{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:25:47Z","timestamp":1793107547318,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Scientific and technological innovation project of China Academy of Chinese Medical Sciences","award":["CI2023E005TS02"],"award-info":[{"award-number":["CI2023E005TS02"]}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["20240484502"],"award-info":[{"award-number":["20240484502"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Nanobiotechnol"],"DOI":"10.1186\/s12951-025-03758-4","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T02:15:38Z","timestamp":1762827338000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Synergistic gambogic acid\/Ga\u00b3\u207a remodels the immunosuppressive tumor microenvironment to enhance triple-negative breast cancer therapy"],"prefix":"10.1186","volume":"23","author":[{"given":"Chong","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchao","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LinYing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfeng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoli","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"3758_CR1","first-page":"12","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74:12\u201349.","journal-title":"CA Cancer J Clin"},{"key":"3758_CR2","doi-asserted-by":"publisher","first-page":"30943","DOI":"10.1021\/acsnano.3c12967","volume":"18","author":"Z Peng","year":"2024","unstructured":"Peng Z, Zhao T, Gao P, Zhang G, Wu X, Tian H, et al. Tumor-derived extracellular vesicles enable tumor tropism chemo-genetherapy for local immune activation in triple-negative breast cancer. ACS Nano. 2024;18:30943\u201356.","journal-title":"ACS Nano"},{"key":"3758_CR3","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1172\/JCI96313","volume":"129","author":"T Gruosso","year":"2019","unstructured":"Gruosso T, Gigoux M, Manem VSK, Bertos N, Zuo D, Perlitch I, et al. Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers. J Clin Invest. 2019;129:1785\u2013800.","journal-title":"J Clin Invest"},{"key":"3758_CR4","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.actbio.2024.01.009","volume":"176","author":"S Huang","year":"2024","unstructured":"Huang S, Wen T, Wang J, Wei H, Xiao Z, Li B, Shuai X. Nanoparticle-integrated dissolving microneedles for the co-delivery of R848\/aPD-1 to synergistically reverse the immunosuppressive microenvironment of triple-negative breast cancer. Acta Biomater. 2024;176:344\u201355.","journal-title":"Acta Biomater"},{"key":"3758_CR5","unstructured":"Xia F, Lu Y, Gong Z, Tu Q, Liang S, Wang C, Yao H, Zhong L, Fu Y, Guo P et al. Cancer Immunotherapy Based on the Bidirectional Reprogramming of the Tumor Microenvironment by a Brakes Off\/ Step on the Accelerator Core-Shell Manganese Phosphate\/siPD-L1 Modulator. Exploration, n\/a:270009."},{"key":"3758_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202201734","volume":"9","author":"Z Li","year":"2022","unstructured":"Li Z, Lai X, Fu S, Ren L, Cai H, Zhang H, et al. Immunogenic cell death activates the tumor immune microenvironment to boost the immunotherapy efficiency. Adv Sci (Weinh). 2022;9:e2201734.","journal-title":"Adv Sci (Weinh)"},{"key":"3758_CR7","doi-asserted-by":"publisher","DOI":"10.1039\/d5tb00305a","volume":"13","author":"X Qiao","year":"2025","unstructured":"Qiao X, Ma P, Guo J, Sun Y, Peng L, Yu N, et al. Transforming cold tumors into hot ones via immunogenic cell death by bufadienolides for reverse immunosuppressive TME in HCC. J Mater Chem B. 2025;13\uff1a7401. https:\/\/doi.org\/10.1039\/d5tb00305a","journal-title":"J Mater Chem B"},{"key":"3758_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188381","volume":"1874","author":"E Hatami","year":"2020","unstructured":"Hatami E, Jaggi M, Chauhan SC, Yallapu MM. Gambogic acid: a shining natural compound to nanomedicine for cancer therapeutics. Biochim Biophys Acta Rev Cancer. 2020;1874:188381.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"3758_CR9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12951-020-00681-8","volume":"18","author":"Z Ma","year":"2020","unstructured":"Ma Z, Li N, Zhang B, Hui Y, Zhang Y, Lu P, Pi J, Liu Z. Dual drug-loaded nano-platform for targeted cancer therapy: toward clinical therapeutic efficacy of multifunctionality. J Nanobiotechnol. 