{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:33:57Z","timestamp":1791549237558,"version":"4.3.4"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Fund Project of Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine","award":["GXZYA20240312"],"award-info":[{"award-number":["GXZYA20240312"]}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["GuikeAB25069047"],"award-info":[{"award-number":["GuikeAB25069047"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2023GXNSFBA026255"],"award-info":[{"award-number":["2023GXNSFBA026255"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-025-03705-3","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:36:50Z","timestamp":1759156610000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel drug-free cascaded nanoparticles induce tumor-specific ROS storms via multimodal synergistic anticancer therapy"],"prefix":"10.1186","volume":"23","author":[{"given":"Mingsen","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuancheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuru","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanying","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qisong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"3705_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101393","volume":"30","author":"SQ Gao","year":"2025","unstructured":"Gao SQ, Golovynska I, Liu JT, Huang ZL, Xu H, Qu JH, et al. Magnetic field-induced synergistic therapy of cancer using magnetoplasmonic nanoplatform. Mater Today Bio. 2025;30:101393.","journal-title":"Mater Today Bio"},{"key":"3705_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2023.115582","volume":"234","author":"H Chen","year":"2023","unstructured":"Chen H, Zhou H, Liang Y, Huang Z, Yang S, Wang X, et al. UHPLC-HRMS-based serum untargeted lipidomics: phosphatidylcholines and sphingomyelins are the main disturbed lipid markers to distinguish colorectal advanced adenoma from cancer. J Pharm Biomed Anal. 2023;234:115582.","journal-title":"J Pharm Biomed Anal"},{"key":"3705_CR3","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1039\/C8CS00618K","volume":"48","author":"YJ Liu","year":"2019","unstructured":"Liu YJ, Bhattarai P, Dai ZF, Chen XY. Photothermal therapy and photoacoustic imaging nanotheranostics in fighting cancer. Chem Soc Rev. 2019;48:2053\u2013108.","journal-title":"Chem Soc Rev"},{"key":"3705_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101427","volume":"30","author":"XZ Yan","year":"2025","unstructured":"Yan XZ, Liu HS, Guo L, Liu C, Zhang SC, Wang X, et al. Multifunctional drug delivery nanoparticles for combined chemotherapy\/chemodynamic\/photothermal therapy against colorectal cancer through synergistic cuproptosis\/ferroptosis\/apoptosis. Mater Today Bio. 2025;30:101427.","journal-title":"Mater Today Bio"},{"key":"3705_CR5","doi-asserted-by":"publisher","first-page":"100478","DOI":"10.1016\/j.mtbio.2022.100478","volume":"17","author":"Z Zheng","year":"2022","unstructured":"Zheng Z, Chen X, Dai R, Wu S, Kang W, Qin Y, Ren S, Zhang R, Cheng Z. Cyclic enhancement of hypoxic microenvironment via an intelligent nanoamplifier for activated NIR-II fluorescence\/photoacoustic imaging-guided precise synergistic therapy. Mater Today Bio. 2022;17:100478.","journal-title":"Mater Today Bio"},{"key":"3705_CR6","doi-asserted-by":"publisher","first-page":"14800","DOI":"10.1021\/acsnano.3c03005","volume":"17","author":"GQ Zhang","year":"2023","unstructured":"Zhang GQ, Chen XM, Chen X, Du KH, Ding KK, He D, et al. Click-reaction-mediated chemotherapy and photothermal therapy synergistically inhibit breast cancer in mice. ACS