{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:19:15Z","timestamp":1793272755770,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Fund of 2023 Chongqing Research Innovation Program for Graduate Student in the First Affiliated Hospital of Chongqing Medical University","award":["CYYY-BSYJSCXXM-202307"],"award-info":[{"award-number":["CYYY-BSYJSCXXM-202307"]}],"id":[{"id":"https:\/\/ror.org\/033vnzz93","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Fund of 2023 Chongqing Research Innovation Program for Graduate Student","award":["CYB23196"],"award-info":[{"award-number":["CYB23196"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82402966"],"award-info":[{"award-number":["82402966"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82172533"],"award-info":[{"award-number":["82172533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82394444"],"award-info":[{"award-number":["82394444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82472601"],"award-info":[{"award-number":["82472601"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"crossref","award":["CSTB2022NSCQ-MSX0064"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX0064"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"crossref","award":["CSTB2024NSCQ-LZX0104"],"award-info":[{"award-number":["CSTB2024NSCQ-LZX0104"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific and Technological Research Program of Chongqing Municipal Education Commission","award":["KJQN202300485"],"award-info":[{"award-number":["KJQN202300485"]}],"id":[{"id":"https:\/\/ror.org\/031nm5713","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["BX20240454"],"award-info":[{"award-number":["BX20240454"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-025-03591-9","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T16:36:46Z","timestamp":1752683806000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Exosomes derived from platelet-rich plasma alleviate synovial inflammation by enhancing synovial lymphatic function"],"prefix":"10.1186","volume":"23","author":[{"given":"Bo","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengtong","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingqun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"3591_CR1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","volume":"386","author":"S Glyn-Jones","year":"2015","unstructured":"Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H, et al. Osteoarthr Lancet (London England). 2015;386:376\u201387.","journal-title":"Osteoarthr Lancet (London England)"},{"key":"3591_CR2","doi-asserted-by":"publisher","first-page":"e23177","DOI":"10.1096\/fj.202300944RR","volume":"37","author":"J Yan","year":"2023","unstructured":"Yan J, Feng G, Yang Y, Zhao X, Ma L, Guo H, et al. Nintedanib ameliorates osteoarthritis in mice by inhibiting synovial inflammation and fibrosis caused by M1 polarization of synovial macrophages via the MAPK\/PI3K-AKT pathway. FASEB Journal: Official Publication Federation Am Soc Experimental Biology. 2023;37:e23177.","journal-title":"FASEB Journal: Official Publication Federation Am Soc Experimental Biology"},{"key":"3591_CR3","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/nrrheum.2010.159","volume":"6","author":"J Sellam","year":"2010","unstructured":"Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol. 2010;6:625\u201335.","journal-title":"Nat Rev Rheumatol"},{"key":"3591_CR4","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","volume":"18","author":"E Sanchez-Lopez","year":"2022","unstructured":"Sanchez-Lopez E, Coras R, Torres A, Lane NE, Guma M. Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol. 2022;18:258\u201375.","journal-title":"Nat Rev Rheumatol"},{"key":"3591_CR5","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1080\/15548627.2019.1664705","volume":"16","author":"B Zhang","year":"2020","unstructured":"Zhang B, Chen H, Ouyang J, Xie Y, Chen L, Tan Q, et al. SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B\/IL-1\u03b2 and contributes to LIPUS-mediated anti-inflammatory effect. Autophagy. 2020;16:1262\u201378.","journal-title":"Autophagy"},{"key":"3591_CR6","first-page":"657","volume-title":"Distribution and alteration of lymphatic vessels in knee joints of normal and Osteoarthritic mice","author":"J Shi","year":"2014","unstructured":"Shi J, Liang Q, Zuscik M, Shen J, Chen D, Xu H, et al. Distribution and alteration of lymphatic vessels in knee joints of normal and Osteoarthritic mice. Volume 66. Hoboken, NJ: Arthritis & rheumatology; 2014. pp. 657\u201366."},{"key":"3591_CR7","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.joca.2022.04.003","volume":"30","author":"M Cao","year":"2022","unstructured":"Cao M, Ong MTY, Yung PSH, Tuan RS, Jiang Y. Role of synovial lymphatic function in osteoarthritis. Osteoarthr Cartil. 