{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T18:40:56Z","timestamp":1794336056980,"version":"4.9.0"},"reference-count":197,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Metastasis remains the leading cause of cancer-related mortality, with a persistently poor prognosis for metastatic cancer patients despite extensive therapeutic efforts. Circulating tumor cells (CTCs), which detach from primary tumors and enter the bloodstream, can establish distant metastatic sites. These CTCs often form heterotypic clusters with white blood cells, especially neutrophils, through various interaction mechanisms, including intercellular adhesion, cytokine secretion, protease release, and the formation of neutrophil extracellular traps (NETs). These interactions enhance CTCs survival, proliferation, invasion, and transendothelial migration while simultaneously remodeling premetastatic niches and the tumor microenvironment. Consequently, pharmacologically disrupting CTC\u2012neutrophil crosstalk represents a promising strategy to curb metastatic spread and improve clinical outcomes. Recent breakthroughs in nanotechnology-based drug delivery systems have shown considerable potential in antimetastatic therapies, offering significant advantages over conventional treatments, which are often associated with severe side effects and limited efficacy. This review systematically explores nanoengineered strategies targeting CTC\u2012neutrophil interactions, addresses the current limitations and outlines future directions for developing clinically translatable nanotherapeutics.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1186\/s12951-025-03522-8","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T13:26:22Z","timestamp":1750166782000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Targeting circulating tumor cell\u2012neutrophil interactions: nanoengineered strategies for inhibiting cancer metastasis"],"prefix":"10.1186","volume":"23","author":[{"given":"Yong","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjing","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"3522_CR1","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.cell.2023.03.003","volume":"186","author":"S Gerstberger","year":"2023","unstructured":"Gerstberger S, Jiang QW, Ganesh K. Metastasis. Cell. 2023;186:1564\u201379.","journal-title":"Cell"},{"key":"3522_CR2","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s41392-024-01937-7","volume":"9","author":"Y Wang","year":"2024","unstructured":"Wang Y, Jia J, Wang F, Fang Y, Yang Y, Zhou Q, et al. Pre-metastatic niche: formation, characteristics and therapeutic implication. Signal Transduct Target Ther. 2024;9:236.","journal-title":"Signal Transduct Target Ther"},{"key":"3522_CR3","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41591-020-01195-4","volume":"27","author":"K Ganesh","year":"2021","unstructured":"Ganesh K, Massagu\u00e9 J. Targeting metastatic cancer. Nat Med. 2021;27:34\u201344.","journal-title":"Nat Med"},{"key":"3522_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7\u201330.","journal-title":"CA Cancer J Clin"},{"key":"3522_CR5","doi-asserted-by":"publisher","first-page":"3771","DOI":"10.1039\/C8CS00896E","volume":"48","author":"W Sang","year":"2019","unstructured":"Sang W, Zhang Z, Dai Y, Chen X. Recent advances in nanomaterial-based synergistic combination cancer immunotherapy. Chem Soc Rev. 2019;48:3771\u2013810.","journal-title":"Chem Soc Rev"},{"key":"3522_CR6","doi-asserted-by":"publisher","first-page":"C707","DOI":"10.1152\/ajpcell.00132.2022","volume":"324","author":"Y Gao","year":"2023","unstructured":"Gao Y, Rosen JM, Zhang XH. The tumor-immune ecosystem in shaping metastasis. Am J Physiol Cell Physiol. 2023;324:C707\u201317.","journal-title":"Am J Physiol Cell Physiol"},{"key":"3522_CR7","doi-asserted-by":"publisher","first-page":"E854","DOI":"10.1073\/pnas.1508541113","volume":"113","author":"KJ Cheung","year":"2016","unstructured":"Cheung KJ, Padmanaban V, Silvestri V, Schipper K, Cohen JD, Fairchild AN, et al. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters. Proc Natl Acad Sci USA. 2016;113:E854\u201363.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3522_CR8","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.trsl.2018.07.003","volume":"201","author":"D Woo","year":"2018","unstructured":"Woo D, Yu M. Circulating tumor cells as \u201cliquid biopsies\u201d to understand cancer metastasis. Transl Res. 2018;201:128\u201335.","journal-title":"Transl Res"},{"key":"3522_CR9","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/nature15726","volume":"527","author":"E Piskounova","year":"2015","unstructured":"Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, et al. Oxidative stress inhibits distant metastasis by human melanoma cells. Nature. 2015;527:186\u201391.","journal-title":"Nature"},{"key":"3522_CR10","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41392-021-00817-8","volume":"6","author":"D Lin","year":"2021","unstructured":"Lin D, Shen L, Luo M, Zhang K, Li J, Yang Q, et al. Circulating tumor cells: biology and clinical significance. Signal Transd Target Ther. 2021;6:404.","journal-title":"Signal Transd Target Ther"},{"key":"3522_CR11","doi-asserted-by":"publisher","first-page":"e000437","DOI":"10.1136\/bmjonc-2024-000437","volume":"3","author":"Y Yang","year":"2024","unstructured":"Yang Y, Huang G, Lian J, Long C, Zhao B, Liu X, et al. Circulating tumour cell clusters: isolation, biological significance and therapeutic implications. BMJ Oncol. 2024;3:e000437.","journal-title":"BMJ Oncol"},{"key":"3522_CR12","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1186\/s12885-023-11711-7","volume":"23","author":"M Ju","year":"2023","unstructured":"Ju M, Gao Z, Gu G, Huang H, Sun A, Zheng C, et al. Prognostic value of circulating tumor cells associated with white blood cells in solid cancer: a systematic review and meta-analysis of 1471 patients with solid tumors. BMC Cancer. 2023;23:1224.","journal-title":"BMC Cancer"},{"key":"3522_CR13","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/s41586-019-0915-y","volume":"566","author":"BM Szczerba","year":"2019","unstructured":"Szczerba BM, Castro-Giner F, Vetter M, Krol I, Gkountela S, Landin J, et al. Neutrophils escort circulating tumour cells to enable cell cycle progression. Nature. 2019;566:553\u20137.","journal-title":"Nature"},{"key":"3522_CR14","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/d41586-019-00341-4","volume":"566","author":"M Egeblad","year":"2019","unstructured":"Egeblad M, de Visser KE. Sticking together helps cancer to spread. Nature. 2019;566:459\u201360.","journal-title":"Nature"},{"key":"3522_CR15","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/s41571-019-0222-4","volume":"16","author":"ME Shaul","year":"2019","unstructured":"Shaul ME, Fridlender ZG. Tumour-associated neutrophils in patients with cancer. Nat Rev Clin Oncol. 2019;16:601\u201320.","journal-title":"Nat Rev Clin Oncol"},{"key":"3522_CR16","doi-asserted-by":"publisher","first-page":"602963","DOI":"10.3389\/fimmu.2021.602963","volume":"12","author":"E McKenna","year":"2021","unstructured":"McKenna E, Mhaonaigh AU, Wubben R, Dwivedi A, Hurley T, Kelly LA, et al. Neutrophils: need for standardized nomenclature. Front Immunol. 2021;12:602963.","journal-title":"Front Immunol"},{"key":"3522_CR17","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s13045-021-01197-w","volume":"14","author":"Z Jiang","year":"2021","unstructured":"Jiang Z, Sun H, Yu J, Tian W, Song Y. Targeting CD47 for cancer immunotherapy. J Hematol Oncol. 2021;14:180.","journal-title":"J Hematol Oncol"},{"key":"3522_CR18","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","volume":"20","author":"MJ Mitchell","year":"2021","unstructured":"Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021;20:101\u201324.","journal-title":"Nat Rev Drug Discov"},{"key":"3522_CR19","first-page":"2004574","volume":"8","author":"E Bolli","year":"2021","unstructured":"Bolli E, Scherger M, Arnouk SM, Pombo Antunes AR, Stra\u00dfburger D, Urschbach M, et al. Targeted repolarization of tumor-associated macrophages via imidazoquinoline-linked nanobodies. Adv Sci (Weinheim, Baden-Wurttemberg, Germany). 2021;8:2004574.","journal-title":"Adv Sci (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"3522_CR20","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.semcancer.2011.01.002","volume":"21","author":"H Peinado","year":"2011","unstructured":"Peinado H, Lavotshkin S, Lyden D. The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts. Semin Cancer Biol. 2011;21:139\u201346.","journal-title":"Semin Cancer Biol"},{"key":"3522_CR21","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12943-023-01909-5","volume":"22","author":"S Guo","year":"2023","unstructured":"Guo S, Huang J, Li G, Chen W, Li Z, Lei J. The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis. Mol Cancer. 2023;22:193.","journal-title":"Mol Cancer"},{"key":"3522_CR22","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.ccell.2016.09.011","volume":"30","author":"Y Liu","year":"2016","unstructured":"Liu Y, Cao X. Characteristics and significance of the pre-metastatic niche. Cancer Cell. 2016;30:668\u201381.","journal-title":"Cancer Cell"},{"key":"3522_CR23","doi-asserted-by":"publisher","first-page":"e144","DOI":"10.1002\/mco2.144","volume":"3","author":"Z Huang","year":"2022","unstructured":"Huang Z, Zhang Z, Zhou C, Liu L, Huang C. Epithelial-mesenchymal transition: the history, regulatory mechanism, and cancer therapeutic opportunities. MedComm. 