{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:44:11Z","timestamp":1792788251794,"version":"4.5.0"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022YFC3600600"],"award-info":[{"award-number":["2022YFC3600600"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82173521"],"award-info":[{"award-number":["82173521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-025-03316-y","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T01:40:17Z","timestamp":1742175617000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Protective effects of bone marrow mesenchymal stem cell-derived exosomes loaded cerium dioxide nanoparticle against deoxynivalenol-induced liver damage"],"prefix":"10.1186","volume":"23","author":[{"given":"Zitong","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingmeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liunan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas K.","family":"N\u00fcssler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liegang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"3316_CR1","doi-asserted-by":"crossref","unstructured":"Gab-Allah MA, Tahoun IF, Yamani RN, Rend EA, Shehata AB. Natural occurrence of Deoxynivalenol, Nivalenol and deoxynivalenol-3-glucoside in cereal-derived products from Egypt. Food Control. 2022;137.","DOI":"10.1016\/j.foodcont.2022.108974"},{"key":"3316_CR2","doi-asserted-by":"crossref","unstructured":"Belasli A, Herrera M, Ari\u00f1o A, Djenane D. Occurrence and exposure assessment of major Mycotoxins in foodstuffs from Algeria. Toxins. 2023;15.","DOI":"10.3390\/toxins15070449"},{"key":"3316_CR3","doi-asserted-by":"crossref","unstructured":"Vin K, Rivi\u00e8re G, Leconte S, Cravedi JP, Fremy JM, Oswald IP, Roudot AC, Vasseur P, Jean J, Hulin M, Sirot V. Dietary exposure to Mycotoxins in the French infant total diet study. Food Chem Toxicol. 2020;140.","DOI":"10.1016\/j.fct.2020.111301"},{"key":"3316_CR4","doi-asserted-by":"crossref","unstructured":"Hooft JM, Bureau DP. Deoxynivalenol: mechanisms of action and its effects on various terrestrial and aquatic species. Food Chem Toxicol. 2021;157.","DOI":"10.1016\/j.fct.2021.112616"},{"key":"3316_CR5","doi-asserted-by":"crossref","unstructured":"Jin J, Beekmann K, Ringo E, Rietjens IMCM, Xing FG. Interaction between food-borne Mycotoxins and gut microbiota: A review. Food Control. 2021;126.","DOI":"10.1016\/j.foodcont.2021.107998"},{"key":"3316_CR6","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1186\/s12916-023-03011-5","volume":"21","author":"T Tan","year":"2023","unstructured":"Tan T, Chen T, Zhu W, Gong L, Yan Y, Li Q, Chen L, Li Y, Liu J, Li Y, et al. Adverse associations between maternal Deoxynivalenol exposure and birth outcomes: a prospective cohort study in China. BMC Med. 2023;21:328.","journal-title":"BMC Med"},{"key":"3316_CR7","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/toxsci\/kfp225","volume":"113","author":"CJ Amuzie","year":"2010","unstructured":"Amuzie CJ, Pestka JJ. Suppression of insulin-like growth factor acid-labile subunit expression\u2013a novel mechanism for deoxynivalenol-induced growth retardation. Toxicol Sci. 2010;113:412\u201321.","journal-title":"Toxicol Sci"},{"key":"3316_CR8","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1093\/toxsci\/kfp287","volume":"113","author":"KA Voss","year":"2010","unstructured":"Voss KA. A new perspective on Deoxynivalenol and growth suppression. Toxicol Sci. 2010;113:281\u20133.","journal-title":"Toxicol Sci"},{"key":"3316_CR9","doi-asserted-by":"crossref","unstructured":"Tang M, Yuan DX, Liao P. Berberine improves intestinal barrier function and reduces inflammation, immunosuppression, and oxidative stress by regulating the NF-\u03baB\/MAPK signaling pathway in deoxynivalenol-challenged piglets. Environ Pollut. 2021;289.","DOI":"10.1016\/j.envpol.2021.117865"},{"key":"3316_CR10","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.toxicon.2009.05.021","volume":"54","author":"X Zhang","year":"2009","unstructured":"Zhang X, Jiang L, Geng C, Cao J, Zhong L. The role of oxidative stress in deoxynivalenol-induced DNA damage in HepG2 cells. Toxicon. 