Nano. 2023;17:14800\u201313.","journal-title":"ACS Nano"},{"key":"3705_CR7","doi-asserted-by":"publisher","first-page":"3771","DOI":"10.1039\/C8CS00896E","volume":"48","author":"W Sang","year":"2019","unstructured":"Sang W, Zhang Z, Dai YL, Chen XY. Recent advances in nanomaterial-based synergistic combination cancer immunotherapy. Chem Soc Rev. 2019;48:3771\u2013810.","journal-title":"Chem Soc Rev"},{"key":"3705_CR8","doi-asserted-by":"publisher","first-page":"119760","DOI":"10.1016\/j.biomaterials.2020.119760","volume":"234","author":"S Li","year":"2020","unstructured":"Li S, Saw PE, Lin C, Nie Y, Tao W, Farokhzad OC, Zhang L, Xu X. Redox-responsive polyprodrug nanoparticles for targeted SiRNA delivery and synergistic liver cancer therapy. Biomaterials. 2020;234:119760.","journal-title":"Biomaterials"},{"key":"3705_CR9","doi-asserted-by":"publisher","first-page":"5338","DOI":"10.1021\/acs.chemrev.5b00589","volume":"116","author":"K Ulbrich","year":"2016","unstructured":"Ulbrich K, Hol\u00e1 K, Subr V, Bakandritsos A, Tucek J, Zboril R. Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies. Chem Rev. 2016;116:5338\u2013431.","journal-title":"Chem Rev"},{"key":"3705_CR10","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1186\/s12951-024-02571-9","volume":"22","author":"Y Jia","year":"2024","unstructured":"Jia Y, Yao Y, Fan L, Huang Q, Wei G, Shen P, Sun J, Zhu G, Sun Z, Zhu C, Han X. Tumor microenvironment responsive nano-herb and CRISPR delivery system for synergistic chemotherapy and immunotherapy. J Nanobiotechnol. 2024;22:346.","journal-title":"J Nanobiotechnol"},{"key":"3705_CR11","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1186\/s12951-023-02152-2","volume":"21","author":"Q Dong","year":"2023","unstructured":"Dong Q, Xue T, Yan H, Liu F, Liu R, Zhang K, Chong Y, Du J, Zhang H. Radiotherapy combined with nano-biomaterials for cancer radio-immunotherapy. J Nanobiotechnol. 2023;21:395.","journal-title":"J Nanobiotechnol"},{"issue":"7","key":"3705_CR12","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20232101","volume":"221","author":"L Wang","year":"2024","unstructured":"Wang L, Lynch C, Pitroda SP, Piffko A, Yang K, Huser AK, et al. Radiotherapy and immunology. J Exp Med. 2024;221(7):e20232101.","journal-title":"J Exp Med"},{"key":"3705_CR13","doi-asserted-by":"publisher","first-page":"10350","DOI":"10.1021\/acs.nanolett.3c02941","volume":"23","author":"ML Zhou","year":"2023","unstructured":"Zhou ML, Liang S, Liu D, Ma KS, Yun KQ, Yao JJ, et al. Manganese-enriched zinc peroxide functional nanoparticles for potentiating cancer immunotherapy. Nano Lett. 2023;23:10350\u20139.","journal-title":"Nano Lett"},{"key":"3705_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101138","volume":"27","author":"Y Ma","year":"2024","unstructured":"Ma Y, Liao J, Cheng H, Yang Q, Yang H. Advanced gene therapy system for the treatment of solid tumour: a review. Mater Today Bio. 2024;27:101138.","journal-title":"Mater Today Bio"},{"key":"3705_CR15","doi-asserted-by":"publisher","first-page":"27587","DOI":"10.1021\/jacs.3c09339","volume":"145","author":"JS Kang","year":"2023","unstructured":"Kang JS, Jeong H, Jeong M, Kim J, Park S, Jung JY, et al. In situ activatable nitrobenzene-cysteine-copper(II) nano-complexes for programmed photodynamic cancer therapy. J Am Chem Soc. 2023;145:27587\u2013600.","journal-title":"J Am Chem Soc"},{"key":"3705_CR16","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.jconrel.2023.11.058","volume":"365","author":"X Liu","year":"2024","unstructured":"Liu X, Lu YC, Li X, Luo LH, You J. Nanoplatform-enhanced photodynamic therapy for the induction of immunogenic cell death. J Control Release. 