{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:28:39Z","timestamp":1790764119968,"version":"4.1.0"},"reference-count":102,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-024-03087-y","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T05:50:22Z","timestamp":1738129822000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anti-inflammatory coupled anti-angiogenic airway stent effectively suppresses tracheal in-stents restenosis"],"prefix":"10.1186","volume":"23","author":[{"given":"Yanan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiheng","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaoqu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechao","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhuang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"3087_CR1","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1111\/resp.13801","volume":"25","author":"N Guibert","year":"2020","unstructured":"Guibert N, Saka H, Dutau H. Airway stenting: Technological advancements and its role in interventional pulmonology. Respirology. 2020;25:953\u201362.","journal-title":"Respirology"},{"key":"3087_CR2","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.chest.2016.02.001","volume":"150","author":"SD Murgu","year":"2016","unstructured":"Murgu SD, Egressy K, Laxmanan B, Doblare G, Ortiz-Comino R, Hogarth DK. Central Airway obstruction: Benign strictures, Tracheobronchomalacia, and malignancy-related obstruction. Chest. 2016;150:426\u201341.","journal-title":"Chest"},{"key":"3087_CR3","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1159\/000530421","volume":"102","author":"L Li","year":"2023","unstructured":"Li L, Zhang X, Shi J, Chen Y, Wan H, Herth FJ, Luo F. Airway stents from now to the future: a narrative review. Respiration. 2023;102:439\u201348.","journal-title":"Respiration"},{"key":"3087_CR4","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.chest.2018.12.001","volume":"155","author":"SK Avasarala","year":"2019","unstructured":"Avasarala SK, Freitag L, Mehta AC. Metallic endobronchial stents: a contemporary resurrection. Chest. 2019;155:1246\u201359.","journal-title":"Chest"},{"key":"3087_CR5","doi-asserted-by":"crossref","unstructured":"Lin L-Q, Chen D-F, Wu H-K, Chen Y, Zhong C-H, Chen X-B, Tang C-L, Zhou Z-Q, Li S-Y. Long-term efficacy and safety of the Dumon stent for treatment of benign airway stenosis. Ther Adv Respir Dis 2023, 17.","DOI":"10.1177\/17534666231181269"},{"key":"3087_CR6","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.21037\/jtd-21-1871","volume":"14","author":"S Tian","year":"2022","unstructured":"Tian S, Huang H, Hu Z, Dong Y, Bai C. A narrative review of progress in airway stents. J Thorac Disease. 2022;14:1674\u201383.","journal-title":"J Thorac Disease"},{"key":"3087_CR7","doi-asserted-by":"crossref","unstructured":"Zhang D, Chen Q, Shi C, Chen M, Ma K, Wan J, Liu R. Dealing with the Foreign-Body response to implanted biomaterials: strategies and applications of new materials. Adv Funct Mater 2020, 31.","DOI":"10.1002\/adfm.202007226"},{"key":"3087_CR8","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/eci.12706","volume":"47","author":"E Arellano-Orden","year":"2017","unstructured":"Arellano-Orden E, Serrano C, Montes-Worboys A, S\u00e1nchez-L\u00f3pez V, Laborda A, Lostal\u00e9 F, Lahuerta C, Rodr\u00edguez-Panadero F, de Gregorio M. Stent-induced tracheal stenosis can be predicted by IL-8 expression in rabbits. Eur J Clin Invest. 2017;47:84\u201392.","journal-title":"Eur J Clin Invest"},{"key":"3087_CR9","doi-asserted-by":"crossref","unstructured":"Yang Y, Gao P, Wang J, Tu Q, Bai L, Xiong K, Qiu H, Zhao X, Maitz MF, Wang H et al. Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy. Research 2020, 2020.","DOI":"10.34133\/2020\/9203906"},{"key":"3087_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2018.09.056","volume":"83","author":"DP Vasconcelos","year":"2019","unstructured":"Vasconcelos DP, \u00c1guas AP, Barbosa MA, Pelegr\u00edn P, Barbosa JN. The inflammasome in host response to biomaterials: bridging inflammation and tissue regeneration. Acta Biomater. 2019;83:1\u201312.","journal-title":"Acta Biomater"},{"key":"3087_CR11","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","volume":"20","author":"JM Anderson","year":"2008","unstructured":"Anderson JM, Rodriguez A, Chang DT. Foreign body reaction to biomaterials. Semin Immunol. 