2009;54:513\u20138.","journal-title":"Toxicon"},{"key":"3316_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.theochem.2005.02.079","volume":"726","author":"CM Nagy","year":"2005","unstructured":"Nagy CM, Fejer SN, Berek L, Molnar J, Viskolcz B. Hydrogen bondings in Deoxynivalenol (DON) conformations - A density functional study. J Mol Structure-Theochem. 2005;726:55\u20139.","journal-title":"J Mol Structure-Theochem"},{"key":"3316_CR12","doi-asserted-by":"publisher","first-page":"108687","DOI":"10.1016\/j.fsi.2023.108687","volume":"135","author":"X Chen","year":"2023","unstructured":"Chen X, Ma J, Chen H. Induction of autophagy via the ROS-dependent AMPK\/mTOR pathway protects Deoxynivalenol exposure grass carp hepatocytes damage. Fish Shellfish Immunol. 2023;135:108687.","journal-title":"Fish Shellfish Immunol"},{"key":"3316_CR13","doi-asserted-by":"crossref","unstructured":"Tang X, Zeng Y, Xiong K, Li M. The inflammatory injury of Porcine small intestinal epithelial cells induced by Deoxynivalenol is related to the decrease in glucose transport. J Anim Sci. 2024;102.","DOI":"10.1093\/jas\/skae107"},{"key":"3316_CR14","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/toxsci\/kfs106","volume":"127","author":"X Wang","year":"2012","unstructured":"Wang X, Liu Q, Ihsan A, Huang L, Dai M, Hao H, Cheng G, Liu Z, Wang Y, Yuan Z. JAK\/STAT pathway plays a critical role in the Proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin. Toxicol Sci. 2012;127:412\u201324.","journal-title":"Toxicol Sci"},{"key":"3316_CR15","doi-asserted-by":"publisher","unstructured":"Gan F, Lin ZM, Tang JY, Chen XX, Huang KH. Deoxynivalenol at No-Observed Adverse-Effect levels aggravates DSS-Induced colitis through the JAK2\/STAT3 signaling pathway in mice. J Agric Food Chem 2023;71:4144\u201352. https:\/\/doi.org\/10.1021\/acs.jafc.3c00252","DOI":"10.1021\/acs.jafc.3c00252"},{"key":"3316_CR16","doi-asserted-by":"publisher","first-page":"161058","DOI":"10.1016\/j.scitotenv.2022.161058","volume":"864","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Fan K, Meng J, Nie D, Zhao Z, Han Z. Deoxynivalenol hijacks the pathway of Janus kinase 2\/signal transducers and activators of transcription 3 (JAK2\/STAT-3) to drive caspase-3-mediated apoptosis in intestinal Porcine epithelial cells. Sci Total Environ. 2023;864:161058.","journal-title":"Sci Total Environ"},{"key":"3316_CR17","doi-asserted-by":"publisher","first-page":"e2300317","DOI":"10.1002\/mnfr.202300317","volume":"67","author":"Y Liao","year":"2023","unstructured":"Liao Y, Peng Z, Xu S, Meng Z, Li D, Zhou X, Zhang R, Shi S, Hao L, Liu L, Yang W. Deoxynivalenol exposure induced colon damage in mice independent of the gut microbiota. Mol Nutr Food Res. 2023;67:e2300317.","journal-title":"Mol Nutr Food Res"},{"key":"3316_CR18","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s00204-022-03431-x","volume":"97","author":"LN Yang","year":"2023","unstructured":"Yang LN, Xu S, Tang M, Zhou X, Liao Y, Nussler AK, Liu L, Yang W. The circadian rhythm gene Bmal1 ameliorates acute deoxynivalenol-induced liver damage. Arch Toxicol. 2023;97:787\u2013804.","journal-title":"Arch Toxicol"},{"key":"3316_CR19","doi-asserted-by":"crossref","unstructured":"Zhang ZQ, Wang SB, Wang RG, Zhang W, Wang PL, Su XO. Phosphoproteome analysis reveals the molecular mechanisms underlying Deoxynivalenol-Induced intestinal toxicity in IPEC-J2 cells. Toxins (Basel). 2016;8.","DOI":"10.3390\/toxins8100270"},{"key":"3316_CR20","doi-asserted-by":"crossref","unstructured":"Meng Z, Wang L, Liao Y, Peng Z, Li D, Zhou X, Liu S, Li Y, Nussler AK, Liu L et al. The protective effect of Heme Oxygenase-1 on liver injury caused by DON-Induced oxidative stress and cytotoxicity. Toxins (Basel). 2021;13.","DOI":"10.3390\/toxins13100732"},{"key":"3316_CR21","doi-asserted-by":"publisher","first-page":"111435","DOI":"10.1016\/j.fct.2020.111435","volume":"141","author":"Y Liao","year":"2020","unstructured":"Liao Y, Peng Z, Wang L, Li D, Yue J, Liu J, Liang C, Liu S, Yan H, Nussler AK, et al. Long noncoding RNA Gm20319, acting as competing endogenous RNA, regulated GNE expression by sponging miR-7240-5p to involve in deoxynivalenol-induced liver damage in vitro. Food Chem Toxicol. 