2024;365:1058\u201373.","journal-title":"J Control Release"},{"key":"3705_CR17","doi-asserted-by":"publisher","first-page":"25205","DOI":"10.1021\/acsnano.3c08409","volume":"17","author":"LP Zhang","year":"2023","unstructured":"Zhang LP, Wang ZY, Zhang RY, Yang H, Wang WJ, Zhao Y, et al. Multi-stimuli-responsive and cell membrane camouflaged aggregation-induced emission nanogels for precise chemo-photothermal synergistic therapy of tumors. ACS Nano. 2023;17:25205\u201321.","journal-title":"ACS Nano"},{"key":"3705_CR18","doi-asserted-by":"publisher","first-page":"119459","DOI":"10.1016\/j.biomaterials.2019.119459","volume":"223","author":"D Wang","year":"2019","unstructured":"Wang D, Zhang Z, Lin L, Liu F, Wang Y, Guo Z, Li Y, Tian H, Chen X. Porphyrin-based covalent organic framework nanoparticles for photoacoustic imaging-guided photodynamic and photothermal combination cancer therapy. Biomaterials. 2019;223:119459.","journal-title":"Biomaterials"},{"key":"3705_CR19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41573-018-0006-z","volume":"18","author":"RS Riley","year":"2019","unstructured":"Riley RS, June CH, Langer R, Mitchell MJ. Delivery technologies for cancer immunotherapy. Nat Rev Drug Discov. 2019;18:175\u201396.","journal-title":"Nat Rev Drug Discov"},{"key":"3705_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116094","volume":"250","author":"Y Wang","year":"2024","unstructured":"Wang Y, Wu J, Chen M, Zhang J, Sun X, Zhou H, et al. Application of near-infrared-activated and ATP-responsive trifunctional upconversion nano-jelly for in vivo tumor imaging and synergistic therapy. Biosens Bioelectron. 2024;250:116094.","journal-title":"Biosens Bioelectron"},{"key":"3705_CR21","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.1021\/acsnano.8b00899","volume":"12","author":"XX Han","year":"2018","unstructured":"Han XX, Huang J, Jing XX, Yang DY, Lin H, Wang ZG, et al. Oxygen-deficient black Titania for synergistic\/enhanced sonodynamic and photoinduced cancer therapy at near Infrared-II Biowindow. ACS Nano. 2018;12:4545\u201355.","journal-title":"ACS Nano"},{"key":"3705_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101542","volume":"31","author":"BC Zheng","year":"2025","unstructured":"Zheng BC, Wang HB, Zhai SY, Li JS, Lu KD. Mitochondria-targeted photothermal-chemodynamic therapy enhances checkpoint blockade immunotherapy on colon cancer. Mater Today Bio. 2025;31:101542.","journal-title":"Mater Today Bio"},{"key":"3705_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101253","volume":"29","author":"L Wang","year":"2024","unstructured":"Wang L, Dai ZH, Bi JQ, Chen YZ, Wang ZY, Sun ZQ, et al. Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration. Mater Today Bio. 2024;29:101253.","journal-title":"Mater Today Bio"},{"key":"3705_CR24","doi-asserted-by":"publisher","first-page":"3546","DOI":"10.1021\/acsnano.9b09871","volume":"14","author":"Z Yuan","year":"2020","unstructured":"Yuan Z, Lin CC, He Y, Tao BL, Chen MW, Zhang JX, et al. Near-infrared light-triggered nitric-oxide-enhanced photodynamic therapy and low-temperature photothermal therapy for biofilm elimination. ACS Nano. 2020;14:3546\u201362.","journal-title":"ACS Nano"},{"key":"3705_CR25","doi-asserted-by":"publisher","first-page":"1900095","DOI":"10.1002\/adfm.201900095","volume":"29","author":"D Wu","year":"2019","unstructured":"Wu D, Duan XH, Guan QQ, Liu J, Yang X, Zhang F, Huang P, Shen J, Shuai XT, Cao Z. Mesoporous polydopamine carrying manganese carbonyl responds to tumor microenvironment for multimodal Imaging-Guided cancer therapy. Adv Funct Mater. 