2008;20:86\u2013100.","journal-title":"Semin Immunol"},{"key":"3087_CR12","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/jbm.a.35958","volume":"105","author":"R Klopfleisch","year":"2017","unstructured":"Klopfleisch R, Jung F. The pathology of the foreign body reaction against biomaterials. J Biomed Mater Res A. 2017;105:927\u201340.","journal-title":"J Biomed Mater Res A"},{"key":"3087_CR13","doi-asserted-by":"publisher","first-page":"e1800112","DOI":"10.1002\/mabi.201800112","volume":"18","author":"G Zhou","year":"2018","unstructured":"Zhou G, Groth T. Host responses to Biomaterials and Anti-inflammatory Design-a brief review. Macromol Biosci. 2018;18:e1800112.","journal-title":"Macromol Biosci"},{"key":"3087_CR14","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12964-023-01214-0","volume":"21","author":"M Zhang","year":"2023","unstructured":"Zhang M, Chen H, Qian H, Wang C. Characterization of the skin keloid microenvironment. Cell Commun Signal. 2023;21:207.","journal-title":"Cell Commun Signal"},{"key":"3087_CR15","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.jconrel.2020.10.035","volume":"329","author":"AS Kumar","year":"2021","unstructured":"Kumar AS, Kamalasanan K. Drug delivery to optimize angiogenesis imbalance in keloid: a review. J Control Release. 2021;329:1066\u201376.","journal-title":"J Control Release"},{"key":"3087_CR16","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1093\/rb\/rbw041","volume":"4","author":"GS Selders","year":"2017","unstructured":"Selders GS, Fetz AE, Radic MZ, Bowlin GL. An overview of the role of neutrophils in innate immunity, inflammation and host-biomaterial integration. Regen Biomater. 2017;4:55\u201368.","journal-title":"Regen Biomater"},{"key":"3087_CR17","doi-asserted-by":"crossref","unstructured":"Roodenburg SA, Pouwels SD, Slebos D-J. Airway granulation response to lung-implantable medical devices: a concise overview. Eur Respiratory Rev 2021, 30.","DOI":"10.1183\/16000617.0066-2021"},{"key":"3087_CR18","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1378\/chest.11-2005","volume":"141","author":"DE Ost","year":"2012","unstructured":"Ost DE, Shah AM, Lei X, Godoy MCB, Jimenez CA, Eapen GA, Jani P, Larson AJ, Sarkiss MG, Morice RC. Respiratory infections increase the risk of granulation tissue formation following airway stenting in patients with malignant airway obstruction. Chest. 2012;141:1473\u201381.","journal-title":"Chest"},{"key":"3087_CR19","doi-asserted-by":"publisher","first-page":"5711","DOI":"10.1166\/jnn.2011.4495","volume":"11","author":"DN Heo","year":"2011","unstructured":"Heo DN, Lee JB, Bae MS, Hwang YS, Kwon KH, Kwon IK. Development of nanofiber coated indomethacin-eluting stent for tracheal regeneration. J Nanosci Nanotechnol. 2011;11:5711\u20136.","journal-title":"J Nanosci Nanotechnol"},{"key":"3087_CR20","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1007\/s00330-004-2564-1","volume":"15","author":"JH Shin","year":"2005","unstructured":"Shin JH, Song HY, Seo TS, Yuk SH, Kim YH, Cho YM, Choi GB, Kim TH, Suh JY. Influence of a dexamethasone-eluting covered stent on tissue reaction: an experimental study in a canine bronchial model. Eur Radiol. 2005;15:1241\u20139.","journal-title":"Eur Radiol"},{"key":"3087_CR21","doi-asserted-by":"crossref","unstructured":"Baskaran R, Ko UJ, Davaa E, Park JE, Jiang Y, Lee J, Yang SG. Doxycycline-Eluting Core-Shell Type Nanofiber-Covered Trachea Stent for Inhibition of Cellular Metalloproteinase and Its Related Fibrotic Stenosis. Pharmaceutics 2019, 11.","DOI":"10.3390\/pharmaceutics11080421"},{"key":"3087_CR22","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1002\/lary.27028","volume":"128","author":"JS Choi","year":"2018","unstructured":"Choi JS, Kim JM, Kim JW, Kim YM, Park IS, Yang SG. Prevention of tracheal inflammation and fibrosis using nitinol stent coated with doxycycline. Laryngoscope. 2018;128:1558\u201363.","journal-title":"Laryngoscope"},{"key":"3087_CR23","doi-asserted-by":"crossref","unstructured":"Zhao Y, Tian C, Wu K, Zhou X, Feng K, Li Z, Wang Z, Han X. Vancomycin-Loaded Polycaprolactone Electrospinning nanofibers modulate the Airway Interfaces to restrain tracheal stenosis. Front Bioeng Biotechnol 2021, 9.","DOI":"10.3389\/fbioe.2021.760395"},{"key":"3087_CR24","doi-asserted-by":"crossref","unstructured":"Morozova OV. Silver nanostructures: limited sensitivity of detection, toxicity and Anti-inflammation effects. Int J Mol Sci 2021, 22.","DOI":"10.3390\/ijms22189928"},{"key":"3087_CR25","doi-asserted-by":"publisher","first-page":"e1701503","DOI":"10.1002\/adhm.201701503","volume":"7","author":"S Tang","year":"2018","unstructured":"Tang S, Zheng J. Antibacterial activity of silver nanoparticles: Structural effects. Adv Healthc Mater. 2018;7:e1701503.","journal-title":"Adv Healthc Mater"},{"key":"3087_CR26","doi-asserted-by":"publisher","first-page":"8996","DOI":"10.7150\/thno.45413","volume":"10","author":"L Xu","year":"2020","unstructured":"Xu L, Wang YY, Huang J, Chen CY, Wang ZX, Xie H. Silver nanoparticles: synthesis, medical applications and biosafety. Theranostics. 