2020;141:111435.","journal-title":"Food Chem Toxicol"},{"key":"3316_CR22","doi-asserted-by":"crossref","unstructured":"Meng Z, Liao Y, Peng Z, Zhou X, Zhou H, Nussler AK, Liu L, Yang W. Bone marrow mesenchymal Stem-Cell-Derived exosomes ameliorate Deoxynivalenol-Induced mice liver damage. Antioxid (Basel). 2023;12.","DOI":"10.3390\/antiox12030588"},{"key":"3316_CR23","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1002\/hep.32129","volume":"75","author":"A Psaraki","year":"2022","unstructured":"Psaraki A, Ntari L, Karakostas C, Korrou-Karava D, Roubelakis MG. Extracellular vesicles derived from mesenchymal stem\/stromal cells: the regenerative impact in liver diseases. Hepatology. 2022;75:1590\u2013603.","journal-title":"Hepatology"},{"key":"3316_CR24","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1080\/08820139.2020.1712416","volume":"49","author":"M Jafarinia","year":"2020","unstructured":"Jafarinia M, Alsahebfosoul F, Salehi H, Eskandari N, Ganjalikhani-Hakemi M. Mesenchymal stem Cell-Derived extracellular vesicles: A novel Cell-Free therapy. Immunol Investig. 2020;49:758\u201380.","journal-title":"Immunol Investig"},{"key":"3316_CR25","doi-asserted-by":"crossref","unstructured":"Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367.","DOI":"10.1126\/science.aau6977"},{"key":"3316_CR26","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S1388-1981(00)00084-6","volume":"1487","author":"JW Borst","year":"2000","unstructured":"Borst JW, Visser NV, Kouptsova O, Visser AJWG. Oxidation of unsaturated phospholipids in membrane bilayer mixtures is accompanied by membrane fluidity changes. Biochim Et Biophys Acta-Molecular Cell Biology Lipids. 2000;1487:61\u201373.","journal-title":"Biochim Et Biophys Acta-Molecular Cell Biology Lipids"},{"key":"3316_CR27","doi-asserted-by":"publisher","first-page":"4896","DOI":"10.1039\/c2cc30485f","volume":"48","author":"JM Dowding","year":"2012","unstructured":"Dowding JM, Dosani T, Kumar A, Seal S, Self WT. Cerium oxide nanoparticles scavenge nitric oxide radical (NO). Chem Commun (Camb). 2012;48:4896\u20138.","journal-title":"Chem Commun (Camb)"},{"key":"3316_CR28","doi-asserted-by":"publisher","unstructured":"Korsvik C, Patil S, Seal S, Self WT. Superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticles. Chem Commun (Camb). 2007;10:1056\u20138. https:\/\/doi.org\/10.1039\/b615134e","DOI":"10.1039\/b615134e"},{"key":"3316_CR29","doi-asserted-by":"publisher","first-page":"10726","DOI":"10.1021\/nn403542p","volume":"7","author":"JD Cafun","year":"2013","unstructured":"Cafun JD, Kvashnina KO, Casals E, Puntes VF, Glatzel P. Absence of Ce3\u2009+\u2009sites in chemically active colloidal ceria nanoparticles. ACS Nano. 2013;7:10726\u201332.","journal-title":"ACS Nano"},{"key":"3316_CR30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2147\/IJN.S15308","volume":"6","author":"KA Amin","year":"2011","unstructured":"Amin KA, Hassan MS, Awad el ST, Hashem KS. The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline. Int J Nanomed. 2011;6:143\u20139.","journal-title":"Int J Nanomed"},{"key":"3316_CR31","doi-asserted-by":"crossref","unstructured":"Tian Y, Zhang Y, Zhao J, Luan F, Wang Y, Lai F, Ouyang D, Tao Y. Combining MSC exosomes and cerium oxide nanocrystals for enhanced dry eye syndrome therapy. Pharmaceutics. 2023;15.","DOI":"10.3390\/pharmaceutics15092301"},{"key":"3316_CR32","doi-asserted-by":"publisher","unstructured":"Wei P, Wang Y, Feng H, Zhang F, Ji Z, Zhang K, Zhang Q, Jiang L, Qian Y, Fu Y. Gene-Engineered Cerium-Exosomes mediate atherosclerosis therapy through remodeling of the inflammatory microenvironment and DNA damage repair. Small. 