2019;29:1900095.","journal-title":"Adv Funct Mater"},{"key":"3705_CR26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1021\/acsabm.1c00926","volume":"5","author":"DD Ren","year":"2022","unstructured":"Ren DD, Williams GR, Zhang YY, Ren R, Lou JD, Zhu LM. Mesoporous doxorubicin-loaded polydopamine nanoparticles coated with a platelet membrane suppress tumor growth in a murine model of human breast cancer. ACS Appl Bio Mater. 2022;5:123\u201333.","journal-title":"ACS Appl Bio Mater"},{"key":"3705_CR27","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jcis.2023.02.041","volume":"639","author":"H Cheng","year":"2023","unstructured":"Cheng H, He Y, Lu J, Yan Z, Song L, Mao Y, et al. Degradable iron-rich mesoporous dopamine as a dual-glutathione depletion nanoplatform for photothermal-enhanced ferroptosis and chemodynamic therapy. J Colloid Interface Sci. 2023;639:249\u201362.","journal-title":"J Colloid Interface Sci"},{"key":"3705_CR28","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.jcis.2024.02.160","volume":"663","author":"SP Feng","year":"2024","unstructured":"Feng SP, Xiao Y, Lu JY, Chen Z, Jiang ZY, Xu QQ, et al. Tumor microenvironment sensitization via dual-catalysis of carbon-based nanoenzyme for enhanced photodynamic therapy. J Colloid Interface Sci. 2024;663:577\u201390.","journal-title":"J Colloid Interface Sci"},{"key":"3705_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215153","volume":"488","author":"HW Xu","year":"2023","unstructured":"Xu HW, Zhang Y, Zhang HT, Zhang YR, Xu QQ, Lu JY, et al. Smart polydopamine-based nanoplatforms for biomedical applications: state-of-art and further perspectives. Coord Chem Rev. 2023;488:215153.","journal-title":"Coord Chem Rev"},{"key":"3705_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.148270","volume":"23","author":"JY Lu","year":"2024","unstructured":"Lu JY, Song LM, Feng SP, Wang KL, Mao YL, Gao YK, et al. Nanozyme-mediated biocatalysis as a mitochondrial oxidative stress amplifier for tumor nanocatalytic immunotherapy. Chem Eng J. 2024;23:148270.","journal-title":"Chem Eng J"},{"key":"3705_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.150448","volume":"487","author":"WH Qi","year":"2024","unstructured":"Qi WH, Liu B, Li Y, Liu Z, Rui SQ, Feng SP, et al. Current advances in porous organic nanoplatforms for tumor theranostics. Chem Eng J. 2024;487:150448.","journal-title":"Chem Eng J"},{"key":"3705_CR32","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1021\/acsnano.3c09011","volume":"18","author":"PJ Xu","year":"2023","unstructured":"Xu PJ, Wen CC, Gao CJ, Liu HH, Li YS, Guo XL, Shen XC, Liang H. Near-Infrared-II-Activatable Self-Assembled manganese Porphyrin-Gold heterostructures for photoacoustic Imaging-Guided Sonodynamic-Augmented photothermal\/photodynamic therapy. ACS Nano. 2023;18:713\u201327.","journal-title":"ACS Nano"},{"key":"3705_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120787","volume":"272","author":"X Jiao","year":"2021","unstructured":"Jiao X, Sun L, Zhang W, Ren J, Zhang L, Cao Y, et al. Engineering oxygen-deficient ZrO(2-x) nanoplatform as therapy-activated immunogenic cell death (ICD) inducer to synergize photothermal-augmented sonodynamic tumor elimination in NIR-II biological window. Biomaterials. 