2020;10:8996\u20139031.","journal-title":"Theranostics"},{"key":"3087_CR27","doi-asserted-by":"publisher","first-page":"3650","DOI":"10.4238\/2015.April.17.15","volume":"14","author":"C Parnsamut","year":"2015","unstructured":"Parnsamut C, Brimson S. Effects of silver nanoparticles and gold nanoparticles on IL-2, IL-6, and TNF-\u03b1 production via MAPK pathway in leukemic cell lines. Genet Mol Res. 2015;14:3650\u201368.","journal-title":"Genet Mol Res"},{"key":"3087_CR28","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.mehy.2009.04.037","volume":"73","author":"J Zhang","year":"2009","unstructured":"Zhang J, Li Q, Bai C, Han Y, Huang Y. Inhalation of TGF-beta1 antibody: a new method to inhibit the airway stenosis induced by the endobronchial tuberculosis. Med Hypotheses. 2009;73:1065\u20136.","journal-title":"Med Hypotheses"},{"key":"3087_CR29","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.tips.2005.02.007","volume":"26","author":"P Csermely","year":"2005","unstructured":"Csermely P, Agoston V, Pongor S. The efficiency of multi-target drugs: the network approach might help drug design. Trends Pharmacol Sci. 2005;26:178\u201382.","journal-title":"Trends Pharmacol Sci"},{"key":"3087_CR30","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s40001-023-01037-2","volume":"28","author":"M Gurusamy","year":"2023","unstructured":"Gurusamy M, Nasseri S, Rampa DR, Feng H, Lee D, Pekcec A, Doods H, Wu D. Triple-tyrosine kinase inhibition by BIBF1000 attenuates airway and pulmonary arterial remodeling following chronic allergen challenges in mice. Eur J Med Res. 2023;28:71.","journal-title":"Eur J Med Res"},{"key":"3087_CR31","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/s41401-020-0381-y","volume":"41","author":"BY Zhou","year":"2020","unstructured":"Zhou BY, Wang WB, Wu XL, Zhang WJ, Zhou GD, Gao Z, Liu W. Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization. Acta Pharmacol Sin. 2020;41:1234\u201345.","journal-title":"Acta Pharmacol Sin"},{"key":"3087_CR32","doi-asserted-by":"crossref","unstructured":"Li G, Han Q, Lu P, Zhang L, Zhang Y, Chen S, Zhang P, Zhang L, Cui W, Wang H, Zhang H. Construction of Dual-Biofunctionalized Chitosan\/Collagen Scaffolds for Simultaneous Neovascularization and Nerve Regeneration. Research 2020, 2020.","DOI":"10.34133\/2020\/2603048"},{"key":"3087_CR33","doi-asserted-by":"crossref","unstructured":"Sun L, Fan L, Bian F, Chen G, Wang Y, Zhao Y. MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing. Research 2021, 2021.","DOI":"10.34133\/2021\/9838490"},{"key":"3087_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.34133\/2022\/9850743","volume":"2022","author":"X Ding","year":"2022","unstructured":"Ding X, Yu Y, Yang C, Wu D, Zhao Y. Multifunctional GO Hybrid Hydrogel scaffolds for Wound Healing. Research. 2022;2022:1\u201314.","journal-title":"Research"},{"key":"3087_CR35","doi-asserted-by":"crossref","unstructured":"Ding X, Zhang W, Xu P, Feng W, Tang X, Yang X, Wang L, Li L, Huang Y, Ji J et al. The Regulatory Effect of Braided Silk Fiber Skeletons with Differential Porosities on In Vivo Vascular Tissue Regeneration and Long-Term Patency. Research 2022, 2022.","DOI":"10.34133\/2022\/9825237"},{"key":"3087_CR36","doi-asserted-by":"crossref","unstructured":"Wu Z, Zhuang H, Ma B, Xiao Y, Koc B, Zhu Y, Wu C. Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing. Research 2021, 2021.","DOI":"10.34133\/2021\/9780943"},{"key":"3087_CR37","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.ijpharm.2017.10.026","volume":"548","author":"W Chen","year":"2018","unstructured":"Chen W, di Carlo C, Devery D, McGrath DJ, McHugh PE, Kleinsteinberg K, Jockenhoevel S, Hennink WE, Kok RJ. Fabrication and characterization of gefitinib-releasing polyurethane foam as a coating for drug-eluting stent in the treatment of bronchotracheal cancer. Int J Pharm. 2018;548:803\u201311.","journal-title":"Int J Pharm"},{"key":"3087_CR38","doi-asserted-by":"crossref","unstructured":"Shen G, Zheng F, Ren D, Du F, Dong Q, Wang Z, Zhao F, Ahmad R, Zhao J. Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development. J Hematol Oncol 2018, 11.","DOI":"10.1186\/s13045-018-0664-7"},{"key":"3087_CR39","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/jphp.13183","volume":"72","author":"H Ruan","year":"2020","unstructured":"Ruan H, Lv Z, Liu S, Zhang L, Huang K, Gao S, Gan W, Liu X, Zhang S, Helian K, et al. Anlotinib attenuated bleomycin-induced pulmonary fibrosis via the TGF-\u03b21 signalling pathway. J Pharm Pharmacol. 