DOI":"10.1002\/jev2.12222","volume":"11","author":"H Wang","year":"2022","unstructured":"Wang H, Wang T, Rui W, Xie J, Xie Y, Zhang X, Guan L, Li G, Lei Z, Schiffelers RM, et al. Extracellular vesicles enclosed-miR-421 suppresses air pollution (PM(2.5))-induced cardiac dysfunction via ACE2 signalling. J Extracell Vesicles. 2022;11(5):e12222.","journal-title":"J Extracell Vesicles"},{"key":"3032_CR11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jconrel.2016.01.009","volume":"224","author":"SAA Kooijmans","year":"2016","unstructured":"Kooijmans SAA, Fliervoet LAL, van der Meel R, Fens M, Heijnen HFG, van Bergen En Henegouwen PMP, Vader P, Schiffelers RM. PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time. J Control Release. 2016;224:77\u201385.","journal-title":"J Control Release"},{"issue":"1","key":"3032_CR12","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1038\/s41467-022-29137-3","volume":"13","author":"N Jiang","year":"2022","unstructured":"Jiang N, Xie B, Xiao W, Fan M, Xu S, Duan Y, Hamsafar Y, Evans AC, Huang J, Zhou W, et al. Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion. Nat Commun. 2022;13(1):1511.","journal-title":"Nat Commun"},{"issue":"4","key":"3032_CR13","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.bbrc.2018.03.227","volume":"499","author":"H Kim","year":"2018","unstructured":"Kim H, Yun N, Mun D, Kang JY, Lee SH, Park H, Park H, Joung B. Cardiac-specific delivery by cardiac tissue-targeting peptide-expressing exosomes. Biochem Biophys Res Commun. 2018;499(4):803\u20138.","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"3032_CR14","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1038\/s41416-019-0722-0","volume":"122","author":"EP Allain","year":"2020","unstructured":"Allain EP, Rouleau M, L\u00e9vesque E, Guillemette C. Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression. Br J Cancer. 2020;122(9):1277\u201387.","journal-title":"Br J Cancer"},{"issue":"3","key":"3032_CR15","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.scr.2009.12.003","volume":"4","author":"RC Lai","year":"2010","unstructured":"Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, Salto-Tellez M, Timmers L, Lee CN, El Oakley RM, et al. Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury. Stem Cell Res. 2010;4(3):214\u201322.","journal-title":"Stem Cell Res"},{"issue":"1","key":"3032_CR16","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12916-023-02778-x","volume":"21","author":"Y Ning","year":"2023","unstructured":"Ning Y, Huang P, Chen G, Xiong Y, Gong Z, Wu C, Xu J, Jiang W, Li X, Tang R, et al. Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p\/Stat1 pathway. BMC Med. 2023;21(1):96.","journal-title":"BMC Med"},{"key":"3032_CR17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jconrel.2017.08.022","volume":"264","author":"P Gangadaran","year":"2017","unstructured":"Gangadaran P, Rajendran RL, Lee HW, Kalimuthu S, Hong CM, Jeong SY, Lee SW, Lee J, Ahn BC. Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia. J Control Release. 2017;264:112\u201326.","journal-title":"J Control Release"},{"issue":"1","key":"3032_CR18","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12951-022-01421-w","volume":"20","author":"C Liu","year":"2022","unstructured":"Liu C, Yan X, Zhang Y, Yang M, Ma Y, Zhang Y, Xu Q, Tu K, Zhang M. Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy. J Nanobiotechnol. 2022;20(1):206.","journal-title":"J Nanobiotechnol"},{"issue":"8","key":"3032_CR19","doi-asserted-by":"publisher","first-page":"e12255","DOI":"10.1002\/jev2.12255","volume":"11","author":"Z Zhu","year":"2022","unstructured":"Zhu Z, Zhai Y, Hao Y, Wang Q, Han F, Zheng W, Hong J, Cui L, Jin W, Ma S, et al. Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides. J Extracell Vesicles. 2022;11(8):e12255.","journal-title":"J Extracell Vesicles"},{"issue":"48","key":"3032_CR20","doi-asserted-by":"publisher","first-page":"e2004492","DOI":"10.1002\/smll.202004492","volume":"16","author":"S Zhou","year":"2020","unstructured":"Zhou S, Hu T, Han G, Wu Y, Hua X, Su J, Jin W, Mou Y, Mou X, Li Q, et al. Accurate cancer diagnosis and stage monitoring enabled by comprehensive profiling of different types of exosomal biomarkers: surface proteins and miRNAs. Small. 2020;16(48):e2004492.","journal-title":"Small"},{"issue":"15","key":"3032_CR21","doi-asserted-by":"publisher","first-page":"12341","DOI":"10.1021\/acsami.7b18135","volume":"10","author":"Z Ye","year":"2018","unstructured":"Ye Z, Zhang T, He W, Jin H, Liu C, Yang Z, Ren J. Methotrexate-loaded extracellular vesicles functionalized with therapeutic and targeted peptides for the treatment of glioblastoma multiforme. ACS Appl Mater Interfaces. 2018;10(15):12341\u201350.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"5","key":"3032_CR22","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1007\/s12274-020-3175-0","volume":"14","author":"L-X Zhang","year":"2021","unstructured":"Zhang L-X, Jia Y-B, Huang Y-R, Liu H-N, Sun X-M, Cai T, Liu R-T, Xu ZP. Efficient delivery of clay-based nanovaccines to the mouse spleen promotes potent anti-tumor immunity for both prevention and treatment of lymphoma. Nano Res. 2021;14(5):1326\u201334.","journal-title":"Nano Res"},{"issue":"13","key":"3032_CR23","doi-asserted-by":"publisher","first-page":"4935","DOI":"10.1039\/D1NR06922E","volume":"14","author":"L Ding","year":"2022","unstructured":"Ding L, Zhou W, Zhang J, Tang Q, Xiao W, Chen M, Shen Z, Chen W. Calming egress of inflammatory monocytes and related septic shock by therapeutic CCR2 silencing using macrophage-derived extracellular vesicles. Nanoscale. 2022;14(13):4935\u201345.","journal-title":"Nanoscale"},{"issue":"3","key":"3032_CR24","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/j.bbrc.2016.08.090","volume":"478","author":"J Wu","year":"2016","unstructured":"Wu J, Wang J, Zeng X, Chen Y, Xia J, Wang S, Huang Z, Chen W, Shen Z. Protein phosphatase 2A regulatory subunit B56\u03b2 modulates erythroid differentiation. Biochem Biophys Res Commun. 2016;478(3):1179\u201384.","journal-title":"Biochem Biophys Res Commun"},{"key":"3032_CR25","doi-asserted-by":"publisher","first-page":"rbad108","DOI":"10.1093\/rb\/rbad108","volume":"11","author":"M Chen","year":"2024","unstructured":"Chen M, Wang S, Chen Y, Shen H, Chen L, Ding L, Tang Q, Yang Z, Chen W, Shen Z. Precision cardiac targeting: empowering curcumin therapy through smart exosome-mediated drug delivery in myocardial infarction. Regen Biomater. 2024;11:rbad108.","journal-title":"Regen Biomater"},{"issue":"16","key":"3032_CR26","doi-asserted-by":"publisher","first-page":"11365","DOI":"10.1021\/acs.jmedchem.3c00837","volume":"66","author":"R Zhang","year":"2023","unstructured":"Zhang R, Su K, Yang L, Tang M, Zhao M, Ye N, Cai X, Jiang X, Li N, Peng J, et al. Design, Synthesis, and Biological Evaluation of Novel P2X7 Receptor Antagonists for the Treatment of Septic Acute Kidney Injury. J Med Chem. 2023;66(16):11365\u201389.","journal-title":"J Med Chem"},{"key":"3032_CR27","doi-asserted-by":"publisher","first-page":"125811","DOI":"10.1016\/j.ijbiomac.2023.125811","volume":"248","author":"X Chen","year":"2023","unstructured":"Chen X, Zhu S, Li HD, Wang JN, Sun LJ, Xu JJ, Hui YR, Li XF, Li LY, Zhao YX, et al. N(6)-methyladenosine-modified circIRF2, identified by YTHDF2, suppresses liver fibrosis via facilitating FOXO3 nuclear translocation. Int J Biol Macromol. 