{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:51:40Z","timestamp":1792842700106,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QH062"],"award-info":[{"award-number":["ZR2023QH062"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32201167"],"award-info":[{"award-number":["32201167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772255"],"award-info":[{"award-number":["81772255"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-025-03335-9","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T11:49:42Z","timestamp":1743162582000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["5-FU@HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia"],"prefix":"10.1186","volume":"23","author":[{"given":"Zuowei","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujia","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"issue":"5940","key":"3335_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/306277a0","volume":"306","author":"CR Bartram","year":"1983","unstructured":"Bartram CR, de Klein A, Hagemeijer A, van Agthoven T, van Geurts A, Bootsma D, et al. Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1983;306(5940):277\u201380.","journal-title":"Nature"},{"issue":"3","key":"3335_CR2","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nrc1567","volume":"5","author":"R Ren","year":"2005","unstructured":"Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer. 2005;5(3):172\u201383.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"3335_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.6004\/jnccn.2024.0007","volume":"22","author":"NP Shah","year":"2024","unstructured":"Shah NP, Bhatia R, Altman JK, Amaya M, Begna KH, Berman E, et al. Chronic myeloid leukemia, version 2.2024, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2024;22(1):43\u201369.","journal-title":"J Natl Compr Canc Netw"},{"issue":"11","key":"3335_CR4","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.3324\/haematol.2017.174953","volume":"102","author":"IGP Geelen","year":"2017","unstructured":"Geelen IGP, Thielen N, Janssen JJWM, Hoogendoorn M, Roosma TJA, Willemsen SP, et al. Treatment outcome in a population-based, \u2018real-world\u2019 cohort of patients with chronic myeloid leukemia. Haematologica. 2017;102(11):1842\u20139.","journal-title":"Haematologica"},{"issue":"15","key":"3335_CR5","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.3390\/cancers14153641","volume":"14","author":"I Stukan","year":"2022","unstructured":"Stukan I, Gryzik M, Hoser G, Want A, Grabowska-Pyrzewicz W, Zdioruk M, et al. Novel Dicarboximide BK124.1 Breaks Multidrug Resistance and Shows Anticancer Efficacy in Chronic Myeloid Leukemia Preclinical Models and Patients\u2019 CD34+\/CD38- Leukemia Stem Cells. Cancers (Basel). 2022;14(15):3641.","journal-title":"Cancers (Basel)"},{"issue":"6","key":"3335_CR6","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1002\/ajh.27271","volume":"99","author":"MM Patnaik","year":"2024","unstructured":"Patnaik MM, Tefferi A. Chronic myelomonocytic leukemia: 2024 update on diagnosis, risk stratification and management. Am J Hematol. 2024;99(6):1142\u201365.","journal-title":"Am J Hematol"},{"issue":"6","key":"3335_CR7","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1038\/s41375-021-01207-3","volume":"35","author":"O Chan","year":"2021","unstructured":"Chan O, Renneville A, Padron E. Chronic myelomonocytic leukemia diagnosis and management. Leukemia. 2021;35(6):1552\u201362.","journal-title":"Leukemia"},{"issue":"5","key":"3335_CR8","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.cell.2020.02.002","volume":"180","author":"K Wang","year":"2020","unstructured":"Wang K, Sun Q, Zhong X, Zeng M, Zeng H, Shi X, et al. Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis. Cell. 2020;180(5):941\u201355.","journal-title":"Cell"},{"issue":"1","key":"3335_CR9","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41392-024-01801-8","volume":"9","author":"C Zhu","year":"2024","unstructured":"Zhu C, Xu S, Jiang R, Yu Y, Bian J, Zou Z. The gasdermin family: emerging therapeutic targets in diseases. Signal Transduct Target Ther. 2024;9(1):87.","journal-title":"Signal Transduct Target Ther"},{"issue":"13","key":"3335_CR10","doi-asserted-by":"publisher","first-page":"4166","DOI":"10.7150\/ijbs.86855","volume":"19","author":"H Huang","year":"2023","unstructured":"Huang H, Weng Y, Tian W, Lin X, Chen J, Luo L. Molecular mechanisms of pyroptosis and its role in anti-tumor immunity. Int J Biol Sci. 2023;19(13):4166\u201380.","journal-title":"Int J Biol Sci"},{"issue":"43","key":"3335_CR11","doi-asserted-by":"publisher","first-page":"eaax7969","DOI":"10.1126\/sciimmunol.aax7969","volume":"5","author":"Y Liu","year":"2020","unstructured":"Liu Y, Fang Y, Chen X, Wang Z, Liang X, Zhang T, et al. Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome. Sci Immunol. 2020;5(43):eaax7969.","journal-title":"Sci Immunol"},{"issue":"7799","key":"3335_CR12","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41586-020-2079-1","volume":"579","author":"Q Wang","year":"2020","unstructured":"Wang Q, Wang Y, Ding J, Wang C, Zhou X, Gao W, et al. A bioorthogonal system reveals antitumour immune function of pyroptosis. Nature. 2020;579(7799):421\u20136.","journal-title":"Nature"},{"issue":"7661","key":"3335_CR13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","volume":"547","author":"Y Wang","year":"2017","unstructured":"Wang Y, Gao W, Shi X, Ding J, Liu W, He H, et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 2017;547(7661):99\u2013103.","journal-title":"Nature"},{"issue":"5","key":"3335_CR14","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41573-021-00154-z","volume":"20","author":"X Liu","year":"2021","unstructured":"Liu X, Xia S, Zhang Z, Wu H, Lieberman J. Channelling inflammation: gasdermins in physiology and disease. Nat Rev Drug Discov. 2021;20(5):384\u2013405.","journal-title":"Nat Rev Drug Discov"},{"issue":"11","key":"3335_CR15","doi-asserted-by":"publisher","first-page":"8049","DOI":"10.1021\/acs.nanolett.9b03245","volume":"19","author":"JX Fan","year":"2019","unstructured":"Fan JX, Deng RH, Wang H, Liu XH, Wang XN, Qin R, et al. Epigenetics-Based tumor cells pyroptosis for enhancing the immunological effect of chemotherapeutic nanocarriers. Nano Lett. 2019;19(11):8049\u201358.","journal-title":"Nano Lett"},{"issue":"3","key":"3335_CR16","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.ccr.2011.12.029","volume":"21","author":"HC Tsai","year":"2012","unstructured":"Tsai HC, Li H, Van Neste L, Cai Y, Robert C, Rassool FV, et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell. 2012;21(3):430\u201346.","journal-title":"Cancer Cell"},{"issue":"15","key":"3335_CR17","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1182\/blood.2022018246","volume":"141","author":"L Penter","year":"2023","unstructured":"Penter L, Liu Y, Wolff JO, Yang L, Taing L, Jhaveri A, et al. Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease. Blood. 2023;141(15):1817\u201330.","journal-title":"Blood"},{"issue":"2","key":"3335_CR18","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/2503","volume":"20","author":"L Van Laer","year":"1998","unstructured":"Van Laer L, Huizing EH, Verstreken M, van Zuijlen D, Wauters JG, Bossuyt PJ, et al. Nonsyndromic hearing impairment is associated with a mutation in DFNA5. Nat Genet. 1998;20(2):194\u20137.","journal-title":"Nat Genet"},{"key":"3335_CR19","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41392-019-0062-9","volume":"4","author":"J Hu","year":"2019","unstructured":"Hu J, Dong Y, Ding L, Dong Y, Wu Z, Wang W, et al. Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment. Signal Transduct Target Ther. 2019;4:28.","journal-title":"Signal Transduct Target Ther"},{"issue":"23","key":"3335_CR20","doi-asserted-by":"publisher","first-page":"6066","DOI":"10.1158\/1078-0432.CCR-18-1478","volume":"24","author":"H Lu","year":"2018","unstructured":"Lu H, Zhang S, Wu J, Chen M, Cai MC, Fu Y, et al. Molecular targeted therapies elicit concurrent apoptotic and GSDME-Dependent pyroptotic tumor cell death. Clin Cancer Res. 2018;24(23):6066\u201377.","journal-title":"Clin Cancer Res"},{"issue":"2","key":"3335_CR21","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41419-021-03458-5","volume":"12","author":"X Shen","year":"2021","unstructured":"Shen X, Wang H, Weng C, Jiang H, Chen J. Caspase 3\/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity. Cell Death Dis. 2021;12(2):186.","journal-title":"Cell Death Dis"},{"issue":"5","key":"3335_CR22","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1517\/17425255.2015.1027684","volume":"11","author":"S Matsusaka","year":"2015","unstructured":"Matsusaka S, Lenz HJ. Pharmacogenomics of fluorouracil-based chemotherapy toxicity. Expert Opin Drug Metab Toxicol. 2015;11(5):811\u201321.","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"1","key":"3335_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.colsurfb.2008.07.020","volume":"68","author":"L Zhu","year":"2009","unstructured":"Zhu L, Ma J, Jia N, Zhao Y, Shen H. Chitosan-coated magnetic nanoparticles as carriers of 5-fluorouracil: preparation, characterization and cytotoxicity studies. Colloids Surf B Biointerfaces. 