2022;3:e144.","journal-title":"MedComm"},{"key":"3522_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41568-022-00536-4","volume":"23","author":"A Ring","year":"2023","unstructured":"Ring A, Nguyen-Str\u00e4uli BD, Wicki A, Aceto N. Biology, vulnerabilities and clinical applications of circulating tumour cells. Nat Rev Cancer. 2023;23:95\u2013111.","journal-title":"Nat Rev Cancer"},{"key":"3522_CR25","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41392-023-01725-9","volume":"8","author":"Q Zhan","year":"2023","unstructured":"Zhan Q, Liu B, Situ X, Luo Y, Fu T, Wang Y, et al. New insights into the correlations between circulating tumor cells and target organ metastasis. Signal Transduct Target Ther. 2023;8:465.","journal-title":"Signal Transduct Target Ther"},{"key":"3522_CR26","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nrc.2016.25","volume":"16","author":"PS Steeg","year":"2016","unstructured":"Steeg PS. Targeting metastasis. Nat Rev Cancer. 2016;16:201\u201318.","journal-title":"Nat Rev Cancer"},{"key":"3522_CR27","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.3390\/ijms21072653","volume":"21","author":"S Amintas","year":"2020","unstructured":"Amintas S, Bedel A, Moreau-Gaudry F, Boutin J, Buscail L, Merlio JP, et al. Circulating tumor cell clusters: united we stand divided we fall. Int J Mol Sci. 2020;21:2653.","journal-title":"Int J Mol Sci"},{"key":"3522_CR28","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.ccr.2011.09.009","volume":"20","author":"M Labelle","year":"2011","unstructured":"Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell. 2011;20:576\u201390.","journal-title":"Cancer Cell"},{"key":"3522_CR29","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.3390\/cancers14163985","volume":"14","author":"L Lu","year":"2022","unstructured":"Lu L, Hu W, Liu B, Yang T. Insights into circulating tumor cell clusters: a barometer for treatment effects and prognosis for prostate cancer patients. Cancers. 2022;14:3985.","journal-title":"Cancers"},{"key":"3522_CR30","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.21873\/anticanres.17150","volume":"44","author":"K Mokbel","year":"2024","unstructured":"Mokbel K. Unveiling the complex ecosystem of breast cancer: crucial insights for patients and doctors. Anticancer Res. 2024;44:3317\u20139.","journal-title":"Anticancer Res"},{"key":"3522_CR31","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1039\/D0CS00152J","volume":"50","author":"GF Luo","year":"2021","unstructured":"Luo GF, Chen WH, Zeng X, Zhang XZ. Cell primitive-based biomimetic functional materials for enhanced cancer therapy. Chem Soc Rev. 2021;50:945\u201385.","journal-title":"Chem Soc Rev"},{"key":"3522_CR32","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.canlet.2015.12.022","volume":"380","author":"SL Shiao","year":"2016","unstructured":"Shiao SL, Chu GC, Chung LW. Regulation of prostate cancer progression by the tumor microenvironment. Cancer Lett. 2016;380:340\u20138.","journal-title":"Cancer Lett"},{"key":"3522_CR33","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12943-019-0976-4","volume":"18","author":"C Wei","year":"2019","unstructured":"Wei C, Yang C, Wang S, Shi D, Zhang C, Lin X, et al. Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis. Mol Cancer. 2019;18:64.","journal-title":"Mol Cancer"},{"key":"3522_CR34","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1158\/0008-5472.CAN-15-1633","volume":"75","author":"Z Ao","year":"2015","unstructured":"Ao Z, Shah SH, Machlin LM, Parajuli R, Miller PC, Rawal S, et al. Identification of cancer-associated fibroblasts in circulating blood from patients with metastatic breast cancer. Cancer Res. 2015;75:4681\u20137.","journal-title":"Cancer Res"},{"key":"3522_CR35","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/s41598-017-19117-9","volume":"8","author":"A Kulasinghe","year":"2018","unstructured":"Kulasinghe A, Schmidt H, Perry C, Whitfield B, Kenny L, Nelson C, et al. A collective route to head and neck cancer metastasis. Sci Rep. 2018;8:746.","journal-title":"Sci Rep"},{"key":"3522_CR36","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1158\/2159-8290.CD-18-0065","volume":"9","author":"X Liu","year":"2019","unstructured":"Liu X, Taftaf R, Kawaguchi M, Chang YF, Chen W, Entenberg D, et al. Homophilic CD44 interactions mediate tumor cell aggregation and polyclonal metastasis in patient-derived breast cancer models. Cancer Discov. 2019;9:96\u2013113.","journal-title":"Cancer Discov"},{"key":"3522_CR37","doi-asserted-by":"publisher","first-page":"111298","DOI":"10.1016\/j.celrep.2022.111298","volume":"40","author":"T Pereira-Veiga","year":"2022","unstructured":"Pereira-Veiga T, Schneegans S, Pantel K, Wikman H. Circulating tumor cell-blood cell crosstalk: biology and clinical relevance. Cell Rep. 2022;40:111298.","journal-title":"Cell Rep"},{"key":"3522_CR38","doi-asserted-by":"publisher","first-page":"117474","DOI":"10.1016\/j.biopha.2024.117474","volume":"180","author":"C Hu","year":"2024","unstructured":"Hu C, Long L, Lou J, Leng M, Yang Q, Xu X, et al. CTC-neutrophil interaction: a key driver and therapeutic target of cancer metastasis. Biomed Pharmacother Biomedecine pharmacotherapie. 2024;180:117474.","journal-title":"Biomed Pharmacother"},{"key":"3522_CR39","doi-asserted-by":"publisher","first-page":"100825","DOI":"10.1016\/j.tranon.2020.100825","volume":"13","author":"R Sun","year":"2020","unstructured":"Sun R, Xiong Y, Liu H, Gao C, Su L, Weng J, et al. Tumor-associated neutrophils suppress antitumor immunity of NK cells through the PD-L1\/PD-1 axis. Transl Oncol. 2020;13:100825.","journal-title":"Transl Oncol"},{"key":"3522_CR40","doi-asserted-by":"publisher","first-page":"6071","DOI":"10.1158\/0008-5472.CAN-09-4442","volume":"70","author":"SJ Huh","year":"2010","unstructured":"Huh SJ, Liang S, Sharma A, Dong C, Robertson GP. Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development. Cancer Res. 2010;70:6071\u201382.","journal-title":"Cancer Res"},{"key":"3522_CR41","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.1158\/0008-5472.CAN-11-2393","volume":"72","author":"JD Spicer","year":"2012","unstructured":"Spicer JD, McDonald B, Cools-Lartigue JJ, Chow SC, Giannias B, Kubes P, et al. Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells. Cancer Res. 2012;72:3919\u201327.","journal-title":"Cancer Res"},{"key":"3522_CR42","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.3390\/cancers14143366","volume":"14","author":"LM Behrens","year":"2022","unstructured":"Behrens LM, van den Berg TK, van Egmond M. Targeting the CD47-SIRP\u03b1 innate immune checkpoint to potentiate antibody therapy in cancer by neutrophils. Cancers. 2022;14:3366.","journal-title":"Cancers"},{"key":"3522_CR43","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.bbamcr.2015.08.010","volume":"1863","author":"S Candido","year":"2016","unstructured":"Candido S, Abrams SL, Steelman LS, Lertpiriyapong K, Fitzgerald TL, Martelli AM, et al. Roles of NGAL and MMP-9 in the tumor microenvironment and sensitivity to targeted therapy. Biochem Biophys Acta. 2016;1863:438\u201348.","journal-title":"Biochem Biophys Acta"},{"key":"3522_CR44","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nrclinonc.2016.144","volume":"14","author":"M Mohme","year":"2017","unstructured":"Mohme M, Riethdorf S, Pantel K. Circulating and disseminated tumour cells\u2014mechanisms of immune surveillance and escape. Nat Rev Clin Oncol. 2017;14:155\u201367.","journal-title":"Nat Rev Clin Oncol"},{"key":"3522_CR45","first-page":"e2409260","volume":"12","author":"JA Ju","year":"2025","unstructured":"Ju JA, Thompson KN, Annis DA, Mull ML, Gilchrist DE, Moriarty A, et al. Tubulin-based microtentacles aid in heterotypic clustering of neutrophil-differentiated HL-60 cells and breast tumor cells. Adv Sci (Weinheim, Baden-Wurttemberg, Germany). 2025;12:e2409260.","journal-title":"Adv Sci (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"3522_CR46","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1083\/jcb.201203170","volume":"198","author":"V Brinkmann","year":"2012","unstructured":"Brinkmann V, Zychlinsky A. Neutrophil extracellular traps: is immunity the second function of chromatin? J Cell Biol. 2012;198:773\u201383.","journal-title":"J Cell Biol"},{"key":"3522_CR47","doi-asserted-by":"publisher","first-page":"e647","DOI":"10.1002\/mco2.647","volume":"5","author":"Y Ma","year":"2024","unstructured":"Ma Y, Wei J, He W, Ren J. Neutrophil extracellular traps in cancer. MedComm. 2024;5:e647.","journal-title":"MedComm"},{"key":"3522_CR48","doi-asserted-by":"publisher","first-page":"112788","DOI":"10.1016\/j.intimp.2024.112788","volume":"140","author":"G Wu","year":"2024","unstructured":"Wu G, Pan B, Shi H, Yi Y, Zheng X, Ma H, et al. Neutrophils\u2019 dual role in cancer: from tumor progression to immunotherapeutic potential. Int Immunopharmacol. 