{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:50:24Z","timestamp":1793746224927,"version":"4.6.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Henan Provincial Medical Science and Technology Public Relations Program Provincial-Ministerial Co-Construction Youth Project","award":["SBGJ202303041"],"award-info":[{"award-number":["SBGJ202303041"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272847"],"award-info":[{"award-number":["82272847"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Henan Province Fund for Cultivating Advantageous Disciplines","award":["222301420012"],"award-info":[{"award-number":["222301420012"]}]},{"name":"Central Plains science and technology innovation leading talent project","award":["234200510005"],"award-info":[{"award-number":["234200510005"]}]},{"name":"Program for Innovative Research Team (in Science and Technology) in Henan Province","award":["25IRTSTHN037"],"award-info":[{"award-number":["25IRTSTHN037"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-025-03468-x","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T01:33:10Z","timestamp":1748223190000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oral administration of probiotic spores-based biohybrid system for efficient attenuation of Salmonella Typhimurium-induced colitis"],"prefix":"10.1186","volume":"23","author":[{"given":"Mengya","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiannan","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"3468_CR1","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/s41579-021-00561-4","volume":"19","author":"JE Galan","year":"2021","unstructured":"Galan JE. Salmonella Typhimurium and inflammation: a pathogen-centric affair. Nat Rev Microbiol. 2021;19:716\u201325.","journal-title":"Nat Rev Microbiol"},{"key":"3468_CR2","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.chom.2017.03.009","volume":"21","author":"SY Wotzka","year":"2017","unstructured":"Wotzka SY, Nguyen BD, Hardt WD. Salmonella Typhimurium diarrhea reveals basic principles of enteropathogen infection and Disease-Promoted DNA exchange. Cell Host Microbe. 2017;21:443\u201354.","journal-title":"Cell Host Microbe"},{"key":"3468_CR3","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.chom.2007.11.001","volume":"3","author":"S Spano","year":"2008","unstructured":"Spano S, Ugalde JE, Gal\u00e1n JE. Delivery of a Typhi exotoxin from a host intracellular compartment. Cell Host Microbe. 2008;3:30\u20138.","journal-title":"Cell Host Microbe"},{"key":"3468_CR4","doi-asserted-by":"publisher","first-page":"1003844","DOI":"10.1371\/journal.ppat.1003844","volume":"10","author":"LP Nedialkova","year":"2014","unstructured":"Nedialkova LP, Denzler R, Koeppel MB, Diehl M, Ring D, Wille T, Gerlach RG, Stecher B. Inflammation fuels colicin Ib-Dependent competition of Salmonella serovar typhimurium and E. coli in enterobacterial blooms. PLoS Pathog. 2014;10:1003844.","journal-title":"PLoS Pathog"},{"key":"3468_CR5","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.chom.2018.07.002","volume":"24","author":"A Jacobson","year":"2018","unstructured":"Jacobson A, Lam L, Rajendram M, Tamburini F, Honeycutt J, Pham T, Van Treuren W, Pruss K, Stabler SR, Lugo K, et al. A gut Commensal-Produced metabolite mediates colonization resistance to infection. Cell Host Microbe. 