2020;18:123.","journal-title":"J Nanobiotechnol"},{"key":"3758_CR10","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.addr.2020.06.006","volume":"158","author":"Z Zhou","year":"2020","unstructured":"Zhou Z, Ni K, Deng H, Chen X. Dancing with reactive oxygen species generation and elimination in nanotheranostics for disease treatment. Adv Drug Deliv Rev. 2020;158:73\u201390.","journal-title":"Adv Drug Deliv Rev"},{"key":"3758_CR11","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/s41568-019-0149-1","volume":"19","author":"JP Friedmann Angeli","year":"2019","unstructured":"Friedmann Angeli JP, Krysko DV, Conrad M. Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion. Nat Rev Cancer. 2019;19:405\u201314.","journal-title":"Nat Rev Cancer"},{"key":"3758_CR12","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311043","volume":"36","author":"Z Wang","year":"2024","unstructured":"Wang Z, Wang Q, Cao H, Wang Z, Wang D, Liu J, et al. Mitochondrial localized in situ self-assembly reprogramming tumor immune and metabolic microenvironment for enhanced cancer therapy. Adv Mater. 2024;36:e2311043.","journal-title":"Adv Mater"},{"key":"3758_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118229","volume":"267","author":"Q Du","year":"2021","unstructured":"Du Q, Lv F, Huang J, Tang X, Zhao Z, Chen J. A multiple environment-sensitive prodrug nanomicelle strategy based on Chitosan graftomer for enhanced tumor therapy of gambogic acid. Carbohydr Polym. 2021;267:118229.","journal-title":"Carbohydr Polym"},{"key":"3758_CR14","doi-asserted-by":"publisher","first-page":"4666","DOI":"10.1039\/D3RA08042K","volume":"14","author":"SA Fahmy","year":"2024","unstructured":"Fahmy SA, Elghanam R, Rashid G, Youness RA, Sedky NK. Emerging tendencies for the nano-delivery of gambogic acid: a promising approach in oncotherapy. RSC Adv. 2024;14:4666\u201391.","journal-title":"RSC Adv"},{"key":"3758_CR15","doi-asserted-by":"publisher","first-page":"32","DOI":"10.15212\/bioi-2024-0063","volume":"5","author":"SSS Ibrahim","year":"2024","unstructured":"Ibrahim SSS, Ansari YN, Puri AV, Patil VV, Gaikwad SS, Haroon RA. Recent progress in the green Synthesis, characterization, and applications of selenium nanoparticles. BIO Integr 2024;5:32","journal-title":"BIO Integr"},{"key":"3758_CR16","doi-asserted-by":"publisher","first-page":"22257","DOI":"10.1021\/acsnano.4c06199","volume":"18","author":"H Lei","year":"2024","unstructured":"Lei H, Hou G, Liu L, Pei Z, Chen Y, Lu Y, et al. A two-pronged nanostrategy of iron metabolism disruption to synergize tumor therapy by triggering the paraptosis-apoptosis hybrid pathway. ACS Nano. 2024;18:22257\u201374.","journal-title":"ACS Nano"},{"key":"3758_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2020.100768","volume":"118","author":"J Yang","year":"2021","unstructured":"Yang J, Zhang X, Liu C, Wang Z, Deng L, Feng C, et al. Biologically modified nanoparticles as theranostic bionanomaterials. Prog Mater Sci. 2021;118:100768.","journal-title":"Prog Mater Sci"},{"key":"3758_CR18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.15212\/bioi-2025-0090","volume":"6","author":"Y Dange","year":"2025","unstructured":"Dange Y, Salunkhe V, Honmane S, Marale P. Anticancer efficacy of 5-Fluorouracil-Loaded Chitin nanohydrogel in enhanced skin cancer therapy. BIO Integr 2025;6:15","journal-title":"BIO Integr"},{"key":"3758_CR19","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1186\/s12951-023-02165-x","volume":"21","author":"C Qiu","year":"2023","unstructured":"Qiu C, Zhang JZ, Wu B, Xu CC, Pang HH, Tu QC, Lu YQ, Guo QY, Xia F, Wang JG. Advanced application of nanotechnology in active constituents of traditional Chinese medicines. J Nanobiotechnol. 2023;21:456.","journal-title":"J Nanobiotechnol"},{"key":"3758_CR20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.15212\/bioi-2024-0107","volume":"6","author":"AS Chauhan","year":"2025","unstructured":"Chauhan AS, Chand P, Parashar T. Lipid-based nanoparticles: strategy for targeted cancer therapy. BIO Integr 2025;6:6","journal-title":"BIO Integr"},{"key":"3758_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1285","volume":"13","author":"N Krishnan","year":"2023","unstructured":"Krishnan N, Fang RH, Zhang L. Cell membrane-coated nanoparticles for the treatment of cancer. Clin Transl Med. 2023;13:e1285.","journal-title":"Clin Transl Med"},{"key":"3758_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscia.2024.100055","volume":"2","author":"PB Lokole","year":"2024","unstructured":"Lokole PB, Ngombe NK, Motomba DI, Safari JB, Mpuza MK, Krause RWM, et al. Preparation and characterization of micellar nanoparticles using crude saponins from five Congolese plant species. Pharmaceutical Science Advances. 