2024;140:112788.","journal-title":"Int Immunopharmacol"},{"key":"3522_CR49","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s13058-019-1237-6","volume":"21","author":"HT Snoderly","year":"2019","unstructured":"Snoderly HT, Boone BA, Bennewitz MF. Neutrophil extracellular traps in breast cancer and beyond: current perspectives on NET stimuli, thrombosis and metastasis, and clinical utility for diagnosis and treatment. Breast Cancer Res BCR. 2019;21:145.","journal-title":"Breast Cancer Res BCR"},{"key":"3522_CR50","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.3389\/fimmu.2020.01749","volume":"11","author":"MT Masucci","year":"2020","unstructured":"Masucci MT, Minopoli M, Del Vecchio S, Carriero MV. The emerging role of neutrophil extracellular traps (NETs) in tumor progression and metastasis. Front Immunol. 2020;11:1749.","journal-title":"Front Immunol"},{"key":"3522_CR51","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/s41467-021-20982-2","volume":"12","author":"H Munir","year":"2021","unstructured":"Munir H, Jones JO, Janowitz T, Hoffmann M, Euler M, Martins CP, et al. Stromal-driven and amyloid \u03b2-dependent induction of neutrophil extracellular traps modulates tumor growth. Nat Commun. 2021;12:683.","journal-title":"Nat Commun"},{"key":"3522_CR52","doi-asserted-by":"publisher","first-page":"eaao4227","DOI":"10.1126\/science.aao4227","volume":"361","author":"J Albrengues","year":"2018","unstructured":"Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science (New York, NY). 2018;361:eaao4227.","journal-title":"Science (New York, NY)."},{"key":"3522_CR53","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.immuni.2020.03.001","volume":"52","author":"\u00c1 Teijeira","year":"2020","unstructured":"Teijeira \u00c1, Garasa S, Gato M, Alfaro C, Migueliz I, Cirella A, et al. CXCR1 and CXCR2 chemokine receptor agonists produced by tumors induce neutrophil extracellular traps that interfere with immune cytotoxicity. Immunity. 2020;52:856-71.e8.","journal-title":"Immunity"},{"key":"3522_CR54","doi-asserted-by":"publisher","first-page":"4495","DOI":"10.3390\/cancers13174495","volume":"13","author":"U Demkow","year":"2021","unstructured":"Demkow U. Neutrophil extracellular traps (NETs) in cancer invasion, evasion and metastasis. Cancers. 2021;13:4495.","journal-title":"Cancers"},{"key":"3522_CR55","doi-asserted-by":"publisher","first-page":"989167","DOI":"10.3389\/fonc.2022.989167","volume":"12","author":"H Zhang","year":"2022","unstructured":"Zhang H, Xu X, Xu R, Ye T. Drug repurposing of ivermectin abrogates neutrophil extracellular traps and prevents melanoma metastasis. Front Oncol. 2022;12:989167.","journal-title":"Front Oncol"},{"key":"3522_CR56","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1002\/ijc.30635","volume":"140","author":"S Najmeh","year":"2017","unstructured":"Najmeh S, Cools-Lartigue J, Rayes RF, Gowing S, Vourtzoumis P, Bourdeau F, et al. Neutrophil extracellular traps sequester circulating tumor cells via \u03b21-integrin mediated interactions. Int J Cancer. 2017;140:2321\u201330.","journal-title":"Int J Cancer"},{"key":"3522_CR57","doi-asserted-by":"publisher","first-page":"e32366","DOI":"10.1371\/journal.pone.0032366","volume":"7","author":"M Saffarzadeh","year":"2012","unstructured":"Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G, Galuska SP, et al. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones. PLoS ONE. 2012;7:e32366.","journal-title":"PLoS ONE"},{"key":"3522_CR58","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.3390\/cancers14051359","volume":"14","author":"MH Shahzad","year":"2022","unstructured":"Shahzad MH, Feng L, Su X, Brassard A, Dhoparee-Doomah I, Ferri LE, et al. Neutrophil extracellular traps in cancer therapy resistance. Cancers. 2022;14:1359.","journal-title":"Cancers"},{"key":"3522_CR59","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.clim.2019.02.005","volume":"201","author":"K Liu","year":"2019","unstructured":"Liu K, Sun E, Lei M, Li L, Gao J, Nian X, et al. BCG-induced formation of neutrophil extracellular traps play an important role in bladder cancer treatment. Clin Immunol (Orlando, FL). 2019;201:4\u201314.","journal-title":"Clin Immunol (Orlando, FL)"},{"key":"3522_CR60","doi-asserted-by":"publisher","first-page":"505","DOI":"10.3390\/cancers12020505","volume":"12","author":"B Muqaku","year":"2020","unstructured":"Muqaku B, Pils D, Mader JC, Aust S, Mangold A, Muqaku L, et al. Neutrophil extracellular trap formation correlates with favorable overall survival in high grade ovarian cancer. Cancers. 2020;12:505.","journal-title":"Cancers"},{"key":"3522_CR61","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3389\/fphys.2018.00113","volume":"9","author":"C Rosales","year":"2018","unstructured":"Rosales C. Neutrophil: a cell with many roles in inflammation or several cell types? Front Physiol. 2018;9:113.","journal-title":"Front Physiol"},{"key":"3522_CR62","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/s41568-020-0281-y","volume":"20","author":"S Jaillon","year":"2020","unstructured":"Jaillon S, Ponzetta A, Di Mitri D, Santoni A, Bonecchi R, Mantovani A. Neutrophil diversity and plasticity in tumour progression and therapy. Nat Rev Cancer. 2020;20:485\u2013503.","journal-title":"Nat Rev Cancer"},{"key":"3522_CR63","doi-asserted-by":"publisher","first-page":"6735","DOI":"10.1158\/1078-0432.CCR-07-4843","volume":"14","author":"DJ Waugh","year":"2008","unstructured":"Waugh DJ, Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res. 2008;14:6735\u201341.","journal-title":"Clin Cancer Res"},{"key":"3522_CR64","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nrc2628","volume":"9","author":"F Balkwill","year":"2009","unstructured":"Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009;9:361\u201371.","journal-title":"Nat Rev Cancer"},{"key":"3522_CR65","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41571-020-0403-1","volume":"18","author":"R Derynck","year":"2021","unstructured":"Derynck R, Turley SJ, Akhurst RJ. TGF\u03b2 biology in cancer progression and immunotherapy. Nat Rev Clin Oncol. 2021;18:9\u201334.","journal-title":"Nat Rev Clin Oncol"},{"key":"3522_CR66","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nrclinonc.2018.8","volume":"15","author":"DE Johnson","year":"2018","unstructured":"Johnson DE, O\u2019Keefe RA, Grandis JR. Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018;15:234\u201348.","journal-title":"Nat Rev Clin Oncol"},{"key":"3522_CR67","doi-asserted-by":"publisher","first-page":"10260","DOI":"10.3390\/ijms221910260","volume":"22","author":"C Stefani","year":"2021","unstructured":"Stefani C, Miricescu D, Stanescu S II, Nica RI, Greabu M, Totan AR, et al. Growth factors, PI3K\/AKT\/mTOR and MAPK signaling pathways in colorectal cancer pathogenesis: where are we now? Int J Mol Sci. 2021;22:10260.","journal-title":"Int J Mol Sci"},{"key":"3522_CR68","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.it.2019.04.009","volume":"40","author":"B Guo","year":"2019","unstructured":"Guo B, Oliver TG. Partners in crime: neutrophil-CTC collusion in metastasis. Trends Immunol. 2019;40:556\u20139.","journal-title":"Trends Immunol"},{"key":"3522_CR69","doi-asserted-by":"publisher","first-page":"189079","DOI":"10.1016\/j.bbcan.2024.189079","volume":"1879","author":"P Shaw","year":"2024","unstructured":"Shaw P, Dwivedi SKD, Bhattacharya R, Mukherjee P, Rao G. VEGF signaling: role in angiogenesis and beyond. Biochim Biophys Acta Rev Cancer. 2024;1879:189079.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"3522_CR70","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nature13638","volume":"515","author":"D Di Mitri","year":"2014","unstructured":"Di Mitri D, Toso A, Chen JJ, Sarti M, Pinton S, Jost TR, et al. Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer. Nature. 2014;515:134\u20137.","journal-title":"Nature"},{"key":"3522_CR71","doi-asserted-by":"publisher","first-page":"101866","DOI":"10.1016\/j.tranon.2023.101866","volume":"40","author":"S Zhang","year":"2024","unstructured":"Zhang S, Sun L, Zuo J, Feng D. Tumor associated neutrophils governs tumor progression through an IL-10\/STAT3\/PD-L1 feedback signaling loop in lung cancer. Transl Oncol. 2024;40:101866.","journal-title":"Transl Oncol"},{"key":"3522_CR72","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/ni1102-991","volume":"3","author":"GP Dunn","year":"2002","unstructured":"Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol. 2002;3:991\u20138.","journal-title":"Nat Immunol"},{"key":"3522_CR73","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nri1001","volume":"3","author":"G Trinchieri","year":"2003","unstructured":"Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 2003;3:133\u201346.","journal-title":"Nat Rev Immunol"},{"key":"3522_CR74","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1158\/0008-5472.CAN-03-1808","volume":"64","author":"Y Koga","year":"2004","unstructured":"Koga Y, Matsuzaki A, Suminoe A, Hattori H, Hara T. Neutrophil-derived TNF-related apoptosis-inducing ligand (TRAIL): a novel mechanism of antitumor effect by neutrophils. Cancer Res. 2004;64:1037\u201343.","journal-title":"Cancer Res"},{"key":"3522_CR75","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1248\/bpb.26.753","volume":"26","author":"S Yui","year":"2003","unstructured":"Yui S, Nakatani Y, Mikami M. Calprotectin (S100A8\/S100A9), an inflammatory protein complex from neutrophils with a broad apoptosis-inducing activity. Biol Pharm Bull. 2003;26:753\u201360.","journal-title":"Biol Pharm Bull"},{"key":"3522_CR76","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nri1841","volume":"6","author":"CT Pham","year":"2006","unstructured":"Pham CT. Neutrophil serine proteases: specific regulators of inflammation. Nat Rev Immunol. 