2024;20:e2404463. https:\/\/doi.org\/10.1002\/smll.202404463","DOI":"10.1002\/smll.202404463"},{"key":"3316_CR33","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1002\/hep.31139","volume":"72","author":"G Fernandez-Varo","year":"2020","unstructured":"Fernandez-Varo G, Perramon M, Carvajal S, Oro D, Casals E, Boix L, Oller L, Macias-Munoz L, Marfa S, Casals G, et al. Bespoken nanoceria: an effective treatment in experimental hepatocellular carcinoma. Hepatology. 2020;72:1267\u201382.","journal-title":"Hepatology"},{"key":"3316_CR34","doi-asserted-by":"crossref","unstructured":"Ahmadi S, Dadashpour M, Abri A, Zarghami N. Long-term proliferation and delayed senescence of bone marrow-derived human mesenchymal stem cells on Metformin co-embedded HA\/Gel electrospun composite nanofibers. J Drug Deliv Sci Technol. 2023;80.","DOI":"10.1016\/j.jddst.2022.104071"},{"key":"3316_CR35","doi-asserted-by":"publisher","first-page":"123880","DOI":"10.1016\/j.ijpharm.2024.123880","volume":"653","author":"S Kamalipooya","year":"2024","unstructured":"Kamalipooya S, Fahimirad S, Abtahi H, Golmohammadi M, Satari M, Dadashpour M, Nasrabadi D. Diabetic wound healing function of PCL\/cellulose acetate nanofiber engineered with Chitosan\/cerium oxide nanoparticles. Int J Pharm. 2024;653:123880.","journal-title":"Int J Pharm"},{"key":"3316_CR36","doi-asserted-by":"crossref","unstructured":"Yasamineh S, Kalajahi HG, Yasamineh P, Gholizadeh O, Youshanlouei HR, Matloub SK, Mozafari M, Jokar E, Yazdani Y, Dadashpour M. Spotlight on therapeutic efficiency of mesenchymal stem cells in viral infections with a focus on COVID-19. Stem Cell Res Ther. 2022;13.","DOI":"10.1186\/s13287-022-02944-7"},{"key":"3316_CR37","doi-asserted-by":"crossref","unstructured":"Serati-Nouri H, Rasoulpoor S, Pourpirali R, Sadeghi-Soureh S, Esmaeilizadeh N, Dadashpour M, Roshangar L, Zarghami N. In vitro expansion of human adipose-derived stem cells with delayed senescence through dual stage release of Curcumin from mesoporous silica nanoparticles\/electrospun nanofibers. Life Sci. 2021;285.","DOI":"10.1016\/j.lfs.2021.119947"},{"key":"3316_CR38","doi-asserted-by":"crossref","unstructured":"Mofarrah M, Jafari-Gharabaghlou D, Dadashpour M, Zarghami N. Fabricating ZSM-5 zeolite\/ Polycaprolactone nano-fibers co-loaded with dexamethasone and ascorbic acid: potential application in osteogenic differentiation of human adipose-derived stem cells. J Drug Deliv Sci Technol. 2023;79.","DOI":"10.1016\/j.jddst.2022.103999"},{"key":"3316_CR39","doi-asserted-by":"crossref","unstructured":"Huseynov E, Khalilov R, Mohamed AJ. Novel nanomaterials for hepatobiliary diseases treatment and future perspectives. Adv Biology Earth Sci. 2024;9.","DOI":"10.62476\/abes9s81"},{"key":"3316_CR40","unstructured":"Khalilov R, Nasibova A, Kavetskyy T, Kaz\u0131ml\u0131 L, Keskin C, Bayramova M. Interactions of nanoparticles and biological systems. Adv Biology Earth Sci. 2024;9."},{"key":"3316_CR41","doi-asserted-by":"crossref","unstructured":"Welsh JA, Goberdhan DCI, O\u2019Driscoll L, Buzas EI, Blenkiron C, Bussolati B, Cai HJ, Di Vizio D, Driedonks TAP, Erdbr\u00fcgger U et al. Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. J Extracell Vesicles. 2024;13.","DOI":"10.1002\/jev2.12451"},{"key":"3316_CR42","doi-asserted-by":"publisher","first-page":"e1904639","DOI":"10.1002\/adma.201904639","volume":"31","author":"F Gao","year":"2019","unstructured":"Gao F, Tang Y, Liu WL, Zou MZ, Huang C, Liu CJ, Zhang XZ. Intra\/Extracellular lactic acid exhaustion for synergistic metabolic therapy and immunotherapy of tumors. Adv Mater. 2019;31:e1904639.","journal-title":"Adv Mater"},{"key":"3316_CR43","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1007\/s12011-019-01696-5","volume":"193","author":"OA Adebayo","year":"2020","unstructured":"Adebayo OA, Akinloye O, Adaramoye OA. Cerium oxide nanoparticles attenuate oxidative stress and inflammation in the liver of Diethylnitrosamine-Treated mice. Biol Trace Elem Res. 2020;193:214\u201325.","journal-title":"Biol Trace Elem Res"},{"key":"3316_CR44","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1038\/s41467-019-09099-9","volume":"10","author":"B Shen","year":"2019","unstructured":"Shen B, Zhu Y, Kim Y, Zhou X, Sun H, Lu Z, Lee M. Autonomous helical propagation of active toroids with mechanical action. Nat Commun. 