2018;24:296\u2013307.","journal-title":"Cell Host Microbe"},{"key":"3468_CR6","doi-asserted-by":"publisher","first-page":"15958","DOI":"10.1039\/C9NR03802G","volume":"11","author":"QL Song","year":"2019","unstructured":"Song QL, Jia JJ, Niu XX, Zheng CX, Zhao HJ, Sun LL, Zhang HL, Wang L, Zhang ZZ, Zhang Y. An oral drug delivery system with programmed drug release and imaging properties for orthotopic colon cancer therapy. Nanoscale. 2019;11:15958\u201370.","journal-title":"Nanoscale"},{"key":"3468_CR7","doi-asserted-by":"crossref","unstructured":"Pillay TD, Hettiarachchi SU, Gan JY, Diaz-Del-Olmo I, Yu XJ, Muench JH, Thurston TLM, Pearson JS. Speaking the host Language: how Salmonella effector proteins manipulate the host. Microbiology-Sgm 2023, 169.","DOI":"10.1099\/mic.0.001342"},{"key":"3468_CR8","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1128\/CMR.05041-11","volume":"25","author":"PD Tamma","year":"2012","unstructured":"Tamma PD, Cosgrove SE, Maragakis LL. Combination therapy for treatment of infections with Gram-Negative Bacteria. Clin Microbiol Rev. 2012;25:450\u201370.","journal-title":"Clin Microbiol Rev"},{"key":"3468_CR9","doi-asserted-by":"crossref","unstructured":"Huang SM, Wu ZH, Li TT, Liu C, Han DD, Tao SY, Pi Y, Li N, Wang JJ. Perturbation of the lipid metabolism and intestinal inflammation in growing pigs with low birth weight is associated with the alterations of gut microbiotavol 719, 137382, (2020). Science of the Total Environment 2021, 789.","DOI":"10.1016\/j.scitotenv.2020.137382"},{"key":"3468_CR10","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/s41575-018-0025-6","volume":"15","author":"PD Cani","year":"2018","unstructured":"Cani PD, Jordan BF. Gut microbiota-mediated inflammation in obesity: a link with Gastrointestinal cancer. Nat Reviews Gastroenterol Hepatol. 2018;15:671\u201382.","journal-title":"Nat Reviews Gastroenterol Hepatol"},{"key":"3468_CR11","doi-asserted-by":"crossref","unstructured":"Kim D, Zeng MY, N\u00fa\u00f1ez G. The interplay between host immune cells and gut microbiota in chronic inflammatory diseases. Experimental Mol Med 2017, 49.","DOI":"10.1038\/emm.2017.24"},{"key":"3468_CR12","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1124\/pharmrev.120.000020","volume":"73","author":"SC Nang","year":"2021","unstructured":"Nang SC, Azad MAK, Velkov T, Zhou Q, Li J. Rescuing the Last-Line polymyxins: achievements and challenges. Pharmacol Rev. 2021;73:679\u2013728.","journal-title":"Pharmacol Rev"},{"key":"3468_CR13","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1126\/science.abl5997","volume":"373","author":"JH Kwon","year":"2021","unstructured":"Kwon JH, Powderly WG. The post-antibiotic era is here. Science. 2021;373:471\u2013471.","journal-title":"Science"},{"key":"3468_CR14","doi-asserted-by":"crossref","unstructured":"Menina S, Eisenbeis J, Kamal MAM, Koch M, Bischoff M, Gordon S, Loretz B, Lehr CM. Bioinspired liposomes for oral delivery of colistin to combat intracellular infections by Salmonella enterica. Adv Healthc Mater 2019, 8.","DOI":"10.1002\/adhm.201900564"},{"key":"3468_CR15","doi-asserted-by":"publisher","first-page":"01390","DOI":"10.1128\/JCM.01390-18","volume":"57","author":"F Ezadi","year":"2019","unstructured":"Ezadi F, Ardebili A, Mirnejad R. Antimicrobial susceptibility testing for polymyxins: challenges, issues, and recommendations. J Clin Microbiol. 2019;57:01390\u201301318.","journal-title":"J Clin Microbiol"},{"key":"3468_CR16","doi-asserted-by":"publisher","first-page":"13382","DOI":"10.1016\/j.molstruc.2022.133382","volume":"1265","author":"CC Tang","year":"2022","unstructured":"Tang CC, Song YR, Wang Z, Wang D, Yao XY, Meng Y, Li Y, Yang L. Hydrophobic modification Thr of polymyxin E: effect on activity and toxicity. J Mol Struct. 