2020;72:44\u201355.","journal-title":"J Pharm Pharmacol"},{"key":"3087_CR40","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/ddr.22019","volume":"84","author":"J Lei","year":"2023","unstructured":"Lei J, Li Q, Xu H, Luo M, Liu Z, Xiang D, Chen P. Anlotinib improves bile duct ligature-induced liver fibrosis in rats via antiangiogenesis regulated by VEGFR2\/mTOR pathway. Drug Dev Res. 2023;84:143\u201355.","journal-title":"Drug Dev Res"},{"key":"3087_CR41","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1007\/s42765-022-00198-9","volume":"4","author":"L Li","year":"2022","unstructured":"Li L, Hao R, Qin J, Song J, Chen X, Rao F, Zhai J, Zhao Y, Zhang L, Xue J. Electrospun fibers Control Drug Delivery for tissue regeneration and Cancer therapy. Adv Fiber Mater. 2022;4:1375\u2013413.","journal-title":"Adv Fiber Mater"},{"key":"3087_CR42","doi-asserted-by":"crossref","unstructured":"Wan X, Zhao Y, Li Z, Li L. Emerging polymeric electrospun fibers: from structural diversity to application in flexible bioelectronics and tissue engineering. Exploration 2022, 2.","DOI":"10.1002\/EXP.20210029"},{"key":"3087_CR43","doi-asserted-by":"crossref","unstructured":"Xia G, Song B, Fang J. Electrical Stimulation Enabled via Electrospun Piezoelectric Polymeric Nanofibers for Tissue Regeneration. Research 2022, 2022.","DOI":"10.34133\/2022\/9896274"},{"key":"3087_CR44","doi-asserted-by":"publisher","first-page":"015013","DOI":"10.1088\/1748-605X\/abb25a","volume":"16","author":"Y Li","year":"2020","unstructured":"Li Y, Li M, Wang X, Wang Y, Li C, Zhao Y, Li Z, Chen J, Li J, Ren K, et al. Arsenic trioxide-eluting electrospun nanofiber-covered self-expandable metallic stent reduces granulation tissue hyperplasia in rabbit trachea. Biomed Mater. 2020;16:015013.","journal-title":"Biomed Mater"},{"key":"3087_CR45","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.bioactmat.2021.07.029","volume":"9","author":"Z Li","year":"2022","unstructured":"Li Z, Tian C, Jiao D, Li J, Li Y, Zhou X, Zhao H, Zhao Y, Han X. Synergistic effects of silver nanoparticles and cisplatin in combating inflammation and hyperplasia of airway stents. Bioactive Mater. 2022;9:266\u201380.","journal-title":"Bioactive Mater"},{"key":"3087_CR46","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1021\/acsnano.3c05829","volume":"18","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Liu Y, Liu Z, Ren K, Jiao D, Ren J, Wu P, Li X, Wang Z, Han X. In situ nanofiber Patch boosts postoperative Hepatocellular Carcinoma Immune activation by Trimodal Combination Therapy. ACS Nano. 2024;18:245\u201363.","journal-title":"ACS Nano"},{"key":"3087_CR47","doi-asserted-by":"publisher","first-page":"124201","DOI":"10.1016\/j.ijbiomac.2023.124201","volume":"239","author":"SA Seyhan","year":"2023","unstructured":"Seyhan SA, Alkaya DB, Cesur S, Sahin A. Investigation of the antitumor effect on breast cancer cells of the electrospun amygdalin-loaded poly(l-lactic acid)\/poly(ethylene glycol) nanofibers. Int J Biol Macromol. 2023;239:124201.","journal-title":"Int J Biol Macromol"},{"key":"3087_CR48","doi-asserted-by":"publisher","first-page":"100746","DOI":"10.1016\/j.mtbio.2023.100746","volume":"22","author":"Y Liu","year":"2023","unstructured":"Liu Y, Tian C, Zhang C, Liu Z, Li J, Li Y, Zhang Q, Ma S, Jiao D, Han X, Zhao Y. One-stop synergistic strategy for hepatocellular carcinoma postoperative recurrence. Mater Today Bio. 2023;22:100746.","journal-title":"Mater Today Bio"},{"key":"3087_CR49","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1002\/adma.201500329","volume":"27","author":"W Liu","year":"2015","unstructured":"Liu W, Lipner J, Moran CH, Feng L, Li X, Thomopoulos S, Xia Y. Generation of electrospun nanofibers with controllable degrees of crimping through a simple, plasticizer-based treatment. Adv Mater. 2015;27:2583\u20138.","journal-title":"Adv Mater"},{"key":"3087_CR50","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ijbiomac.2014.04.039","volume":"68","author":"CC Lin","year":"2014","unstructured":"Lin CC, Fu SJ, Lin YC, Yang IK, Gu Y. Chitosan-coated electrospun PLA fibers for rapid mineralization of calcium phosphate. Int J Biol Macromol. 2014;68:39\u201347.","journal-title":"Int J Biol Macromol"},{"key":"3087_CR51","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/s41428-020-0311-3","volume":"52","author":"Y Yataka","year":"2020","unstructured":"Yataka Y, Suzuki A, Iijima K, Hashizume M. Enhancement of the mechanical properties of polysaccharide composite films utilizing cellulose nanofibers. Polym J. 2020;52:645\u201353.","journal-title":"Polym J"},{"key":"3087_CR52","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.mattod.2019.04.018","volume":"28","author":"Y Huang","year":"2019","unstructured":"Huang Y, Song J, Yang C, Long Y, Wu H. Scalable manufacturing and applications of nanofibers. Mater Today. 