2019;10:1080.","journal-title":"Nat Commun"},{"key":"3316_CR45","doi-asserted-by":"publisher","first-page":"7556","DOI":"10.1038\/s41467-024-52016-y","volume":"15","author":"X Ma","year":"2024","unstructured":"Ma X, Luo S, Hua Y, Seetharaman S, Zhu X, Hou J, Zhang L, Wang W, Sun Y. An alumina phase induced composite transition shuttle to stabilize carbon capture cycles. Nat Commun. 2024;15:7556.","journal-title":"Nat Commun"},{"key":"3316_CR46","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1186\/s12951-023-02043-6","volume":"21","author":"Z Meng","year":"2023","unstructured":"Meng Z, Zhou D, Lv D, Gan Q, Liao Y, Peng Z, Zhou X, Xu S, Chi P, Wang Z, et al. Human milk extracellular vesicles enhance muscle growth and physical performance of immature mice associating with Akt\/mTOR\/p70s6k signaling pathway. J Nanobiotechnol. 2023;21:304.","journal-title":"J Nanobiotechnol"},{"key":"3316_CR47","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.ecoenv.2018.10.013","volume":"167","author":"G Wu","year":"2019","unstructured":"Wu G, Zhang Z, Chen X, Yu Q, Ma X, Liu L. Chemosensitization effect of cerium oxide nanosheets by suppressing drug detoxification and efflux. Ecotoxicol Environ Saf. 2019;167:301\u20138.","journal-title":"Ecotoxicol Environ Saf"},{"key":"3316_CR48","doi-asserted-by":"publisher","first-page":"121686","DOI":"10.1016\/j.biomaterials.2022.121686","volume":"287","author":"L Zhou","year":"2022","unstructured":"Zhou L, Tang S, Li F, Wu Y, Li S, Cui L, Luo J, Yang L, Ren Z, Zhang J, et al. Ceria nanoparticles prophylactic used for renal ischemia-reperfusion injury treatment by attenuating oxidative stress and inflammatory response. Biomaterials. 2022;287:121686.","journal-title":"Biomaterials"},{"key":"3316_CR49","doi-asserted-by":"publisher","unstructured":"Zhen K, Wei X, Zhi Z, Shang S, Zhang S, Xu Y, Fu X, Cheng L, Yao J, Li Y et al. Circulating extracellular vesicles from heart failure patients inhibit human cardiomyocyte activities. J Cardiovasc Transl Res 2024;17:1\u201318. https:\/\/doi.org\/10.1007\/s12265-024-10571-1","DOI":"10.1007\/s12265-024-10571-1"},{"key":"3316_CR50","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1007\/s00204-022-03344-9","volume":"96","author":"X Mao","year":"2022","unstructured":"Mao X, Li J, Xie X, Chen S, Huang Q, Mu P, Jiang J, Deng Y. Deoxynivalenol induces caspase-3\/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells. Arch Toxicol. 2022;96:3091\u2013112.","journal-title":"Arch Toxicol"},{"key":"3316_CR51","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.jhep.2015.10.020","volume":"64","author":"D Or\u00f3","year":"2016","unstructured":"Or\u00f3 D, Yudina T, Fern\u00e1ndez-Varo G, Casals E, Reichenbach V, Casals G, de la Presa BG, Sandalinas S, Carvajal S, Puntes V, Jim\u00e9nez W. Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti-inflammatory properties in rats with liver fibrosis. J Hepatol. 2016;64:691\u20138.","journal-title":"J Hepatol"},{"key":"3316_CR52","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1074\/mcp.TIR118.000900","volume":"17","author":"F Meier","year":"2018","unstructured":"Meier F, Brunner AD, Koch S, Koch H, Lubeck M, Krause M, Goedecke N, Decker J, Kosinski T, Park MA, et al. Online parallel Accumulation-Serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer. Mol Cell Proteom. 2018;17:2534\u201345.","journal-title":"Mol Cell Proteom"},{"key":"3316_CR53","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1074\/mcp.M400129-MCP200","volume":"3","author":"PL Ross","year":"2004","unstructured":"Ross PL, Huang YN, Marchese JN, Williamson B, Parker K, Hattan S, Khainovski N, Pillai S, Dey S, Daniels S, et al. Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol Cell Proteom. 