2022;1265:13382.","journal-title":"J Mol Struct"},{"key":"3468_CR17","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1128\/JCM.43.2.925-927.2005","volume":"43","author":"RN Jones","year":"2005","unstructured":"Jones RN, Anderegg TR, Swenson JM, Quality Control Working G. Quality control guidelines for testing gram-negative control strains with polymyxin B and colistin (polymyxin E) by standardized methods. J Clin Microbiol. 2005;43:925\u20137.","journal-title":"J Clin Microbiol"},{"key":"3468_CR18","doi-asserted-by":"publisher","first-page":"11498","DOI":"10.1074\/jbc.M806587200","volume":"284","author":"J Mares","year":"2009","unstructured":"Mares J, Kumaran S, Gobbo M, Zerbe O. Interactions of lipopolysaccharide and polymyxin studied by NMR spectroscopy. J Biol Chem. 2009;284:11498\u2013506.","journal-title":"J Biol Chem"},{"key":"3468_CR19","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3390\/ph13050083","volume":"13","author":"NV Dubashynskaya","year":"2020","unstructured":"Dubashynskaya NV, Skorik YA. Polymyxin delivery systems: recent advances and challenges. Pharmaceuticals (Basel). 2020;13:83.","journal-title":"Pharmaceuticals (Basel)"},{"key":"3468_CR20","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1039\/C7BM00069C","volume":"5","author":"P Wadhwani","year":"2017","unstructured":"Wadhwani P, Heidenreich N, Podeyn B, Burck J, Ulrich AS. Antibiotic gold: tethering of antimicrobial peptides to gold nanoparticles maintains conformational flexibility of peptides and improves trypsin susceptibility. Biomater Sci. 2017;5:817\u201327.","journal-title":"Biomater Sci"},{"key":"3468_CR21","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3390\/antibiotics13020124","volume":"13","author":"PP Sarma","year":"2024","unstructured":"Sarma PP, Rai A, Baruah PK. Recent advances in the development of Antibiotics-Coated gold nanoparticles to combat antimicrobial resistance. Antibiot (Basel). 2024;13:124.","journal-title":"Antibiot (Basel)"},{"key":"3468_CR22","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.1021\/acs.nanolett.1c04968","volume":"22","author":"L Wang","year":"2022","unstructured":"Wang L, Zheng W, Li S, Zhong L, Jiang X. Aminophenol-Decorated gold nanoparticles for curing bacterial infections. Nano Lett. 2022;22:3576\u201382.","journal-title":"Nano Lett"},{"key":"3468_CR23","doi-asserted-by":"publisher","first-page":"3973","DOI":"10.1007\/s00253-022-12001-1","volume":"106","author":"MAA Agreles","year":"2022","unstructured":"Agreles MAA, Cavalcanti IDL, Cavalcanti IMF. Synergism between metallic nanoparticles and antibiotics. Appl Microbiol Biotechnol. 2022;106:3973\u201384.","journal-title":"Appl Microbiol Biotechnol"},{"key":"3468_CR24","doi-asserted-by":"crossref","unstructured":"Chen B, Guan L, Wu C, Gong Y, Wu L, Zhang M, Cao Z, Chen Y, Yang C, Wang B et al. Gut microbiota-butyrate-PPAR\u03b3 axis modulates adipose regulatory T cell population. Adv Sci (Weinh) 2025:e2411086.","DOI":"10.1002\/advs.202411086"},{"key":"3468_CR25","doi-asserted-by":"publisher","first-page":"8696","DOI":"10.1039\/D1CS00915J","volume":"51","author":"JA Doolan","year":"2022","unstructured":"Doolan JA, Williams GT, Hilton KLF, Chaudhari R, Fossey JS, Goult BT, Hiscock JR. Advancements in antimicrobial nanoscale materials and self-assembling systems. Chem Soc Rev. 2022;51:8696\u2013755.","journal-title":"Chem Soc Rev"},{"key":"3468_CR26","doi-asserted-by":"crossref","unstructured":"Yao