2022;30:1186\u201397.","journal-title":"Osteoarthr Cartil"},{"key":"3591_CR8","doi-asserted-by":"crossref","unstructured":"Spakova T, Janockova J, Rosocha J. Characterization and therapeutic use of extracellular vesicles derived from platelets. Int J Mol Sci. 2021;22.","DOI":"10.3390\/ijms22189701"},{"key":"3591_CR9","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrrheum.2013.141","volume":"9","author":"I Andia","year":"2013","unstructured":"Andia I, Maffulli N. Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nat Rev Rheumatol. 2013;9:721\u201330.","journal-title":"Nat Rev Rheumatol"},{"key":"3591_CR10","doi-asserted-by":"publisher","first-page":"733","DOI":"10.7150\/thno.17450","volume":"7","author":"SC Tao","year":"2017","unstructured":"Tao SC, Yuan T, Rui BY, Zhu ZZ, Guo SC, Zhang CQ. Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated Endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt\/Bad\/Bcl-2 signal pathway. Theranostics. 2017;7:733\u201350.","journal-title":"Theranostics"},{"key":"3591_CR11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.22203\/eCM.v028a11","volume":"28","author":"E Torreggiani","year":"2014","unstructured":"Torreggiani E, Perut F, Roncuzzi L, Zini N. Bagl\u00eco SR and Baldini N. Exosomes: novel effectors of human platelet lysate activity. Eur Cells Mater. 2014;28:137\u201351. discussion 151.","journal-title":"Eur Cells Mater"},{"key":"3591_CR12","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jconrel.2024.01.043","volume":"367","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Yi D, Hong Q, Cao J, Geng X, Liu J, et al. Platelet-rich plasma-derived exosomes boost mesenchymal stem cells to promote peripheral nerve regeneration. J Controlled Release: Official J Controlled Release Soc. 2024;367:265\u201382.","journal-title":"J Controlled Release: Official J Controlled Release Soc"},{"key":"3591_CR13","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1186\/s13018-019-1529-7","volume":"14","author":"X Liu","year":"2019","unstructured":"Liu X, Wang L, Ma C, Wang G, Zhang Y, Sun S. Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt\/\u03b2-catenin signaling pathway. J Orthop Surg Res. 2019;14:470.","journal-title":"J Orthop Surg Res"},{"key":"3591_CR14","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12951-022-01245-8","volume":"20","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Wang X, Chen J, Qian D, Gao P, Qin T, et al. Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis. J Nanobiotechnol. 2022;20:56.","journal-title":"J Nanobiotechnol"},{"key":"3591_CR15","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1177\/03635465231188122","volume":"51","author":"C Xu","year":"2023","unstructured":"Xu C, Mi Z, Dong Z, Chen X, Ji G, Kang H, et al. Platelet-Derived exosomes alleviate knee osteoarthritis by attenuating cartilage degeneration and subchondral bone loss. Am J Sports Med. 2023;51:2975\u201385.","journal-title":"Am J Sports Med"},{"key":"3591_CR16","doi-asserted-by":"crossref","unstructured":"Ban Y, Yang X, Xing Y, Que W, Yu Z, Gui W et al. Intrauterine infusion of Leukocyte-Poor Platelet-Rich plasma is an effective therapeutic protocol for patients with recurrent implantation failure: A retrospective cohort study. J Clin Med. 2023;12.","DOI":"10.3390\/jcm12082823"},{"key":"3591_CR17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jot.2021.08.002","volume":"30","author":"B Liao","year":"2021","unstructured":"Liao B, Guan M, Tan Q, Wang G, Zhang R, Huang J, et al. Low-intensity pulsed ultrasound inhibits fibroblast-like synoviocyte proliferation and reduces synovial fibrosis by regulating Wnt\/\u03b2-catenin signaling. J Orthop Translation. 2021;30:41\u201350.","journal-title":"J Orthop Translation"},{"key":"3591_CR18","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1161\/CIRCULATIONAHA.122.060799","volume":"147","author":"K Chen","year":"2023","unstructured":"Chen K, Mou R, Zhu P, Xu X, Wang H, Jiang L, et al. The effect of lymphangiogenesis in transplant arteriosclerosis. Circulation. 2023;147:482\u201397.","journal-title":"Circulation"},{"key":"3591_CR19","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41586-023-06888-7","volume":"625","author":"W Fu","year":"2024","unstructured":"Fu W, Vasylyev D, Bi Y, Zhang M, Sun G, Khleborodova A, et al. Na(v)1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis. Nature. 2024;625:557\u201365.","journal-title":"Nature"},{"key":"3591_CR20","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.joca.2015.03.001","volume":"23","author":"CB Hamilton","year":"2015","unstructured":"Hamilton CB, Pest MA, Pitelka V, Ratneswaran A, Beier F, Chesworth BM. Weight-bearing asymmetry and vertical activity differences in a rat model of post-traumatic knee osteoarthritis. Osteoarthr Cartil. 