2009;68(1):1\u20136.","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"1","key":"3335_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12951-016-0245-2","volume":"15","author":"T Wang","year":"2017","unstructured":"Wang T, Hou J, Su C, Zhao L, Shi Y. Hyaluronic acid-coated Chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44. J Nanobiotechnol. 2017;15(1):7.","journal-title":"J Nanobiotechnol"},{"issue":"6","key":"3335_CR25","first-page":"631","volume":"14","author":"Y Sun","year":"2019","unstructured":"Sun Y, Zhao D, Wang G, Jiang Q, Guo M, Kan Q, et al. A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates. Asian J Pharm Sci. 2019;14(6):631\u20139.","journal-title":"Asian J Pharm Sci"},{"issue":"17","key":"3335_CR26","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1021\/acs.accounts.1c00267","volume":"54","author":"N Song","year":"2021","unstructured":"Song N, Zhang J, Zhai J, Hong J, Yuan C, Liang M. Ferritin: A multifunctional nanoplatform for biological detection, imaging diagnosis, and drug delivery. Acc Chem Res. 2021;54(17):3313\u201325.","journal-title":"Acc Chem Res"},{"issue":"3","key":"3335_CR27","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.1021\/acsnano.1c10029","volume":"16","author":"J Pang","year":"2022","unstructured":"Pang J, Feng X, Liang Q, Zheng X, Duan Y, Zhang X, et al. Ferritin-Nanocaged ATP traverses the Blood-Testis barrier and enhances sperm motility in an asthenozoospermia model. ACS Nano. 2022;16(3):4175\u201385.","journal-title":"ACS Nano"},{"issue":"21","key":"3335_CR28","doi-asserted-by":"publisher","first-page":"e2205606","DOI":"10.1002\/smll.202205606","volume":"19","author":"M Budiarta","year":"2023","unstructured":"Budiarta M, Roy S, Katenkamp T, Feliu N, Beck T. Overcoming Non-Specific interactions for efficient encapsulation of doxorubicin in ferritin nanocages for targeted drug delivery. Small. 2023;19(21):e2205606.","journal-title":"Small"},{"issue":"41","key":"3335_CR29","doi-asserted-by":"publisher","first-page":"14900","DOI":"10.1073\/pnas.1407808111","volume":"111","author":"M Liang","year":"2014","unstructured":"Liang M, Fan K, Zhou M, Duan D, Zheng J, Yang D, et al. H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection. Proc Natl Acad Sci U S A. 2014;111(41):14900\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"3335_CR30","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1073\/pnas.0913192107","volume":"107","author":"L Li","year":"2010","unstructured":"Li L, Fang CJ, Ryan JC, Niemi EC, Lebr\u00f3n JA, Bj\u00f6rkman PJ, et al. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A. 2010;107(8):3505\u201310.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"3335_CR31","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.1021\/acsnano.5b07408","volume":"10","author":"Y Zhao","year":"2016","unstructured":"Zhao Y, Liang M, Li X, Fan K, Xiao J, Li Y, et al. Bioengineered Magnetoferritin nanoprobes for Single-Dose Nuclear-Magnetic resonance tumor imaging. ACS Nano. 2016;10(4):4184\u201391.","journal-title":"ACS Nano"},{"key":"3335_CR32","doi-asserted-by":"crossref","unstructured":"Jiang B, Chen X, Sun G, Chen X, Yin Y, Jin Y et al. A natural drug entry channel in the ferritin nanocage. Nano Today. 2020, 35100948.","DOI":"10.1016\/j.nantod.2020.100948"},{"issue":"4760","key":"3335_CR33","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1126\/science.3460176","volume":"233","author":"Y Ben-Neriah","year":"1986","unstructured":"Ben-Neriah Y, Daley GQ, Mes-Masson AM, Witte ON, Baltimore D. The chronic myelogenous leukemia-specific P210 protein is the product of the Bcr\/abl hybrid gene. Science. 1986;233(4760):212\u20134.","journal-title":"Science"},{"issue":"1","key":"3335_CR34","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41408-023-00823-9","volume":"13","author":"J Senapati","year":"2023","unstructured":"Senapati J, Sasaki K, Issa GC, Lipton JH, Radich JP, Jabbour E, et al. Management of chronic myeloid leukemia in 2023-common ground and common sense. Blood Cancer J. 2023;13(1):58.","journal-title":"Blood Cancer J"},{"issue":"12","key":"3335_CR35","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1182\/bloodadvances.2019001329","volume":"4","author":"C Vener","year":"2020","unstructured":"Vener C, Banzi R, Ambrogi F, Ferrero A, Saglio G, Pravettoni G, et al. First-line Imatinib vs second- and third-generation TKIs for chronic-phase CML: a systematic review and meta-analysis. Blood Adv. 2020;4(12):2723\u201335.","journal-title":"Blood Adv"},{"issue":"1","key":"3335_CR36","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41392-023-01536-y","volume":"8","author":"D Fan","year":"2023","unstructured":"Fan D, Cao Y, Cao M, Wang Y, Cao Y, Gong T. Nanomedicine in cancer therapy. Signal Transduct Target Ther. 2023;8(1):293.","journal-title":"Signal Transduct Target Ther"},{"issue":"10","key":"3335_CR37","doi-asserted-by":"publisher","first-page":"4878","DOI":"10.1038\/s41596-021-00602-5","volume":"16","author":"J Zhang","year":"2021","unstructured":"Zhang J, Cheng D, He J, Hong J, Yuan C, Liang M. Cargo loading within ferritin nanocages in Preparation for tumor-targeted delivery. Nat Protoc. 