2004;3:1154\u201369.","journal-title":"Mol Cell Proteom"},{"key":"3316_CR54","doi-asserted-by":"publisher","first-page":"4541","DOI":"10.1021\/pr300330z","volume":"11","author":"J Wu","year":"2012","unstructured":"Wu J, Xie X, Liu Y, He J, Benitez R, Buckanovich RJ, Lubman DM. Identification and confirmation of differentially expressed fucosylated glycoproteins in the serum of ovarian cancer patients using a lectin array and LC-MS\/MS. J Proteome Res. 2012;11:4541\u201352.","journal-title":"J Proteome Res"},{"key":"3316_CR55","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1074\/mcp.TIR120.002048","volume":"19","author":"F Yu","year":"2020","unstructured":"Yu F, Haynes SE, Teo GC, Avtonomov DM, Polasky DA, Nesvizhskii AI. Fast quantitative analysis of TimsTOF PASEF data with MSFragger and ionquant. Mol Cell Proteom. 2020;19:1575\u201385.","journal-title":"Mol Cell Proteom"},{"key":"3316_CR56","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1016\/j.cell.2020.05.002","volume":"181","author":"L Liang","year":"2020","unstructured":"Liang L, Rasmussen MLH, Piening B, Shen XT, Chen SJ, R\u00f6st H, Snyder JK, Tibshirani R, Skotte L, Lee NC, et al. Metabolic dynamics and prediction of gestational age and time to delivery in pregnant women. Cell. 2020;181:1680\u2013.","journal-title":"Cell"},{"key":"3316_CR57","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1146\/annurev.pharmtox.48.113006.094715","volume":"48","author":"R Kaddurah-Daouk","year":"2008","unstructured":"Kaddurah-Daouk R, Kristal BS, Weinshilboum RM. Metabolomics: A global biochemical approach to drug response and disease. Annu Rev Pharmacol Toxicol. 2008;48:653\u201383.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"3316_CR58","doi-asserted-by":"crossref","unstructured":"Lu D, Lin ZY, Wang R, Chen Z, Zhuo JY, Xu L, Pan LH, Li HH, Yang XY, He CY et al. Multi-omics profiling reveals Chitinase-3-like protein 1 as a key mediator in the crosstalk between sarcopenia and liver cancer. Redox Biol. 2022;58.","DOI":"10.1016\/j.redox.2022.102538"},{"key":"3316_CR59","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41419-024-06579-9","volume":"15","author":"N Zhang","year":"2024","unstructured":"Zhang N, Ji Q, Chen Y, Wen X, Shan F. TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits. Cell Death Dis. 2024;15:193.","journal-title":"Cell Death Dis"},{"key":"3316_CR60","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00204-019-02649-6","volume":"94","author":"Z Peng","year":"2020","unstructured":"Peng Z, Liao YX, Wang XQ, Chen LK, Wang LL, Qin CY, Wang ZT, Cai MY, Hu JW, Li D, et al. Heme oxygenase-1 regulates autophagy through carbon-oxygen to alleviate deoxynivalenol-induced hepatic damage. Arch Toxicol. 2020;94:573\u201388.","journal-title":"Arch Toxicol"},{"key":"3316_CR61","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.mattod.2023.03.024","volume":"65","author":"B Li","year":"2023","unstructured":"Li B, Zhang Q, Du W, Wu J, Cheng J, Zhang Y, Gao R, Zhao X, Jiang L, Wu Y, et al. Reshaping cardiac microenvironments by macrophage-derived extracellular vesicles-coated Pd@CeO2 heterostructures for myocardial ischemia\/reperfusion injury therapy. Mater Today. 2023;65:47\u201361.","journal-title":"Mater Today"},{"key":"3316_CR62","doi-asserted-by":"crossref","unstructured":"Xue C, Yao QF, Gu XY, Shi QM, Yuan X, Chu QF, Bao ZY, Lu J, Li LJ. Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer. Signal Transduct Target Therapy. 2023;8.","DOI":"10.1038\/s41392-023-01468-7"},{"key":"3316_CR63","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1126\/science.8511589","volume":"260","author":"M Murakami","year":"1993","unstructured":"Murakami M, Hibi M, Nakagawa N, Nakagawa T, Yasukawa K, Yamanishi K, Taga T, Kishimoto T. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science. 1993;260:1808\u201310.","journal-title":"Science"},{"key":"3316_CR64","doi-asserted-by":"publisher","first-page":"3855","DOI":"10.2147\/DDDT.S442154","volume":"17","author":"YY Yuan","year":"2023","unstructured":"Yuan YY, Wang F, Liu XX, Shuai B, Fan H. The role of AMPK signaling in ulcerative colitis. Drug Des Dev Therapy. 