2015;23:1178\u201385.","journal-title":"Osteoarthr Cartil"},{"key":"3591_CR21","doi-asserted-by":"publisher","first-page":"4391","DOI":"10.1038\/s41467-021-24643-2","volume":"12","author":"D Zhang","year":"2021","unstructured":"Zhang D, Huang J, Sun X, Chen H, Huang S, Yang J, et al. Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway. Nat Commun. 2021;12:4391.","journal-title":"Nat Commun"},{"key":"3591_CR22","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","volume":"49","author":"V Krenn","year":"2006","unstructured":"Krenn V, Morawietz L, Burmester GR, Kinne RW, Mueller-Ladner U, Muller B, et al. Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology. 2006;49:358\u201364.","journal-title":"Histopathology"},{"key":"3591_CR23","doi-asserted-by":"publisher","first-page":"e27385","DOI":"10.1371\/journal.pone.0027385","volume":"6","author":"E Zudaire","year":"2011","unstructured":"Zudaire E, Gambardella L, Kurcz C, Vermeren S. A computational tool for quantitative analysis of vascular networks. PLoS ONE. 2011;6:e27385.","journal-title":"PLoS ONE"},{"key":"3591_CR24","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/j.joca.2022.06.004","volume":"30","author":"X Wang","year":"2022","unstructured":"Wang X, Chen T, Liang W, Fan T, Zhu Z, Cao P, et al. Synovitis mediates the association between bone marrow lesions and knee pain in osteoarthritis: data from the foundation for the National Institute of health (FNIH) osteoarthritis biomarkers consortium. Osteoarthr Cartil. 2022;30:1270\u20137.","journal-title":"Osteoarthr Cartil"},{"key":"3591_CR25","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.joca.2004.03.003","volume":"12","author":"AB Blom","year":"2004","unstructured":"Blom AB, van Lent PL, Holthuysen AE, van der Kraan PM, Roth J, van Rooijen N, et al. Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. Osteoarthr Cartil. 2004;12:627\u201335.","journal-title":"Osteoarthr Cartil"},{"key":"3591_CR26","first-page":"1226","volume":"143","author":"PL Van Lent","year":"1993","unstructured":"Van Lent PL, Van den Hoek AE, Van den Bersselaar LA, Spanjaards MF, Van Rooijen N, Dijkstra CD, et al. In vivo role of phagocytic synovial lining cells in onset of experimental arthritis. Am J Pathol. 1993;143:1226\u201337.","journal-title":"Am J Pathol"},{"key":"3591_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","volume":"7","author":"M Kapoor","year":"2011","unstructured":"Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of Proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7:33\u201342.","journal-title":"Nat Rev Rheumatol"},{"key":"3591_CR28","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3389\/fimmu.2019.00308","volume":"10","author":"S Schwager","year":"2019","unstructured":"Schwager S, Detmar M. Inflammation and lymphatic function. Front Immunol. 2019;10:308.","journal-title":"Front Immunol"},{"key":"3591_CR29","doi-asserted-by":"crossref","unstructured":"De Paoli SH, Tegegn TZ, Elhelu OK, Strader MB, Patel M, Diduch LL et al. Dissecting the biochemical architecture and morphological release pathways of the human platelet extracellular vesiculome. Cellular and molecular life sciences: CMLS. 2018;75:3781\u20133801.","DOI":"10.1007\/s00018-018-2771-6"},{"key":"3591_CR30","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41420-022-01263-3","volume":"8","author":"M Vismara","year":"2022","unstructured":"Vismara M, Manfredi M, Zar\u00e0 M, Trivigno SMG, Galgano L, Barbieri SS, et al. Proteomic and functional profiling of platelet-derived extracellular vesicles released under physiological or tumor-associated conditions. Cell Death Discovery. 2022;8:467.","journal-title":"Cell Death Discovery"},{"key":"3591_CR31","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13075-017-1229-9","volume":"19","author":"A Mathiessen","year":"2017","unstructured":"Mathiessen A, Conaghan PG. Synovitis in osteoarthritis: current Understanding with therapeutic implications. Arthritis Res Therapy. 2017;19:18.","journal-title":"Arthritis Res Therapy"},{"key":"3591_CR32","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1177\/0363546520924011","volume":"48","author":"N Araya","year":"2020","unstructured":"Araya N, Miyatake K, Tsuji K, Katagiri H, Nakagawa Y, Hoshino T, et al. Intra-articular injection of pure Platelet-Rich plasma is the most effective treatment for joint pain by modulating synovial inflammation and calcitonin Gene-Related peptide expression in a rat arthritis model. Am J Sports Med. 2020;48:2004\u201312.","journal-title":"Am J Sports Med"},{"key":"3591_CR33","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1186\/s12951-024-02737-5","volume":"22","author":"X Nie","year":"2024","unstructured":"Nie X, Liu Y, Yuan T, Yu T, Yun Z, Xue W, et al. Platelet-rich plasma-derived exosomes promote blood-spinal cord barrier repair and attenuate neuroinflammation after spinal cord injury. J Nanobiotechnol. 