2021;272:120787.","journal-title":"Biomaterials"},{"key":"3705_CR34","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1186\/s12951-022-01659-4","volume":"20","author":"LB Chen","year":"2022","unstructured":"Chen LB, Xue W, Cao J, Zhang SM, Zeng YQ, Ma L, Qian XC, Wen Q, Hong YR, Shi Z, Xu YF. TiSe - mediated sonodynamic and checkpoint Blockade combined immunotherapy in hypoxic pancreatic cancer. J Nanobiotechnol 2022;20:453.","journal-title":"J Nanobiotechnol"},{"key":"3705_CR35","first-page":"409","volume":"8","author":"GQ Li","year":"2022","unstructured":"Li GQ, Zhong XY, Wang XW, Gong F, Lei HL, Zhou YK, et al. Titanium carbide nanosheets with defect structure for photothermal-enhanced sonodynamic therapy. Bioact Mater. 2022;8:409\u201319.","journal-title":"Bioact Mater"},{"key":"3705_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101407","volume":"30","author":"J Chen","year":"2025","unstructured":"Chen J, Zhan QY, Li L, Xi SM, Cai LM, Liu RY, et al. Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapy. Mater Today Bio. 2025;30:101407.","journal-title":"Mater Today Bio"},{"key":"3705_CR37","doi-asserted-by":"publisher","first-page":"6042","DOI":"10.1021\/acs.nanolett.1c01220","volume":"21","author":"M Yuan","year":"2021","unstructured":"Yuan M, Liang S, Zhou Y, Xiao X, Liu B, Yang C, et al. A robust oxygen-carrying hemoglobin-based natural sonosensitizer for sonodynamic cancer therapy. Nano Lett. 2021;21:6042\u201350.","journal-title":"Nano Lett"},{"key":"3705_CR38","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.actbio.2022.12.065","volume":"158","author":"K Song","year":"2023","unstructured":"Song K, Chen G, He Z, Shen J, Ping J, Li Y, et al. Protoporphyrin-sensitized degradable bismuth nanoformulations for enhanced sonodynamic oncotherapy. Acta Biomater. 2023;158:637\u201348.","journal-title":"Acta Biomater"},{"key":"3705_CR39","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1021\/acs.nanolett.3c00434","volume":"23","author":"KR Chen","year":"2023","unstructured":"Chen KR, Zhou AW, Zhou XY, Liu YH, Xu YR, Ning XH. An intelligent cell-derived nanorobot bridges synergistic crosstalk between sonodynamic therapy and cuproptosis to promote cancer treatment. Nano Lett. 2023;23:3038\u201347.","journal-title":"Nano Lett"},{"key":"3705_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.109979","volume":"104","author":"L Chudal","year":"2019","unstructured":"Chudal L, Pandey NK, Phan J, Johnson O, Li XY, Chen W. Investigation of PPIX-Lipo-MnO to enhance photodynamic therapy by improving tumor hypoxia. Mater Sci Eng C-Materials Biol Appl 2019;104:109979.","journal-title":"Mater Sci Eng C-Materials Biol Appl"},{"key":"3705_CR41","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12951-021-00837-0","volume":"19","author":"J Wang","year":"2021","unstructured":"Wang J, Huang J, Zhou W, Zhao J, Peng Q, Zhang L, Wang Z, Li P, Li R. Hypoxia modulation by dual-drug nanoparticles for enhanced synergistic sonodynamic and starvation therapy. J Nanobiotechnol. 2021;19:87.","journal-title":"J Nanobiotechnol"},{"key":"3705_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101005","volume":"25","author":"HJ Liao","year":"2024","unstructured":"Liao HJ, Cao YC, Hu C, Shen SF, Zhang ZF, Li DR, et al. Oxygen-producing and pH-responsive targeted DNA nanoflowers for enhanced chemo-sonodynamic therapy of lung cancer. Mater Today Bio. 2024;25:101005.","journal-title":"Mater Today Bio"},{"key":"3705_CR43","doi-asserted-by":"publisher","first-page":"8055","DOI":"10.1039\/D0SC03173A","volume":"11","author":"KY Wang","year":"2020","unstructured":"Wang KY, Xiang YA, Pan W, Wang HY, Li N, Tang B. Dual-targeted photothermal agents for enhanced cancer therapy. Chem Sci. 2020;11:8055\u201372.","journal-title":"Chem Sci"},{"key":"3705_CR44","doi-asserted-by":"publisher","first-page":"23889","DOI":"10.1021\/acsnano.3c08174","volume":"17","author":"Y Gao","year":"2023","unstructured":"Gao Y, Ouyang ZJ, Shen SY, Yu HW, Jia