2023;17:3855\u201375.","journal-title":"Drug Des Dev Therapy"},{"key":"3316_CR65","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/boc.202000008","volume":"112","author":"X Tong","year":"2020","unstructured":"Tong X, Ganta RR, Liu Z. AMP-activated protein kinase (AMPK) regulates autophagy, inflammation and immunity and contributes to osteoclast differentiation and functionabs. Biol Cell. 2020;112:251\u201364.","journal-title":"Biol Cell"},{"key":"3316_CR66","doi-asserted-by":"publisher","first-page":"e60374","DOI":"10.1371\/journal.pone.0060374","volume":"8","author":"YJ Hou","year":"2013","unstructured":"Hou YJ, Zhao YY, Xiong B, Cui XS, Kim NH, Xu YX, Sun SC. Mycotoxin-containing diet causes oxidative stress in the mouse. PLoS ONE. 2013;8:e60374.","journal-title":"PLoS ONE"},{"key":"3316_CR67","doi-asserted-by":"publisher","first-page":"6971","DOI":"10.1039\/C8NR00325D","volume":"10","author":"V Baldim","year":"2018","unstructured":"Baldim V, Bedioui F, Mignet N, Margaill I, Berret JF. The enzyme-like catalytic activity of cerium oxide nanoparticles and its dependency on Ce(3+) surface area concentration. Nanoscale. 2018;10:6971\u201380.","journal-title":"Nanoscale"},{"key":"3316_CR68","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.nano.2008.10.003","volume":"5","author":"J Colon","year":"2009","unstructured":"Colon J, Herrera L, Smith J, Patil S, Komanski C, Kupelian P, Seal S, Jenkins DW, Baker CH. Protection from radiation-induced pneumonitis using cerium oxide nanoparticles. Nanomed. 2009;5:225\u201331.","journal-title":"Nanomed"},{"key":"3316_CR69","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1016\/j.biomaterials.2006.11.036","volume":"28","author":"M Das","year":"2007","unstructured":"Das M, Patil S, Bhargava N, Kang JF, Riedel LM, Seal S, Hickman JJ. Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons. Biomaterials. 2007;28:1918\u201325.","journal-title":"Biomaterials"},{"key":"3316_CR70","doi-asserted-by":"crossref","unstructured":"Chen Q, Chen JW, Yang ZJ, Xu J, Xu LG, Liang C, Han X, Liu Z. Nanoparticle-Enhanced radiotherapy to trigger robust cancer immunotherapy. Adv Mater. 2019;31.","DOI":"10.1002\/adma.201802228"},{"key":"3316_CR71","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1039\/c3sc50697e","volume":"4","author":"M Li","year":"2013","unstructured":"Li M, Shi P, Xu C, Ren JS, Qu XG. Cerium oxide caged metal chelator: anti-aggregation and anti-oxidation integrated HO-responsive controlled drug release for potential Alzheimer\u2019s disease treatment. Chem Sci. 2013;4:2536\u201342.","journal-title":"Chem Sci"},{"key":"3316_CR72","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/adhm.201200464","volume":"2","author":"C Xu","year":"2013","unstructured":"Xu C, Lin YH, Wang JS, Wu L, Wei WL, Ren JS, Qu XG. Nanoceria-Triggered synergetic drug release based on ceo-Capped mesoporous silica Host-Guest interactions and switchable enzymatic activity and cellular effects of ceo. Adv Healthc Mater. 2013;2:1591\u20139.","journal-title":"Adv Healthc Mater"},{"key":"3316_CR73","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.jhep.2015.10.020","volume":"64","author":"D Oro","year":"2016","unstructured":"Oro D, Yudina T, Fernandez-Varo G, Casals E, Reichenbach V, Casals G, Gonzalez de la Presa B, Sandalinas S, Carvajal S, Puntes V, Jimenez W. Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti-inflammatory properties in rats with liver fibrosis. J Hepatol. 2016;64:691\u20138.","journal-title":"J Hepatol"},{"key":"3316_CR74","doi-asserted-by":"publisher","first-page":"6287","DOI":"10.1039\/C4CS00487F","volume":"44","author":"TL Moore","year":"2015","unstructured":"Moore TL, Rodriguez-Lorenzo L, Hirsch V, Balog S, Urban D, Jud C, Rothen-Rutishauser B, Lattuada M, Petri-Fink A. Nanoparticle colloidal stability in cell culture media and impact on cellular interactions. Chem Soc Rev. 2015;44:6287\u2013305.","journal-title":"Chem Soc Rev"},{"key":"3316_CR75","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3389\/fimmu.2017.00970","volume":"8","author":"E Casals","year":"2017","unstructured":"Casals E, Gusta MF, Piella J, Casals G, Jimenez W, Puntes V. Intrinsic and extrinsic properties affecting innate immune responses to nanoparticles: the case of cerium oxide. Front Immunol. 