2024;2:100055.","journal-title":"Pharmaceutical Science Advances"},{"key":"3758_CR23","doi-asserted-by":"publisher","first-page":"4214","DOI":"10.1038\/s41467-022-31799-y","volume":"13","author":"G Lu","year":"2022","unstructured":"Lu G, Wang X, Li F, Wang S, Zhao J, Wang J, Liu J, Lyu C, Ye P, Tan H, et al. Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma. Nat Commun. 2022;13:4214.","journal-title":"Nat Commun"},{"key":"3758_CR24","doi-asserted-by":"publisher","first-page":"9567","DOI":"10.1021\/acsnano.7b07214","volume":"11","author":"A Nel","year":"2017","unstructured":"Nel A, Ruoslahti E, Meng H. New insights into permeability as in the enhanced permeability and retention effect of cancer nanotherapeutics. ACS Nano. 2017;11:9567\u20139.","journal-title":"ACS Nano"},{"key":"3758_CR25","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jconrel.2021.07.021","volume":"337","author":"F Jin","year":"2021","unstructured":"Jin F, Qi J, Liu D, You Y, Shu G, Du Y, et al. Cancer-cell-biomimetic upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer. J Control Release. 2021;337:90\u2013104.","journal-title":"J Control Release"},{"key":"3758_CR26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.15212\/bioi-2022-0015","volume":"4","author":"S He","year":"2023","unstructured":"He S, Fu Y, Tan Z, Jiang Q, Huang K, Saw PE, et al. Optimization of ultra-small nanoparticles for enhanced drug delivery. BIO Integr. 2023;4:62\u20139.","journal-title":"BIO Integr"},{"key":"3758_CR27","doi-asserted-by":"publisher","first-page":"12511","DOI":"10.1021\/acsnano.9b02875","volume":"13","author":"J Zhang","year":"2019","unstructured":"Zhang J, Shen L, Li X, Song W, Liu Y, Huang L. Nanoformulated codelivery of Quercetin and Alantolactone promotes an antitumor response through synergistic immunogenic cell death for microsatellite-stable colorectal cancer. ACS Nano. 2019;13:12511\u201324.","journal-title":"ACS Nano"},{"key":"3758_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscia.2024.100046","volume":"2","author":"Y Yao","year":"2024","unstructured":"Yao Y, Hu Y, Meng X, Feng F, Xu F, Wang G, et al. Dual-targeting liposomal delivery of Sorafenib and docetaxel for enhanced synergistic therapy in advanced hepatocellular carcinoma. Pharmaceutical Science Advances. 2024;2:100046.","journal-title":"Pharmaceutical Science Advances"},{"key":"3758_CR29","doi-asserted-by":"publisher","first-page":"e2408511","DOI":"10.1002\/adma.202408511","volume":"36","author":"J Lan","year":"2024","unstructured":"Lan J, Zeng R, Li Z, Yang X, Liu L, Chen L, Sun L, Shen Y, Zhang T, Ding Y. Biomimetic nanomodulators with synergism of photothermal therapy and vessel normalization for boosting potent anticancer immunity. Adv Mater. 2024;36:e2408511.","journal-title":"Adv Mater"},{"key":"3758_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202410841","volume":"34","author":"W Xiong","year":"2024","unstructured":"Xiong W, Cheng Z, Chen H, Liang H, Wang M, Chen Y, et al. Biomimetic tumor cell membrane-encapsulated nanoparticles combine NIR-II photothermal therapy and chemotherapy for enhanced immunotherapy in Triple-Negative breast cancer. Adv Funct Mater. 2024;34:2410841.","journal-title":"Adv Funct Mater"},{"key":"3758_CR31","doi-asserted-by":"publisher","first-page":"10979","DOI":"10.1021\/acsnano.3c11154","volume":"18","author":"G Liang","year":"2024","unstructured":"Liang G, Cao W, Tang D, Zhang H, Yu Y, Ding J, Karges J, Xiao H, Nanomedomics. ACS Nano. 2024;18:10979\u20131024.","journal-title":"ACS Nano"},{"key":"3758_CR32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12943-025-02242-9","volume":"24","author":"C Qiu","year":"2025","unstructured":"Qiu C, Xia F, Tu Q, Tang H, Liu Y, Liu H, Wang C, Yao H, Zhong L, Fu Y, et al. Multimodal lung cancer theranostics via manganese phosphate\/quercetin particle. Mol Cancer. 2025;24:43.","journal-title":"Mol Cancer"},{"key":"3758_CR33","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/972913","volume":"2013","author":"N Traverso","year":"2013","unstructured":"Traverso N, Ricciarelli R, Nitti M, Marengo B, Furfaro AL, Pronzato MA, et al. Role of glutathione in cancer progression and chemoresistance. Oxid Med Cell Longev. 