2019;28:98\u2013113.","journal-title":"Mater Today"},{"key":"3087_CR53","doi-asserted-by":"crossref","unstructured":"Chen X, Cao H, He Y, Zhou Q, Li Z, Wang W, He Y, Tao G, Hou C. Advanced functional nanofibers: strategies to improve performance and expand functions. Front Optoelectron 2022, 15.","DOI":"10.1007\/s12200-022-00051-2"},{"key":"3087_CR54","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1039\/D2NP00084A","volume":"40","author":"G Kumar","year":"2023","unstructured":"Kumar G, Engle K. Natural products acting against S. Aureus through membrane and cell wall disruption. Nat Prod Rep. 2023;40:1608\u201346.","journal-title":"Nat Prod Rep"},{"key":"3087_CR55","doi-asserted-by":"crossref","unstructured":"Lakhundi S, Zhang K. Methicillin-Resistant Staphylococcus aureus: molecular characterization, evolution, and Epidemiology. Clin Microbiol Rev 2018, 31.","DOI":"10.1128\/CMR.00020-18"},{"key":"3087_CR56","doi-asserted-by":"crossref","unstructured":"Dondossola E, Holzapfel BM, Alexander S, Filippini S, Hutmacher DW, Friedl P. Examination of the foreign body response to biomaterials by nonlinear intravital microscopy. Nat Biomed Eng 2016, 1.","DOI":"10.1038\/s41551-016-0007"},{"key":"3087_CR57","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nbt.2580","volume":"31","author":"L Zhang","year":"2013","unstructured":"Zhang L, Cao Z, Bai T, Carr L, Ella-Menye JR, Irvin C, Ratner BD, Jiang S. Zwitterionic hydrogels implanted in mice resist the foreign-body reaction. Nat Biotechnol. 2013;31:553\u20136.","journal-title":"Nat Biotechnol"},{"key":"3087_CR58","doi-asserted-by":"crossref","unstructured":"Wang X, Yang C, Yu Y, Zhao Y. In Situ 3D Bioprinting Living Photosynthetic Scaffolds for Autotrophic Wound Healing. Research 2022, 2022.","DOI":"10.34133\/2022\/9794745"},{"key":"3087_CR59","doi-asserted-by":"publisher","first-page":"153734","DOI":"10.1016\/j.tox.2024.153734","volume":"502","author":"J He","year":"2024","unstructured":"He J, Ma Y, Niu X, Pei J, Yan R, Xu F, Ma J, Ma X, Jia S, Ma W. Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: the protective role of N-acetylcysteine. Toxicology. 2024;502:153734.","journal-title":"Toxicology"},{"key":"3087_CR60","doi-asserted-by":"publisher","first-page":"6657","DOI":"10.1016\/j.biomaterials.2014.04.093","volume":"35","author":"J Shi","year":"2014","unstructured":"Shi J, Sun X, Lin Y, Zou X, Li Z, Liao Y, Du M, Zhang H. Endothelial cell injury and dysfunction induced by silver nanoparticles through oxidative stress via IKK\/NF-\u03baB pathways. Biomaterials. 2014;35:6657\u201366.","journal-title":"Biomaterials"},{"key":"3087_CR61","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s13045-018-0664-7","volume":"11","author":"G Shen","year":"2018","unstructured":"Shen G, Zheng F, Ren D, Du F, Dong Q, Wang Z, Zhao F, Ahmad R, Zhao J. Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development. J Hematol Oncol. 2018;11:120.","journal-title":"J Hematol Oncol"},{"key":"3087_CR62","doi-asserted-by":"publisher","first-page":"116904","DOI":"10.1016\/j.bios.2024.116904","volume":"268","author":"Z Zhen","year":"2025","unstructured":"Zhen Z, Xiang L, Li S, Li H, Lei Y, Chen W, Jin JM, Liang C, Tang SY. Designing a whole-cell biosensor applicable for S-adenosyl-l-methionine-dependent methyltransferases. Biosens Bioelectron. 2025;268:116904.","journal-title":"Biosens Bioelectron"},{"key":"3087_CR63","doi-asserted-by":"publisher","first-page":"8876","DOI":"10.1038\/s41467-024-53109-4","volume":"15","author":"J Wu","year":"2024","unstructured":"Wu J, Zhang S, Yu S, An G, Wang Y, Yu Y, Liang L, Wang Y, Xu X, Xiong Y, et al. Nivolumab plus anlotinib hydrochloride in advanced gastric adenocarcinoma and esophageal squamous cell carcinoma: the phase II OASIS trial. Nat Commun. 2024;15:8876.","journal-title":"Nat Commun"},{"key":"3087_CR64","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1146\/annurev.pathol.2.010506.134925","volume":"2","author":"JA Nagy","year":"2007","unstructured":"Nagy JA, Dvorak AM, Dvorak HF. VEGF-A and the induction of pathological angiogenesis. Annu Rev Pathol. 2007;2:251\u201375.","journal-title":"Annu Rev Pathol"},{"key":"3087_CR65","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/s41573-023-00671-z","volume":"22","author":"Y Cao","year":"2023","unstructured":"Cao Y, Langer R, Ferrara N. Targeting angiogenesis in oncology, ophthalmology and beyond. Nat Rev Drug Discov. 