BY, Wang H, et al. Manganese dioxide-entrapping dendrimers co-deliver protein and nucleotide for magnetic resonance imaging-guided chemodynamic\/starvation\/immune therapy of tumors. ACS Nano. 2023;17:23889\u2013902.","journal-title":"ACS Nano"},{"key":"3705_CR45","doi-asserted-by":"publisher","first-page":"9662","DOI":"10.1021\/acsnano.0c00910","volume":"14","author":"W Ying","year":"2020","unstructured":"Ying W, Zhang Y, Gao W, Cai X, Wang G, Wu X, et al. Hollow magnetic nanocatalysts drive starvation-chemodynamic-hyperthermia synergistic therapy for tumor. ACS Nano. 2020;14:9662\u201374.","journal-title":"ACS Nano"},{"key":"3705_CR46","doi-asserted-by":"publisher","first-page":"6406","DOI":"10.1039\/D1TB01222C","volume":"9","author":"J Yu","year":"2021","unstructured":"Yu J, He X, Wang Z, Liu S, Hao D, Li X, et al. Combination of starvation therapy and Pt-NP based chemotherapy for synergistic cancer treatment. J Mater Chem B. 2021;9:6406\u201311.","journal-title":"J Mater Chem B"},{"key":"3705_CR47","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s12951-022-01439-0","volume":"20","author":"X Wang","year":"2022","unstructured":"Wang X, Li YH, Jia F, Cui XY, Pan ZA, Wu Y. Boosting nutrient starvation-dominated cancer therapy through curcumin-augmented mitochondrial Ca overload and obatoclax-mediated autophagy inhibition as supported by a novel nano-modulator GO-Alg@CaP\/CO. J Nanobiotechnol. 2022;20:225.","journal-title":"J Nanobiotechnol"},{"key":"3705_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100421","volume":"16","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Wang KP, Xing GZ, Dong X, Zhu DW, Yang WZ, et al. Nanozyme-laden intelligent macrophage EXPRESS amplifying cancer photothermal-starvation therapy by responsive stimulation. Mater Today Bio. 2022;16:100421.","journal-title":"Mater Today Bio"},{"key":"3705_CR49","doi-asserted-by":"publisher","first-page":"155834","DOI":"10.1016\/j.phymed.2024.155834","volume":"132","author":"S Yang","year":"2024","unstructured":"Yang S, Wei Z, Luo J, Wang X, Chen G, Guan X, She Z, Liu W, Tong Y, Liu H, et al. Integrated bioinformatics and multiomics reveal Liupao tea extract alleviating NAFLD via regulating hepatic lipid metabolism and gut microbiota. Phytomedicine. 2024;132:155834.","journal-title":"Phytomedicine"},{"key":"3705_CR50","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1186\/s12885-024-12321-7","volume":"24","author":"X Wang","year":"2024","unstructured":"Wang X, Guan X, Tong Y, Liang Y, Huang Z, Wen M, Luo J, Chen H, Yang S, She Z, et al. UHPLC-HRMS-based multiomics to explore the potential mechanisms and biomarkers for colorectal cancer. BMC Cancer. 2024;24:644.","journal-title":"BMC Cancer"},{"key":"3705_CR51","doi-asserted-by":"publisher","first-page":"8781","DOI":"10.1039\/C7NR01857F","volume":"9","author":"Y Xing","year":"2017","unstructured":"Xing Y, Zhang J, Chen F, Liu J, Cai K. Mesoporous polydopamine nanoparticles with co-delivery function for overcoming multidrug resistance via synergistic chemo-photothermal therapy. Nanoscale. 2017;9:8781\u201390.","journal-title":"Nanoscale"},{"key":"3705_CR52","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1016\/j.jcis.2021.08.150","volume":"606","author":"L Cheng","year":"2022","unstructured":"Cheng L, Liu CB, Wu H, Zhao HC, Wang LP. Interfacial assembled mesoporous polydopamine nanoparticles reduced graphene oxide for high performance of waterborne epoxy-based anticorrosive coatings. J Colloid Interface Sci. 2022;606:1572\u201385.","journal-title":"J Colloid Interface Sci"},{"key":"3705_CR53","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1002\/tcr.202000170","volume":"21","author":"JH