2006;6:541\u201350.","journal-title":"Nat Rev Immunol"},{"key":"3522_CR77","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1161\/01.CIR.0000072792.65250.4A","volume":"107","author":"CM Dollery","year":"2003","unstructured":"Dollery CM, Owen CA, Sukhova GK, Krettek A, Shapiro SD, Libby P. Neutrophil elastase in human atherosclerotic plaques: production by macrophages. Circulation. 2003;107:2829\u201336.","journal-title":"Circulation"},{"key":"3522_CR78","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12931-016-0449-x","volume":"17","author":"R Boxio","year":"2016","unstructured":"Boxio R, Wartelle J, Nawrocki-Raby B, Lagrange B, Malleret L, Hirche T, et al. Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium. Respir Res. 2016;17:129.","journal-title":"Respir Res"},{"key":"3522_CR79","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1021\/acsnano.1c09318","volume":"16","author":"J Chen","year":"2022","unstructured":"Chen J, Hou S, Liang Q, He W, Li R, Wang H, et al. Localized degradation of neutrophil extracellular traps by photoregulated enzyme delivery for cancer immunotherapy and metastasis suppression. ACS Nano. 2022;16:2585\u201397.","journal-title":"ACS Nano"},{"key":"3522_CR80","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1083\/jcb.200806072","volume":"184","author":"Y Wang","year":"2009","unstructured":"Wang Y, Li M, Stadler S, Correll S, Li P, Wang D, et al. Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol. 2009;184:205\u201313.","journal-title":"J Cell Biol"},{"key":"3522_CR81","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nrc1821","volume":"6","author":"CM Overall","year":"2006","unstructured":"Overall CM, Kleifeld O. Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer. 2006;6:227\u201339.","journal-title":"Nat Rev Cancer"},{"key":"3522_CR82","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1007\/s00404-012-2456-6","volume":"286","author":"X Hu","year":"2012","unstructured":"Hu X, Li D, Zhang W, Zhou J, Tang B, Li L. Matrix metalloproteinase-9 expression correlates with prognosis and involved in ovarian cancer cell invasion. Arch Gynecol Obstet. 2012;286:1537\u201343.","journal-title":"Arch Gynecol Obstet"},{"key":"3522_CR83","doi-asserted-by":"publisher","first-page":"12574","DOI":"10.1038\/s41598-021-91947-0","volume":"11","author":"R Garc\u00eda-Navas","year":"2021","unstructured":"Garc\u00eda-Navas R, Gajate C, Mollinedo F. Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release. Sci Rep. 2021;11:12574.","journal-title":"Sci Rep"},{"key":"3522_CR84","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1002\/2211-5463.13445","volume":"12","author":"K He","year":"2022","unstructured":"He K, Liu X, Hoffman RD, Shi RZ, Lv GY, Gao JL. G-CSF\/GM-CSF-induced hematopoietic dysregulation in the progression of solid tumors. FEBS Open Bio. 2022 ;12:1268-1285.","journal-title":"FEBS Open Bio"},{"key":"3522_CR85","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1172\/JCI81340","volume":"125","author":"M Rokavec","year":"2015","unstructured":"Rokavec M, \u00d6ner MG, Li H, Jackstadt R, Jiang L, Lodygin D, et al. Corrigendum. IL-6R\/STAT3\/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Investig. 2015;125:1362.","journal-title":"J Clin Investig"},{"key":"3522_CR86","doi-asserted-by":"publisher","first-page":"532","DOI":"10.3389\/fimmu.2020.00532","volume":"11","author":"M Ohms","year":"2020","unstructured":"Ohms M, M\u00f6ller S, Laskay T. An attempt to polarize human neutrophils toward N1 and N2 phenotypes in vitro. Front Immunol. 2020;11:532.","journal-title":"Front Immunol"},{"key":"3522_CR87","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/molecules27010137","volume":"27","author":"ZJ Han","year":"2021","unstructured":"Han ZJ, Li YB, Yang LX, Cheng HJ, Liu X, Chen H. Roles of the CXCL8-CXCR1\/2 axis in the tumor microenvironment and immunotherapy. Molecules (Basel, Switzerland). 2021;27:137.","journal-title":"Molecules (Basel, Switzerland)."},{"key":"3522_CR88","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41423-020-0412-0","volume":"17","author":"M Metzemaekers","year":"2020","unstructured":"Metzemaekers M, Gouwy M, Proost P. Neutrophil chemoattractant receptors in health and disease: double-edged swords. Cell Mol Immunol. 2020;17:433\u201350.","journal-title":"Cell Mol Immunol"},{"key":"3522_CR89","doi-asserted-by":"publisher","first-page":"734188","DOI":"10.3389\/fimmu.2021.734188","volume":"12","author":"S SenGupta","year":"2021","unstructured":"SenGupta S, Hein LE, Parent CA. The recruitment of neutrophils to the tumor microenvironment is regulated by multiple mediators. Front Immunol. 2021;12:734188.","journal-title":"Front Immunol"},{"key":"3522_CR90","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.bcp.2006.04.011","volume":"72","author":"G Gloire","year":"2006","unstructured":"Gloire G, Legrand-Poels S, Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol. 2006;72:1493\u2013505.","journal-title":"Biochem Pharmacol"},{"key":"3522_CR91","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.ccell.2023.02.004","volume":"41","author":"N Bancaro","year":"2023","unstructured":"Bancaro N, Cal\u00ec B, Troiani M, Elia AR, Arzola RA, Attanasio G, et al. Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer. Cancer Cell. 2023;41:602-19.e11.","journal-title":"Cancer Cell"},{"key":"3522_CR92","doi-asserted-by":"publisher","first-page":"28418","DOI":"10.18632\/oncotarget.16084","volume":"8","author":"YC Li","year":"2017","unstructured":"Li YC, Zou JM, Luo C, Shu Y, Luo J, Qin J, et al. Circulating tumor cells promote the metastatic colonization of disseminated carcinoma cells by inducing systemic inflammation. Oncotarget. 2017;8:28418\u201330.","journal-title":"Oncotarget"},{"key":"3522_CR93","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.15252\/embj.201490147","volume":"34","author":"N Antonio","year":"2015","unstructured":"Antonio N, B\u00f8nnelykke-Behrndtz ML, Ward LC, Collin J, Christensen IJ, Steiniche T, et al. The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer. EMBO J. 2015;34:2219\u201336.","journal-title":"EMBO J"},{"key":"3522_CR94","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1038\/s41590-020-0783-5","volume":"21","author":"P Li","year":"2020","unstructured":"Li P, Lu M, Shi J, Gong Z, Hua L, Li Q, et al. Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis. Nat Immunol. 2020;21:1444\u201355.","journal-title":"Nat Immunol"},{"key":"3522_CR95","doi-asserted-by":"publisher","first-page":"11060","DOI":"10.1073\/pnas.1811717115","volume":"115","author":"W Liang","year":"2018","unstructured":"Liang W, Li Q, Ferrara N. Metastatic growth instructed by neutrophil-derived transferrin. Proc Natl Acad Sci USA. 2018;115:11060\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3522_CR96","doi-asserted-by":"publisher","first-page":"4867","DOI":"10.1038\/s41467-021-25189-z","volume":"12","author":"R Taftaf","year":"2021","unstructured":"Taftaf R, Liu X, Singh S, Jia Y, Dashzeveg NK, Hoffmann AD, et al. ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer. Nat Commun. 2021;12:4867.","journal-title":"Nat Commun"},{"key":"3522_CR97","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrc.2016.108","volume":"17","author":"J Shi","year":"2017","unstructured":"Shi J, Kantoff PW, Wooster R, Farokhzad OC. Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer. 2017;17:20\u201337.","journal-title":"Nat Rev Cancer"},{"key":"3522_CR98","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3390\/ph17030315","volume":"17","author":"M Arafat","year":"2024","unstructured":"Arafat M, Sakkal M, Beiram R, AbuRuz S. Nanomedicines: emerging platforms in smart chemotherapy treatment\u2014a recent review. Pharmaceuticals (Basel, Switzerland). 2024;17:315.","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"key":"3522_CR99","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.tcb.2011.06.005","volume":"21","author":"LM McCaffrey","year":"2011","unstructured":"McCaffrey LM, Macara IG. Epithelial organization, cell polarity and tumorigenesis. Trends Cell Biol. 2011;21:727\u201335.","journal-title":"Trends Cell Biol"},{"key":"3522_CR100","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/s10555-020-09898-3","volume":"39","author":"O Gires","year":"2020","unstructured":"Gires O, Pan M, Schinke H, Canis M, Baeuerle PA. Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years? Cancer Metastasis Rev. 2020;39:969\u201387.","journal-title":"Cancer Metastasis Rev"},{"key":"3522_CR101","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13058-020-01323-5","volume":"22","author":"A Nanou","year":"2020","unstructured":"Nanou A, Zeune LL, Bidard FC, Pierga JY, Terstappen L. HER2 expression on tumor-derived extracellular vesicles and circulating tumor cells in metastatic breast cancer. Breast Cancer Res BCR. 2020;22:86.","journal-title":"Breast Cancer Res BCR"},{"key":"3522_CR102","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1093\/annonc\/mdq323","volume":"22","author":"A Gradilone","year":"2011","unstructured":"Gradilone A, Naso G, Raimondi C, Cortesi E, Gandini O, Vincenzi B, et al. Circulating tumor cells (CTCs) in metastatic breast cancer (MBC): prognosis, drug resistance and phenotypic characterization. Ann Oncol. 2011;22:86\u201392.","journal-title":"Ann Oncol"},{"key":"3522_CR103","doi-asserted-by":"publisher","first-page":"e190972","DOI":"10.1001\/jamasurg.2019.0972","volume":"154","author":"S Wei","year":"2019","unstructured":"Wei S, Guo C, He J, Tan Q, Mei J, Yang Z, et al. Effect of vein-first vs artery-first surgical technique on circulating tumor cells and survival in patients with non-small cell lung cancer: a randomized clinical trial and registry-based propensity score matching analysis. JAMA Surg. 2019;154:e190972.","journal-title":"JAMA Surg"},{"key":"3522_CR104","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1097\/CM9.0000000000002459","volume":"136","author":"Q Gao","year":"2023","unstructured":"Gao Q, Sun Z, Fang D. Integrins in human hepatocellular carcinoma tumorigenesis and therapy. Chin Med J. 2023;136:253\u201368.","journal-title":"Chin Med J"},{"key":"3522_CR105","doi-asserted-by":"publisher","first-page":"5053","DOI":"10.1021\/acsami.1c22432","volume":"14","author":"W Zuo","year":"2022","unstructured":"Zuo W, Chen W, Liu J, Huang S, Chen L, Liu Q, et al. Macrophage-mimic hollow mesoporous Fe-based nanocatalysts for self-amplified chemodynamic therapy and metastasis inhibition via tumor microenvironment remodeling. ACS Appl Mater Interfaces. 2022;14:5053\u201365.","journal-title":"ACS Appl Mater Interfaces"},{"key":"3522_CR106","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s13045-021-01187-y","volume":"14","author":"S Xiong","year":"2021","unstructured":"Xiong S, Dong L, Cheng L. Neutrophils in cancer carcinogenesis and metastasis. J Hematol Oncol. 2021;14:173.","journal-title":"J Hematol Oncol"},{"key":"3522_CR107","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.actbio.2020.01.011","volume":"104","author":"V Naumenko","year":"2020","unstructured":"Naumenko V, Nikitin A, Garanina A, Melnikov P, Vodopyanov S, Kapitanova K, et al. Neutrophil-mediated transport is crucial for delivery of short-circulating magnetic nanoparticles to tumors. Acta Biomater. 2020;104:176\u201387.","journal-title":"Acta Biomater"},{"key":"3522_CR108","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.3390\/cancers15102734","volume":"15","author":"D Li","year":"2023","unstructured":"Li D, Hemati H, Park Y, Taftaf R, Zhang Y, Liu J, et al. ICAM-1-suPAR-CD11b axis is a novel therapeutic target for metastatic triple-negative breast cancer. Cancers. 2023;15:2734.","journal-title":"Cancers"},{"key":"3522_CR109","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1021\/acsnano.6b06477","volume":"11","author":"T Kang","year":"2017","unstructured":"Kang T, Zhu Q, Wei D, Feng J, Yao J, Jiang T, et al. Nanoparticles coated with neutrophil membranes can effectively treat cancer metastasis. ACS Nano. 2017;11:1397\u2013411.","journal-title":"ACS Nano"},{"key":"3522_CR110","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1080\/14686996.2019.1629835","volume":"20","author":"T Yamamoto","year":"2019","unstructured":"Yamamoto T, Kosaka N, Ochiya T. Latest advances in extracellular vesicles: from bench to bedside. Sci Technol Adv Mater. 2019;20:746\u201357.","journal-title":"Sci Technol Adv Mater"},{"key":"3522_CR111","doi-asserted-by":"publisher","first-page":"6748","DOI":"10.1021\/acsnano.3c06462","volume":"18","author":"X Cheng","year":"2024","unstructured":"Cheng X, Henick BS, Cheng K. Anticancer therapy targeting cancer-derived extracellular vesicles. ACS Nano. 2024;18:6748\u201365.","journal-title":"ACS Nano"},{"key":"3522_CR112","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.3390\/cancers16081569","volume":"16","author":"P Ziranu","year":"2024","unstructured":"Ziranu P, Pretta A, Aimola V, Cau F, Mariani S, D\u2019Agata AP, et al. CD44: a new prognostic marker in colorectal cancer? Cancers. 2024;16:1569.","journal-title":"Cancers"},{"key":"3522_CR113","doi-asserted-by":"publisher","first-page":"7282","DOI":"10.1021\/jacs.8b03584","volume":"140","author":"G Cheng","year":"2018","unstructured":"Cheng G, Li W, Ha L, Han X, Hao S, Wan Y, et al. Self-assembly of extracellular vesicle-like metal\u2013organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins. J Am Chem Soc. 2018;140:7282\u201391.","journal-title":"J Am Chem Soc"},{"key":"3522_CR114","doi-asserted-by":"publisher","first-page":"120224","DOI":"10.1016\/j.biomaterials.2020.120224","volume":"257","author":"K Wang","year":"2020","unstructured":"Wang K, Ye H, Zhang X, Wang X, Yang B, Luo C, et al. An exosome-like programmable-bioactivating paclitaxel prodrug nanoplatform for enhanced breast cancer metastasis inhibition. Biomaterials. 2020;257:120224.","journal-title":"Biomaterials"},{"key":"3522_CR115","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1186\/s12951-024-02835-4","volume":"22","author":"H Mengyuan","year":"2024","unstructured":"Mengyuan H, Aixue L, Yongwei G, Qingqing C, Huanhuan C, Xiaoyan L, et al. Biomimetic nanocarriers in cancer therapy: based on intercellular and cell-tumor microenvironment communication. J Nanobiotechnol. 2024;22:604.","journal-title":"J Nanobiotechnol"},{"key":"3522_CR116","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1080\/21691401.2018.1436553","volume":"46","author":"J Cao","year":"2018","unstructured":"Cao J, Chen Z, Chi J, Sun Y, Sun Y. Recent progress in synergistic chemotherapy and phototherapy by targeted drug delivery systems for cancer treatment. Artif Cells Nanomed Biotechnol. 2018;46:817\u201330.","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"3522_CR117","doi-asserted-by":"publisher","first-page":"C907","DOI":"10.1152\/ajpcell.00463.2007","volume":"294","author":"CS Alves","year":"2008","unstructured":"Alves CS, Burdick MM, Thomas SN, Pawar P, Konstantopoulos K. The dual role of CD44 as a functional P-selectin ligand and fibrin receptor in colon carcinoma cell adhesion. Am J Physiol Cell Physiol. 2008;294:C907\u201316.","journal-title":"Am J Physiol Cell Physiol"},{"key":"3522_CR118","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2019.03.024","volume":"206","author":"H Ye","year":"2019","unstructured":"Ye H, Wang K, Wang M, Liu R, Song H, Li N, et al. Bioinspired nanoplatelets for chemo-photothermal therapy of breast cancer metastasis inhibition. Biomaterials. 2019;206:1\u201312.","journal-title":"Biomaterials"},{"key":"3522_CR119","doi-asserted-by":"publisher","first-page":"7043","DOI":"10.1002\/adma.201503323","volume":"27","author":"Q Hu","year":"2015","unstructured":"Hu Q, Sun W, Qian C, Wang C, Bomba HN, Gu Z. Anticancer platelet-mimicking nanovehicles. Adv Mater (Deerfield Beach, FL). 2015;27:7043\u201350.","journal-title":"Adv Mater (Deerfield Beach, FL)"},{"key":"3522_CR120","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1002\/adma.201404498","volume":"27","author":"T Jiang","year":"2015","unstructured":"Jiang T, Sun W, Zhu Q, Burns NA, Khan SA, Mo R, et al. Furin-mediated sequential delivery of anticancer cytokine and small-molecule drug shuttled by graphene. Adv Mater (Deerfield Beach, FL). 2015;27:1021\u20138.","journal-title":"Adv Mater (Deerfield Beach, FL)"},{"key":"3522_CR121","doi-asserted-by":"publisher","first-page":"10636","DOI":"10.1021\/nn403146t","volume":"7","author":"MH Xiong","year":"2013","unstructured":"Xiong MH, Bao Y, Du XJ, Tan ZB, Jiang Q, Wang HX, et al. Differential anticancer drug delivery with a nanogel sensitive to bacteria-accumulated tumor artificial environment. ACS Nano. 2013;7:10636\u201345.","journal-title":"ACS Nano"},{"key":"3522_CR122","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.biomaterials.2015.10.046","volume":"76","author":"J Li","year":"2016","unstructured":"Li J, Ai Y, Wang L, Bu P, Sharkey CC, Wu Q, et al. Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles. Biomaterials. 2016;76:52\u201365.","journal-title":"Biomaterials"},{"key":"3522_CR123","doi-asserted-by":"publisher","first-page":"5464","DOI":"10.7150\/thno.54822","volume":"11","author":"FH Kong","year":"2021","unstructured":"Kong FH, Ye QF, Miao XY, Liu X, Huang SQ, Xiong L, et al. Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma. Theranostics. 2021;11:5464\u201390.","journal-title":"Theranostics"},{"key":"3522_CR124","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.bbrc.2023.05.124","volume":"671","author":"X Da","year":"2023","unstructured":"Da X, Mo J, Li Q, Cao B, Huang J, Lu Y, et al. Targeted co-delivery of PD-L1 monoclonal antibody and sorafenib to circulating tumor cells via platelet-functionalized nanocarriers. Biochem Biophys Res Commun. 2023;671:335\u201342.","journal-title":"Biochem Biophys Res Commun"},{"key":"3522_CR125","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s10456-013-9405-2","volume":"17","author":"SL Rego","year":"2014","unstructured":"Rego SL, Helms RS, Dreau D. Breast tumor cell TACE-shed MCSF promotes pro-angiogenic macrophages through NF-kappaB signaling. Angiogenesis. 