2023;22:476\u201395.","journal-title":"Nat Rev Drug Discov"},{"key":"3087_CR66","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nrd.2015.17","volume":"15","author":"N Ferrara","year":"2016","unstructured":"Ferrara N, Adamis AP. Ten years of anti-vascular endothelial growth factor therapy. Nat Rev Drug Discov. 2016;15:385\u2013403.","journal-title":"Nat Rev Drug Discov"},{"key":"3087_CR67","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.ctrv.2013.11.009","volume":"40","author":"G Limaverde-Sousa","year":"2014","unstructured":"Limaverde-Sousa G, Sternberg C, Ferreira CG. Antiangiogenesis beyond VEGF inhibition: a journey from antiangiogenic single-target to broad-spectrum agents. Cancer Treat Rev. 2014;40:548\u201357.","journal-title":"Cancer Treat Rev"},{"key":"3087_CR68","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.gene.2018.02.026","volume":"654","author":"B Lin","year":"2018","unstructured":"Lin B, Song X, Yang D, Bai D, Yao Y, Lu N. Anlotinib inhibits angiogenesis via suppressing the activation of VEGFR2, PDGFR\u03b2 and FGFR1. Gene. 2018;654:77\u201386.","journal-title":"Gene"},{"key":"3087_CR69","doi-asserted-by":"publisher","first-page":"4937","DOI":"10.2147\/CMAR.S252181","volume":"12","author":"Q Yang","year":"2020","unstructured":"Yang Q, Ni L, Imani S, Xiang Z, Hai R, Ding R, Fu S, Wu Jb, Wen Q. Anlotinib suppresses Colorectal Cancer Proliferation and Angiogenesis via Inhibition of AKT\/ERK Signaling Cascade. Cancer Manage Res. 2020;12:4937\u201348.","journal-title":"Cancer Manage Res"},{"key":"3087_CR70","doi-asserted-by":"publisher","first-page":"6341","DOI":"10.1016\/j.biomaterials.2009.08.008","volume":"30","author":"S Gurunathan","year":"2009","unstructured":"Gurunathan S, Lee KJ, Kalishwaralal K, Sheikpranbabu S, Vaidyanathan R, Eom SH. Antiangiogenic properties of silver nanoparticles. Biomaterials. 2009;30:6341\u201350.","journal-title":"Biomaterials"},{"key":"3087_CR71","first-page":"1329","volume":"7","author":"S Jang","year":"2012","unstructured":"Jang S, Park JW, Cha HR, Jung SY, Lee JE, Jung SS, Kim JO, Kim SY, Lee CS, Park HS. Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation. Int J Nanomed. 2012;7:1329\u201343.","journal-title":"Int J Nanomed"},{"key":"3087_CR72","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.colsurfb.2009.04.025","volume":"73","author":"K Kalishwaralal","year":"2009","unstructured":"Kalishwaralal K, Banumathi E, Ram Kumar Pandian S, Deepak V, Muniyandi J, Eom SH, Gurunathan S. Silver nanoparticles inhibit VEGF induced cell proliferation and migration in bovine retinal endothelial cells. Colloids Surf B Biointerfaces. 2009;73:51\u20137.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"3087_CR73","doi-asserted-by":"crossref","unstructured":"Wang Z, Zhao H, Tang X, Meng T, Khutsishvili D, Xu B, Ma S. CNS Organoid Surpasses Cell-Laden Microgel Assembly to Promote Spinal Cord Injury Repair. Research 2022, 2022.","DOI":"10.34133\/2022\/9832128"},{"key":"3087_CR74","doi-asserted-by":"publisher","first-page":"134","DOI":"10.14712\/fb2015061040134","volume":"61","author":"M Klabusay","year":"2015","unstructured":"Klabusay M, Skopal\u00edk J, Erceg S, Hrdli\u010dka A. Aequorin as intracellular Ca2\u2009+\u2009Indicator Incorporated in Follicular Lymphoma cells by hypoosmotic shock treatment. Folia Biol (Praha). 2015;61:134\u20139.","journal-title":"Folia Biol (Praha)"},{"key":"3087_CR75","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s10565-020-09536-2","volume":"37","author":"Y Wang","year":"2021","unstructured":"Wang Y, Li H, Xue C, Chen H, Xue Y, Zhao F, Zhu MX, Cao Z. TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways. Cell Biol Toxicol. 2021;37:313\u201330.","journal-title":"Cell Biol Toxicol"},{"key":"3087_CR76","doi-asserted-by":"publisher","first-page":"744826","DOI":"10.3389\/fphar.2021.744826","volume":"12","author":"W Chen","year":"2021","unstructured":"Chen W, Zhang J, Zhong W, Liu Y, Lu Y, Zeng Z, Huang H, Wan X, Meng X, Zou F, et al. Anlotinib inhibits PFKFB3-Driven glycolysis in Myofibroblasts to reverse pulmonary fibrosis. Front Pharmacol. 2021;12:744826.","journal-title":"Front Pharmacol"},{"key":"3087_CR77","doi-asserted-by":"publisher","first-page":"1412660","DOI":"10.3389\/fonc.2024.1412660","volume":"14","author":"Y Xiong","year":"2024","unstructured":"Xiong Y, Xu X, Zhou X, Tong Y, Yu C. Anlotinib inhibits cervical cancer cell proliferation and invasion by suppressing cytokine secretion in activated cancer-associated fibroblasts. Front Oncol. 