Lu","year":"2021","unstructured":"Lu JH, Cai LL, Dai Y, Liu YW, Zuo FM, Ni C, et al. Polydopamine-based nanoparticles for photothermal therapy\/chemotherapy and their synergistic therapy with autophagy inhibitor to promote antitumor treatment. Chem Rec. 2021;21:781\u201396.","journal-title":"Chem Rec"},{"key":"3705_CR54","doi-asserted-by":"publisher","first-page":"5057","DOI":"10.1021\/cr400407a","volume":"114","author":"YL Liu","year":"2014","unstructured":"Liu YL, Ai KL, Lu LH. Polydopamine and its derivative materials: synthesis and promising applications in energy, environmental, and biomedical fields. Chem Rev. 2014;114:5057\u2013115.","journal-title":"Chem Rev"},{"key":"3705_CR55","doi-asserted-by":"publisher","first-page":"8270","DOI":"10.7150\/thno.60758","volume":"11","author":"Y Zeng","year":"2021","unstructured":"Zeng Y, Zhou HY, Ding JS, Zhou WH. Cell membrane inspired nano-shell enabling long-acting glucose oxidase for melanoma starvation therapy via microneedles-based percutaneous delivery. Theranostics. 2021;11:8270\u201382.","journal-title":"Theranostics"},{"key":"3705_CR56","doi-asserted-by":"publisher","first-page":"3876","DOI":"10.1021\/nn500722y","volume":"8","author":"LS Lin","year":"2014","unstructured":"Lin LS, Cong ZX, Cao JB, Ke KM, Peng QL, Gao JH, et al. Multifunctional feo@polydopamine core-shell nanocomposites for intracellular mRNA detection and imaging-guided photothermal therapy. ACS Nano. 2014;8:3876\u201383.","journal-title":"ACS Nano"},{"issue":"9","key":"3705_CR57","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15092275","volume":"15","author":"J Li","year":"2023","unstructured":"Li J, Hu Z, Zhu J, Lin X, Gao X, Lv G. Antitumor effects of pegylated zinc protoporphyrin-mediated sonodynamic therapy in ovarian cancer. Pharmaceutics. 2023;15(9):2275.","journal-title":"Pharmaceutics"},{"key":"3705_CR58","doi-asserted-by":"publisher","first-page":"6973","DOI":"10.1038\/s41467-023-42509-7","volume":"14","author":"Y Li","year":"2023","unstructured":"Li Y, Chen W, Kang Y, Zhen X, Zhou Z, Liu C, Chen S, Huang X, Liu HJ, Koo S, et al. Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity. Nat Commun. 2023;14:6973.","journal-title":"Nat Commun"},{"key":"3705_CR59","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1021\/acs.molpharmaceut.9b00083","volume":"16","author":"A Spadea","year":"2019","unstructured":"Spadea A, de la Rosa JMR, Tirella A, Ashford MB, Williams KJ, Stratford IJ, Tirelli N, Mehibel M. Evaluating the efficiency of hyaluronic acid for tumor targeting via CD44. Mol Pharm. 2019;16:2481\u201393.","journal-title":"Mol Pharm"},{"key":"3705_CR60","doi-asserted-by":"publisher","first-page":"9536","DOI":"10.1021\/acsanm.1c01897","volume":"4","author":"S Acter","year":"2021","unstructured":"Acter S, Vidallon MLP, Crawford S, Tabor RF, Teo BM. Bowl-shaped mesoporous polydopamine nanoparticles for size-dependent endocytosis into HeLa cells. ACS Appl Nano Mater. 2021;4:9536\u201346.","journal-title":"ACS Appl Nano Mater"},{"key":"3705_CR61","volume":"18","author":"B Chen","year":"2023","unstructured":"Chen B, Mei L, Fan R, Chuan D, Ren Y, Mu M, et al. Polydopamine-coated i-motif dna\/gold nanoplatforms for synergistic photothermal-chemotherapy. Asian J Pharm Sci. 2023;18:100781.","journal-title":"Asian J Pharm Sci"},{"key":"3705_CR62","doi-asserted-by":"publisher","first-page":"6790","DOI":"10.1021\/acs.nanolett.7b03021","volume":"17","author":"L Ding","year":"2017","unstructured":"Ding L, Zhu X, Wang Y, Shi B, Ling X, Chen H, et al. Intracellular fate of nanoparticles with polydopamine surface engineering and a novel strategy for exocytosis-inhibiting, lysosome impairment-based cancer therapy. Nano Lett. 2017;17:6790\u2013801.","journal-title":"Nano Lett"},{"issue":"18","key":"3705_CR63","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202009733","volume":"31","author":"RR Fan","year":"2021","unstructured":"Fan RR, Chen CL, Hou H, Chuan D, Mu M, Liu ZY, et al. Tumor acidity and near-infrared light responsive dual drug delivery Polydopamine-based nanoparticles for chemo-photothermal therapy. Adv Funct Mater. 