2017;8:970.","journal-title":"Front Immunol"},{"key":"3316_CR76","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/aps.2017.12","volume":"38","author":"X Luan","year":"2017","unstructured":"Luan X, Sansanaphongpricha K, Myers I, Chen HW, Yuan HB, Sun DX. Engineering exosomes as refined biological nanoplatforms for drug delivery. Acta Pharmacol Sin. 2017;38:754\u201363.","journal-title":"Acta Pharmacol Sin"},{"key":"3316_CR77","doi-asserted-by":"crossref","unstructured":"Sen S, Xavier J, Kumar N, Ahmad MZ, Ranjan OP. Exosomes as natural nanocarrier-based drug delivery system: recent insights and future perspectives. 3 Biotech. 2023;13.","DOI":"10.1007\/s13205-023-03521-2"},{"key":"3316_CR78","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3233\/CH-200946","volume":"77","author":"JX Chen","year":"2021","unstructured":"Chen JX, Huang XY, Wang P, Lin WT, Xu WX, Zeng M. Effects and mechanism of arachidonic acid against TNF-alpha induced apoptosis of endothelial cells. Clin Hemorheol Microcirc. 2021;77:259\u201365.","journal-title":"Clin Hemorheol Microcirc"},{"key":"3316_CR79","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.3945\/jn.109.112417","volume":"139","author":"S Jiang","year":"2009","unstructured":"Jiang S, Wang ZG, Riethoven JJ, Xia YN, Miner J, Fromm M. Conjugated Linoleic acid activates AMP-Activated protein kinase and reduces adiposity more effectively when used with Metformin in mice. J Nutr. 2009;139:2244\u201351.","journal-title":"J Nutr"},{"key":"3316_CR80","doi-asserted-by":"crossref","unstructured":"Yang B, Zhou Y, Wu MJ, Li XS, Mai KS, Ai QH. \u03c9-6 polyunsaturated fatty acids (linoleic acid) activate both autophagy and antioxidation in a synergistic feedback loop via TOR-dependent and TOR-independent signaling pathways. Cell Death Dis. 2020;11.","DOI":"10.1038\/s41419-020-02750-0"},{"key":"3316_CR81","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/boc.202000008","volume":"112","author":"XS Tong","year":"2020","unstructured":"Tong XS, Ganta RR, Liu ZP. AMP-activated protein kinase (AMPK) regulates autophagy, inflammation and immunity and contributes to osteoclast differentiation and functionabs. Biol Cell. 2020;112:251\u201364.","journal-title":"Biol Cell"},{"key":"3316_CR82","doi-asserted-by":"publisher","first-page":"5014","DOI":"10.1021\/es8001508","volume":"42","author":"EG Heckert","year":"2008","unstructured":"Heckert EG, Seal S, Self WT. Fenton-like reaction catalyzed by the rare Earth inner transition metal cerium. Environ Sci Technol. 2008;42:5014\u20139.","journal-title":"Environ Sci Technol"},{"key":"3316_CR83","doi-asserted-by":"publisher","first-page":"6971","DOI":"10.1039\/C8NR00325D","volume":"10","author":"V Baldim","year":"2018","unstructured":"Baldim V, Bedioui F, Mignet N, Margaill I, Berret JF. The enzyme-like catalytic activity of cerium oxide nanoparticles and its dependency on Ce surface area concentration. Nanoscale. 2018;10:6971\u201380.","journal-title":"Nanoscale"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03316-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-025-03316-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03316-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T02:13:50Z","timestamp":1742177630000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03316-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":83,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3316"],"URL":"https:\/\/doi.org\/10.1186\/s12951-025-03316-y","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,17]]},"assertion":[{"value":"1 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal housing and experimental processes adhered strictly to the \u201cRegulations on the Administration of Laboratory Animals in China\u201d. Experiments involving mice and the protocols were approved by the Institutional Animal Care and Use Committee of Huazhong University of Science and Technology (IACUC Number: 3622).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics and consent to Participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"215"}}