2014;17:573\u201385.","journal-title":"Angiogenesis"},{"key":"3522_CR126","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.1039\/C9BM00630C","volume":"7","author":"Y Li","year":"2019","unstructured":"Li Y, Yan T, Chang W, Cao C, Deng D. Fabricating an intelligent cell-like nano-prodrug via hierarchical self-assembly based on the DNA skeleton for suppressing lung metastasis of breast cancer. Biomater Sci. 2019;7:3652\u201361.","journal-title":"Biomater Sci"},{"key":"3522_CR127","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.1038\/s41467-020-18626-y","volume":"11","author":"L Rao","year":"2020","unstructured":"Rao L, Wu L, Liu Z, Tian R, Yu G, Zhou Z, et al. Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis. Nat Commun. 2020;11:4909.","journal-title":"Nat Commun"},{"key":"3522_CR128","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1182\/blood.2019004119","volume":"137","author":"S Lazar","year":"2021","unstructured":"Lazar S, Goldfinger LE. Platelets and extracellular vesicles and their cross talk with cancer. Blood. 2021;137:3192\u2013200.","journal-title":"Blood"},{"key":"3522_CR129","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.7150\/thno.30716","volume":"9","author":"P Wang","year":"2019","unstructured":"Wang P, Wang H, Huang Q, Peng C, Yao L, Chen H, et al. Exosomes from M1-polarized macrophages enhance paclitaxel antitumor activity by activating macrophages-mediated inflammation. Theranostics. 2019;9:1714\u201327.","journal-title":"Theranostics"},{"key":"3522_CR130","doi-asserted-by":"publisher","first-page":"E3053","DOI":"10.1073\/pnas.1411082111","volume":"111","author":"M Labelle","year":"2014","unstructured":"Labelle M, Begum S, Hynes RO. Platelets guide the formation of early metastatic niches. Proc Natl Acad Sci USA. 2014;111:E3053\u201361.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3522_CR131","doi-asserted-by":"publisher","first-page":"4387","DOI":"10.1038\/s41467-020-18125-0","volume":"11","author":"P Li","year":"2020","unstructured":"Li P, Lu M, Shi J, Hua L, Gong Z, Li Q, et al. Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status. Nat Commun. 2020;11:4387.","journal-title":"Nat Commun"},{"key":"3522_CR132","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1158\/0008-5472.CAN-20-3222","volume":"81","author":"J Ren","year":"2021","unstructured":"Ren J, He J, Zhang H, Xia Y, Hu Z, Loughran P, et al. Platelet TLR4-ERK5 axis facilitates NET-mediated capturing of circulating tumor cells and distant metastasis after surgical stress. Cancer Res. 2021;81:2373\u201385.","journal-title":"Cancer Res"},{"key":"3522_CR133","doi-asserted-by":"publisher","first-page":"119932","DOI":"10.1016\/j.biomaterials.2020.119932","volume":"242","author":"H Ye","year":"2020","unstructured":"Ye H, Wang K, Lu Q, Zhao J, Wang M, Kan Q, et al. Nanosponges of circulating tumor-derived exosomes for breast cancer metastasis inhibition. Biomaterials. 2020;242:119932.","journal-title":"Biomaterials"},{"key":"3522_CR134","doi-asserted-by":"publisher","first-page":"e1900772","DOI":"10.1002\/adhm.201900772","volume":"9","author":"L Zhang","year":"2020","unstructured":"Zhang L, Deng S, Zhang Y, Peng Q, Li H, Wang P, et al. Homotypic targeting delivery of siRNA with artificial cancer cells. Adv Healthc Mater. 2020;9:e1900772.","journal-title":"Adv Healthc Mater"},{"key":"3522_CR135","doi-asserted-by":"publisher","first-page":"e2101349","DOI":"10.1002\/adhm.202101349","volume":"11","author":"D Wang","year":"2022","unstructured":"Wang D, Wang S, Zhou Z, Bai D, Zhang Q, Ai X, et al. White blood cell membrane-coated nanoparticles: recent development and medical applications. Adv Healthc Mater. 2022;11:e2101349.","journal-title":"Adv Healthc Mater"},{"key":"3522_CR136","doi-asserted-by":"publisher","first-page":"116575","DOI":"10.1016\/j.bios.2024.116575","volume":"263","author":"J Sun","year":"2024","unstructured":"Sun J, Han S, Yang R, Guo L, Li J, Li C, et al. Combining hybrid cell membrane modified magnetic nanoparticles and inverted microfluidic chip for in situ CTCs capture and inactivation. Biosens Bioelectron. 2024;263:116575.","journal-title":"Biosens Bioelectron"},{"key":"3522_CR137","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.apsb.2017.11.009","volume":"8","author":"R Li","year":"2018","unstructured":"Li R, He Y, Zhang S, Qin J, Wang J. Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment. Acta Pharm Sin B. 2018;8:14\u201322.","journal-title":"Acta Pharm Sin B"},{"key":"3522_CR138","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.cis.2014.02.012","volume":"208","author":"AH Bahrami","year":"2014","unstructured":"Bahrami AH, Raatz M, Agudo-Canalejo J, Michel R, Curtis EM, Hall CK, et al. Wrapping of nanoparticles by membranes. Adv Coll Interface Sci. 2014;208:214\u201324.","journal-title":"Adv Coll Interface Sci"},{"key":"3522_CR139","doi-asserted-by":"publisher","first-page":"899","DOI":"10.3390\/nano8110899","volume":"8","author":"X Meng","year":"2018","unstructured":"Meng X, Li X. Size limit and energy analysis of nanoparticles during wrapping process by membrane. Nanomaterials. 2018;8:899.","journal-title":"Nanomaterials"},{"key":"3522_CR140","doi-asserted-by":"publisher","first-page":"5726","DOI":"10.1038\/s41467-021-26052-x","volume":"12","author":"L Liu","year":"2021","unstructured":"Liu L, Bai X, Martikainen MV, K\u00e5rlund A, Roponen M, Xu W, et al. Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles. Nat Commun. 2021;12:5726.","journal-title":"Nat Commun"},{"key":"3522_CR141","doi-asserted-by":"publisher","first-page":"e1542","DOI":"10.1002\/wnan.1542","volume":"11","author":"B Li","year":"2019","unstructured":"Li B, Lane LA. Probing the biological obstacles of nanomedicine with gold nanoparticles. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019;11:e1542.","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"3522_CR142","doi-asserted-by":"publisher","first-page":"e10441","DOI":"10.1002\/btm2.10441","volume":"8","author":"N Jan","year":"2023","unstructured":"Jan N, Madni A, Khan S, Shah H, Akram F, Khan A, et al. Biomimetic cell membrane-coated poly(lactic-glycolic acid) nanoparticles for biomedical applications. Bioeng Transl Med. 2023;8:e10441.","journal-title":"Bioeng Transl Med"},{"key":"3522_CR143","doi-asserted-by":"publisher","first-page":"134004","DOI":"10.1088\/1361-6528\/aaa7c7","volume":"29","author":"QF Meng","year":"2018","unstructured":"Meng QF, Rao L, Zan M, Chen M, Yu GT, Wei X, et al. Macrophage membrane-coated iron oxide nanoparticles for enhanced photothermal tumor therapy. Nanotechnology. 2018;29:134004.","journal-title":"Nanotechnology"},{"key":"3522_CR144","first-page":"3865","volume":"6","author":"T Zhang","year":"2021","unstructured":"Zhang T, Liu H, Li L, Guo Z, Song J, Yang X, et al. Leukocyte\/platelet hybrid membrane-camouflaged dendritic large pore mesoporous silica nanoparticles co-loaded with photo\/chemotherapeutic agents for triple negative breast cancer combination treatment. Bioact Mater. 2021;6:3865\u201378.","journal-title":"Bioact Mater"},{"key":"3522_CR145","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1021\/mp800051m","volume":"5","author":"F Alexis","year":"2008","unstructured":"Alexis F, Pridgen E, Molnar LK, Farokhzad OC. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm. 2008;5:505\u201315.","journal-title":"Mol Pharm"},{"key":"3522_CR146","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.semcancer.2010.04.005","volume":"20","author":"H Laubli","year":"2010","unstructured":"Laubli H, Borsig L. Selectins promote tumor metastasis. Semin Cancer Biol. 2010;20:169\u201377.","journal-title":"Semin Cancer Biol"},{"key":"3522_CR147","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1186\/s12885-021-08589-8","volume":"21","author":"N Ortiz-Otero","year":"2021","unstructured":"Ortiz-Otero N, Marshall JR, Glenn A, Matloubieh J, Joseph J, Sahasrabudhe DM, et al. TRAIL-coated leukocytes to kill circulating tumor cells in the flowing blood from prostate cancer patients. BMC Cancer. 2021;21:898.","journal-title":"BMC Cancer"},{"key":"3522_CR148","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jconrel.2015.12.048","volume":"223","author":"EC Wayne","year":"2016","unstructured":"Wayne EC, Chandrasekaran S, Mitchell MJ, Chan MF, Lee RE, Schaffer CB, et al. TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer. J Control Release. 2016;223:215\u201323.","journal-title":"J Control Release"},{"key":"3522_CR149","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1073\/pnas.1316312111","volume":"111","author":"MJ Mitchell","year":"2014","unstructured":"Mitchell MJ, Wayne E, Rana K, Schaffer CB, King MR. TRAIL-coated leukocytes that kill cancer cells in the circulation. Proc Natl Acad Sci USA. 2014;111:930\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3522_CR150","doi-asserted-by":"publisher","first-page":"831263","DOI":"10.1155\/2012\/831263","volume":"2012","author":"MJ Mitchell","year":"2012","unstructured":"Mitchell MJ, Castellanos CA, King MR. Nanostructured surfaces to target and kill circulating tumor cells while repelling leukocytes. J Nanomater. 