QF, Yuan X, Chen TK, Leong DT, Xie JP. Engineering functional metal materials at the atomic level. Adv Mater 2018, 30.","DOI":"10.1002\/adma.201802751"},{"key":"3468_CR27","doi-asserted-by":"publisher","first-page":"5036","DOI":"10.1021\/acs.nanolett.0c01196","volume":"20","author":"L Wang","year":"2020","unstructured":"Wang L, Li SX, Yin JX, Yang JC, Li QZ, Zheng WF, Liu SQ, Jiang XY. The density of surface coating can contribute to different antibacterial activities of gold nanoparticles. Nano Lett. 2020;20:5036\u201342.","journal-title":"Nano Lett"},{"key":"3468_CR28","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1021\/acs.nanolett.0c04578","volume":"21","author":"L Wang","year":"2021","unstructured":"Wang L, Yang JC, Li SX, Li QZ, Liu SQ, Zheng WF, Jiang XY. Oral administration of starting materials for synthesis of antibacterial gold nanoparticles for curing remote infections. Nano Lett. 2021;21:1124\u201331.","journal-title":"Nano Lett"},{"key":"3468_CR29","doi-asserted-by":"publisher","first-page":"5002","DOI":"10.1021\/acsnano.9b01002","volume":"13","author":"JJ Li","year":"2019","unstructured":"Li JJ, Cha RT, Zhao XH, Guo HB, Luo HZ, Wang MZ, Zhou FS, Jiang XY. Gold nanoparticles cure bacterial infection with benefit to intestinal microflora. ACS Nano. 2019;13:5002\u201314.","journal-title":"ACS Nano"},{"key":"3468_CR30","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1007\/s10876-020-01864-x","volume":"32","author":"D Sharma","year":"2021","unstructured":"Sharma D, Chaudhary A. One pot synthesis of gentamicin conjugated gold nanoparticles as an efficient antibacterial agent. J Cluster Sci. 2021;32:995\u20131002.","journal-title":"J Cluster Sci"},{"key":"3468_CR31","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.3390\/ma15031108","volume":"15","author":"T Al Hagbani","year":"2022","unstructured":"Al Hagbani T, Yadav H, Moin A, Abu Lila AS, Mehmood K, Alshammari F, Khan S, Khafagy E, Hussain T, Rizvi SMD, Abdallah MH. Enhancement of Vancomycin potential against pathogenic bacterial strains via gold Nano-Formulations: A Nano-Antibiotic approach. Materials. 2022;15:1108.","journal-title":"Materials"},{"key":"3468_CR32","doi-asserted-by":"publisher","first-page":"3643","DOI":"10.3390\/nano12203643","volume":"12","author":"A Alafnan","year":"2022","unstructured":"Alafnan A, Rizvi SMD, Alshammari AS, Faiyaz SSM, Abu Lila AS, Katamesh AA, Khafagy ES, Alotaibi HF, Ahmed ABF. Gold Nanoparticle-Based resuscitation of cefoxitin against clinical pathogens: A Nano-Antibiotic strategy to overcome resistance. Nanomaterials. 2022;12:3643.","journal-title":"Nanomaterials"},{"key":"3468_CR33","doi-asserted-by":"publisher","first-page":"4270","DOI":"10.1021\/acs.nanolett.1c00408","volume":"21","author":"XN Wang","year":"2021","unstructured":"Wang XN, Niu MT, Fan JX, Chen QW, Zhang XZ. Photoelectric Bacteria enhance the in situ production of Tetrodotoxin for antitumor therapy. Nano Lett. 2021;21:4270\u20139.","journal-title":"Nano Lett"},{"key":"3468_CR34","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/nnano.2015.141","volume":"10","author":"AP Richter","year":"2015","unstructured":"Richter AP, Brown JS, Bharti B, Wang A, Gangwal S, Houck K, Cohen Hubal EA, Paunov VN, Stoyanov SD, Velev OD. An environmentally benign antimicrobial nanoparticle based on a silver-infused lignin core. Nat Nanotechnol. 