2013;2013:972913.","journal-title":"Oxid Med Cell Longev"},{"key":"3758_CR34","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171:273\u201385.","journal-title":"Cell"},{"key":"3758_CR35","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156:317\u201331.","journal-title":"Cell"},{"key":"3758_CR36","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1182\/blood-2018-99-112198","volume":"132","author":"P La","year":"2018","unstructured":"La P, Ghiaccio V, Zhang J, Rivella S. An orchestrated balance between mitochondria biogenesis, iron-sulfur cluster synthesis and cellular iron acquisition. Blood. 2018;132:1048\u20131048.","journal-title":"Blood"},{"key":"3758_CR37","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.jconrel.2022.06.002","volume":"348","author":"Y Han","year":"2022","unstructured":"Han Y, Dong Z, Wang C, Li Q, Hao Y, Yang Z, Zhu W, Zhang Y, Liu Z, Feng L. Ferrous ions doped calcium carbonate nanoparticles potentiate chemotherapy by inducing ferroptosis. J Control Release. 2022;348:346\u201356.","journal-title":"J Control Release"},{"key":"3758_CR38","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202404971","volume":"36","author":"S Lu","year":"2024","unstructured":"Lu S, Li Y, Yu Y. Glutathione-scavenging Celastrol-Cu nanoparticles induce self-amplified cuproptosis for augmented cancer immunotherapy. Adv Mater. 2024;36:e2404971.","journal-title":"Adv Mater"},{"key":"3758_CR39","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202101410","volume":"33","author":"C Xu","year":"2021","unstructured":"Xu C, Jiang Y, Huang J, Huang J, Pu K. Second near-infrared light-activatable polymeric nanoantagonist for photothermal immunometabolic cancer therapy. Adv Mater. 2021;33:e2101410.","journal-title":"Adv Mater"},{"key":"3758_CR40","doi-asserted-by":"publisher","first-page":"3676","DOI":"10.1038\/s41467-022-31218-2","volume":"13","author":"B Wiernicki","year":"2022","unstructured":"Wiernicki B, Maschalidi S, Pinney J, Adjemian S, Vanden Berghe T, Ravichandran KS, Vandenabeele P. Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity. Nat Commun. 2022;13:3676.","journal-title":"Nat Commun"},{"key":"3758_CR41","doi-asserted-by":"publisher","first-page":"e2417422","DOI":"10.1002\/adma.202417422","volume":"37","author":"H Xu","year":"2025","unstructured":"Xu H, Qiao X, Liang J, Qiu L, Xue L, Fang Y, Xiang H, Li X, Chen Y, Ding H. Organomolecular ferroelectric nanocatalyst augments tumor immunotherapy by inducing apoptosis and ferroptosis. Adv Mater. 2025;37:e2417422.","journal-title":"Adv Mater"},{"key":"3758_CR42","doi-asserted-by":"publisher","first-page":"6458","DOI":"10.1021\/acsnano.8b02881","volume":"12","author":"F Meng","year":"2018","unstructured":"Meng F, Wang J, Ping Q, Yeo Y. Quantitative assessment of nanoparticle biodistribution by fluorescence imaging, revisited. ACS Nano. 2018;12:6458\u201368.","journal-title":"ACS Nano"},{"key":"3758_CR43","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/s41419-019-1459-7","volume":"10","author":"K He","year":"2019","unstructured":"He K, Jia S, Lou Y, Liu P, Xu LX. Cryo-thermal therapy induces macrophage polarization for durable anti-tumor immunity. Cell Death Dis. 2019;10:216.","journal-title":"Cell Death Dis"},{"key":"3758_CR44","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202306540","volume":"20","author":"Y Lu","year":"2024","unstructured":"Lu Y, Fan L, Wang J, Hu M, Wei B, Shi P, et al. Cancer cell membrane-based materials for biomedical applications. Small. 2024;20:e2306540.","journal-title":"Small"}],"container-title":["Journal of Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03758-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12951-025-03758-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12951-025-03758-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:20:47Z","timestamp":1762874447000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03758-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,11]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3758"],"URL":"https:\/\/doi.org\/10.1186\/s12951-025-03758-4","relation":{},"ISSN":["1477-3155"],"issn-type":[{"value":"1477-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,11]]},"assertion":[{"value":"21 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were conducted in accordance with the Guide for the Care and Use of Laboratory Animals in China and were approved by the Laboratory Animal Ethics Committee of the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences (Ethics Approval No. 2025B070).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"710"}}