2024;22:456.","journal-title":"J Nanobiotechnol"},{"key":"3591_CR34","doi-asserted-by":"publisher","first-page":"108962","DOI":"10.1016\/j.intimp.2022.108962","volume":"110","author":"J Qian","year":"2022","unstructured":"Qian J, Wang X, Su G, Shu X, Huang Z, Jiang H, et al. Platelet-rich plasma-derived exosomes attenuate intervertebral disc degeneration by promoting NLRP3 autophagic degradation in macrophages. Int Immunopharmacol. 2022;110:108962.","journal-title":"Int Immunopharmacol"},{"key":"3591_CR35","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1002\/art.30421","volume":"63","author":"Q Zhou","year":"2011","unstructured":"Zhou Q, Guo R, Wood R, Boyce BF, Liang Q, Wang YJ, et al. Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice. Arthritis Rheum. 2011;63:2318\u201328.","journal-title":"Arthritis Rheum"},{"key":"3591_CR36","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/s42003-024-06675-8","volume":"7","author":"L Vachon","year":"2024","unstructured":"Vachon L, Jean G, Milasan A, Babran S, Lacroix E, Guadarrama Bello D, et al. Platelet extracellular vesicles preserve lymphatic endothelial cell integrity and enhance lymphatic vessel function. Commun Biology. 2024;7:975.","journal-title":"Commun Biology"},{"key":"3591_CR37","doi-asserted-by":"publisher","first-page":"265","DOI":"10.7150\/thno.90940","volume":"14","author":"S Zhou","year":"2024","unstructured":"Zhou S, Zhao G, Chen R, Li Y, Huang J, Kuang L, et al. Lymphatic vessels: roles and potential therapeutic intervention in rheumatoid arthritis and osteoarthritis. Theranostics. 2024;14:265\u201382.","journal-title":"Theranostics"},{"key":"3591_CR38","doi-asserted-by":"crossref","unstructured":"Kraus VB, Birmingham J, Stabler TV, Feng S, Taylor DC, Moorman CT 3, et al. Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254). Osteoarthr Cartil. 2012;20:271\u20138.","DOI":"10.1016\/j.joca.2011.12.009"},{"key":"3591_CR39","doi-asserted-by":"publisher","first-page":"101149","DOI":"10.1016\/j.jbc.2021.101149","volume":"297","author":"H Song","year":"2021","unstructured":"Song H, Zhu J, Li P, Han F, Fang L, Yu P. Metabolic flexibility maintains proliferation and migration of FGFR signaling-deficient lymphatic endothelial cells. J Biol Chem. 2021;297:101149.","journal-title":"J Biol Chem"},{"key":"3591_CR40","doi-asserted-by":"publisher","first-page":"e026889","DOI":"10.1161\/JAHA.122.026889","volume":"11","author":"J Suzuki","year":"2022","unstructured":"Suzuki J, Shimizu Y, Hayashi T, Che Y, Pu Z, Tsuzuki K, et al. Hydrogen sulfide attenuates lymphedema via the induction of lymphangiogenesis through a PI3K\/Akt-Dependent mechanism. J Am Heart Association. 2022;11:e026889.","journal-title":"J Am Heart Association"},{"key":"3591_CR41","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.2353\/ajpath.2010.091301","volume":"177","author":"F Zhou","year":"2010","unstructured":"Zhou F, Chang Z, Zhang L, Hong YK, Shen B, Wang B, et al. Akt\/Protein kinase B is required for lymphatic network formation, remodeling, and valve development. Am J Pathol. 2010;177:2124\u201333.","journal-title":"Am J Pathol"},{"key":"3591_CR42","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1161\/CIRCULATIONAHA.111.030296","volume":"125","author":"I Choi","year":"2012","unstructured":"Choi I, Lee S, Kyoung Chung H, Suk Lee Y, Eui Kim K, Choi D, et al. 9-cis retinoic acid promotes lymphangiogenesis and enhances lymphatic vessel regeneration: therapeutic implications of 9-cis retinoic acid for secondary lymphedema. Circulation. 2012;125:872\u201382.","journal-title":"Circulation"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03591-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-025-03591-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03591-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T12:42:41Z","timestamp":1757248961000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03591-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,16]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3591"],"URL":"https:\/\/doi.org\/10.1186\/s12951-025-03591-9","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,16]]},"assertion":[{"value":"6 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures involved in this study was approved by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University (Approval No: K2023-397).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors of this study agreed to publish.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"522"}}