2015;10:817\u201323.","journal-title":"Nat Nanotechnol"},{"key":"3468_CR35","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/s41565-018-0108-0","volume":"13","author":"B Peng","year":"2018","unstructured":"Peng B, Zhang X, Aarts D, Dullens RPA. Superparamagnetic nickel colloidal nanocrystal clusters with antibacterial activity and bacteria binding ability. Nat Nanotechnol. 2018;13:478\u201382.","journal-title":"Nat Nanotechnol"},{"key":"3468_CR36","doi-asserted-by":"crossref","unstructured":"Dong X, Wu W, Pan P, Zhang XZ. Engineered living materials for advanced diseases therapy. Adv Mater 2023:e2304963.","DOI":"10.1002\/adma.202304963"},{"key":"3468_CR37","doi-asserted-by":"publisher","first-page":"e2412429","DOI":"10.1002\/adma.202412429","volume":"37","author":"J Yu","year":"2025","unstructured":"Yu J, Li S, Xiong B, Shen Y, Guan X, Zhu Y, Fang Y, Zhang S, Ding S, Liu C, et al. Probiotics Bi-Enzymatic cascade repair system for editing the inflammatory microenvironment to boost probiotic therapy in inflammatory bowel disease. Adv Mater. 2025;37:e2412429.","journal-title":"Adv Mater"},{"key":"3468_CR38","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1186\/s12951-024-02647-6","volume":"22","author":"H Huang","year":"2024","unstructured":"Huang H, Liu X, Lang Y, Cui J, Zhong D, Zhou M. Breaking barriers: bacterial-microalgae symbiotic systems as a probiotic delivery system. J Nanobiotechnol. 2024;22:371.","journal-title":"J Nanobiotechnol"},{"key":"3468_CR39","doi-asserted-by":"publisher","first-page":"4977","DOI":"10.1016\/j.apsb.2024.09.015","volume":"14","author":"M Niu","year":"2024","unstructured":"Niu M, Pei Y, Jin T, Li J, Bai L, Zheng C, Song Q, Zhao H, Zhang Y, Wang L. Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer. Acta Pharm Sin B. 2024;14:4977\u201393.","journal-title":"Acta Pharm Sin B"},{"key":"3468_CR40","doi-asserted-by":"publisher","first-page":"110180","DOI":"10.1016\/j.cclet.2024.110180","volume":"36","author":"K Junfei Yanga","year":"2025","unstructured":"Junfei Yanga K, Wang S, Sun T, Pei J, Li X, Gong C, Zheng Y, Zhang Q, Song, Wang L. A spore-likeoral nanodrug delivery platform for precision targeted therapy of inflammatory bowel disease. Chin Chem Lett. 2025;36:110180.","journal-title":"Chin Chem Lett"},{"key":"3468_CR41","doi-asserted-by":"crossref","unstructured":"Zhang W, Xi G, Zhang H, Bi J, Zhou T, Zhu J, Zhang Z, Wang S, Song M, Wang J. Pasteurized Akkermansia muciniphila promotes GP2 expression in microfold cells and facilitates Salmonella infection. Protein Cell 2025.","DOI":"10.1093\/procel\/pwaf017"},{"key":"3468_CR42","doi-asserted-by":"publisher","first-page":"8247","DOI":"10.1080\/10408398.2021.1895061","volume":"62","author":"A Abbasi","year":"2022","unstructured":"Abbasi A, Rad AH, Ghasempour Z, Sabahi S, Kafil HS, Hasannezhad P, Saadat YR, Shahbazi N. The biological activities of postbiotics in Gastrointestinal disorders (10, Pg 1, 2021). Crit Rev Food Sci Nutr. 2022;62:8247\u20138247.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"3468_CR43","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jconrel.2022.10.030","volume":"352","author":"Y Luo","year":"2022","unstructured":"Luo Y, De Souza C, Ramachandran M, Wang SL, Yi HX, Ma Z, Zhang LW, Lin K. Precise oral delivery systems for probiotics: A review. J Controlled Release. 2022;352:371\u201384.","journal-title":"J Controlled Release"},{"key":"3468_CR44","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1038\/s41565-019-0589-5","volume":"14","author":"WT Song","year":"2019","unstructured":"Song WT, Anselmo AC, Huang L. Nanotechnology intervention of the Microbiome for cancer therapy. Nat Nanotechnol. 