2023;248:125811.","journal-title":"Int J Biol Macromol"},{"issue":"3","key":"3032_CR28","doi-asserted-by":"publisher","first-page":"e762","DOI":"10.1002\/ctm2.762","volume":"12","author":"W Zhou","year":"2022","unstructured":"Zhou W, Jiang X, Tang Q, Ding L, Xiao W, Li J, Wu Y, Ruan HB, Shen Z, Chen W. Glucosamine facilitates cardiac ischemic recovery via recruiting Ly6C(low) monocytes in a STAT1 and O-GlcNAcylation-dependent fashion. Clin Transl Med. 2022;12(3):e762.","journal-title":"Clin Transl Med"},{"issue":"18","key":"3032_CR29","doi-asserted-by":"publisher","first-page":"e2300585","DOI":"10.1002\/advs.202300585","volume":"10","author":"Y Bei","year":"2023","unstructured":"Bei Y, Zhu Y, Wei M, Yin M, Li L, Chen C, Huang Z, Liang X, Gao J, Yao J, et al. HIPK1 inhibition protects against pathological cardiac hypertrophy by inhibiting the CREB-C\/EBP\u03b2 axis. Adv Sci (Weinh). 2023;10(18):e2300585.","journal-title":"Adv Sci (Weinh)"},{"issue":"4","key":"3032_CR30","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1111\/jcmm.14972","volume":"24","author":"P Zhao","year":"2020","unstructured":"Zhao P, Zhou W, Zhang Y, Li J, Zhao Y, Pan L, Shen Z, Chen W, Hui J. Aminooxyacetic acid attenuates post-infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice. J Cell Mol Med. 2020;24(4):2593\u2013609.","journal-title":"J Cell Mol Med"},{"key":"3032_CR31","doi-asserted-by":"publisher","first-page":"111883","DOI":"10.1016\/j.intimp.2024.111883","volume":"131","author":"W Zhou","year":"2024","unstructured":"Zhou W, Tang Q, Wang S, Ding L, Chen M, Liu H, Wu Y, Xiong X, Shen Z, Chen W. Local thiamet-G delivery by a thermosensitive hydrogel confers ischemic cardiac repair via myeloid M2-like activation in a STAT6 O-GlcNAcylation-dependent manner. Int Immunopharmacol. 2024;131:111883.","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"3032_CR32","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1161\/CIRCRESAHA.115.306829","volume":"117","author":"L Jiang","year":"2015","unstructured":"Jiang L, Yin M, Wei X, Liu J, Wang X, Niu C, Kang X, Xu J, Zhou Z, Sun S, et al. Bach1 represses Wnt\/\u03b2-Catenin signaling and angiogenesis. Circ Res. 2015;117(4):364\u201375.","journal-title":"Circ Res"},{"key":"3032_CR33","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.actbio.2023.02.003","volume":"160","author":"J Xie","year":"2023","unstructured":"Xie J, Hu Y, Li H, Wang Y, Fan X, Lu W, Liao R, Wang H, Cheng Y, Yang Y, et al. Targeted therapy for peri-prosthetic osteolysis using macrophage membrane-encapsulated human urine-derived stem cell extracellular vesicles. Acta Biomater. 2023;160:297\u2013310.","journal-title":"Acta Biomater"},{"issue":"5","key":"3032_CR34","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1097\/HJH.0000000000001979","volume":"37","author":"H Li","year":"2019","unstructured":"Li H, Li J, Jiang X, Liu S, Liu Y, Chen W, Yang J, Zhang C, Zhang W. Melatonin enhances atherosclerotic plaque stability by inducing prolyl-4-hydroxylase \u03b11 expression. J Hypertens. 2019;37(5):964\u201371.","journal-title":"J Hypertens"},{"key":"3032_CR35","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jconrel.2023.06.017","volume":"360","author":"B Li","year":"2023","unstructured":"Li B, Li Y, Chen S, Wang Y, Zheng Y. VEGF mimetic peptide-conjugated nanoparticles for magnetic resonance imaging and therapy of myocardial infarction. J Control Release. 