2024;14:1412660.","journal-title":"Front Oncol"},{"key":"3087_CR78","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1021\/acsbiomaterials.8b00252","volume":"5","author":"Y Chandorkar","year":"2019","unstructured":"Chandorkar Y, K R, Basu B. The foreign body response demystified. ACS Biomater Sci Eng. 2019;5:19\u201344.","journal-title":"ACS Biomater Sci Eng"},{"key":"3087_CR79","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/jbm.a.36798","volume":"108","author":"C Chu","year":"2020","unstructured":"Chu C, Liu L, Rung S, Wang Y, Ma Y, Hu C, Zhao X, Man Y, Qu Y. Modulation of foreign body reaction and macrophage phenotypes concerning microenvironment. J Biomed Mater Res A. 2020;108:127\u201335.","journal-title":"J Biomed Mater Res A"},{"key":"3087_CR80","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.addr.2019.08.010","volume":"144","author":"O Veiseh","year":"2019","unstructured":"Veiseh O, Vegas AJ. Domesticating the foreign body response: recent advances and applications. Adv Drug Deliv Rev. 2019;144:148\u201361.","journal-title":"Adv Drug Deliv Rev"},{"key":"3087_CR81","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3070","volume":"11","author":"C Shi","year":"2011","unstructured":"Shi C, Pamer EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol. 2011;11:762\u201374.","journal-title":"Nat Rev Immunol"},{"key":"3087_CR82","first-page":"4739","volume":"12","author":"P Wei","year":"2020","unstructured":"Wei P, Huang Z, Gan L, Li Y, Qin C, Liu G. Nintedanib ameliorates tracheal stenosis by activating HDAC2 and suppressing IL-8 and VEGF in rabbit. Am J Transl Res. 2020;12:4739\u201348.","journal-title":"Am J Transl Res"},{"key":"3087_CR83","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s12964-023-01099-z","volume":"21","author":"W Daido","year":"2023","unstructured":"Daido W, Nakashima T, Masuda T, Sakamoto S, Yamaguchi K, Horimasu Y, Miyamoto S, Iwamoto H, Fujitaka K, Hamada H, Hattori N. Nestin and Notch3 collaboratively regulate angiogenesis, collagen production, and endothelial-mesenchymal transition in lung endothelial cells. Cell Commun Signal. 2023;21:247.","journal-title":"Cell Commun Signal"},{"key":"3087_CR84","doi-asserted-by":"crossref","unstructured":"Zhang Y, He F, Zhang Q, Lu H, Yan S, Shi X. 3D-Printed flat-bone-mimetic bioceramic scaffolds for cranial restoration. Research 2023, 6.","DOI":"10.34133\/research.0255"},{"key":"3087_CR85","first-page":"105","volume":"145","author":"HP Ehrlich","year":"1994","unstructured":"Ehrlich HP, Desmouli\u00e8re A, Diegelmann RF, Cohen IK, Compton CC, Garner WL, Kapanci Y, Gabbiani G. Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol. 1994;145:105\u201313.","journal-title":"Am J Pathol"},{"key":"3087_CR86","doi-asserted-by":"crossref","unstructured":"Shook BA, Wasko RR, Rivera-Gonzalez GC, Salazar-Gatzimas E, L\u00f3pez-Gir\u00e1ldez F, Dash BC, Mu\u00f1oz-Rojas AR, Aultman KD, Zwick RK, Lei V et al. Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair. Science 2018, 362.","DOI":"10.1126\/science.aar2971"},{"key":"3087_CR87","doi-asserted-by":"publisher","first-page":"5","DOI":"10.26502\/fccm.92920302","volume":"7","author":"D Singh","year":"2023","unstructured":"Singh D, Rai V, Agrawal DK. Regulation of collagen I and Collagen III in tissue Injury and Regeneration. Cardiol Cardiovasc Med. 2023;7:5\u201316.","journal-title":"Cardiol Cardiovasc Med"},{"key":"3087_CR88","doi-asserted-by":"crossref","unstructured":"Mathew-Steiner SS, Roy S, Sen CK. Collagen in Wound Healing. Bioeng (Basel) 2021, 8.","DOI":"10.3390\/bioengineering8050063"},{"key":"3087_CR89","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/s41586-018-0394-6","volume":"560","author":"LW Plasschaert","year":"2018","unstructured":"Plasschaert LW, \u017dilionis R, Choo-Wing R, Savova V, Knehr J, Roma G, Klein AM, Jaffe AB. A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte. Nature. 2018;560:377\u201381.","journal-title":"Nature"},{"key":"3087_CR90","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41586-018-0393-7","volume":"560","author":"DT Montoro","year":"2018","unstructured":"Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, et al. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature. 2018;560:319\u201324.","journal-title":"Nature"},{"key":"3087_CR91","doi-asserted-by":"publisher","first-page":"216412","DOI":"10.1016\/j.canlet.2023.216412","volume":"576","author":"P Wang","year":"2023","unstructured":"Wang P, Song Y, Li H, Zhuang J, Shen X, Yang W, Mi R, Lu Y, Yang B, Ma M, Shen H. SIRPA enhances osteosarcoma metastasis by stabilizing SP1 and promoting SLC7A3-mediated arginine uptake. Cancer Lett. 2023;576:216412.","journal-title":"Cancer Lett"},{"key":"3087_CR92","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.4103\/0366-6999.193461","volume":"129","author":"T Wang","year":"2016","unstructured":"Wang T, Zhang J, Wang J, Pei YH, Qiu XJ, Wang YL. Paclitaxel Drug-eluting Tracheal Stent could reduce Granulation tissue formation in a Canine Model. Chin Med J (Engl). 