2019;14:1093\u2013103.","journal-title":"Nat Nanotechnol"},{"key":"3468_CR45","doi-asserted-by":"publisher","first-page":"1831339","DOI":"10.1080\/19490976.2020.1831339","volume":"12","author":"WF Van Zyl","year":"2020","unstructured":"Van Zyl WF, Deane SM, Dicks LMT. Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria. Gut Microbes. 2020;12:1831339.","journal-title":"Gut Microbes"},{"key":"3468_CR46","doi-asserted-by":"publisher","first-page":"1415790","DOI":"10.3389\/fcimb.2024.1415790","volume":"14","author":"J Liang","year":"2024","unstructured":"Liang J, Li CH, Chen ZQ, Guo FY, Dou JX, Wang T, Xu ZS. Progress of research and application of Heyndrickxia coagulans (Bacillus coagulans) as probiotic bacteria. Front Cell Infect Microbiol. 2024;14:1415790.","journal-title":"Front Cell Infect Microbiol"},{"key":"3468_CR47","doi-asserted-by":"publisher","first-page":"103643","DOI":"10.1016\/j.jff.2019.103643","volume":"64","author":"J Cao","year":"2020","unstructured":"Cao J, Yu ZM, Liu WY, Zhao JX, Zhang H, Zhai QX, Chen W. Probiotic characteristics of Bacillus coagulans and associated implications for human health and diseases. J Funct Foods. 2020;64:103643.","journal-title":"J Funct Foods"},{"key":"3468_CR48","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.chom.2019.03.004","volume":"25","author":"S Herp","year":"2019","unstructured":"Herp S, Brugiroux S, Garzetti D, Ring D, Jochum LM, Beutler M, Eberl C, Hussain S, Walter S, Gerlach RG, et al. Mucispirillum schaedleri antagonizes Salmonella virulence to protect mice against colitis. Cell Host Microbe. 2019;25:681\u2013e694688.","journal-title":"Cell Host Microbe"},{"key":"3468_CR49","doi-asserted-by":"publisher","first-page":"105218","DOI":"10.1016\/j.yrtph.2022.105218","volume":"133","author":"K Chaudhari","year":"2022","unstructured":"Chaudhari K, Mohan M, Saudagar P, Sable C, Shinde S, Bedade D. In vitro and in vivo evaluation of probiotic potential and safety assessment of SKB LAB-19 (MCC 0554) in humans and animal healthcare. Regul Toxicol Pharmacol. 2022;133:105218.","journal-title":"Regul Toxicol Pharmacol"},{"key":"3468_CR50","doi-asserted-by":"publisher","first-page":"100561","DOI":"10.1016\/j.animal.2022.100561","volume":"16","author":"TH Sun","year":"2022","unstructured":"Sun TH, Miao HB, Zhang CB, Wang YS, Liu S, Jiao P, Li W, Li Y, Huang ZX. Effect of dietary Bacillus coagulans on the performance and intestinal microbiota of weaned piglets. Animal. 2022;16:100561.","journal-title":"Animal"},{"key":"3468_CR51","doi-asserted-by":"publisher","first-page":"103052","DOI":"10.1016\/j.redox.2024.103052","volume":"70","author":"V Gutierrez","year":"2024","unstructured":"Gutierrez V, Kim-Vasquez D, Shum M, Yang QH, Dikeman D, Shirihai OS, Tsukamoto H, Liesa M. The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis. Redox Biol. 2024;70:103052.","journal-title":"Redox Biol"},{"key":"3468_CR52","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1080\/19490976.2019.1629235","volume":"11","author":"M Stephens","year":"2020","unstructured":"Stephens M, von der Weid PY. Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner. Gut Microbes. 2020;11:421\u201332.","journal-title":"Gut Microbes"},{"key":"3468_CR53","doi-asserted-by":"publisher","first-page":"2309459","DOI":"10.1002\/advs.202309459","volume":"11","author":"K Kadier","year":"2024","unstructured":"Kadier K, Niu T, Ding BL, Chen BY, Qi XX, Chen DN, Cheng XR, Fang YZ, Zhou JH, Zhao WY, et al. PROTAC-Mediated HDAC7 protein degradation unveils its Deacetylase-Independent Proinflammatory function in macrophages. Adv Sci. 2024;11:2309459.","journal-title":"Adv Sci"},{"key":"3468_CR54","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3390\/microorganisms8030407","volume":"8","author":"M Wang","year":"2020","unstructured":"Wang M, Qazi IH, Wang L, Zhou G, Han H. Salmonella virulence and immune escape. Microorganisms. 