2023;360:44\u201356.","journal-title":"J Control Release"},{"issue":"1\u20132","key":"3032_CR36","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s11010-015-2624-7","volume":"412","author":"W Chen","year":"2016","unstructured":"Chen W, Wang S, Xia J, Huang Z, Tu X, Shen Z. Protein phosphatase 2A plays an important role in migration of bone marrow stroma cells. Mol Cell Biochem. 2016;412(1\u20132):173\u201380.","journal-title":"Mol Cell Biochem"},{"key":"3032_CR37","first-page":"240","volume":"142","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Zhao X, Xu H, Xing Y, Wu T, Sun X, Kuang M, Ma X, Liu W, Yang Q. Wharton\u2019s jelly MSC-derived extracellular vehicles\u2014loaded hyaluronic acid-alginate adhesives for treatment of osteoarthritis. J Mater Sci Mater Med. 2023;142:240\u201352.","journal-title":"J Mater Sci Mater Med"},{"issue":"1","key":"3032_CR38","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s42765-022-00226-8","volume":"5","author":"Y Chen","year":"2023","unstructured":"Chen Y, Yuan Z, Sun W, Shafiq M, Zhu J, Chen J, Tang H, Hu L, Lin W, Zeng Y, et al. Vascular endothelial growth factor-recruiting nanofiber bandages promote multifunctional skin regeneration via improved angiogenesis and immunomodulation. Adv Fiber Mater. 2023;5(1):327\u201348.","journal-title":"Adv Fiber Mater"},{"issue":"2","key":"3032_CR39","first-page":"100565","volume":"5","author":"Z Fang","year":"2024","unstructured":"Fang Z, Zhao G, Zhao S, Yu X, Feng R, Zhang YE, Li H, Huang L, Guo Z, Zhang Z, et al. GTF2H4 regulates partial EndMT via NF-\u03baB activation through NCOA3 phosphorylation in ischemic diseases. Innov (Camb). 2024;5(2):100565.","journal-title":"Innov (Camb)"},{"issue":"3","key":"3032_CR40","doi-asserted-by":"publisher","first-page":"e10471","DOI":"10.1002\/btm2.10471","volume":"8","author":"W Xiao","year":"2023","unstructured":"Xiao W, Chen M, Zhou W, Ding L, Yang Z, Shao L, Li J, Chen W, Shen Z. An immunometabolic patch facilitates mesenchymal stromal\/stem cell therapy for myocardial infarction through a macrophage-dependent mechanism. Bioeng Transl Med. 2023;8(3):e10471.","journal-title":"Bioeng Transl Med"},{"issue":"1","key":"3032_CR41","doi-asserted-by":"publisher","first-page":"e2106265","DOI":"10.1002\/adma.202106265","volume":"34","author":"F Xu","year":"2022","unstructured":"Xu F, Fei Z, Dai H, Xu J, Fan Q, Shen S, Zhang Y, Ma Q, Chu J, Peng F, et al. Mesenchymal stem cell-derived extracellular vesicles with high PD-L1 expression for autoimmune diseases treatment. Adv Mater. 2022;34(1):e2106265.","journal-title":"Adv Mater"},{"issue":"9","key":"3032_CR42","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1038\/s41418-023-01211-3","volume":"30","author":"X Li","year":"2023","unstructured":"Li X, Zhang T, Kang L, Xin R, Sun M, Chen Q, Pei J, Chen Q, Gao X, Lin Z. Apoptotic caspase-7 activation inhibits non-canonical pyroptosis by GSDMB cleavage. Cell Death Differ. 2023;30(9):2120\u201334.","journal-title":"Cell Death Differ"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-024-03032-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-024-03032-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-024-03032-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T01:02:54Z","timestamp":1734570174000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-024-03032-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3032"],"URL":"https:\/\/doi.org\/10.1186\/s12951-024-03032-z","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"23 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors of the manuscript have agreed to its content and publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"770"}}