2021;31:2009733.","journal-title":"Adv Funct Mater"},{"key":"3705_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110103","volume":"105","author":"W Lei","year":"2019","unstructured":"Lei W, Sun C, Jiang T, Gao Y, Yang Y, Zhao Q, et al. Polydopamine-coated mesoporous silica nanoparticles for multi-responsive drug delivery and combined chemo-photothermal therapy. Mater Sci Eng C Mater Biol Appl. 2019;105:110103.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"3705_CR65","doi-asserted-by":"publisher","first-page":"21125","DOI":"10.1021\/acsami.8b04799","volume":"10","author":"B Poinard","year":"2018","unstructured":"Poinard B, Neo SZY, Yeo ELL, Heng HPS, Neoh KG, Kah JCY. Polydopamine nanoparticles enhance drug release for combined photodynamic and photothermal therapy. ACS Appl Mater Interfaces. 2018;10:21125\u201336.","journal-title":"ACS Appl Mater Interfaces"},{"issue":"32","key":"3705_CR66","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202300348","volume":"33","author":"C Deng","year":"2023","unstructured":"Deng C, Zheng M, Han S, Wang Y, Xin J, Aras O, et al. GSH-activated porphyrin sonosensitizer prodrug for fluorescence imaging-guided cancer sonodynamic therapy. Adv Funct Mater. 2023;33(32):2300348.","journal-title":"Adv Funct Mater"},{"key":"3705_CR67","doi-asserted-by":"publisher","first-page":"6863","DOI":"10.1021\/acsnano.3c06987","volume":"18","author":"P Zheng","year":"2024","unstructured":"Zheng P, He J, Fu Y, Yang Y, Li S, Duan B, et al. Engineered bacterial biomimetic vesicles reprogram tumor-associated macrophages and remodel tumor microenvironment to promote innate and adaptive antitumor immune responses. ACS Nano. 2024;18:6863\u201386.","journal-title":"ACS Nano"},{"key":"3705_CR68","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1016\/j.apsb.2020.02.002","volume":"10","author":"K Kuerban","year":"2020","unstructured":"Kuerban K, Gao X, Zhang H, Liu J, Dong M, Wu L, et al. Doxorubicin-loaded bacterial outer-membrane vesicles exert enhanced anti-tumor efficacy in non-small-cell lung cancer. Acta Pharm Sin B. 2020;10:1534\u201348.","journal-title":"Acta Pharm Sin B"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03705-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-025-03705-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03705-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:05:03Z","timestamp":1759158303000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03705-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3705"],"URL":"https:\/\/doi.org\/10.1186\/s12951-025-03705-3","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"6 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were conducted in accordance with the protocols approved by the Guide for the Care and Use of Laboratory Animals of Guangxi University and were approved by the Animal Experimental Ethics Committee of Guangxi University (Approval Number: GXU-2024-001 and GXU-2025-263).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors agree to submit the manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"620"}}