2020;8:407.","journal-title":"Microorganisms"},{"key":"3468_CR55","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.4049\/jimmunol.174.5.2892","volume":"174","author":"C Cheminay","year":"2005","unstructured":"Cheminay C, Mohlenbrink A, Hensel M. Intracellular Salmonella inhibit antigen presentation by dendritic cells. J Immunol. 2005;174:2892\u20139.","journal-title":"J Immunol"},{"key":"3468_CR56","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.immuni.2017.04.008","volume":"46","author":"Y Belkaid","year":"2017","unstructured":"Belkaid Y, Harrison OJ. Homeostatic immunity and the microbiota. Immunity. 2017;46:562\u201376.","journal-title":"Immunity"},{"key":"3468_CR57","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1099\/mic.0.000732","volume":"165","author":"C Godlee","year":"2019","unstructured":"Godlee C, Cerny O, Durkin CH, Holden DW. SrcA is a chaperone for the Salmonella SPI-2 type three secretion system effector sted. Microbiol (Reading). 2019;165:15\u201325.","journal-title":"Microbiol (Reading)"},{"key":"3468_CR58","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.chom.2016.10.007","volume":"20","author":"E Bayer-Santos","year":"2016","unstructured":"Bayer-Santos E, Durkin CH, Rigano LA, Kupz A, Alix E, Cerny O, Jennings E, Liu M, Ryan AS, Lapaque N, et al. The Salmonella effector sted mediates MARCH8-Dependent ubiquitination of MHC II molecules and inhibits T cell activation. Cell Host Microbe. 2016;20:584\u201395.","journal-title":"Cell Host Microbe"},{"key":"3468_CR59","doi-asserted-by":"crossref","unstructured":"Gillis CC, Hughes ER, Spiga L, Winter MG, Zhu WH, de Carvalho TF, Chanin RB, Behrendt CL, Hooper LV, Santos RL, Winter SE. Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growthvol 23, pg 54, (2018). Cell Host & Microbe 2018, 23:570\u2013570.","DOI":"10.1016\/j.chom.2018.03.013"},{"key":"3468_CR60","doi-asserted-by":"publisher","first-page":"e1903793","DOI":"10.1002\/adma.201903793","volume":"31","author":"Q Song","year":"2019","unstructured":"Song Q, Zheng C, Jia J, Zhao H, Feng Q, Zhang H, Wang L, Zhang Z, Zhang Y. A probiotic spore-based oral autonomous nanoparticles generator for cancer therapy. Adv Mater. 2019;31:e1903793.","journal-title":"Adv Mater"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03468-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-025-03468-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03468-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T03:18:26Z","timestamp":1748229506000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03468-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3468"],"URL":"https:\/\/doi.org\/10.1186\/s12951-025-03468-x","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]},"assertion":[{"value":"6 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the work performed on animals was in accordance with the Guidelines for Care and Use of Laboratory Animals of Zhengzhou University, and the experiments were approved by the Animal Ethics Committee of Zhengzhou University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors agree for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"378"}}