2021;16(10):4878\u201396.","journal-title":"Nat Protoc"},{"issue":"7","key":"3335_CR38","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nm.2385","volume":"17","author":"Q Huang","year":"2011","unstructured":"Huang Q, Li F, Liu X, Li W, Shi W, Liu FF, et al. Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med. 2011;17(7):860\u20136.","journal-title":"Nat Med"},{"issue":"Pt 2","key":"3335_CR39","doi-asserted-by":"publisher","first-page":"124832","DOI":"10.1016\/j.ijbiomac.2023.124832","volume":"242","author":"AA Bhat","year":"2023","unstructured":"Bhat AA, Thapa R, Afzal O, Agrawal N, Almalki WH, Kazmi I, et al. The pyroptotic role of Caspase-3\/GSDME signalling pathway among various cancer: A review. Int J Biol Macromol. 2023;242(Pt 2):124832.","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"3335_CR40","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.ijrobp.2022.07.1841","volume":"115","author":"W Cao","year":"2023","unstructured":"Cao W, Chen G, Wu L, Yu KN, Sun M, Yang M, et al. Ionizing radiation triggers the antitumor immunity by inducing gasdermin E-Mediated pyroptosis in tumor cells. Int J Radiat Oncol Biol Phys. 2023;115(2):440\u201352.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"3335_CR41","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1186\/s12967-023-04481-0","volume":"21","author":"F Ye","year":"2023","unstructured":"Ye F, Zhang W, Fan C, Dong J, Peng M, Deng W, et al. Antileukemic effect of venetoclax and hypomethylating agents via caspase-3\/GSDME-mediated pyroptosis. J Transl Med. 2023;21(1):606.","journal-title":"J Transl Med"},{"issue":"10","key":"3335_CR42","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.6004\/jnccn.2019.7303","volume":"17","author":"MP Banegas","year":"2019","unstructured":"Banegas MP, Rivera DR, O\u2019Keeffe-Rosetti MC, Carroll NM, Pawloski PA, Tabano DC, et al. Long-Term patterns of oral anticancer agent adoption, duration, and switching in patients with CML. J Natl Compr Canc Netw. 2019;17(10):1166\u201372.","journal-title":"J Natl Compr Canc Netw"},{"issue":"1","key":"3335_CR43","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41375-022-01736-5","volume":"37","author":"J Senapati","year":"2023","unstructured":"Senapati J, Jabbour E, Kantarjian H, Short NJ. Pathogenesis and management of accelerated and blast phases of chronic myeloid leukemia. Leukemia. 2023;37(1):5\u201317.","journal-title":"Leukemia"},{"issue":"10","key":"3335_CR44","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41568-022-00491-0","volume":"22","author":"TJ Laskowski","year":"2022","unstructured":"Laskowski TJ, Biederst\u00e4dt A, Rezvani K. Natural killer cells in antitumour adoptive cell immunotherapy. Nat Rev Cancer. 2022;22(10):557\u201375.","journal-title":"Nat Rev Cancer"},{"issue":"7897","key":"3335_CR45","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41586-021-04390-6","volume":"602","author":"JJ Melenhorst","year":"2022","unstructured":"Melenhorst JJ, Chen GM, Wang M, Porter DL, Chen C, Collins MA, et al. Decade-long leukaemia remissions with persistence of CD4+ CAR T cells. Nature. 2022;602(7897):503\u20139.","journal-title":"Nature"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03335-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-025-03335-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03335-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T01:02:50Z","timestamp":1745197370000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03335-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3335"],"URL":"https:\/\/doi.org\/10.1186\/s12951-025-03335-9","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"assertion":[{"value":"1 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were in accordance with the National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications No.8023, revised 1978). All animal procedures employed in the project were approved by the Institutional Animal Care and Use Committee of Chongqing Medical University (IACUC-CQMU-2023-0113).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"252"}}