2016;129:2708\u201313.","journal-title":"Chin Med J (Engl)"},{"key":"3087_CR93","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1039\/C8BM01623B","volume":"7","author":"M Duvvuri","year":"2019","unstructured":"Duvvuri M, Motz K, Murphy M, Feeley M, Ding D, Lee A, Elisseeff JH, Hillel AT. Engineering an immunomodulatory drug-eluting stent to treat laryngotracheal stenosis. Biomater Sci. 2019;7:1863\u201374.","journal-title":"Biomater Sci"},{"key":"3087_CR94","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1002\/lary.22175","volume":"121","author":"GH Zhu","year":"2011","unstructured":"Zhu GH, Ng AH, Venkatraman SS, Boey FY, Wee AL, Trasti SL. Yee Lim LH: a novel bioabsorbable drug-eluting tracheal stent. Laryngoscope. 2011;121:2234\u20139.","journal-title":"Laryngoscope"},{"key":"3087_CR95","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1097\/00005537-200308000-00024","volume":"113","author":"F Schm\u00e4l","year":"2003","unstructured":"Schm\u00e4l F, Fegeler W, Terpe HJ, Hermann W, Stoll W, Becker K. Bacteria and granulation tissue associated with Montgomery T-tubes. Laryngoscope. 2003;113:1394\u2013400.","journal-title":"Laryngoscope"},{"key":"3087_CR96","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1001\/archotol.132.10.1086","volume":"132","author":"SA Nouraei","year":"2006","unstructured":"Nouraei SA, Petrou MA, Randhawa PS, Singh A, Howard DJ, Sandhu GS. Bacterial colonization of airway stents: a promoter of granulation tissue formation following laryngotracheal reconstruction. Arch Otolaryngol Head Neck Surg. 2006;132:1086\u201390.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"3087_CR97","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.addr.2016.06.018","volume":"107","author":"B Tyler","year":"2016","unstructured":"Tyler B, Gullotti D, Mangraviti A, Utsuki T, Brem H. Polylactic acid (PLA) controlled delivery carriers for biomedical applications. Adv Drug Deliv Rev. 2016;107:163\u201375.","journal-title":"Adv Drug Deliv Rev"},{"key":"3087_CR98","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s12951-024-02491-8","volume":"22","author":"N Palani","year":"2024","unstructured":"Palani N, Vijayakumar P, Monisha P, Ayyadurai S, Rajadesingu S. Electrospun nanofibers synthesized from polymers incorporated with bioactive compounds for wound healing. J Nanobiotechnol. 2024;22:211.","journal-title":"J Nanobiotechnol"},{"key":"3087_CR99","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s42765-022-00223-x","volume":"5","author":"Z Wang","year":"2023","unstructured":"Wang Z, Hu W, Wang W, Xiao Y, Chen Y, Wang X. Antibacterial Electrospun Nanofibrous materials for Wound Healing. Adv Fiber Mater. 2023;5:107\u201329.","journal-title":"Adv Fiber Mater"},{"key":"3087_CR100","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s42765-020-00053-9","volume":"2","author":"J Zhao","year":"2020","unstructured":"Zhao J, Cui W. Functional Electrospun fibers for local therapy of Cancer. Adv Fiber Mater. 2020;2:229\u201345.","journal-title":"Adv Fiber Mater"},{"key":"3087_CR101","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s44174-023-00121-9","volume":"2","author":"R Naveenkumar","year":"2024","unstructured":"Naveenkumar R, Senthilvelan S, Karthikeyan B. A review on the recent developments in Electrospinned nanofibers for Drug Delivery. Biomedical Mater Devices. 2024;2:342\u201364.","journal-title":"Biomedical Mater Devices"},{"key":"3087_CR102","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1007\/s42765-022-00178-z","volume":"4","author":"Y Yang","year":"2022","unstructured":"Yang Y, Du Y, Zhang J, Zhang H, Guo B. Structural and functional design of Electrospun nanofibers for Hemostasis and Wound Healing. Adv Fiber Mater. 2022;4:1027\u201357.","journal-title":"Adv Fiber Mater"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-024-03087-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-024-03087-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-024-03087-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T08:33:38Z","timestamp":1738139618000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-024-03087-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":102,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3087"],"URL":"https:\/\/doi.org\/10.1186\/s12951-024-03087-y","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]},"assertion":[{"value":"3 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were granted approval by the animal care committee of the First Affiliated Hospital of Zhengzhou University (2023042602).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"59"}}