2012;2012:831263.","journal-title":"J Nanomater"},{"key":"3522_CR151","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1111\/j.1349-7006.2011.01897.x","volume":"102","author":"S Shigdar","year":"2011","unstructured":"Shigdar S, Lin J, Yu Y, Pastuovic M, Wei M, Duan W. RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule. Cancer Sci. 2011;102:991\u20138.","journal-title":"Cancer Sci"},{"key":"3522_CR152","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.10.033","volume":"113","author":"J Yao","year":"2017","unstructured":"Yao J, Feng J, Gao X, Wei D, Kang T, Zhu Q, et al. Neovasculature and circulating tumor cells dual-targeting nanoparticles for the treatment of the highly-invasive breast cancer. Biomaterials. 2017;113:1\u201317.","journal-title":"Biomaterials"},{"key":"3522_CR153","doi-asserted-by":"publisher","first-page":"eaao1641","DOI":"10.1126\/scitranslmed.aao1641","volume":"10","author":"MC Bourgeois-Daigneault","year":"2018","unstructured":"Bourgeois-Daigneault MC, Roy DG, Aitken AS, El Sayes N, Martin NT, Varette O, et al. Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy. Sci Transl Med. 2018;10:eaao1641.","journal-title":"Sci Transl Med."},{"key":"3522_CR154","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41419-018-1265-7","volume":"10","author":"L Ma","year":"2019","unstructured":"Ma L, Dong L, Chang P. CD44v6 engages in colorectal cancer progression. Cell Death Dis. 2019;10:30.","journal-title":"Cell Death Dis"},{"key":"3522_CR155","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jconrel.2021.01.022","volume":"331","author":"F Andrade","year":"2021","unstructured":"Andrade F, Rafael D, Vilar-Hernandez M, Montero S, Martinez-Trucharte F, Seras-Franzoso J, et al. Polymeric micelles targeted against CD44v6 receptor increase niclosamide efficacy against colorectal cancer stem cells and reduce circulating tumor cells in vivo. J Control Release. 2021;331:198\u2013212.","journal-title":"J Control Release"},{"key":"3522_CR156","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s00280-021-04343-w","volume":"88","author":"L Li","year":"2021","unstructured":"Li L, Xiao Y, Xu Z, Wang S. Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models. Cancer Chemother Pharmacol. 2021;88:953\u201360.","journal-title":"Cancer Chemother Pharmacol"},{"key":"3522_CR157","doi-asserted-by":"publisher","first-page":"102106","DOI":"10.1016\/j.nano.2019.102106","volume":"24","author":"P Gener","year":"2020","unstructured":"Gener P, Montero S, Xandri-Monje H, Diaz-Riascos ZV, Rafael D, Andrade F, et al. Zileuton loaded in polymer micelles effectively reduce breast cancer circulating tumor cells and intratumoral cancer stem cells. Nanomed Nanotechnol Biol Med. 2020;24:102106.","journal-title":"Nanomed Nanotechnol Biol Med"},{"key":"3522_CR158","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.biomaterials.2018.10.019","volume":"188","author":"Y Li","year":"2019","unstructured":"Li Y, Xiao Y, Lin HP, Reichel D, Bae Y, Lee EY, et al. In vivo beta-catenin attenuation by the integrin alpha5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis. Biomaterials. 2019;188:160\u201372.","journal-title":"Biomaterials"},{"key":"3522_CR159","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.jconrel.2020.10.015","volume":"329","author":"Y Li","year":"2021","unstructured":"Li Y, Qian D, Lin HP, Xie J, Yang P, Maddy D, et al. Nanoparticle-delivered miriplatin ultrasmall dots suppress triple negative breast cancer lung metastasis by targeting circulating tumor cells. J Control Release. 2021;329:833\u201346.","journal-title":"J Control Release"},{"key":"3522_CR160","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.pharmthera.2019.03.007","volume":"199","author":"A Worrede","year":"2019","unstructured":"Worrede A, Meucci O, Fatatis A. Limiting tumor seeding as a therapeutic approach for metastatic disease. Pharmacol Ther. 2019;199:117\u201328.","journal-title":"Pharmacol Ther"},{"key":"3522_CR161","doi-asserted-by":"publisher","first-page":"5460","DOI":"10.1039\/D0TB00501K","volume":"8","author":"CS Chiang","year":"2020","unstructured":"Chiang CS, Kao YC, Webster TJ, Shyu WC, Cheng HW, Liu TY, et al. Circulating tumor-cell-targeting Au-nanocage-mediated bimodal phototherapeutic properties enriched by magnetic nanocores. J Mater Chem B. 2020;8:5460\u201371.","journal-title":"J Mater Chem B"},{"key":"3522_CR162","doi-asserted-by":"publisher","first-page":"3446","DOI":"10.1172\/JCI67484","volume":"123","author":"J Cools-Lartigue","year":"2013","unstructured":"Cools-Lartigue J, Spicer J, McDonald B, Gowing S, Chow S, Giannias B, et al. Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. J Clin Invest. 2013;123:3446\u201358.","journal-title":"J Clin Invest"},{"key":"3522_CR163","doi-asserted-by":"publisher","first-page":"361ra138","DOI":"10.1126\/scitranslmed.aag1711","volume":"8","author":"J Park","year":"2016","unstructured":"Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, et al. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci Transl Med. 2016;8:361ra138.","journal-title":"Sci Transl Med."},{"key":"3522_CR164","doi-asserted-by":"publisher","first-page":"59683","DOI":"10.1021\/acsami.1c18660","volume":"13","author":"H Yin","year":"2021","unstructured":"Yin H, Lu H, Xiong Y, Ye L, Teng C, Cao X, et al. Tumor-associated neutrophil extracellular traps regulating nanocarrier-enhanced inhibition of malignant tumor growth and distant metastasis. ACS Appl Mater Interfaces. 2021;13:59683\u201394.","journal-title":"ACS Appl Mater Interfaces"},{"key":"3522_CR165","doi-asserted-by":"publisher","first-page":"10265","DOI":"10.3390\/ijms241210265","volume":"24","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Niu R, Zhao L, Wang Y, Liu G. Mechanisms of neutrophil extracellular trap formation and regulation in cancers. Int J Mol Sci. 2023;24:10265.","journal-title":"Int J Mol Sci"},{"key":"3522_CR166","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1016\/j.apsb.2021.11.006","volume":"12","author":"D Zhu","year":"2022","unstructured":"Zhu D, Lu Y, Gui L, Wang W, Hu X, Chen S, et al. Self-assembling, pH-responsive nanoflowers for inhibiting PAD4 and neutrophil extracellular trap formation and improving the tumor immune microenvironment. Acta Pharm Sin B. 2022;12:2592\u2013608.","journal-title":"Acta Pharm Sin B"},{"key":"3522_CR167","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.actbio.2023.11.020","volume":"173","author":"Y Shi","year":"2024","unstructured":"Shi Y, Dong M, Wu Y, Gong F, Wang Z, Xue L, et al. An elastase-inhibiting, plaque-targeting and neutrophil-hitchhiking liposome against atherosclerosis. Acta Biomater. 2024;173:470\u201381.","journal-title":"Acta Biomater"},{"key":"3522_CR168","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3390\/pharmaceutics11080379","volume":"11","author":"M Hill","year":"2019","unstructured":"Hill M, Twigg M, Sheridan EA, Hardy JG, Elborn JS, Taggart CC, et al. Alginate\/chitosan particle-based drug delivery systems for pulmonary applications. Pharmaceutics. 2019;11:379.","journal-title":"Pharmaceutics"},{"key":"3522_CR169","doi-asserted-by":"publisher","first-page":"119836","DOI":"10.1016\/j.biomaterials.2020.119836","volume":"238","author":"EB Okeke","year":"2020","unstructured":"Okeke EB, Louttit C, Fry C, Najafabadi AH, Han K, Nemzek J, et al. Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock. Biomaterials. 2020;238:119836.","journal-title":"Biomaterials"},{"key":"3522_CR170","doi-asserted-by":"publisher","first-page":"5841","DOI":"10.2147\/IJN.S141839","volume":"12","author":"H Rizwan","year":"2017","unstructured":"Rizwan H, Mohanta J, Si S, Pal A. Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR\/NF-\u03baB pathways in macrophages. Int J Nanomed. 2017;12:5841\u201362.","journal-title":"Int J Nanomed"},{"key":"3522_CR171","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1186\/s12951-024-02726-8","volume":"22","author":"S Lu","year":"2024","unstructured":"Lu S, Mi Z, Liu P, Ding J, Ma Y, Yang J, et al. Repolarizing neutrophils via MnO(2) nanoparticle-activated STING pathway enhances Salmonella-mediated tumor immunotherapy. J Nanobiotechnol. 2024;22:443.","journal-title":"J Nanobiotechnol"},{"key":"3522_CR172","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.3390\/cells10092486","volume":"10","author":"RV Sionov","year":"2021","unstructured":"Sionov RV. Leveling up the controversial role of neutrophils in cancer: when the complexity becomes entangled. Cells. 2021;10:2486.","journal-title":"Cells"},{"key":"3522_CR173","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jconrel.2024.03.030","volume":"369","author":"Q Zhang","year":"2024","unstructured":"Zhang Q, Hu C, Feng J, Long H, Wang Y, Wang P, et al. Anti-inflammatory mechanisms of neutrophil membrane-coated nanoparticles without drug loading. J Control Release. 2024;369:12\u201324.","journal-title":"J Control Release"},{"key":"3522_CR174","doi-asserted-by":"publisher","first-page":"3528","DOI":"10.1021\/acsnano.2c09931","volume":"17","author":"J Yang","year":"2023","unstructured":"Yang J, Wang P, Jiang X, Xu J, Zhang M, Liu F, et al. A nanotherapy of octanoic acid ameliorates cardiac arrest\/cardiopulmonary resuscitation-induced brain injury via RVG29- and neutrophil membrane-mediated injury relay targeting. ACS Nano. 2023;17:3528\u201348.","journal-title":"ACS Nano"},{"key":"3522_CR175","first-page":"5864","volume":"18","author":"J Wu","year":"2024","unstructured":"Wu J, Ma T, Zhu M, Mu J, Huang T, Xu D, et al. A pluripotential neutrophil-mimic nanovehicle modulates immune microenvironment with targeted drug delivery for augmented antitumor chemotherapy. ACS Nano. 2024;18:5864\u201377.","journal-title":"ACS Nano"},{"key":"3522_CR176","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12951-022-01433-6","volume":"20","author":"J Chen","year":"2022","unstructured":"Chen J, Song Y, Wang Q, Li Q, Tan H, Gao J, et al. Targeted neutrophil-mimetic liposomes promote cardiac repair by adsorbing proinflammatory cytokines and regulating the immune microenvironment. J Nanobiotechnol. 2022;20:218.","journal-title":"J Nanobiotechnol"},{"key":"3522_CR177","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2353\/ajpath.2008.070502","volume":"172","author":"A Zarbock","year":"2008","unstructured":"Zarbock A, Ley K. Mechanisms and consequences of neutrophil interaction with the endothelium. Am J Pathol. 2008;172:1\u20137.","journal-title":"Am J Pathol"},{"key":"3522_CR178","doi-asserted-by":"publisher","first-page":"659","DOI":"10.2174\/1381612824666180123110042","volume":"24","author":"C Angelidis","year":"2018","unstructured":"Angelidis C, Kotsialou Z, Kossyvakis C, Vrettou AR, Zacharoulis A, Kolokathis F, et al. Colchicine pharmacokinetics and mechanism of action. Curr Pharm Des. 2018;24:659\u201363.","journal-title":"Curr Pharm Des"},{"key":"3522_CR179","doi-asserted-by":"publisher","first-page":"121684","DOI":"10.1016\/j.ijpharm.2022.121684","volume":"620","author":"M Chen","year":"2022","unstructured":"Chen M, Wu W, Wang S, Lai X, Liu M, Sun Y, et al. Neutrophils as emerging immunotherapeutic targets: indirect treatment of tumors by regulating the tumor immune environment based on a sialic acid derivative-modified nanocomplex platform. Int J Pharm. 2022;620:121684.","journal-title":"Int J Pharm"},{"key":"3522_CR180","doi-asserted-by":"publisher","first-page":"7363","DOI":"10.1021\/acsnano.3c08946","volume":"18","author":"W Zeng","year":"2024","unstructured":"Zeng W, Wang Y, Zhang Q, Hu C, Li J, Feng J, et al. Neutrophil nanodecoys inhibit tumor metastasis by blocking the interaction between tumor cells and neutrophils. ACS Nano. 2024;18:7363\u201378.","journal-title":"ACS Nano"},{"key":"3522_CR181","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.2147\/IJN.S415139","volume":"18","author":"R Huang","year":"2023","unstructured":"Huang R, Fan D, Cheng H, Huo J, Wang S, He H, et al. Multi-site attack, neutrophil membrane-camouflaged nanomedicine with high drug loading for enhanced cancer therapy and metastasis inhibition. Int J Nanomed. 2023;18:3359\u201375.","journal-title":"Int J Nanomed"},{"key":"3522_CR182","first-page":"2101472","volume":"9","author":"W Mu","year":"2022","unstructured":"Mu W, Chu Q, Yang H, Guan L, Fu S, Gao T, et al. Multipoint costriking nanodevice eliminates primary tumor cells and associated-circulating tumor cells for enhancing metastasis inhibition and therapeutic effect on HCC. Adv Sci (Weinheim, Baden-Wurttemberg, Germany). 2022;9:2101472.","journal-title":"Adv Sci (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"3522_CR183","doi-asserted-by":"publisher","first-page":"98-+","DOI":"10.1016\/j.cell.2018.11.046","volume":"176","author":"S Gkountela","year":"2019","unstructured":"Gkountela S, Castro-Giner F, Szczerba BM, Vetter M, Landin J, Scherrer R, et al. Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding. Cell. 2019;176:98-+.","journal-title":"Cell"},{"key":"3522_CR184","doi-asserted-by":"publisher","first-page":"241","DOI":"10.2147\/JHC.S270532","volume":"8","author":"A Dipasquale","year":"2021","unstructured":"Dipasquale A, Marinello A, Santoro A. A comparison of lenvatinib versus sorafenib in the first-line treatment of unresectable hepatocellular carcinoma: selection criteria to guide physician\u2019s choice in a new therapeutic scenario. J Hepatocell Carcinoma. 2021;8:241\u201351.","journal-title":"J Hepatocell Carcinoma"},{"key":"3522_CR185","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/nnano.2016.239","volume":"12","author":"M Poudineh","year":"2017","unstructured":"Poudineh M, Aldridge PM, Ahmed S, Green BJ, Kermanshah L, Nguyen V, et al. Tracking the dynamics of circulating tumour cell phenotypes using nanoparticle-mediated magnetic ranking. Nat Nanotechnol. 2017;12:274\u201381.","journal-title":"Nat Nanotechnol"},{"key":"3522_CR186","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.7150\/thno.11742","volume":"5","author":"MO Durymanov","year":"2015","unstructured":"Durymanov MO, Rosenkranz AA, Sobolev AS. Current approaches for improving intratumoral accumulation and distribution of nanomedicines. Theranostics. 2015;5:1007\u201320.","journal-title":"Theranostics"},{"key":"3522_CR187","doi-asserted-by":"publisher","first-page":"536","DOI":"10.3390\/cancers14030536","volume":"14","author":"I Ozel","year":"2022","unstructured":"Ozel I, Duerig I, Domnich M, Lang S, Pylaeva E, Jablonska J. The good, the bad, and the ugly: neutrophils, angiogenesis, and cancer. Cancers. 2022;14:536.","journal-title":"Cancers"},{"key":"3522_CR188","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1172\/JCI122085","volume":"129","author":"V Butin-Israeli","year":"2019","unstructured":"Butin-Israeli V, Bui TM, Wiesolek HL, Mascarenhas L, Lee JJ, Mehl LC, et al. Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing. J Clin Investig. 2019;129:712\u201326.","journal-title":"J Clin Investig"},{"key":"3522_CR189","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/mutage\/gep053","volume":"25","author":"N G\u00fcng\u00f6r","year":"2010","unstructured":"G\u00fcng\u00f6r N, Knaapen AM, Munnia A, Peluso M, Haenen GR, Chiu RK, et al. Genotoxic effects of neutrophils and hypochlorous acid. Mutagenesis. 2010;25:149\u201354.","journal-title":"Mutagenesis"},{"key":"3522_CR190","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nm.2084","volume":"16","author":"AM Houghton","year":"2010","unstructured":"Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, et al. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med. 2010;16:219\u201323.","journal-title":"Nat Med"},{"key":"3522_CR191","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.semcancer.2013.02.004","volume":"23","author":"C Tecchio","year":"2013","unstructured":"Tecchio C, Scapini P, Pizzolo G, Cassatella MA. On the cytokines produced by human neutrophils in tumors. Semin Cancer Biol. 2013;23:159\u201370.","journal-title":"Semin Cancer Biol"},{"key":"3522_CR192","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nature14407","volume":"522","author":"V Finisguerra","year":"2015","unstructured":"Finisguerra V, Di Conza G, Di Matteo M, Serneels J, Costa S, Thompson AA, et al. MET is required for the recruitment of anti-tumoural neutrophils. Nature. 2015;522:349\u201353.","journal-title":"Nature"},{"key":"3522_CR193","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1084\/jem.141.6.1442","volume":"141","author":"RA Clark","year":"1975","unstructured":"Clark RA, Klebanoff SJ. Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system. J Exp Med. 1975;141:1442\u20137.","journal-title":"J Exp Med"},{"key":"3522_CR194","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.it.2016.03.005","volume":"37","author":"JM Adrover","year":"2016","unstructured":"Adrover JM, Nicol\u00e1s-\u00c1vila JA, Hidalgo A. Aging: a temporal dimension for neutrophils. Trends Immunol. 2016;37:334\u201345.","journal-title":"Trends Immunol"},{"key":"3522_CR195","doi-asserted-by":"crossref","unstructured":"Neutrophils Help Circulating Tumor Cells Metastasize. Cancer Discov. 2019 ;9:458-459.","DOI":"10.1158\/2159-8290.CD-NB2019-025"},{"key":"3522_CR196","doi-asserted-by":"crossref","unstructured":"Luo Z, Huang Y, Batra N, Chen Y, Huang H, Wang Y, et al. Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy. Nature communications. 2024; 15:255.","DOI":"10.1038\/s41467-023-44572-6"},{"key":"3522_CR197","doi-asserted-by":"crossref","unstructured":"Xia JX, Ma SJ, Zhu X, Chen C, Zhang R, Cao ZL, et al. Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches. Science advances. 2022; 8: eabj1262.\u00a0","DOI":"10.1126\/sciadv.abj1262"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03522-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-025-03522-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03522-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T14:47:00Z","timestamp":1750171620000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03522-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":197,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3522"],"URL":"https:\/\/doi.org\/10.1186\/s12951-025-03522-8","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,17]]},"assertion":[{"value":"23 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"We agree on the publication of any human face that might be detected in the images contained in this article. All authors have read the journal policies and submit this manuscript in accordance with thosepolicies. All authors agree to publish.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"449"}}